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1. Impact of Lipidic Plaque on In-Stent and Stent Edge–Related Events After PCI in Myocardial Infarction: A PROSPECT II Substudy

Author

Kjøller-Hansen, Lars, Maehara, Akiko, Kelbæk, Henning, Matsumura, Mitsuaki, Maeng, Michael, Engstrøm, Thomas, Fröbert, Ole, Persson, Jonas, Wiseth, Rune, Larsen, Alf Inge, Jensen, Lisette Okkels, Nordrehaug, Jan Erik, Omerovic, Elmir, Held, Claes, James, Stefan, Mintz, Gary S., Ali, Ziad A., Stone, Gregg W., and Erlinge, David

Published
2024
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2. Discharge Information About Adverse Drug Reactions Indicates Lower Self-Reported Adverse Drug Reactions and Fewer Concerns in Patients After Percutaneous Coronary Intervention

Author

Pettersen, Trond Røed, Schjøtt, Jan, Allore, Heather, Bendz, Bjørn, Borregaard, Britt, Fridlund, Bengt, Hadjistavropoulos, Heather D., Larsen, Alf Inge, Nordrehaug, Jan Erik, Rasmussen, Trine Bernholdt, Rotevatn, Svein, Valaker, Irene, Wentzel-Larsen, Tore, and Norekvål, Tone M.

Published
2024
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3. mpact of Lipidic Plaque on In-Stent and Stent Edge–Related Events After PCI in Myocardial Infarction: A PROSPECT II Substudy.

Author

Kjøller-Hansen, Lars, Maehara, Akiko, Kelbæk, Henning, Matsumura, Mitsuaki, Maeng, Michael, Engstrøm, Thomas, Fröbert, Ole, Persson, Jonas, Wiseth, Rune, Larsen, Alf Inge, Jensen, Lisette Okkels, Nordrehaug, Jan Erik, Omerovic, Elmir, Held, Claes, James, Stefan, Mintz, Gary S., Ali, Ziad A., Stone, Gregg W., and Erlinge, David

Abstract

BACKGROUND: Lipid content in untreated nonobstructive coronary artery lesions is associated with adverse clinical outcomes, and residual in-stent or stent edge lipid may worsen outcomes after percutaneous coronary intervention (PCI). METHODS: Near-infrared spectroscopy-intravascular ultrasound was performed before and after PCI in patients with myocardial infarction. We evaluated the impact of lipid assessed by near-infrared spectroscopy (maximal lipid core burden index over 4 mm [maxLCBI4mm]) along with intravascular ultrasound information including residual plaque burden on in-stent or edge-related major adverse cardiac events (MACE) in de novo PCI-treated culprit coronary artery lesions. The primary end point was culprit lesion-related MACE (CL-MACE), defined as cardiac death, myocardial infarction, or unstable or progressive angina either requiring revascularization or with rapid lesion progression and classified as in-stent or stent edge–related. RESULTS: During a median follow-up of 3.8 years, 25 CL-MACE (11 stent edge–related, 13 in-stent, and 1 in-lesion without a stent) occurred in 1041 PCI-treated lesions in 768 patients. Pre-PCI or post-PCI measures of lipid content were not related to in-stent CL-MACE. However, stent edge–related CL-MACE was increased if both the post-PCI stent edge maxLCBI4mm was greater than the upper quartile (108.7) and the stent edge plaque burden was >50% (adjusted odds ratio, 4.11 [95% CI, 1.12–15.2]; P=0.03). CONCLUSIONS: In PROSPECT II (Providing Regional Observations to Study Predictors of Events in the Coronary Tree), CL stent implantation leaving behind greater stent edge–related lipid and uncovered plaque burden was associated with an increased risk of stent edge–related CL-MACE during follow-up. In contrast, CL lipid content was not related to in-stent CL-MACE. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Delirium is frequently underdiagnosed among older hospitalised patients despite available information in hospital medical records

Author

Titlestad, Irit, primary, Haugarvoll, Kristoffer, additional, Solvang, Stein-Erik H, additional, Norekvål, Tone Merete, additional, Skogseth, Ragnhild E, additional, Andreassen, Ole A, additional, Årsland, Dag, additional, Neerland, Bjørn Erik, additional, Nordrehaug, Jan Erik, additional, Tell, Grethe S, additional, and Giil, Lasse M, additional

Published
2024
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7. Baseline frailty status and outcomes important for shared decision-making in older adults receiving transcatheter aortic valve implantation, a prospective observational study

