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98 results on '"Nour, Y."'

2. The Role of Social Media Presence and Personalization in Increasing Sales and Achieving Sustainable Business Growth

Author

Shmait, Lilian, Hamati, Lea, Remlaoui, Barbara, Khalil, Nour Y., Haidar, Christine, Nasr, Sana, Nasr, Rita, Nemar, Sam El, Hamdan, Allam, Editorial Board Member, Al Madhoun, Wesam, Editorial Board Member, Alareeni, Bahaaeddin, Editor-in-Chief, Baalousha, Mohammed, Editorial Board Member, Elgedawy, Islam, Editorial Board Member, Hussainey, Khaled, Editorial Board Member, Eleyan, Derar, Editorial Board Member, Hamdan, Reem, Editorial Board Member, Salem, Mohammed, Editorial Board Member, Jallouli, Rim, Editorial Board Member, Assaidi, Abdelouahid, Editorial Board Member, Nawi, Noorshella Binti Che, Editorial Board Member, AL-Kayid, Kholoud, Editorial Board Member, Wolf, Martin, Editorial Board Member, El Khoury, Rim, Editorial Board Member, El-Chaarani, Hani, editor, El Dandachi, Ibtihaj, editor, El Nemar, Sam, editor, and EL Abiad, Zouhour, editor

Published
2023
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8. Non-invasive physical plasma for preventing radiation dermatitis in breast cancer: Results from an intrapatient-randomised double-blind placebo-controlled trial

Author

Dejonckheere, C.S., Layer, J.P., Nour, Y., Layer, K., Glasmacher, A., Wiegreffe, S., Fuhrmann, A., Caglayan, L., Grau, F., Sarria, G.R., Scafa, D., Koch, D., Heimann, M., Leitzen, C., Köksal, M.A., Rohner, F., Müdder, T., Dejonckheere, E., Schmeel, F.C., Anzbock, T., Lindner, K., Bachmann, A., Abramian, A., Kaiser, C., Faridi, A., Mustea, A., Giordano, F.A., Stope, M.B., Schmeel, L.C., Dejonckheere, C.S., Layer, J.P., Nour, Y., Layer, K., Glasmacher, A., Wiegreffe, S., Fuhrmann, A., Caglayan, L., Grau, F., Sarria, G.R., Scafa, D., Koch, D., Heimann, M., Leitzen, C., Köksal, M.A., Rohner, F., Müdder, T., Dejonckheere, E., Schmeel, F.C., Anzbock, T., Lindner, K., Bachmann, A., Abramian, A., Kaiser, C., Faridi, A., Mustea, A., Giordano, F.A., Stope, M.B., and Schmeel, L.C.

Abstract

Background and Purpose To investigate the effect of topical non-invasive physical plasma (NIPP), a volatile mix generated out of ambient air, on prevention of acute radiation dermatitis (RD) during and after whole-breast irradiation (WBI). Materials and Methods Lateral and medial breast halves were randomised within each patient to receive either 120 s of NIPP or sham treatment daily during WBI. Standard skin care with urea lotion was applied to the whole breast. Blinded acute skin toxicity was assessed weekly for each breast half separately and included clinician-(CTCAE) and patient-reported (modified RISRAS), and objective (spectrophotometry) assessments. As an additional external control, a comparable standard of care (SoC) patient collective from a previous prospective trial was used. Results Sixty-four patients were included. There were no significant differences between breast halves. Post-hoc comparison with a similar SoC control collective revealed OR = 0.28 (95% CI 0.11–0.76; p = 0.014) for grade ≥ 2 RD upon WBI completion, along with less hyperpigmentation (p < 0.001), oedema (p = 0.020), dry (p < 0.001) and moist desquamation (p = 0.017), pain, itching, and burning (p < 0.001 for each). Tolerability of NIPP was excellent and side effects were not observed. Conclusion Even though there were no differences between intrapatient-randomised breast halves, the overall incidence and severity of acute radiation-induced skin toxicity were considerably lower when compared to a prospectively collected SoC cohort. Our data suggest the potential benefit of NIPP in RD prevention. A randomised trial with a physical control group is warranted to confirm these promising results (DRKS00026225).

Published
2024

9. Two Patients with Atypical Choroidal Detachment

Author

Joseph W. Fong, Heather V. Broyles, Nour Y. Atassi, Ahmed B. Sallam, and Sami H. Uwaydat

Subjects
rhegmatogenous retinal detachment with choroidal detachment, serous choroidal detachment, choroidal detachment, Ophthalmology, RE1-994
Abstract

Serous choroidal detachment that is caused by rhegmatogenous retinal detachment (RRD) may present a significant diagnostic challenge as delayed recognition and repair of the underlying RRD can severely impact the final anatomical and visual outcome. We report 2 consecutive patients with atypical choroidal detachments who were later found to have underlying RRDs. A 71-year-old female presented with a 1-week history of painful vision loss and floaters in the left eye. Examination revealed choroidal detachments in the nasal and temporal periphery and an overlying retinal detachment with shifting subretinal fluid. However, no retinal breaks were identified. An extensive laboratory workup and imaging of the orbits were unrevealing. She was treated with 80 mg oral prednisone daily for 2 weeks with subsequent resolution of the choroidals but persistence of the retinal detachment. Similarly, a 52-year-old male presented with a 3-week history of flashes and floaters followed by painful vision loss in the left eye 1 day prior to presentation. He had hand motion vision OS and the intraocular pressure was undetectable by hand-held tonometry OS. Dense brunescent cataract prevented adequate viewing of the posterior pole. B-scan ultrasonography revealed a funnel retinal detachment, with homogenous choroidal echogenicities suggestive of hemorrhagic choroidal detachment. Extensive laboratory workup was unrevealing. The patient was started on 60 mg oral prednisone and re-evaluated every 2 days, but ultrasonography revealed persistence of the choroidal detachment after 1 week. The diagnosis of RRD with an associated choroidal detachment should be considered, even in the absence of an identifiable causative retinal break.

Published
2021
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10. HIV-1 elite controllers: an immunovirological review and clinical perspectives

Author

Nour Y. Gebara, Vanessa El Kamari, and Nesrine Rizk

Subjects
Microbiology, QR1-502, Public aspects of medicine, RA1-1270
Abstract

HIV type 1 (HIV-1) elite controllers (ECs) represent a rare group of individuals with an ability to maintain an undetectable HIV-1 viral load overtime in the absence of previous antiretroviral therapy. The mechanisms associated with this paradigm remain not clearly defined. However, loss of virological control, morbidity and mortality persist in these individuals, such as progress to AIDS-defining conditions together with persistent high rate of immune activation. Further insight into potential therapeutic options is therefore warranted. In this review, we discuss recent data on the type of immune responses understood to be associated with chronic virological control, the potential for disease progression and therapeutic options in ECs.

Published
2019
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12. Combined radiotherapy and concurrent tumor treating fields (TTFields) for glioblastoma: Dosimetric consequences on non-coplanar IMRT as initial results from a phase I trial

Author

Guberina, N., Pöttgen, C., Kebir, S., Lazaridis, L., Scharmberg, C., Lübcke, W., Niessen, M., Guberina, M., Scheffler, B., Jendrossek, V., Jabbarli, R., Pierscianek, D., Sure, U., Schmidt, T., Oster, C., Hau, P., Grosu, A. L., Stuschke, M., Glas, M., Nour, Y., and Lüdemann, L.

