Search

Your search keyword '"Norris, Robert B."' showing total 10 results
Start Over Author "Norris, Robert B."
10 results on '"Norris, Robert B."'

2. Lipid disorders: you could be undertreating patients

Author

Norris, Robert B., Cardenas, Joel, Moghbeli, Nazanin, and Nemiroff, Richard

Subjects
Dyslipidemias -- Care and treatment, Dyslipidemias -- Demographic aspects, Dyslipidemias -- Case studies, Health
Published
2009

3. Oral Apolipoprotein A-I Mimetic D-4F Lowers HDL-Inflammatory Index in High-Risk Patients: A First-in-Human Multiple-Dose, Randomized Controlled Trial.

Author

Dunbar, Richard L., Movva, Rajesh, Bloedon, LeAnne T., Duffy, Danielle, Norris, Robert B., Navab, Mohamad, Fogelman, Alan M., Rader, Daniel J., Dunbar, Richard L., Movva, Rajesh, Bloedon, LeAnne T., Duffy, Danielle, Norris, Robert B., Navab, Mohamad, Fogelman, Alan M., and Rader, Daniel J.

Abstract

A single dose of the apolipoprotein (apo)A-I mimetic peptide D-4F rendered high-density lipoprotein (HDL) less inflammatory, motivating the first multiple-dose study. We aimed to assess safety/tolerability, pharmacokinetics, and pharmacodynamics of daily, orally administered D-4F. High-risk coronary heart disease (CHD) subjects added double-blinded placebo or D-4F to statin for 13 days, randomly assigned 1:3 to ascending cohorts of 100, 300, then 500 mg (n = 62; 46 men/16 women). D-4F was safe and well-tolerated. Mean ± SD plasma D-4F area under the curve (AUC, 0-8h) was 6.9 ± 5.7 ng/mL*h (100 mg), 22.7 ± 19.6 ng/mL*h (300 mg), and 104.0 ± 60.9 ng/mL*h (500 mg) among men, higher among women. Whereas placebo dropped HDL inflammatory index (HII) 28% 8 h postdose (range, 1.25-0.86), 300-500 mg D-4F effectively halved HII: 1.35-0.57 and 1.22-0.63, respectively (P < 0.03 vs. placebo). Oral D-4F peptide dose predicted HII suppression, whereas plasma D-4F exposure was dissociated, suggesting plasma penetration is unnecessary. In conclusion, oral D-4F dosing rendered HDL less inflammatory, affirming oral D-4F as a potential therapy to improve HDL function.

Published
2017

8. Quemoy and Matsu: A Historical Footnote Revisited.

Author

Norris, Robert B.

Subjects
ISLANDS, DEBATE
Abstract

The article focuses on the condition of Chinese islands Quemoy and Matsu, which were the subject during the presidential debates in the U.S. It notes the debate of Senator John F. Kennedy and Vice President Richard Nixon on the U.S. involvement during the invasion of two islands by Taiwan communists, in which the issue became an important factor for Kennedy's victory during election. It cites that the islands were still under Taiwan territory and had become tourists' destinations.

Published
2010

10. Resection of a large atrial hemangioma using a bloodless surgical technique: a case report.

Author

Fan D, Yarnall C, Parmet JL, Norris RB, Isidro AB, Maher MB, and Bridges CR

Subjects
Aged, Female, Heart Atria surgery, Humans, Treatment Outcome, Heart Neoplasms surgery, Hemangioma surgery, Jehovah's Witnesses, Minimally Invasive Surgical Procedures methods, Vascular Surgical Procedures methods
Abstract

We present a biatrial hemangioma in a Jehovah's Witness patient. Hemangioma is extremely rare, accounting for 1% to 2% of benign cardiac tumors. Complete resection of a large hemangioma is mandatory due to its potentially life-threatening risk. In Jehovah's Witness patients, it is necessary to employ bloodless surgery protocols to maximize the patient's outcome. Our patient had undergone 6 weeks of monitoring and erythropoietin therapy prior to surgery, raising her hemoglobin level from 11.6 g/dL to 16.8 g/dL. Intraoperative bloodless surgical protocols as well as a continuous blood circuit were utilized. The patient's hemoglobin level on postoperative day one was 14.5 g/dL; one year postsurgery, the patient was symptom free.

Published
2007
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results