Author

Skaar, Elisabeth, Øksnes, Anja, Eide, Leslie Sofia Pareja, Norekvål, Tone Merete, Ranhoff, Anette Hylen, Nordrehaug, Jan Erik, Forman, Daniel Edward, Schoenenberger, Andreas W., Hufthammer, Karl Ove, Kuiper, Karel Kier-Jan, Bleie, Øyvind, Packer, Erik Jerome Stene, Langørgen, Jørund, Haaverstad, Rune, and Schaufel, Margrethe Aase

Published
2021
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12. Sex-specific responses in glucose-insulin homeostasis and lipoprotein-lipid components after high-dose supplementation with marine n-3 PUFAs in abdominal obesity: a randomized double-blind crossover study

Author

Laupsa-Borge, Johnny, primary, Grytten, Elise, additional, Bohov, Pavol, additional, Bjørndal, Bodil, additional, Strand, Elin, additional, Skorve, Jon, additional, Nordrehaug, Jan Erik, additional, Berge, Rolf K., additional, Rostrup, Espen, additional, Mellgren, Gunnar, additional, Dankel, Simon N., additional, and Nygård, Ottar K., additional

Published
2023
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16. The inverse association between the apolipoprotein E ε4 allele and C‐reactive protein levels is stronger in persons with obesity and diabetes.

Author

Giil, Lasse Melvaer, Hanseth, Silja, Bojovic, Ognjen, Nordrehaug, Jan Erik, Ueland, Per Magne, Meyer, Klaus, and Tell, Grethe S.

Subjects
APOLIPOPROTEIN E, DIABETES, MANN Whitney U Test, STATINS (Cardiovascular agents), BODY mass index
Abstract

Background: C‐reactive protein (CRP) is lower in patients who carry the apolipoprotein E epsilon 4 allele variant (APOEε4) of the APOE gene. This could however be explained by other factors observed in APOEε4 carriers, such as lower body mass index (BMI), possibly less diabetes and more use of statins, all associated with CRP concentrations. Objectives: To assess the association between CRP and APOEε4 stratified by BMI, statin use and diabetes. Methods: We included 2700 community‐dwelling older adults from the Hordaland health study with genotyping of the APOE gene by a one‐step polymerase chain reaction and CRP measured using immuno‐MALDI‐TOF MS. Differences in CRP concentrations by APOE (ε4 vs no ε4) were assessed using the Mann–Whitney U tests, also stratified by statin use, diabetes and BMI categories. Finally, we performed linear regression with log (CRP) as the outcome and APOEε4 together with statin use, diabetes, BMI and their respective interactions. Results: CRP was higher in APOEε4 carriers irrespective of BMI, diabetes and statin use. In APOEε4 non‐carriers, CRP was elevated with diabetes and obesity as expected. However, this was attenuated or even reversed in APOEε4 carriers. Such differences were not observed for statin use. Conclusions: Statin use, obesity or diabetes did not confound the known association between the APOEε4 allele and lower CRP. Our data suggest that CRP is less responsive to inflammatory cues involved in diabetes and obesity in APOEε4 carriers. Epidemiological studies should take note of these relationships, as CRP, APOEε4, diabetes and obesity are both linked to neurodegenerative and cardiovascular disease. [ABSTRACT FROM AUTHOR]

Published
2024
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20. The Effect of Protease-Activated Receptor-1 (PAR-1) Inhibition on Endothelial-Related Biomarkers in Patients with Coronary Artery Disease

Author

Nilsen, Dennis W. T., additional, Røysland, Michelle, additional, Ueland, Thor, additional, Aukrust, Pål, additional, Michelsen, Annika E., additional, Staines, Harry, additional, Barvik, Ståle, additional, Kontny, Frederic, additional, Nordrehaug, Jan Erik, additional, and Bonarjee, Vernon V. S., additional

Published
2022
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21. Everolimus-eluting bioresorbable scaffold versus everolimus-eluting metallic stent in primary percutaneous coronary intervention of ST-segment elevation myocardial infarction: a randomized controlled trial

Author

Eriksen, Erlend, primary, Neghabat, Omeed, additional, Saeed, Sahrai, additional, Herstad, Jon, additional, Nordrehaug, Jan Erik, additional, Tuseth, Vegard, additional, Holm, Niels Ramsing, additional, Holck, Emil Nielsen, additional, Sejr-Hansen, Martin, additional, Maule, Camilla Fox, additional, Barkholt, Trine Ørhøj, additional, Andreasen, Lene Nyhus, additional, Christiansen, Evald Høj, additional, and Bleie, Øyvind, additional