Published
2020
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13. Two Patients with Atypical Choroidal Detachment

Author

Ahmed Sallam, Nour Y Atassi, Heather V. Broyles, Joseph W Fong, and Sami H. Uwaydat

Subjects
Intraocular pressure, medicine.medical_specialty, Retinal breaks, choroidal detachment, business.industry, Posterior pole, Retinal detachment, Case Report, serous choroidal detachment, Retinal, RE1-994, medicine.disease, eye diseases, Ophthalmology, chemistry.chemical_compound, Serous choroidal detachment, chemistry, Prednisone, Choroidal detachment, Medicine, sense organs, business, rhegmatogenous retinal detachment with choroidal detachment, medicine.drug
Abstract

Serous choroidal detachment that is caused by rhegmatogenous retinal detachment (RRD) may present a significant diagnostic challenge as delayed recognition and repair of the underlying RRD can severely impact the final anatomical and visual outcome. We report 2 consecutive patients with atypical choroidal detachments who were later found to have underlying RRDs. A 71-year-old female presented with a 1-week history of painful vision loss and floaters in the left eye. Examination revealed choroidal detachments in the nasal and temporal periphery and an overlying retinal detachment with shifting subretinal fluid. However, no retinal breaks were identified. An extensive laboratory workup and imaging of the orbits were unrevealing. She was treated with 80 mg oral prednisone daily for 2 weeks with subsequent resolution of the choroidals but persistence of the retinal detachment. Similarly, a 52-year-old male presented with a 3-week history of flashes and floaters followed by painful vision loss in the left eye 1 day prior to presentation. He had hand motion vision OS and the intraocular pressure was undetectable by hand-held tonometry OS. Dense brunescent cataract prevented adequate viewing of the posterior pole. B-scan ultrasonography revealed a funnel retinal detachment, with homogenous choroidal echogenicities suggestive of hemorrhagic choroidal detachment. Extensive laboratory workup was unrevealing. The patient was started on 60 mg oral prednisone and re-evaluated every 2 days, but ultrasonography revealed persistence of the choroidal detachment after 1 week. The diagnosis of RRD with an associated choroidal detachment should be considered, even in the absence of an identifiable causative retinal break.

Published
2021
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16. Silybum marianum total extract, silymarin and silibinin abate hepatocarcinogenesis and hepatocellular carcinoma growth via modulation of the HGF/c-Met, Wnt/β-catenin, and PI3K/Akt/mTOR signaling pathways

Author

Tarek Mohamed Ali, Nour Y. S. Yassin, Osama M. Ahmed, Asmaa M. El-Kalaawy, Mazen Almehmadi, and Sameh AbouZid

Subjects
Male, endocrine system, Carcinoma, Hepatocellular, C-Met, Hepatocellular carcinoma, Silibinin, CCL4, RM1-950, Pharmacology, Antioxidants, PI3K/Akt/mTOR pathways, chemistry.chemical_compound, Silybum marianum, Liver Neoplasms, Experimental, Cell Line, Tumor, HGF/c-Met, Animals, Humans, Milk Thistle, Rats, Wistar, Wnt Signaling Pathway, Protein kinase B, PI3K/AKT/mTOR pathway, Wnt/β-catenin, Hepatocyte Growth Factor, Plant Extracts, Chemistry, Liver Neoplasms, Wnt signaling pathway, Hep G2 Cells, General Medicine, Proto-Oncogene Proteins c-met, digestive system diseases, Rats, Silybin, Catenin, Liver function, Therapeutics. Pharmacology, Phosphatidylinositol 3-Kinase, Proto-Oncogene Proteins c-akt, Silymarin
Abstract

Hepatocellular carcinoma (HCC) has been identified as one of the most deadly malignancies with limited therapeutic efficacy worldwide. However, understanding the molecular mechanisms of crosstalk between signaling pathways in HCC and predicting cancer cell responses to targeted therapeutic interventions remain to be challenge. Thus, in this study, we aimed to evaluate the anticancerous efficacy of Silybum marianum total extract (STE), silymarin (Sm), and silibinin (Sb) against experimentally-induced HCC in rats. In vitro investigations were also performed and the anticancer effects against HCC cell lines (HepG2 and Huh7) were confirmed. Wistar rats were given diethylnitrosamine (DEN)/2-acetylaminofluorene (AAF)/carbon tetrachloride (CCl4) and were orally treated with STE (200 mg/kg body weight (bw)), Sm (150 mg/kg bw), and Sb (5 mg/kg bw) every other day from the 1st or 16th week to the 25th week of DEN/AAF/CCl4 injection. Treatment with STE, Sm, and Sb inhibited the growth of cancerous lesions in DEN/AAF/CCl4-treated rats. This inhibition was associated with inhibition of Ki-67 expression and repression of HGF/cMet, Wnt/β-catenin, and PI3K/Akt/mTOR signaling pathways. STE, Sm, and Sb improved liver function biomarkers and tumor markers (AFP, CEA, and CA19.9) and increased total protein and albumin levels in serum. STE, Sm, and Sb treatment was also noted to reduce the hepatic production of lipid peroxides, increase hepatic glutathione content, and induce the activities of hepatic antioxidant enzymes in DEN/AAF/CCl4-treated rats. These results indicate that STE, Sm, and Sb exert anti-HCC effects through multiple pathways, including suppression of Ki-67 expression and HGF/cMet, Wnt/β-catenin, and PI3K/Akt/mTOR pathways and enhancement of antioxidant defense mechanisms.

Published
2022

19. HIV-related stigma among health-care workers in the MENA region

Author

Tala Ballouz, Nour Y. Gebara, and Nesrine Rizk

Subjects
Acquired Immunodeficiency Syndrome, medicine.medical_specialty, Epidemiology, business.industry, Health Personnel, Social Stigma, Immunology, Saudi Arabia, MEDLINE, HIV, HIV Infections, Infectious Diseases, Attitude, Virology, Family medicine, Health care, Humans, Medicine, business, Hiv related stigma
Published
2020
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21. Tackling of Renal Carcinogenesis in Wistar Rats by Silybum marianum Total Extract, Silymarin, and Silibinin via Modulation of Oxidative Stress, Apoptosis, Nrf2, PPARγ, NF-κB, and PI3K/Akt Signaling Pathways

Author

Tarek Mohamed Ali, Basem H. Elesawy, Osama M. Ahmed, Nour Y. S. Yassin, Asmaa M. El-Kalaawy, and Sameh AbouZid

Subjects
Male, Aging, Article Subject, Carcinogenesis, NF-E2-Related Factor 2, Silibinin, Apoptosis, Pharmacology, medicine.disease_cause, Biochemistry, Proinflammatory cytokine, Silybum marianum, Lipid peroxidation, Phosphatidylinositol 3-Kinases, chemistry.chemical_compound, medicine, Animals, Milk Thistle, Rats, Wistar, PI3K/AKT/mTOR pathway, Kidney, QH573-671, biology, Plant Extracts, NF-kappa B, Cell Biology, General Medicine, biology.organism_classification, Antineoplastic Agents, Phytogenic, Kidney Neoplasms, Rats, PPAR gamma, Disease Models, Animal, Oxidative Stress, medicine.anatomical_structure, chemistry, Silybin, Cytology, Proto-Oncogene Proteins c-akt, Oxidative stress, Research Article, Phytotherapy, Signal Transduction, Silymarin
Abstract

