1. Fruits and vegetables consumption and the risk of histological subtypes of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)
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Petra H.M. Peeters, C. Navarro, Françoise Clavel-Chapelon, H. B. Bueno-De-Mesquita, Tonje Braaten, Kim Overvad, Salvatore Panico, Teresa Norat, Marina Touillaud, E. Wirfält, Eva Ardanaz, M. C. Boutron-Ruault, Rudolf Kaaks, Sabina Sieri, Inger T. Gram, Sabine Rohrmann, Martine M. Ros, Carlos Martinez, Elio Riboli, Sheila Bingham, Domenico Palli, Antonia Trichopoulou, Timothy J. Key, Jonas Manjer, Lambertus A. Kiemeney, Andrew W. Roddam, Antonio Agudo, Rosario Tumino, Louise Hansen, Torgny Rasmuson, C. H. van Gils, K-T Khaw, Paolo Vineis, Dominique S. Michaud, Heiner Boeing, Jakob Linseisen, Dimosthenis Zylis, Eiliv Lund, Nadia Slimani, Graham Byrnes, Anne Tjønneland, Ole Raaschou-Nielsen, U. Nöthlings, Hendriek C. Boshuizen, Göran Hallmans, L. Arriola, P. Bofetta, Frederike L. Büchner, Vardis Dilis, L. Rodríguez, Büchner, Fl, Bueno de Mesquita, Hb, Linseisen, J, Boshuizen, Hc, Kiemeney, La, Rosmm, Overvad, K, Hansen, L, Tjonneland, A, Raaschou Nielsen, O, Clavel Chapelon, F, Boutron Ruault, Mc, Touillaud, M, Kaaks, R, Rohrmann, S, Boeing, H, Nöthlings, U, Trichopoulou, A, Zylis, D, Dilis, V, Palli, D, Sieri, S, Vineis, P, Tumino, R, Panico, Salvatore, Peeters, Ph, van Gils, Ch, Lund, E, Gram, It, Braaten, T, Martinez, C, Agudo, A, Arriolal, Ardanaz, E, Navarro, C, Rodríguez, L, Manjer, J, Wirfält, E, Hallmans, G, Rasmusont, Key, Tj, Roddam, Aw, Bingham, S, Khaw, Kt, Slimani, N, Bofetta, P, Byrnes, G, Noratt, Michaud, D, and Riboli, E.
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Oncology ,Male ,Cancer Research ,Pathology ,Lung Neoplasms ,Aetiology, screening and detection [ONCOL 5] ,Antioxidants ,0302 clinical medicine ,Carcinoma, Non-Small-Cell Lung ,Vegetables ,Odds Ratio ,Medicine ,Non-small-cell lung carcinoma ,Prospective Studies ,Carcinoma, Small Cell ,Prospective cohort study ,Public, Environmental & Occupational Health ,2. Zero hunger ,0303 health sciences ,Smoking ,WOMEN ,MEN ,Middle Aged ,3. Good health ,European Prospective Investigation into Cancer and Nutrition ,Europe ,Large cell carcinoma ,Research Design ,030220 oncology & carcinogenesis ,Adenocarcinoma ,Female ,Small Cell Lung Carcinoma ,Risk assessment ,Life Sciences & Biomedicine ,Adult ,medicine.medical_specialty ,DIET ,Fruits ,Molecular epidemiology [NCEBP 1] ,03 medical and health sciences ,Young Adult ,Internal medicine ,Humans ,COHORT ,Small cell lung carcinoma ,ddc:610 ,Lung cancer ,030304 developmental biology ,Proportional Hazards Models ,Original Paper ,Science & Technology ,business.industry ,Large cell ,Odds ratio ,medicine.disease ,ONCOLOGY ,Evaluation of complex medical interventions [NCEBP 2] ,Fruit ,PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH, SCI ,Multivariate Analysis ,business - Abstract
Contains fulltext : 88547.pdf (Publisher’s version ) (Closed access) OBJECTIVE: To examine the association between fruit and vegetable consumption and risk of different histological subtypes of lung cancer among participants of the European Prospective Investigation into Cancer and Nutrition study. METHODS: Multivariable Cox proportional hazard models were used to analyze the data. A calibration study in a subsample was used to reduce dietary measurement errors. RESULTS: During a mean follow-up of 8.7 years, 1,830 incident cases of lung cancer (574 adenocarcinoma, 286 small cell, 137 large cell, 363 squamous cell, 470 other histologies) were identified. In line with our previous conclusions, we found that after calibration a 100 g/day increase in fruit and vegetables consumption was associated with a reduced lung cancer risk (HR 0.94; 95% CI 0.89-0.99). This was also seen among current smokers (HR 0.93; 95% CI 0.90-0.97). Risks of squamous cell carcinomas in current smokers were reduced for an increase of 100 g/day of fruit and vegetables combined (HR 0.85; 95% CI 0.76-0.94), while no clear effects were seen for the other histological subtypes. CONCLUSION: We observed inverse associations between the consumption of vegetables and fruits and risk of lung cancer without a clear effect on specific histological subtypes of lung cancer. In current smokers, consumption of vegetables and fruits may reduce lung cancer risk, in particular the risk of squamous cell carcinomas. 01 maart 2010
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- 2009
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