Published
2022
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22. Kynurenine Pathway Metabolites in the Blood and Cerebrospinal Fluid Are Associated with Human Aging

Author

Solvang, Stein-Erik H., primary, Hodge, Allison, additional, Watne, Leiv Otto, additional, Cabral-Marques, Otavio, additional, Nordrehaug, Jan Erik, additional, Giles, Graham G., additional, Dugué, Pierre-Antoine, additional, Nygård, Ottar, additional, Ueland, Per Magne, additional, McCann, Adrian, additional, Idland, Ane-Victoria, additional, Midttun, Øivind, additional, Ulvik, Arve, additional, Halaas, Nathalie B., additional, Tell, Grethe S., additional, and Giil, Lasse M., additional

Published
2022
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23. Perceptions of generic medicines and medication adherence after percutaneous coronary intervention: a prospective multicentre cohort study

Author

Pettersen, Trond Røed, primary, Schjøtt, Jan, additional, Allore, Heather G, additional, Bendz, Bjørn, additional, Borregaard, Britt, additional, Fridlund, Bengt, additional, Larsen, Alf Inge, additional, Nordrehaug, Jan Erik, additional, Rotevatn, Svein, additional, Wentzel-Larsen, Tore, additional, and Norekvål, Tone Merete, additional

Published
2022
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26. Perceptions of generic medicines and medication adherence after percutaneous coronary intervention : a prospective multicentre cohort study

Author

Pettersen, Trond Roed, Schjott, Jan, Allore, Heather G., Bendz, Bjorn, Borregaard, Britt, Fridlund, Bengt, Larsen, Alf Inge, Nordrehaug, Jan Erik, Rotevatn, Svein, Wentzel-Larsen, Tore, Norekval, Tone Merete, Pettersen, Trond Roed, Schjott, Jan, Allore, Heather G., Bendz, Bjorn, Borregaard, Britt, Fridlund, Bengt, Larsen, Alf Inge, Nordrehaug, Jan Erik, Rotevatn, Svein, Wentzel-Larsen, Tore, and Norekval, Tone Merete

Abstract

Objective To determine patient perceptions of generic medicines 2 and 6 months after percutaneous coronary intervention (PCI), and to determine whether these perceptions moderate medication adherence. Design Prospective multicentre cohort study with repeated measures of perceptions of generic medicines and medication adherence. Setting The CONCARD(PCI) study conducted at seven large referral PCI centres in Norway and Denmark between June 2017 and May 2020. Participants A total of 3417 adults (78% men), using both generic and brand name medicines, with a mean age of 66 years (SD 11) who underwent PCI were followed up 2 and 6 months after discharge from hospital. Main outcome measures Perceptions of generic medicines were the main outcome. The secondary outcome was medication adherence. Results Perceptions of generic medicines were significantly more negative at 2 than at 6 months (1.10, 95% CI 0.41 to 1.79, p=0.002). Female sex (-4.21, 95% CI -6.75 to -1.71, p=0.001), older age (-0.12, 95% CI -0.23 to -0.02, p=0.020), lower education level (overall p<0.001), ethnicity (overall p=0.002), Norwegian nationality (10.27, 95% CI 8.19 to 12.40, p<0.001) and reduced self-reported health status (0.19, 95% CI 0.09 to 0.41, p=0.003) were significantly associated with negative perceptions of generic medicines. There was no evidence to suggest that perceptions of generic medicines moderate the association between sociodemographic and clinical variables and medication adherence (p >= 0.077 for all covariates). Moreover, self-reported medication adherence was high, with 99% scoring at or above the Medication Adherence Report Scale midpoint at both time points. There were no substantial correlations between negative perceptions of generic medicines and medication non-adherence at 2 months (r=0.041, 95% CI 0.002 to 0.081, p=0.037) or 6 months (r=0.038, 95% CI -0.005 to 0.081, p=0.057). Conclusions Mistrust and uncertainty about the safety and efficacy of generic medicines re

Published
2022
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33. Drug-eluting versus bare metal stents in saphenous vein grafts compared to native coronary vessels. The NORSTENT study.

Author

Mølstad, Per Morten, primary, Nordrehaug, Jan Erik, additional, Steigen, Terje K., additional, Wilsgaard, Tom, additional, Wiseth, Rune, additional, Rotevatn, Svein, additional, Mannsverk, Jan, additional, Larsen, Tommy, additional, Larsby, Kristina Elisabet, additional, Skarstad, Sigrun Ådnegard, additional, Fosse, Eivind Øygard, additional, Dahl-Eriksen, Øystein, additional, and Bønaa, Kaare Harald, additional

Published
2021
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34. Everolimus-eluting bioresorbable scaffold versus everolimus-eluting metallic stent in primary percutaneous coronary intervention of ST-segment elevation myocardial infarction: a randomized controlled trial.