The present work was designed to assess the efficacy of Silybum marianum total extract (STE), silymarin (Sm), and silibinin (Sb) against experimentally induced renal carcinogenesis in male Wistar rats and their roles in regulating oxidative stress, inflammation, apoptosis, and carcinogenesis. The diethylnitrosamine (DEN)/2-acetylaminofluorene (AAF)/carbon tetrachloride (CCl4)-administered rats were orally treated with STE (200 mg/kg b.w.), Sm (150 mg/kg b.w.), and Sb (5 mg/kg b.w.) every other day either from the 1st week or from the 16th week of carcinogen administration to the end of 25th week. The treatments with STE, Sm, and Sb attenuated markers of toxicity in serum, decreased kidney lipid peroxidation (LPO), and significantly reinforced the renal antioxidant armory. The biochemical results were further confirmed by the histopathological alterations. The treatments also led to suppression of proinflammatory mediators such as NF-κβ, p65, Iκβα, and IL-6 in association with inhibition of the PI3K/Akt pathway. Furthermore, they activated the expressions of PPARs, Nrf2, and IL-4 in addition to downregulation of apoptotic proteins p53 and caspase-3 and upregulation of antiapoptotic mediator Bcl-2. The obtained data supply potent proof for the efficacy of STE, Sm, and Sb to counteract renal carcinogenesis via alteration of varied molecular pathways.

Published
2021
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23. Spatiotemporal dynamics of the COVID-19 pandemic in the State of Kuwait

Author

Sulaiman Al Mazeedi, Sumayah Alhardan, Sarah Al Youha, Mohammad M. Khajah, Nour Y. Ben Haider, Ahmad Nabeel, Moh A. Alkhamis, and Salman Al-Sabah

Subjects
Male, Microbiology (medical), medicine.medical_specialty, Migrant worker, Coronavirus disease 2019 (COVID-19), Scan statistic, Pneumonia, Viral, Article, lcsh:Infectious and parasitic diseases, law.invention, Betacoronavirus, law, Epidemiology, Pandemic, medicine, Humans, lcsh:RC109-216, Pandemics, Socioeconomic status, Transients and Migrants, Government, Models, Statistical, Surveillance, SARS-CoV-2, Spatiotemporal cluster, COVID-19, General Medicine, Time-dependent reproductive number, Transmission (mechanics), Geography, Infectious Diseases, Kuwait, Spatial ecology, Female, Coronavirus Infections, Demography
Abstract

Highlights • COVID-19 has distinct spreading and clustering patterns within migrant workers, citizens, residents’ communities in Kuwait. • Densely populated areas and poor living conditions of migrant workers resulted in the highest number of significant spreading and clustering events within their communities. • Targeted intervention measures within migrant worker communities substantially lowered the magnitude and number of spreading and clustering events, respectively. • Increased epidemic growth reflected by the predicted cases, and the number of emerging clusters was inferred by the end of the study period in Kuwait., Objectives The prompt understanding of the temporal and spatial patterns of the epidemic on a national level is a critical step for the timely allocation of surveillance resources. Therefore, we explored the temporal and spatiotemporal dynamics of the COVID-19 epidemic in Kuwait using daily confirmed case data collected between the 23rd of February and the 7th of May, 2020. Methods We quantified the epidemic progression using the time-dependent reproductive number (R(t)), while we used the spatiotemporal scan statistic model to identify local clustering events. We accounted for the variability in the transmission dynamics within and between two socioeconomic classes, including citizens-residents and migrant workers. Results Overall, the epidemic size in Kuwait continues to grow (R(t)s ≥ 2), indicating significant ongoing spread. Significant spreading and clustering events were detected among migrant workers due to their densely populated areas and poor living conditions. However, the government's aggressive intervention measures substantially lowered epidemic growth in migrant worker areas. Yet, at a later stage of the study period, we inferred active spreading and clustering events among both socioeconomic classes. Conclusions Our analyses unveiled deeper insights into the epidemiology of COVID-19 in Kuwait and provided an important platform for rapid guidance of decisions related to intervention activities.

Published
2020
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25. DEGRO 2004: 10. Jahreskongress der Deutschen Gesellschaft für Radioonkologie

