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165 results on '"Nousiainen, Tapio"'

3. Efficacy of conventional-dose cytarabine, idarubicin and thioguanine versus intermediate-dose cytarabine and idarubicin in the induction treatment of acute myeloid leukemia: Long-term results of the prospective randomized nationwide AML-2003 study by the Finnish Leukemia Group

Author

Kolonen, Aarne, Sinisalo, Marjatta, Huhtala, Heini, Rimpiläinen, Johanna, Rintala, Hannele, Sankelo, Marja, Koivunen, Elli, Silvennoinen, Raija, Räty, Riikka, Ruutu, Tapani, Volin, Liisa, Porkka, Kimmo, Jantunen, Esa, Nousiainen, Tapio, Kuittinen, Taru, Penttilä, Karri, Pyörälä, Marja, Säily, Marjaana, Koistinen, Pirjo, Kauppila, Marjut, Itälä-Remes, Maija, Ollikainen, Hanna, Rauhala, Auvo, Kairisto, Veli, Pelliniemi, Tarja Terttu, Elonen, Erkki, Tampere University, Department of Internal medicine, Clinical Medicine, Health Sciences, and Department of Clinical Chemistry

Subjects
Leukemia, Myeloid, Acute, Neoplasm, Residual, Antineoplastic Combined Chemotherapy Protocols, Remission Induction, Cytarabine, Humans, Prospective Studies, Middle Aged, 3121 Internal medicine, Idarubicin, Thioguanine, Finland
Abstract

Objectives: AML-2003 study sought to compare the long-term efficacy and safety of IAT and IdAraC-Ida in induction chemotherapy of acute myeloid leukemia (AML) and introduce the results of an integrated genetic and clinical risk classification guided treatment strategy. Methods: Patients were randomized to receive either IAT or IdAraC-Ida as the first induction treatment. Intensified postremission strategies were employed based on measurable residual disease (MRD) and risk classification. Structured questionnaire forms were used to gather data prospectively. Results: A total of 356 AML patients with a median age of 53 years participated in the study. Long-term overall survival (OS) and relapse-free survival (RFS) were both 49% at 10 years. The median follow-up was 114 months. No significant difference in remission rate, OS or RFS was observed between the two induction treatments. Risk classification according to the protocol, MRD after the first and the last consolidation treatment affected the OS and RFS significantly (p

Published
2022

19. A prospective comparison of cardiac magnetic resonance imaging and radionuclide ventriculography in the assessment of cardiac function in patients treated with anthracycline-based chemotherapy

Author

Petri, Sipola, Sipola, Petri, Esko, Vanninen, Vanninen, Esko, Esa, Jantunen, Jantunen, Esa, Tapio, Nousiainen, Nousiainen, Tapio, Mikko, Kiviniemi, Kiviniemi, Mikko, Juha, Hartikainen, Hartikainen, Juha, Taru, Kuittinen, and Kuittinen, Taru

Subjects
Adult, Male, Cardiac function curve, Heart Diseases, Anthracycline, Radionuclide ventriculography, CHOP, Ventricular Function, Left, Cardiac magnetic resonance imaging, medicine, Humans, Radiology, Nuclear Medicine and imaging, Doxorubicin, Prospective Studies, Radionuclide Ventriculography, Aged, Antibiotics, Antineoplastic, Ejection fraction, medicine.diagnostic_test, business.industry, Lymphoma, Non-Hodgkin, Reproducibility of Results, Stroke Volume, General Medicine, Middle Aged, medicine.disease, Treatment Outcome, Heart failure, cardiovascular system, Female, Nuclear medicine, business, Magnetic Resonance Angiography, Follow-Up Studies, medicine.drug
Abstract

PURPOSE To compare cardiac MRI and radionuclide ventriculography (RVG) in cardiac monitoring during anthracycline (doxorubicin)-based chemotherapy. MATERIALS AND METHODS We studied 10 previously untreated adult non-Hodgkin lymphoma patients. Left ventricular ejection fraction (LVEF) was assessed by MRI and RVG simultaneously. In addition, left ventricular (LV) and left atrial size were determined by MRI. Both MRI and RVG measurements were determined at baseline and then repeated after eight cycles of CHOP chemotherapy (cumulative doxorubicin dose of 400 mg/m²). Power calculations were made on the basis of reproducibility measurements. RESULTS Clinical heart failure was not observed in any patient during the study. MRI detected a statistically significant increase in LV end-diastolic volume (128 ± 39 vs. 151 ± 46 ml, P

Published
2012

20. Old enemies in new disguises: emergence ofEnterococcus faeciumas a significant clinical problem at an adult haematology ward

Author

Hämäläinen, Sari, primary, Pentikäinen, Jaana, additional, Reijula, Jori, additional, Mauranen, Ella, additional, Koivula, Irma, additional, Lindholm, Laura, additional, Juutilainen, Auni, additional, Nousiainen, Tapio, additional, Pyörälä, Marja, additional, Vuopio, Jaana, additional, and Jantunen, Esa, additional

Published
2017
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21. Early MRD-Negativity May Predict for Favorable Outcome Irrespective of Allotransplantation in TKI-Treated Patients with Ph-Positive Acute Lymphoblastic Leukemia