Author

Eriksen, Erlend, Neghabat, Omeed, Saeed, Sahrai, Herstad, Jon, Nordrehaug, Jan Erik, Tuseth, Vegard, Holm, Niels Ramsing, Holck, Emil Nielsen, Sejr-Hansen, Martin, Maule, Camilla Fox, Barkholt, Trine Ørhøj, Andreasen, Lene Nyhus, Christiansen, Evald Høj, and Bleie, Øyvind

Published
2023
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36. TCT-84 Serial NIRS-IVUS Assessment of Changes in Coronary Lumen Area During 2-Year Follow-Up: Insights From the PROSPECT ABSORB Trial

Author

Matsumura, Mitsuaki, primary, Maehara, Akiko, additional, Mintz, Gary, additional, Ben-Yehuda, Ori, additional, Maeng, Michael, additional, Kjoller-Hansen, Lars, additional, Engstroem, Thomas, additional, Fröbert, Ole, additional, Persson, Jonas, additional, Wiseth, Rune, additional, Larsen, Alf Inge, additional, Jensen, Lisette Okkels, additional, Nordrehaug, Jan Erik, additional, Bleie, Oyvind, additional, Omerovic, Elmir, additional, Zhou, Zhipeng, additional, Held, Claes, additional, James, Stefan, additional, Ali, Ziad, additional, Erlinge, David, additional, and Stone, Gregg, additional

Published
2021
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37. TCT-79 Changes in Coronary Lipid Composition During 2-Year Follow-Up After Acute Myocardial Infarction: Serial NIRS-IVUS Assessment From the PROSPECT ABSORB Trial

Author

Matsumura, Mitsuaki, primary, Maehara, Akiko, additional, Zhou, Zhipeng, additional, Mintz, Gary, additional, Ben-Yehuda, Ori, additional, Maeng, Michael, additional, Kjoller-Hansen, Lars, additional, Engstroem, Thomas, additional, Fröbert, Ole, additional, Persson, Jonas, additional, Wiseth, Rune, additional, Larsen, Alf Inge, additional, Jensen, Lisette Okkels, additional, Nordrehaug, Jan Erik, additional, Bleie, Oyvind, additional, Omerovic, Elmir, additional, Held, Claes, additional, James, Stefan, additional, Ali, Ziad, additional, Erlinge, David, additional, and Stone, Gregg, additional

Published
2021
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38. Effect of intravenous TRO40303 as an adjunct to primary percutaneous coronary intervention for acute ST-elevation myocardial infarction: MITOCARE study results

Author

Atar, Dan, Arheden, Håkan, Berdeaux, Alain, Bonnet, Jean-Louis, Carlsson, Marcus, Clemmensen, Peter, Cuvier, Valérie, Danchin, Nicolas, Dubois-Randé, Jean-Luc, Engblom, Henrik, Erlinge, David, Firat, Hüseyin, Halvorsen, Sigrun, Hansen, Henrik Steen, Hauke, Wilfried, Heiberg, Einar, Koul, Sasha, Larsen, Alf-Inge, Le Corvoisier, Philippe, Nordrehaug, Jan Erik, Paganelli, Franck, Pruss, Rebecca M., Rousseau, Hélène, Schaller, Sophie, Sonou, Giles, Tuseth, Vegard, Veys, Julien, Vicaut, Eric, and Jensen, Svend Eggert

Published
2015
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41. Effects of Add-On Left Ventricular Assist Device to Extracorporeal Membrane Oxygenation During Refractory Cardiac Arrest in a Porcine Model

Author

Packer, Erik J. S., primary, Solholm, Atle, additional, Omdal, Tom Roar, additional, Stangeland, Lodve, additional, Zhang, Liqun, additional, Mongstad, Arve, additional, Urban, Malte, additional, Wentzel-Larsen, Tore, additional, Haaverstad, Rune, additional, Slettom, Grete, additional, Nordrehaug, Jan Erik, additional, Grong, Ketil, additional, and Tuseth, Vegard, additional

Published
2021
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42. Identification of vulnerable plaques and patients by intracoronary near-infrared spectroscopy and ultrasound (PROSPECT II) : a prospective natural history study