Author

Wendt, Thomas G., Gademann, G., Pambor, C., Grießbach, I., von Specht, H., Martin, T., Baltas, D., Kurek, R., Röddiger, S., Tunn, U. W., Zamboglou, N., Eich, H. T., Staar, S., Gossmann, A., Hansemann, K., Semrau, R., Skripnitchenko, R., Diehl, V., Müller, R.-P., Sehlen, S., Willich, N., Rühl, U., Lukas, P., Dühmke, E., Engel, K., Tabbert, E., Bolck, M., Knaack, S., Annweiler, H., Krempien, R., Hoppe, H., Harms, W., Daeuber, S., Schorr, O., Treiber, M., Debus, J., Alber, M., Paulsen, F., Birkner, M., Bakai, A., Belka, C., Budach, W., Grosser, K.-H., Kramer, R., Kober, B., Reinert, M., Schneider, P., Hertel, A., Feldmann, H., Csere, P., Hoinkis, C., Rothe, G., Zahn, P., Alheit, H., Cavanaugh, S. X., Kupelian, P., Reddy, C., Pollock, B., Fuss, M., Roeddiger, S., Dannenberg, T., Rogge, B., Drechsler, D., Herrmann, T., Alberti, W., Schwarz, R., Graefen, M., Krüll, A., Rudat, V., Huland, H., Fehr, C., Baum, C., Glocker, S., Nüsslin, F., Heil, T., Lemnitzer, H., Knips, M., Baumgart, O., Thiem, W., Kloetzer, K.-H., Hoffmann, L., Neu, B., Hültenschmidt, B., Sautter-Bihl, M.-L., Micke, O., Seegenschmiedt, M. H., Köppen, D., Klautke, G., Fietkau, R., Schultze, J., Schlichting, G., Koltze, H., Kimmig, B., Glatzel, M., Fröhlich, D., Bäsecke, S., Krauß, A., Strauß, D., Buth, K.-J., Böhme, R., Oehler, W., Bottke, D., Keilholz, U., Heufelder, K., Wiegel, T., Hinkelbein, W., Rödel, C., Papadopoulos, T., Munnes, M., Wirtz, R., Sauer, R., Rödel, F., Lubgan, D., Distel, L., Grabenbauer, G. G., Sak, A., Stüben, G., Pöttgen, C., Grehl, S., Stuschke, M., Müller, K., Pfaffendorf, C., Mayerhofer, A., Köhn, F. M., Ring, J., van Beuningen, D., Meineke, V., Neubauer, S., Keller, U., Wittlinger, M., Riesenbeck, D., Greve, B., Exeler, R., Ibrahim, M., Liebscher, C., Severin, E., Ott, O., Pötter, R., Hammer, J., Hildebrandt, G., Beckmann, M. W., Strnad, V., Fehlauer, F., Tribius, S., Bajrovic, A., Höller, U., Rades, D., Warszawski, A., Baumann, R., Madry-Gevecke, B., Karstens, J. H., Grehn, C., Hensley, F., Berns, C., Wannenmacher, M., Semrau, S., Reimer, T., Gerber, B., Ketterer, P., Koepcke, E., Hänsgen, G., Strauß, H. G., Dunst, J., Füller, J., Kalb, S., Wendt, T., Weitmann, H. D., Waldhäusl, C., Knocke, T.-H., Lamprecht, U., Classen, J., Kaulich, T. W., Aydeniz, B., Bamberg, M., Wiezorek, T., Banz, N., Salz, H., Scheithauer, M., Schwedas, M., Lutterbach, J., Bartelt, S., Frommhold, H., Lambert, J., Hornung, D., Swiderski, S., Walke, M., Siefert, A., Pöllinger, B., Krimmel, K., Schaffer, M., Koelbl, O., Bratengeier, K., Vordermark, D., Flentje, M., Hero, B., Berthold, F., Combs, S. E., Gutwein, S., Schulz-Ertner, D., van Kampen, M., Thilmann, C., Kocher, M., Kunze, S., Schild, S., Ikezaki, K., Müller, B., Sieber, R., Weiß, C., Wolf, I., Wenz, F., Weber, K.-J., Schäfer, J., Engling, A., Laufs, S., Veldwijk, M. R., Milanovic, D., Fleckenstein, K., Zeller, W., Fruehauf, S., Herskind, C., Weinmann, M., Jendrossek, V., Rübe, C., Appold, S., Kusche, S., Hölscher, T., Brüchner, K., Geyer, P., Baumann, M., Kumpf, R., Zimmermann, F., Schill, S., Geinitz, H., Nieder, C., Jeremic, B., Molls, M., Liesenfeld, S., Petrat, H., Hesselmann, S., Schäfer, U., Bruns, F., Horst, E., Wilkowski, R., Assmann, G., Nolte, A., Diebold, J., Löhrs, U., Fritz, P., Hans-Jürgen, K., Mühlnickel, W., Bach, P., Wahlers, B., Kraus, H.-J., Wulf, J., Hädinger, U., Baier, K., Krieger, T., Müller, G., Hof, H., Herfarth, K., Brunner, T., Hahn, S. M., Schreiber, F. S., Rustgi, A. K., McKenna, W. G., Bernhard, E. J., Guckenberger, M., Meyer, K., Willner, J., Schmidt, M., Kolb, M., Li, M., Gong, P., Abdollahi, A., Trinh, T., Huber, P. E., Christiansen, H., Saile, B., Neubauer-Saile, K., Tippelt, S., Rave-Fränk, M., Hermann, R. M., Dudas, J., Hess, C. F., Schmidberger, H., Ramadori, G., Andratschke, N., Price, R., Ang, K.-K., Schwarz, S., Kulka, U., Busch, M., Schlenger, L., Bohsung, J., Eichwurzel, I., Matnjani, G., Sandrock, D., Richter, M., Wurm, R., Budach, V., Feussner, A., Gellermann, J., Jordan, A., Scholz, R., Gneveckow, U., Maier-Hauff, K., Ullrich, R., Wust, P., Felix, R., Waldöfner, N., Seebass, M., Ochel, H.-J., Dani, A., Varkonyi, A., Osvath, M., Szasz, A., Messer, P. M., Blumstein, N. M., Gottfried, H.-W., Schneider, E., Reske, S. N., Röttinger, E. M., Grosu, A.-L., Franz, M., Stärk, S., Weber, W., Heintz, M., Indenkämpen, F., Beyer, T., Lübcke, W., Levegrün, S., Hayen, J., Czech, N., Mbarek, B., Köster, R., Thurmann, H., Todorovic, M., Schuchert, A., Meinertz, T., Münzel, T., Grundtke, H., Hornig, B., Hehr, T., Dilcher, C., Chan, R. C., Mintz, G. S., Kotani, J.-I., Shah, V. M., Canos, D. A., Weissman, N. J., Waksman, R., Wolfram, R., Bürger, B., Schrappe, M., Timmermann, B., Lomax, A., Goitein, G., Schuck, A., Mattke, A., Int-Veen, C., Brecht, I., Bernhard, S., Treuner, J., Koscielniak, E., Heinze, F., Kuhlen, M., von Schorlemer, I., Ahrens, S., Hunold, A., Könemann, S., Winkelmann, W., Jürgens, H., Gerstein, J., Polivka, B., Sykora, K.-W., Bremer, M., Thamm, R., Höpfner, C., Gumprecht, H., Jäger, R., Leonardi, M. A., Frank, A. M., Trappe, A. E., Lumenta, C. B., Östreicher, E., Pinsker, K., Müller, A., Fauser, C., Arnold, W., Henzel, M., Groß, M. W., Engenhart-Cabillic, R., Schüller, P., Palkovic, S., Schröder, J., Wassmann, H., Block, A., Bauer, R., Keffel, F.-W., Theophil, B., Wisser, L., Rogger, M., Niewald, M., van Lengen, V., Mathias, K., Welzel, G., Bohrer, M., Steinvorth, S., Schleußner, C., Leppert, K., Röhrig, B., Strauß, B., van Oorschot, B., Köhler, N., Anselm, R., Winzer, A., Schneider, T., Koch, U., Schönekaes, K., Mücke, R., Büntzel, J., Kisters, K., Scholz, C., Keller, M., Winkler, C., Prause, N., Busch, R., Roth, S., Haas, I., Willers, R., Schultze-Mosgau, S., Wiltfang, J., Kessler, P., Neukam, F. W., Röper, B., Nüse, N., Auer, F., Melzner, W., Geiger, M., Lotter, M., Kuhnt, T., Müller, A. C., Jirsak, N., Gernhardt, C., Schaller, H.