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14 results on '"Noujima-Harada, Mai"'

4. Characteristic Distribution Pattern of CD30-positive Cytotoxic T Cells Aids Diagnosis of Kikuchi-Fujimoto Disease

Author

Tabata, Tetsuya, primary, Takata, Katsuyoshi, additional, Miyata-Takata, Tomoko, additional, Sato, Yasuharu, additional, Ishizawa, Shin, additional, Kunitomo, Tomoyoshi, additional, Nagakita, Keina, additional, Ohnishi, Nobuhiko, additional, Taniguchi, Kohei, additional, Noujima-Harada, Mai, additional, Maeda, Yoshinobu, additional, Tanimoto, Mitsune, additional, and Yoshino, Tadashi, additional

Published
2018
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6. Frequent downregulation of BTB and CNC homology 2 expression in Epstein-Barr virus-positive diffuse large B-cell lymphoma

Author

Noujima-Harada, Mai, primary, Takata, Katsuyoshi, additional, Miyata-Takata, Tomoko, additional, Sakurai, Hiroaki, additional, Igarashi, Kazuhiko, additional, Ito, Etsuro, additional, Nagakita, Keina, additional, Taniguchi, Kohei, additional, Ohnishi, Nobuhiko, additional, Omote, Shizuma, additional, Tabata, Tetsuya, additional, Sato, Yasuharu, additional, and Yoshino, Tadashi, additional

Published
2017
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7. CD10 down expression in follicular lymphoma correlates with gastrointestinal lesion involving the stomach and large intestine

Author

Ohnishi, Nobuhiko, primary, Takata, Katsuyoshi, additional, Miyata‐Takata, Tomoko, additional, Sato, Yasuharu, additional, Tari, Akira, additional, Gion, Yuka, additional, Noujima‐Harada, Mai, additional, Taniguchi, Kohei, additional, Tabata, Tetsuya, additional, Nagakita, Keina, additional, Omote, Shizuma, additional, Takahata, Hiroyuki, additional, Iwamuro, Masaya, additional, Okada, Hiroyuki, additional, Maeda, Yoshinobu, additional, Yanai, Hiroyuki, additional, and Yoshino, Tadashi, additional

Published
2016
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9. Clinicopathological features of 49 primary gastrointestinal diffuse large B-cell lymphoma cases; comparison with location, cell-of-origin, and frequency of MYD88 L265P

Author

Nagakita, Keina, primary, Takata, Katsuyoshi, additional, Taniguchi, Kohei, additional, Miyata-Takata, Tomoko, additional, Sato, Yasuharu, additional, Tari, Akira, additional, Ohnishi, Nobuhiko, additional, Noujima-Harada, Mai, additional, Omote, Shizuma, additional, Nakamura, Naoya, additional, Iwamuro, Masaya, additional, Maeda, Yoshinobu, additional, Okada, Hiroyuki, additional, Tanimoto, Mitsune, additional, and Yoshino, Tadashi, additional

Published
2016
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10. Frequent MYD88 L265P and CD79B Mutations in Primary Breast Diffuse Large B-Cell Lymphoma

Author

Taniguchi, Kohei, primary, Takata, Katsuyoshi, additional, Chuang, Shih-Sung, additional, Miyata-Takata, Tomoko, additional, Sato, Yasuharu, additional, Satou, Akira, additional, Hashimoto, Yuko, additional, Tamura, Maiko, additional, Nagakita, Keina, additional, Ohnishi, Nobuhiko, additional, Noujima-Harada, Mai, additional, Tabata, Tetsuya, additional, Kikuti, Yara Yukie, additional, Maeda, Yoshinobu, additional, Nakamura, Naoya, additional, Tanimoto, Mitsune, additional, and Yoshino, Tadashi, additional

Published
2016
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12. Clinicopathologic Analysis of 6 Lymphomatoid Gastropathy Cases

Author

Takata, Katsuyoshi, primary, Noujima-Harada, Mai, additional, Miyata-Takata, Tomoko, additional, Ichimura, Koichi, additional, Sato, Yasuharu, additional, Miyata, Takafumi, additional, Naruse, Keishi, additional, Iwamoto, Toshiyuki, additional, Tari, Akira, additional, Masunari, Taro, additional, Sonobe, Hiroshi, additional, Okada, Hiroyuki, additional, Iwamuro, Masaya, additional, Mizobuchi, Kohichi, additional, Gion, Yuka, additional, and Yoshino, Tadashi, additional

Published
2015
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14. Frequent MYD88L265P and CD79BMutations in Primary Breast Diffuse Large B-Cell Lymphoma

Author

Taniguchi, Kohei, Takata, Katsuyoshi, Chuang, Shih-Sung, Miyata-Takata, Tomoko, Sato, Yasuharu, Satou, Akira, Hashimoto, Yuko, Tamura, Maiko, Nagakita, Keina, Ohnishi, Nobuhiko, Noujima-Harada, Mai, Tabata, Tetsuya, Kikuti, Yara Yukie, Maeda, Yoshinobu, Nakamura, Naoya, Tanimoto, Mitsune, and Yoshino, Tadashi

Abstract

Supplemental Digital Content is available in the text.Primary breast diffuse large B-cell lymphoma (PB-DLBCL) is a rare disease comprising <3% of extranodal lymphomas. It frequently reveals an activated B-cell (ABC)-like phenotype. ABC-like DLBCL was reported to have gain-of-function mutations in MYD88, CD79B, CARD11, and TNFAIP3, resulting in constitutive activation of the NFκB pathway. Because of the rare occurrence of PB-DLBCL, the frequency of MYD88and CD79Bmutations is still unknown. We used Sanger sequencing to study these mutations from 46 breast DLBCL cases and also investigated the associated clinicopathologic factors. MYD88L265P was confirmed by allele-specific polymerase chain reaction and compared with the Sanger sequencing results. MYD88L265P and CD79Bmutations were detected in 27/46 (58.7%) and 11/33 (33.3%) cases, respectively. Twenty-eight of 46 cases met the criteria for PB-DLBCL, and the latter 18 cases were further classified as clinical breast DLBCL (CLB-DLBCL). The frequency of MYD88L265P and CD79Bmutations was 16/28 (57.1%) and 9/23 (39.1%), respectively, in PB-DLBCL and 11/18 (61.1%) and 2/10 (20%), respectively, in CLB-DLBCL. When the cutoff value was set at ΔCt≤1, the result of allele-specific polymerase chain reaction for MYD88corresponded to those of the Sanger sequence at 92.6% sensitivity and 100% specificity. According to Choi’s algorithm, 16/27 (59.3%) demonstrated an ABC-like phenotype in PB-DLBCL, and 15/18 (83.3%) demonstrated an ABC-like phenotype in CLB-DLBCL. In conclusion, MYD88L265P and CD79Bmutations were frequently detected in PB-DLBCL, and they may be key molecules associated with PB-DLBCL lymphomagenesis. Further analysis will be required to clarify the mechanism of its pathogenesis.

Published
2016
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