Author

Erlinge, David, Maehara, Akiko, Ben-Yehuda, Ori, Bötker, Hans Erik, Maeng, Michael, Kjöller-Hansen, Lars, Engström, Thomas, Matsumura, Mitsuaki, Crowley, Aaron, Dressler, Ovidiu, Mintz, Gary S., Fröbert, Ole, Persson, Jonas, Wiseth, Rune, Larsen, Alf Inge, Jensen, Lisette Okkels, Nordrehaug, Jan Erik, Bleie, Öyvind, Omerovic, Elmir, Held, Claes, James, Stefan, Ali, Ziad A., Muller, James E., Stone, Gregg W., Christersson, Christina, Sarno, Giovanna, Erlinge, David, Maehara, Akiko, Ben-Yehuda, Ori, Bötker, Hans Erik, Maeng, Michael, Kjöller-Hansen, Lars, Engström, Thomas, Matsumura, Mitsuaki, Crowley, Aaron, Dressler, Ovidiu, Mintz, Gary S., Fröbert, Ole, Persson, Jonas, Wiseth, Rune, Larsen, Alf Inge, Jensen, Lisette Okkels, Nordrehaug, Jan Erik, Bleie, Öyvind, Omerovic, Elmir, Held, Claes, James, Stefan, Ali, Ziad A., Muller, James E., Stone, Gregg W., Christersson, Christina, and Sarno, Giovanna

Abstract

Background: Near-infrared spectroscopy (NIRS) and intravascular ultrasound are promising imaging modalities to identify non-obstructive plaques likely to cause coronary-related events. We aimed to assess whether combined NIRS and intravascular ultrasound can identify high-risk plaques and patients that are at risk for future major adverse cardiac events (MACEs). Methods: PROSPECT II is an investigator-sponsored, multicentre, prospective natural history study done at 14 university hospitals and two community hospitals in Denmark, Norway, and Sweden. We recruited patients of any age with recent (within past 4 weeks) myocardial infarction. After treatment of all flow-limiting coronary lesions, three-vessel imaging was done with a combined NIRS and intravascular ultrasound catheter. Untreated lesions (also known as non-culprit lesions) were identified by intravascular ultrasound and their lipid content was assessed by NIRS. The primary outcome was the covariate-adjusted rate of MACEs (the composite of cardiac death, myocardial infarction, unstable angina, or progressive angina) arising from untreated non-culprit lesions during follow-up. The relations between plaques with high lipid content, large plaque burden, and small lumen areas and patient-level and lesion-level events were determined. This trial is registered with ClinicalTrials.gov, NCT02171065. Findings: Between June 10, 2014, and Dec 20, 2017, 3629 non-culprit lesions were characterised in 898 patients (153 [17%] women, 745 [83%] men; median age 63 [IQR 55-70] years). Median follow-up was 3.7 (IQR 3.0-4.4) years. Adverse events within 4 years occurred in 112 (13.2%, 95% CI 11.0-15.6) of 898 patients, with 66 (8.0%, 95% CI 6.2-10.0) arising from 78 untreated non-culprit lesions (mean baseline angiographic diameter stenosis 46.9% [SD 15.9]). Highly lipidic lesions (851 [24%] of 3500 lesions, present in 520 [59%] of 884 patients) were an independent predictor of patient-level non-culprit lesion-related MACEs (adj

Published
2021
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43. Identification of vulnerable plaques and patients by intracoronary near-infrared spectroscopy and ultrasound (PROSPECT II):a prospective natural history study