-G., Al-Nawas, B., Klein, M. O., Ludwig, C., Körholz, J., Grötz, K. A., Huppers, K., Kunkel, M., Olschewski, T., Bajor, K., Lang, B., Lang, E., Kraus-Tiefenbacher, U., Hofheinz, R., von Gerstenberg-Helldorf, B., Willeke, F., Hochhaus, A., Roebel, M., Oertel, S., Riedl, S., Buechler, M., Foitzik, T., Ludwig, K., Klar, E., Meyer, A., Meier zu Eissen, J., Schwab, D., Meyer, T., Höcht, S., Siegmann, A., Sieker, F., Pigorsch, S., Milicic, B., Acimovic, L., Milisavljevic, S., Radosavljevic-Asic, G., Presselt, N., Baum, R. P., Treutler, D., Bonnet, R., Schmücking, M., Sammour, D., Fink, T., Ficker, J., Pradier, O., Lederer, K., Weiss, E., Hille, A., Welz, S., Sepe, S., Friedel, G., Spengler, W., Susanne, E., Kölbl, O., Hoffmann, W., Wörmann, B., Günther, A., Becker-Schiebe, M., Güttler, J., Schul, C., Nitsche, M., Körner, M. K., Oppenkowski, R., Guntrum, F., Malaimare, L., Raub, M., Schöfl, C., Averbeck, T., Hacker, I., Blank, H., Böhme, C., Imhoff, D., Eberlein, K., Weidauer, S., Böttcher, H. D., Edler, L., Tatagiba, M., Molina, H., Ostertag, C., Milker-Zabel, S., Zabel, A., Schlegel, W., Hartmann, A., Wildfang, I., Kleinert, G., Hamm, K., Reuschel, W., Wehrmann, R., Kneschaurek, P., Münter, M. W., Nikoghosyan, A., Didinger, B., Nill, S., Rhein, B., Küstner, D., Schalldach, U., Eßer, D., Göbel, H., Wördehoff, H., Pachmann, S., Hollenhorst, H., Dederer, K., Evers, C., Lamprecht, J., Dastbaz, A., Schick, B., Fleckenstein, J., Plinkert, P. K., Rübe, Chr., Merz, T., Sommer, B., Mencl, A., Ghilescu, V., Astner, S., Martin, A., Momm, F., Volegova-Neher, N. J., Schulte-Mönting, J., Guttenberger, R., Buchali, A., Blank, E., Sidow, D., Huhnt, W., Gorbatov, T., Heinecke, A., Beckmann, G., Bentia, A.-M., Schmitz, H., Spahn, U., Heyl, V., Prott, P.-J., Galalae, R., Schneider, R., Voith, C., Scheda, A., Hermann, B., Bauer, L., Melchert, F., Kröger, N., Grüneisen, A., Jänicke, F., Zander, A., Zuna, I., Schlöcker, I., Wagner, K., John, E., Dörk, T., Lochhas, G., Houf, M., Lorenz, D., Link, K.-H., Prott, F.-J., Thoma, M., Schauer, R., Heinemann, V., Romano, M., Reiner, M., Quanz, A., Oppitz, U., Bahrehmand, R., Tine, M., Naszaly, A., Patonay, P., Mayer, Á., Markert, K., Mai, S.-K., Lohr, F., Dobler, B., Pinkawa, M., Fischedick, K., Treusacher, P., Cengiz, D., Mager, R., Borchers, H., Jakse, G., Eble, M. J., Asadpour, B., Krenkel, B., Holy, R., Kaplan, Y., Block, T., Czempiel, H., Haverkamp, U., Prümer, B., Christian, T., Benkel, P., Weber, C., Gruber, S., Reimann, P., Blumberg, J., Krause, K., Fischedick, A.-R., Kaube, K., Steckler, K., Henzel, B., Licht, N., Loch, T., Krystek, A., Lilienthal, A., Alfia, H., Claßen, J., Spillner, P., Knutzen, B., Souchon, R., Schulz, I., Grüschow, K., Küchenmeister, U., Vogel, H., Wolff, D., Ramm, U., Licner, J., Rudolf, F., Moog, J., Rahl, C. G., Mose, S., Vorwerk, H., Weiß, E., Engert, A., Seufert, I., Schwab, F., Dahlke, J., Zabelina, T., Krüger, W., Kabisch, H., Platz, V., Wolf, J., Pfistner, B., Stieltjes, B., Wilhelm, T., Schmuecking, M., Junker, K., Treutier, D., Schneider, C. P., Leonhardi, J., Niesen, A., Hoeffken, K., Schmidt, A., Mueller, K.-M., Schmid, I., Lehmann, K., Blumstein, C. G., Kreienberg, R., Freudenberg, L., Kühl, H., Stahl, M., Elo, B., Erichsen, P., Stattaus, H., Welzel, T., Mende, U., Heiland, S., Salter, B. J., Schmid, R., Stratakis, D., Huber, R. M., Haferanke, J., Zöller, N., Henke, M., Lorenzen, J., Grzyska, B., Kuhlmey, A., Adam, G., Hamelmann, V., Bölling, T., Job, H., Panke, J. E., Feyer, P., Püttmann, S., Siekmeyer, B., Jung, H., Gagel, B., Militz, U., Piroth, M., Schmachtenberg, A., Hoelscher, T., Verfaillie, C., Kaminski, B., Lücke, E., Mörtel, H., Eyrich, W., Fritsch, M., Georgi, J.-C., Plathow, C., Zieher, H., Kiessling, F., Peschke, P., Kauczor, H.-U., Licher, J., Schneider, O., Henschler, R., Seidel, C., Kolkmeyer, A., Nguyen, T. P., Janke, K., Michaelis, M., Bischof, M., Stoffregen, C., Lipson, K., Weber, K., Ehemann, V., Jürgen, D., Achanta, P., Thompson, K., Martinez, J. L., Körschgen, T., Pakala, R., Pinnow, E., Hellinga, D., O’Tio, F., Katzer, A., Kaffer, A., Kuechler, A., Steinkirchner, S., Dettmar, N., Cordes, N., Frick, S., Kappler, M., Taubert, H., Bartel, F., Schmidt, H., Bache, M., Frühauf, S., Wenk, T., Litzenberger, K., Erren, M., van Valen, F., Liu, L., Yang, K., Palm, J., Püsken, M., Behe, M., Behr, T. M., Marini, P., Johne, A., Claussen, U., Liehr, T., Steil, V., Moustakis, C., Griessbach, I., Oettel, A., Schaal, C., Reinhold, M., Strasssmann, G., Braun, I., Vacha, P., Richter, D., Osterham, T., Wolf, P., Guenther, G., Miemietz, M., Lazaridis, E. A., Forthuber, B., Sure, M., Klein, J., Saleske, H., Riedel, T., Hirnle, P., Horstmann, G., Schoepgens, H., Van Eck, A., Bundschuh, O., Van Oosterhut, A., Xydis, K., Theodorou, K., Kappas, C., Zurheide, J., Fridtjof, N., Ganswindt, U., Weidner, N., Buchgeister, M., Weigel, B., Müller, S. B., Glashörster, M., Weining, C., Hentschel, B., Sauer, O. A., Kleen, W., Beck, J., Lehmann, D., Ley, S., Fink, C., Puderbach, M., Hosch, W., Schmähl, A., Jung, K., Stoßberg, A., Rolf, E., Damrau, M., Oetzel, D., Maurer, U., Maurer, G., Lang, K., Zumbe, J., Hahm, D., Fees, H., Robrandt, B., Melcher, U., Niemeyer, M., Mondry, A., Kanellopoulos-Niemeyer, V., Karle, H., Jacob-Heutmann, D., Born, C., Mohr, W., Kutzner, J., Thelen, M., Schiebe, M., Pinkert, U., Piasswilm, L., Pohl, F., Garbe, S., Wolf, K., Nour, Y., Barwig, P., Trog, D., Schäfer, C., Herbst, M., Dietl, B., Cartes, M., Schroeder, F., Sigingan-Tek, G., Feierabend, R., Theden, S., Schlieck, A., Gotthardt, M., Glowalla, U., Kremp, S., Hamid, O., Riefenstahl, N., Michaelis, B., Schaal, G., Liebermeister, E., Niewöhner-Desbordes, U., Kowalski, M., Franz, N., Stahl, W., Baumbach, C., Thale, J., Wagner, W., Justus, B., Huston, A. L., Seaborn, R., Rai, P., Rha, S.-W., Sakas, G., Wesarg, S., Zogal, P., Schwald, B., Seibert, H., Berndt-Skorka, R., Seifert, G., Schoenekaes, K., Bilecen, C., Ito, W., Matschuck, G., and Isik, D.