Author

Erlinge, David, Maehara, Akiko, Ben-Yehuda, Ori, Bøtker, Hans Erik, Maeng, Michael, Kjøller-Hansen, Lars, Engstrøm, Thomas, Matsumura, Mitsuaki, Crowley, Aaron, Dressler, Ovidiu, Mintz, Gary S., Fröbert, Ole, Persson, Jonas, Wiseth, Rune, Larsen, Alf Inge, Okkels Jensen, Lisette, Nordrehaug, Jan Erik, Bleie, Øyvind, Omerovic, Elmir, Held, Claes, James, Stefan K., Ali, Ziad A., Muller, James E., Stone, Gregg W., Ahlehoff, Ole, Amin, Azad, Angerås, Oskar, Appikonda, Praveen, Balachandran, Saranya, Barvik, Ståle, Bendix, Kristoffer, Bertilsson, Maria, Boden, Ulrika, Bogale, Nigussie, Bonarjee, Vernon, Calais, Fredrik, Carlsson, Jörg, Carstensen, Steen, Christersson, Christina, Christiansen, Evald Høj, Corral, Maria, De Backer, Ole, Helqvist, Steffen, Holmvang, Lene, Iversen, Allan, Jørgensen, Erik, Kelbæk, Henning, Lønborg, Jacob, Sørensen, Rikke, Thuesen, Anne, Erlinge, David, Maehara, Akiko, Ben-Yehuda, Ori, Bøtker, Hans Erik, Maeng, Michael, Kjøller-Hansen, Lars, Engstrøm, Thomas, Matsumura, Mitsuaki, Crowley, Aaron, Dressler, Ovidiu, Mintz, Gary S., Fröbert, Ole, Persson, Jonas, Wiseth, Rune, Larsen, Alf Inge, Okkels Jensen, Lisette, Nordrehaug, Jan Erik, Bleie, Øyvind, Omerovic, Elmir, Held, Claes, James, Stefan K., Ali, Ziad A., Muller, James E., Stone, Gregg W., Ahlehoff, Ole, Amin, Azad, Angerås, Oskar, Appikonda, Praveen, Balachandran, Saranya, Barvik, Ståle, Bendix, Kristoffer, Bertilsson, Maria, Boden, Ulrika, Bogale, Nigussie, Bonarjee, Vernon, Calais, Fredrik, Carlsson, Jörg, Carstensen, Steen, Christersson, Christina, Christiansen, Evald Høj, Corral, Maria, De Backer, Ole, Helqvist, Steffen, Holmvang, Lene, Iversen, Allan, Jørgensen, Erik, Kelbæk, Henning, Lønborg, Jacob, Sørensen, Rikke, and Thuesen, Anne

Abstract

Background: Near-infrared spectroscopy (NIRS) and intravascular ultrasound are promising imaging modalities to identify non-obstructive plaques likely to cause coronary-related events. We aimed to assess whether combined NIRS and intravascular ultrasound can identify high-risk plaques and patients that are at risk for future major adverse cardiac events (MACEs). Methods: PROSPECT II is an investigator-sponsored, multicentre, prospective natural history study done at 14 university hospitals and two community hospitals in Denmark, Norway, and Sweden. We recruited patients of any age with recent (within past 4 weeks) myocardial infarction. After treatment of all flow-limiting coronary lesions, three-vessel imaging was done with a combined NIRS and intravascular ultrasound catheter. Untreated lesions (also known as non-culprit lesions) were identified by intravascular ultrasound and their lipid content was assessed by NIRS. The primary outcome was the covariate-adjusted rate of MACEs (the composite of cardiac death, myocardial infarction, unstable angina, or progressive angina) arising from untreated non-culprit lesions during follow-up. The relations between plaques with high lipid content, large plaque burden, and small lumen areas and patient-level and lesion-level events were determined. This trial is registered with ClinicalTrials.gov, NCT02171065. Findings: Between June 10, 2014, and Dec 20, 2017, 3629 non-culprit lesions were characterised in 898 patients (153 [17%] women, 745 [83%] men; median age 63 [IQR 55–70] years). Median follow-up was 3·7 (IQR 3·0–4·4) years. Adverse events within 4 years occurred in 112 (13·2%, 95% CI 11·0–15·6) of 898 patients, with 66 (8·0%, 95% CI 6·2–10·0) arising from 78 untreated non-culprit lesions (mean baseline angiographic diameter stenosis 46·9% [SD 15·9]). Highly lipidic lesions (851 [24%] of 3500 lesions, present in 520 [59%] of 884 patients) were an independent predictor of patient-level non-culprit lesion-related MACEs (

Published
2021

44. Serial NIRS-IVUS Assessment of Changes in Coronary Lumen Area During 2-Year Follow-Up : Insights From the PROSPECT ABSORB Trial

Author

Matsumura, Mitsuaki, Maehara, Akiko, Mintz, Gary, Ben-Yehuda, Ori, Maeng, Michael, Kjoller-Hansen, Lars, Engstroem, Thomas, Fröbert, Ole, Persson, Jonas, Wiseth, Rune, Larsen, Alf Inge, Jensen, Lisette Okkels, Nordrehaug, Jan Erik, Bleie, Oyvind, Omerovic, Elmir, Zhou, Zhipeng, Held, Claes, James, Stefan, Ali, Ziad, Erlinge, David, Stone, Gregg, Matsumura, Mitsuaki, Maehara, Akiko, Mintz, Gary, Ben-Yehuda, Ori, Maeng, Michael, Kjoller-Hansen, Lars, Engstroem, Thomas, Fröbert, Ole, Persson, Jonas, Wiseth, Rune, Larsen, Alf Inge, Jensen, Lisette Okkels, Nordrehaug, Jan Erik, Bleie, Oyvind, Omerovic, Elmir, Zhou, Zhipeng, Held, Claes, James, Stefan, Ali, Ziad, Erlinge, David, and Stone, Gregg

Abstract

Background: In PROSPECT II, 182 patients with plaque burden (PB) ≥ 65% were randomized to bioresorbable vascular scaffold (BVS) + guideline-directed medical therapy (GDMT) versus GDMT alone. Protocol-directed 3-vessel near-infrared spectroscopy (NIRS)-IVUS was repeated at 25 months. Methods: Excluding lesions treated by BVS, paired (baseline and follow-up) NIRS-IVUS was available in 626 nonculprit lesions in 165 patients. Follow-up minimum lumen area (MLA) and the corresponding baseline sites were measured: rapid lesion progression (RLP) was a ≥ 0.5 mm2 decrease of MLA, and rapid lesion regression (RLR) was a ≥ 0.5 mm2 increase of MLA. Results: RLP occurred in 34.5%, RLR occurred in 15.5%, and 49.8% had “no change.” The % change in vessel area correlated with the % change of plaque area (r = 0.81, P < 0.001), demonstrating vessel remodeling (Figure 1). At baseline, the RLP lesions had larger plaque areas, longer lesions, and higher prevalence of lipid-rich plaque (maxLCBI4mm ≥ 324.7). During follow-up, 80.2% of RLP lesions had negative remodeling irrespective of the change in plaque area, whereas 76.3% of RLR lesions had a decrease in plaque area irrespective of negative or positive remodeling. In lesions without change in lumen area, there were compensatory changes in plaque and vessel areas. Conclusion: In stabilized patients post-MI treated with GDMT, half of untreated non–flow- limiting lesions had significant lumen changes at 25 months, with RLP twice as frequent as RLR. The predominant mechanism of RLP was negative vessel remodeling whereas the predominant mechanism of RLR was reduction in plaque area.

Published
2021

47. Cancer incidence and mortality after treatment with folic acid and vitamin B12

Author

Ebbing, Marta, Bonaa, Kaare Harald, Nygard, Ottar, Arnesen, Egil, Ueland, Per Magne, Nordrehaug, Jan Erik, Rasmussen, Knut, Njolstad, Inger, Refsum, Helga, Nilsen, Dennis W., Tverdal, Aage, Meyer, Klaus, and Vollset, Stein Emil

Subjects
Cancer -- Care and treatment, Folic acid -- Usage, Mortality -- United States, Mortality -- Causes of, Vitamin B12 -- Usage
Abstract

The study attempts to evaluate the efficacy of vitamin B12 treatment on cancer outcomes and mortality. The results indicate that treatment with vitamin B12 and folic acid led to increased outcomes and mortality among patients with ischemic heart disease where folic acid fortification of foods was not given.

Published
2009

48. Changes in lipoprotein particle subclasses, standard lipids, and apolipoproteins after supplementation with n-3 or n-6 PUFAs in abdominal obesity: A randomized double-blind crossover study

Author

Grytten, Elise, primary, Laupsa-Borge, Johnny, additional, Bohov, Pavol, additional, Bjørndal, Bodil, additional, Strand, Elin, additional, Skorve, Jon, additional, Nordrehaug, Jan Erik, additional, Berge, Rolf K., additional, Rostrup, Espen, additional, Mellgren, Gunnar, additional, Dankel, Simon N., additional, and Nygård, Ottar K., additional

Published
2021
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49. Incidence and risk factors for major bleeding among patients undergoing percutaneous coronary intervention: Findings from the Norwegian Coronary Stent Trial (NORSTENT)

Author

Samuelsen, Per-Jostein, primary, Eggen, Anne Elise, additional, Steigen, Terje, additional, Wilsgaard, Tom, additional, Kristensen, Andreas, additional, Skogsholm, Anne, additional, Holme, Elizabeth, additional, van den Heuvel, Christian, additional, Nordrehaug, Jan Erik, additional, Bendz, Bjørn, additional, Nilsen, Dennis W. T., additional, and Bønaa, Kaare Harald, additional

Published
2021
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50. Identification of vulnerable plaques and patients by intracoronary near-infrared spectroscopy and ultrasound (PROSPECT II): a prospective natural history study