Published
2004
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26. Metabolic inflexibility in youth with obesity: Is it a feature of obesity or distinctive of youth who are metabolically unhealthy?

Author

Gebara, Nour Y., Kim, Joon Young, Bacha, Fida, Lee, SoJung, and Arslanian, Silva

Subjects
*OBESITY, *RESPIRATORY quotient, *INSULIN sensitivity, *ADIPOSE tissues, *LIPOLYSIS
Abstract

Summary: Individuals with obesity have metabolic inflexibility with diminished fasting fat oxidation and blunted increase in respiratory quotient (RQ) in insulin‐stimulated states. However, it is unclear if metabolic inflexibility is a characteristic of obesity per se or is unique to youth who have metabolically unhealthy obesity (MUO) compared with metabolically healthy obesity (MHO). We investigated metabolic flexibility in youth with MUO, MHO and normal weight (NW) and compared their metabolic characteristics. Youth (n = 188) were divided, based on cut‐off points for in vivo insulin sensitivity (IS) of adolescents with NW, into 137 with MUO and 51 with MHO. Fasting hepatic IS (HIS) from hepatic glucose production by [6,6‐2H2]glucose, adipose tissue IS (ATIS) from whole‐body lipolysis by [2H5]glycerol, RQ (indirect calorimetry) during fasting and a hyperinsulinemic (80 mU/m2/min)‐euglycemic clamp were measured. Youth with MUO versus MHO had blunted ΔRQ (p =.035) and lower HIS and ATIS (both p <.0001), while ΔRQ, HIS and ATIS were not different between youth with MHO and NW. In a pair‐matched sub‐analyses of 30 MUO and 30 MHO the results were similar to the total cohort. Metabolic inflexibility, does not appear to be a feature of obesity per se rather distinctive of youth with MUO, who also have worse HIS and ATIS compared with youth with MHO. [ABSTRACT FROM AUTHOR]

Published
2022
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27. PBI15 The Economic Burden for the Management of Moderate-to-Severe Psoriasis in the Kingdom of Saudi Arabia

Author

Al-Omar, H., primary, Altawil, E., additional, R. Hamadah, I., additional, Alsaqa'aby, M., additional, Al Shahwan, M.A., additional, Al-Haddab, M.A., additional, Abu-Shraie, N., additional, Mohamed, O., additional, Basu, S., additional, Roshdy, A., additional, Rateb, M., additional, Nour, Y., additional, and A. Al-Sheikh, A., additional

Published
2020
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30. 1331-P: OGTT Glucose-Response-Curve (GRC) in Islet Cell Antibody-Positive (Ab+) vs. -Negative (Ab-) Obese Youth Clinically Diagnosed with Type 2 Diabetes (CDX-T2D)

Author

Silva A. Arslanian, Nour Y. Gebara, Joon Young Kim, Fida Bacha, and Hala Tfayli

Subjects
Type 1 diabetes, medicine.medical_specialty, business.industry, Insulin deficiency, Endocrinology, Diabetes and Metabolism, Insulin, medicine.medical_treatment, Insulin sensitivity, Type 2 diabetes, medicine.disease, Child health, Endocrinology, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, Islet cell antibody, business
Abstract

The OGTT-GRCs [Incessant Increase (IIn), Monophasic (Mph), and Biphasic (Bph)] reflect insulin sensitivity (IS) and β-cell function (BCF), being worse in the former and best in the latter. Accordingly, the prevalence of these GRCs differ in diabetic and nondiabetic individuals (Table). While islet cell Ab- obese youth CDX-T2D have worse IS, Ab+ youth have severe impairment in BCF [Diabetes 58: 2009]. Here, we examined the prevalence of OGTT-GRC patterns, clamp-measured IS, and BCF in obese Ab+ (GAD65 and IA2) vs. Ab- youth CDX-T2D. The dominant GRC was IIn in Ab+ and Mph in Ab- youth while Bph was scarce in both (Table). In Ab+ youth, 1st- (32.5 ± 5.6 vs. 40.2 ± 8.0 µU/mL, p=0.13) and 2nd-phase insulin (39.6 ± 8.6 vs. 62.8 ± 12.2 µU/mL, p=0.04), were 20% and 40% lower in IIn vs. the other two combined. In Ab-, while 1st- (67.3 ± 19.1 vs. 122.4 ± 28.3 µU/mL, p=0.049) and 2nd-phase insulin (110.3 ± 31.4 vs. 171.6 ± 28.6 µU/mL, p=0.054) were lower in IIn vs. Mph, overall BCF was less impaired than in Ab+ youth. IS did not differ by GRC type in either group but was lower in Ab- vs. Ab+ irrespective of GRC type. The prevalence of IIn-GRC is 3-fold higher in Ab+ vs. Ab- obese youth CDX-T2D, and the prevalence in Ab- youth is similar to that in the TODAY study (Table). The higher prevalence of IIn-GRC in Ab+ obese youth signifies the severe insulin deficiency characteristic of type 1 diabetes. Disclosure J. Kim: None. N. Gebara: None. H. Tfayli: Other Relationship; Self; Sanofi. F. Bacha: Research Support; Self; National Institute of Diabetes and Digestive and Kidney Diseases, Pediatric Diabetes Consortium. Other Relationship; Self; AstraZeneca, Jaeb Center for Health Research. S.A. Arslanian: None. Funding Eunice Kennedy Shriver National Institute of Child Health and Human Development (K24-HD01357, R01HD27503 to S.A.A.); National Center for Advancing Translational Sciences (UL1TR000005); National Center for Research Resources (UL1RR024153)

Published
2019
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31. OR33-1 Metabolic Inflexibility in Obese versus Lean Women with Polycystic Ovary Syndrome (PCOS): Is PCOS Status or Adiposity the Critical Factor?