Author

Erlinge, David, primary, Maehara, Akiko, additional, Ben-Yehuda, Ori, additional, Bøtker, Hans Erik, additional, Maeng, Michael, additional, Kjøller-Hansen, Lars, additional, Engstrøm, Thomas, additional, Matsumura, Mitsuaki, additional, Crowley, Aaron, additional, Dressler, Ovidiu, additional, Mintz, Gary S, additional, Fröbert, Ole, additional, Persson, Jonas, additional, Wiseth, Rune, additional, Larsen, Alf Inge, additional, Okkels Jensen, Lisette, additional, Nordrehaug, Jan Erik, additional, Bleie, Øyvind, additional, Omerovic, Elmir, additional, Held, Claes, additional, James, Stefan K, additional, Ali, Ziad A, additional, Muller, James E, additional, Stone, Gregg W, additional, Ahlehoff, Ole, additional, Amin, Azad, additional, Angerås, Oskar, additional, Appikonda, Praveen, additional, Balachandran, Saranya, additional, Barvik, Ståle, additional, Bendix, Kristoffer, additional, Bertilsson, Maria, additional, Boden, Ulrika, additional, Bogale, Nigussie, additional, Bonarjee, Vernon, additional, Calais, Fredrik, additional, Carlsson, Jörg, additional, Carstensen, Steen, additional, Christersson, Christina, additional, Christiansen, Evald Høj, additional, Corral, Maria, additional, De Backer, Ole, additional, Dhaha, Usama, additional, Dworeck, Christian, additional, Eggers, Kai, additional, Elfström, Charlotta, additional, Ellert, Julia, additional, Eriksen, Erlend, additional, Fallesen, Christian, additional, Forsman, Margareta, additional, Fransson, Helena, additional, Gaballa, Mohsen, additional, Gacki, Marek, additional, Götberg, Matthias, additional, Hagström, Lars, additional, Hallberg, Theresa, additional, Hambraeus, Kristina, additional, Haraldsson, Inger, additional, Harnek, Jan, additional, Havndrup, Ole, additional, Hegbom, Knut, additional, Heigert, Matthias, additional, Helqvist, Steffen, additional, Herstad, Jon, additional, Hijazi, Ziad, additional, Holmvang, Lene, additional, Ioanes, Dan, additional, Iqbal, Amjid, additional, Iversen, Allan, additional, Jacobson, Jaclyn, additional, Jakobsen, Lars, additional, Jankovic, Ivana, additional, Jensen, Ulf, additional, Jensevik, Karin, additional, Johnston, Nina, additional, Jonasson, Torfi Fjalar, additional, Jørgensen, Erik, additional, Joshi, Francis, additional, Kajermo, Ulf, additional, Kåver, Frida, additional, Kelbæk, Henning, additional, Kellerth, Thomas, additional, Kish, Mitra, additional, Koenig, Wolfgang, additional, Koul, Sasha, additional, Lagerqvist, Bo, additional, Larsson, Bertil, additional, Lassen, Jens Flensted, additional, Leiren, Olav, additional, Li, Zhe, additional, Lidell, Christer, additional, Linder, Rikard, additional, Lindstaedt, Michael, additional, Lindström, Gunilla, additional, Liu, Shen, additional, Løland, Kjetil Halvorsen, additional, Lønborg, Jacob, additional, Márton, László, additional, Mir-Akbari, Habib, additional, Mohamed, Shameema, additional, Odenstedt, Jacob, additional, Ogne, Christer, additional, Oldgren, Jonas, additional, Olivecrona, Göran, additional, Östlund-Papadogeorgos, Nikolas, additional, Ottesen, Michael, additional, Packer, Erik, additional, Palmquist, Åsa Michelgård, additional, Paracha, Quratulain, additional, Pedersen, Frans, additional, Petursson, Petur, additional, Råmunddal, Truls, additional, Rotevatn, Svein, additional, Sanchez, Raquel, additional, Sarno, Giovanna, additional, Saunamäki, Kari I, additional, Scherstén, Fredrik, additional, Serruys, Patrick W, additional, Sjögren, Iwar, additional, Sørensen, Rikke, additional, Srdanovic, Iva, additional, Subhani, Zuka, additional, Svensson, Eva, additional, Thuesen, Anne, additional, Tijssen, Jan, additional, Tilsted, Hans-Henrik, additional, Tödt, Tim, additional, Trovik, Thor, additional, Våga, Bjørn Inge, additional, Varenhorst, Christoph, additional, Veien, Karsten, additional, Vestman, Emma, additional, Völz, Sebastian, additional, Wallentin, Lars, additional, Wykrzykowska, Joanna, additional, Zagozdzon, Leszek, additional, Zamfir, Manuela, additional, Zedigh, Crister, additional, Zhong, Hang, additional, and Zhou, Zhipeng, additional

Published
2021
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