Author

Laure Morin-Papunen, Nour Y. Gebara, Joon Young Kim, Juha S. Tapanainen, and Silva A. Arslanian

Subjects
2. Zero hunger, medicine.medical_specialty, endocrine system diseases, business.industry, Endocrinology, Diabetes and Metabolism, Polycystic ovary syndrome (PCOS), nutritional and metabolic diseases, Modulation of the HPG Axis in the Female, medicine.disease, Endocrinology, Internal medicine, medicine, Reproductive Endocrinology, business
Abstract

Metabolic flexibility reflects the ability to switch from lipid to carbohydrate oxidation during insulin stimulation manifested in increased respiratory quotient (∆RQ). Obese adolescent girls with PCOS have metabolic inflexibility compared with their non-PCOS obese peers (JCEM 2018, PMID 29220530). To examine if metabolic inflexibility is also present in lean PCOS or is unique to obese PCOS, we investigated metabolic flexibility in lean and obese women (ages 18-42 yrs.) with PCOS. Data in 24 obese (body mass index, BMI 33.4 ± 4.7 [SD] kg/m2) and 15 lean (BMI 22.7 ± 2.0 kg/m2) PCOS women (diagnosed by the Rotterdam criteria), and 14 obese (BMI 32.5 ± 5.0 kg/m2) and 16 lean (22.9 ± 1.4 kg/m2) control women without PCOS were examined. RQ and lipid oxidation, by indirect calorimetry, were analyzed at fasting and during a hyperinsulinemic-euglycemic clamp. The relationship between metabolic flexibility (assessed as ∆RQ from fasting to hyperinsulinemia) and clamp insulin sensitivity (IS), sex hormones, C-reactive protein (CRP), BMI and leptin concentrations was evaluated. Despite similar BMI and leptin levels, obese PCOS women had lower ∆RQ compared with obese control women (0.07 ± 0.04 vs. 0.11 ± 0.04, p< 0.0001). However, ∆RQ was not different between obese and lean PCOS women, nor was fasting lipid oxidation and suppression in lipid oxidation during hyperinsulinemia. Insulin sensitivity was lower (3.9 ± 1.4 vs. 7.4 ± 2.6 mg/Kg/min per mU/L, p< 0.0001), and CRP and leptin concentrations were higher in obese PCOS vs. lean PCOS (3.34 ± 1.87 vs. 1.29 ± 1.18 mg/L; and 33.6 ± 11.0 vs. 12.4 ± 8.5 ng/L, respectively, all p< 0.05). In the total cohort, ∆RQ correlated with free androgen index (r = -0.359), androstenedione (r = -0.271), and IS (r = 0.452) (all p< 0.05). Multiple regression analysis in the total cohort revealed that the best predictor of metabolic flexibility was PCOS status (partial r = -0.243, p= 0.05) independent of BMI and age. In PCOS women, IS (partial r = 0.503, p= 0.002) and baseline RQ (partial r = -0.489, p= 0.003) explained 46% of the variance in metabolic flexibility with no significant effect of BMI and age. Findings were similar in non-PCOS women (model R2 = 0.750, p= 0.001). Replacing BMI with leptin in the models for PCOS or control women did not change the results. In conclusion, our data suggest that PCOS status, rather than adiposity plays a role in the metabolic inflexibility observed in women with PCOS. It remains to be determined if the lack of a difference in metabolic inflexibility between obese and lean PCOS women applies across the lifespan and holds true in adolescents too, or if metabolic flexibility differs early in the course of PCOS between obese and lean adolescents, but the difference fades as they get older and enter womanhood. Sources of Research Support: Juselius Foundation and Academy of Finland

Published
2019
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32. Prevalence of prediabetes and its association with obesity among college students in Kuwait: A cross-sectional study

Author

Nour Y. Ben Haider and Ali H. Ziyab

Subjects
Adult, Male, Gerontology, Cross-sectional study, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Prediabetic State, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Surveys and Questionnaires, Diabetes mellitus, Prevalence, Internal Medicine, medicine, Humans, Obesity, 030212 general & internal medicine, Prediabetes, Young adult, Students, business.industry, General Medicine, medicine.disease, Cross-Sectional Studies, Kuwait, Female, business
Abstract

This cross-sectional study sought to estimate the prevalence of prediabetes and assess its association with obesity among young adults in Kuwait; a country with a high prevalence of obesity and diabetes. The estimated prevalence of prediabetes was 6.3% (95% CI: 4.8-8.1) and obesity was associated with elevated prediabetes prevalence.

Published
2016
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33. An Analysis of English for PalestineTextbook of Grade Eight Based on Reflective Thinking Skills.

Author

Jarbou, Nour Y. and Abu Moummar, Rana N.

Subjects
ENGLISH language, EIGHTH grade (Education), CRITICAL thinking, TEXTBOOKS, CONTENT analysis
Abstract

Copyright of IUG Journal of Educational & Psychological Studies is the property of Islamic University of Gaza and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2021
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35. Neuroproteomics and microRNAs studies in multiple sclerosis: transforming research and clinical knowledge in biomarker research

Author

Farah S. Andary, Hala Darwish, Stefania Mondello, Angelo Quartarone, Asad Zeidan, Nour Y. Gebara, Mohammad El-Sayyed, Iman Makki, Jalal M. Kazan, Cherine N. Fawaz, and Muheiddine M. Itani

Subjects
Proteomics, Proteome, Nerve Tissue Proteins, Disease, Bioinformatics, Biochemistry, Clinical knowledge, Multiple sclerosis, microRNA, medicine, Animals, Humans, Lymphocytes, Biomarker discovery, Diagnostics, Prognostics, Molecular Biology, business.industry, medicine.disease, MicroRNAs, Biomarkers, Diagnostics, MiRNA, Multiple sclerosis, Prognostics, Proteomics, Neuroproteomics, Biomarker (medicine), MiRNA, business, Biomarkers
Abstract

Multiple sclerosis (MS) is a complex disease characterized by extensive phenotypic variability. Biomarkers to capture the different aspects of MS heterogeneity, and to help make a diagnosis and monitor disease progression, while providing insights into etiopathogenesis and response to treatment, are urgently needed. Omics technologies and research efforts with microRNAs have provide unparalleled opportunities for exploring altered protein profiles associated with molecular mechanisms of disease, substantially expanding the list of candidate biomarkers for MS. This review presents evidence from proteomic studies that have focused on identification of biomarkers released in biofluids as a result of the different pathophysiological processes of MS. Also discussed is the emerging role of miRNAs as complementary biomarkers related to cellular processes occurring in MS patients. Also provided is an overview of candidate biomarkers that have been proposed for elucidating pathophysiological processes and disease activity and for guiding clinical diagnosis and/or therapeutic interventions in MS.

Published
2015
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36. Delayed sleep phase syndrome and bipolar disorder: Pathogenesis and available common biomarkers

Author

Stefania Mondello, Raffaele Ferri, Firas Kobeissy, Farid Talih, Farah S. Andary, and Nour Y. Gebara

Subjects
Pulmonary and Respiratory Medicine, Bipolar Disorder, business.industry, Delayed sleep phase, Bioinformatics, medicine.disease, 030227 psychiatry, Pathogenesis, Melatonin, 03 medical and health sciences, 0302 clinical medicine, Neurology, Sleep Disorders, Circadian Rhythm, Circadian rhythm sleep-wake disorders, Bipolar disorder, Delayed sleep wake phase disorder, Biomarkers, Mood disorder, Sleep disorders, Melatonin, Physiology (medical), Etiology, Medicine, Humans, Neurology (clinical), Circadian rhythm, Bipolar disorder, business, 030217 neurology & neurosurgery, Biomarkers, medicine.drug
Abstract

Circadian rhythm disturbances are common in bipolar affective disorder (BD). Delayed sleep-wake phase syndrome (DSWPD) is the most prevalent circadian rhythm sleep-wake disorder (CRSWDs) and is frequently observed in BD. It is unclear whether DSWPD in BD is an independent process or is a consequence of BD. In this hypothetical review, we discuss the overlap between BD and DSWPD and potential common biomarkers for DSWPD and BD. The review will include a discussion of the genetics of DSWPD and BD. Biomarkers elucidating the pathophysiological processes occurring in these two disorders may offer insight into the etiology and prognosis of both conditions.

Published
2016

40. Ubiquitous GPS vehicle tracking and management system

Author

Enas M. Ahmad, Rania M. Jodeh, Iman Almomani, and Nour Y. Alkhalil

Subjects
Vehicle tracking system, Ubiquitous computing, GPS tracking server, IVMS, business.industry, Computer science, Assisted GPS, Global Positioning System, Automatic vehicle location, General Packet Radio Service, business, Computer network
Abstract

Global Positioning System (GPS) is becoming widely used for tracking and monitoring vehicles. Many systems have been created to provide such services which make them popular and needed more than ever before. In this paper a “GPS vehicle tracking system” is proposed. This system is useful for fleet operators in monitoring driving behavior of employees or parents monitoring their teen drivers. Moreover, this system can be used in theft prevention as a retrieval device in addition of working as a security system combined with car alarms. The main contribution of this paper is providing two types of end user applications, a web application and a mobile application. This way the proposed system provides a ubiquitous vehicle tracking system with maximum accessibility for the user anytime and anywhere. The system's tracking services includes acquiring the location and ground speed of a given vehicle in the current moment or on any previous date. It also monitors the vehicle by setting speed and geographical limits and therefore receiving SMS alerts when the vehicle exceeds these pre-defined limits. Additionally, all the movements and stops of a given vehicle can also be monitored. Tracking vehicles in our system uses a wide range of new technologies and communication networks including General Packet Radio Service (GPRS), Global System for Mobile Communication (GSM), the Internet or the World Wide Web and Global Positioning System (GPS).

Published
2011
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41. Neuroproteomics and microRNAs studies in multiple sclerosis: transforming research and clinical knowledge in biomarker research

Author

Fawaz, Cherine N., primary, Makki, Iman S., additional, Kazan, Jalal M., additional, Gebara, Nour Y., additional, Andary, Farah S., additional, Itani, Muheiddine M., additional, El-Sayyed, Mohammad, additional, Zeidan, Asad, additional, Quartarone, Angelo, additional, Darwish, Hala, additional, and Mondello, Stefania, additional

Published
2015
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44. ERK1/2 Pathway Is Required for Differentiation of AML Triggered by Anti-CD44 Monoclonal Antibodies

Author

Samah Zeineb Gadhoum, Nour Y. Al-Madhoun, and Jasmeen S. Merzaban

Subjects
MAPK/ERK pathway, Myeloid, biology, MEK inhibitor, Immunology, CD44, Myeloid leukemia, Cell Biology, Hematology, Biochemistry, Haematopoiesis, medicine.anatomical_structure, Differentiation therapy, biology.protein, Cancer research, medicine, Signal transduction
Abstract

Abstract 4334 Acute myeloid leukemia (AML) is a heterogeneous disease characterized by accumulation of immature hematopoietic cells due to a blockage in myeloid differentiation at various stages. Since the current chemotherapy rarely eradicates the leukemic clones entirely, differentiation induction therapy has evolved. Previous experiments have shown that ligation of CD44, a cell surface glycoprotein strongly expressed on all AML cells, with anti-CD44 monoclonal antibodies (mAbs) could reverse the differentiation blockage of leukemic blasts and inhibit their proliferation in most AML subtypes, rendering CD44 a promising target for AML therapy. However, the underlying molecular mechanisms of the induction of differentiation by anti-CD44 mAbs have not been fully elucidated. Here, we investigated the signaling pathways triggered during anti-CD44 mAb (A3D8)-induced granulocytic differentiation of HL60, a human leukemic cell line commonly used as a model of human AML type2/3. Extracellular signal regulated kinase (ERK1/2) pathway plays a major role in the regulation of differentiation and proliferation for myeloid cells and has been reported to be aberrantly activated in AML. In our studies, we observed an increase of ERK1/2 phosphorylation by mitogen-activated ERK kinase (MEK) following A3D8 treatment. The use of U0126 (a MEK inhibitor) significantly abrogated the anti-CD44 induced granulocytic differentiation of HL60 cells, suggesting that ERK1/2 is critical for the induction of differentiation via CD44 in AML-M2/3. Our work provides the first evidence for the importance of the ERK pathway in granulocytic differentiation via CD44 and adds a new argument to the use of CD44 in differentiation therapy of AML. Disclosures: No relevant conflicts of interest to declare.

Published
2012
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49. DEGRO 2004

Author

Wendt, Thomas G., primary, Gademann, G., additional, Pambor, C., additional, Grießbach, I., additional, von Specht, H., additional, Martin, T., additional, Baltas, D., additional, Kurek, R., additional, Röddiger, S., additional, Tunn, U. W., additional, Zamboglou, N., additional, Eich, H. T., additional, Staar, S., additional, Gossmann, A., additional, Hansemann, K., additional, Semrau, R., additional, Skripnitchenko, R., additional, Diehl, V., additional, Müller, R.-P., additional, Sehlen, S., additional, Willich, N., additional, Rühl, U., additional, Lukas, P., additional, Dühmke, E., additional, Engel, K., additional, Tabbert, E., additional, Bolck, M., additional, Knaack, S., additional, Annweiler, H., additional, Krempien, R., additional, Hoppe, H., additional, Harms, W., additional, Daeuber, S., additional, Schorr, O., additional, Treiber, M., additional, Debus, J., additional, Alber, M., additional, Paulsen, F., additional, Birkner, M., additional, Bakai, A., additional, Belka, C., additional, Budach, W., additional, Grosser, K.-H., additional, Kramer, R., additional, Kober, B., additional, Reinert, M., additional, Schneider, P., additional, Hertel, A., additional, Feldmann, H., additional, Csere, P., additional, Hoinkis, C., additional, Rothe, G., additional, Zahn, P., additional, Alheit, H., additional, Cavanaugh, S. X., additional, Kupelian, P., additional, Reddy, C., additional, Pollock, B., additional, Fuss, M., additional, Roeddiger, S., additional, Dannenberg, T., additional, Rogge, B., additional, Drechsler, D., additional, Herrmann, T., additional, Alberti, W., additional, Schwarz, R., additional, Graefen, M., additional, Krüll, A., additional, Rudat, V., additional, Huland, H., additional, Fehr, C., additional, Baum, C., additional, Glocker, S., additional, Nüsslin, F., additional, Heil, T., additional, Lemnitzer, H., additional, Knips, M., additional, Baumgart, O., additional, Thiem, W., additional, Kloetzer, K.-H., additional, Hoffmann, L., additional, Neu, B., additional, Hültenschmidt, B., additional, Sautter-Bihl, M.-L., additional, Micke, O., additional, Seegenschmiedt, M. 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L., additional, Seaborn, R., additional, Rai, P., additional, Rha, S.-W., additional, Sakas, G., additional, Wesarg, S., additional, Zogal, P., additional, Schwald, B., additional, Seibert, H., additional, Berndt-Skorka, R., additional, Seifert, G., additional, Schoenekaes, K., additional, Bilecen, C., additional, Ito, W., additional, Matschuck, G., additional, and Isik, D., additional

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2004
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