Author

Hohtari, Helena, primary, Sinisalo, Marjatta, additional, Nousiainen, Tapio, additional, Koskenvesa, Perttu, additional, Wartiovaara-Kautto, Ulla, additional, Mustjoki, Satu, additional, Koistinen, Pirjo, additional, Säily, Marjaana, additional, Itälä-Remes, Maija, additional, Elonen, Erkki, additional, Remes, Kari, additional, and Porkka, Kimmo, additional

Published
2016
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22. Promising treatment results with blood brain barrier disruption (BBBD) based immunochemotherapy combined with autologous stem cell transplantation (ASCT) in patients with primary central nervous system lymphoma (PCNSL)

Author

Kuitunen, Hanne, primary, Tokola, Susanna, additional, Siniluoto, Topi, additional, Isokangas, Matti, additional, Sonkajärvi, Eila, additional, Alahuhta, Seppo, additional, Turpeenniemi-Hujanen, Taina, additional, Jantunen, Esa, additional, Nousiainen, Tapio, additional, Vasala, Kaija, additional, and Kuittinen, Outi, additional

Published
2016
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23. Early immune recovery after autologous transplantation in non-Hodgkin lymphoma patients: predictive factors and clinical significance

Author

Valtola, Jaakko, primary, Varmavuo, Ville, additional, Ropponen, Antti, additional, Selander, Tuomas, additional, Kuittinen, Outi, additional, Kuitunen, Hanne, additional, Keskinen, Leena, additional, Vasala, Kaija, additional, Nousiainen, Tapio, additional, Mäntymaa, Pentti, additional, Pelkonen, Jukka, additional, and Jantunen, Esa, additional

Published
2016
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24. Factors Affecting Early Immune Recovery after Autologous Transplantation and Its Clinical Significance - a Prospective Analysis of Patients with Non-Hodgkin Lymphoma

Author

Valtola, Jaakko, primary, Varmavuo, Ville, additional, Ropponen, Antti, additional, Selander, Tuomas, additional, Kuitunen, Hanne, additional, Keskinen, Leena, additional, Vasala, Kaija, additional, Nousiainen, Tapio, additional, Mäntymaa, Pentti, additional, Pelkonen, Jukka, additional, and Jantunen, Esa, additional

Published
2015
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25. Bloodstream infections in acute myeloid leukemia patients treated according to the Finnish Leukemia Group AML-2003 protocol – a prospective nationwide study.

Author

Kolonen, Aarne, Sinisalo, Marjatta, Huttunen, Reetta, Syrjänen, Jaana, Aittoniemi, Janne, Huhtala, Heini, Sankelo, Marja, Rintala, Hannele, Räty, Riikka, Jantunen, Esa, Nousiainen, Tapio, Säily, Marjaana, Kauppila, Marjut, Itälä-Remes, Maija, Ollikainen, Hanna, Rauhala, Auvo, Koistinen, Pirjo, and Elonen, Erkki

Subjects
GRAM-positive bacterial infections, ENTEROCOCCAL infections, BLOOD testing, BLOODBORNE infections, CANCER chemotherapy, CANCER patients, CELL culture, CHI-squared test, DIABETES, DISEASES, REPORTING of diseases, FISHER exact test, GRAM-negative bacterial diseases, HEART diseases, LONGITUDINAL method, OBSTRUCTIVE lung diseases, MEDICAL protocols, POPULATION, RESEARCH funding, T-test (Statistics), ACUTE myeloid leukemia, DISEASE incidence, HUMAN research subjects, PATIENT selection, DATA analysis software, CATHETER-related infections, TUMOR grading, DIAGNOSIS
Abstract

Background: Infections greatly influence the outcome of acute myeloid leukemia (AML) patients receiving intensive treatment. The aim of this study was to establish the incidence, microbial etiology, risk factors and prognosis of bloodstream infections (BSIs) in patients with AML and compare the results with the previous treatment protocol (AML-92). Methods: Registery data were gathered prospectively from 357 patients aged 16–65 years recruited on the AML-2003 treatment protocol between November 2003 and November 2011 during different treatment cycles. Results: Blood culture data were available on 977 treatment episodes, in which there were 503 BSIs (51%). The overall incidence rate (IR) for BSIs (per 1000 hospital days) was 16.7. Twenty patients (5.6%) died due to an infection and 16 of them (80%) had a BSI. The most commonly detected microbes (polymicrobial episodes included) in blood cultures were coagulase-negative staphylococci (CoNS, 24.7%), viridans group streptococci (VGS, 19.1%), enterococci (13.9%) and Enterobacteriacae group (25.9%). The etiology of BSIs varied greatly from treatment cycle to cycle. Conclusions: Enterococcal BSIs have increased compared to our previous treatment protocol, and they represent significant pathogens in blood cultures. Infection-related mortality has decreased despite the increase in the IR of BSIs. Enterococci seem to be an increasingly prominent pathogen underlying BSIs in the AML patients, especially during induction therapy (20%). [ABSTRACT FROM AUTHOR]

Published
2017
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26. Constant pattern of relapse in primary central nervous lymphoma patients treated with high-dose methotrexate combinations. A Finnish retrospective study

Author

Harjama, Liisa, primary, Kuitunen, Hanne, additional, Turpeenniemi-Hujanen, Taina, additional, Haapasaari, Kirsi Maria, additional, Leppä, Sirpa, additional, Mannisto, Susanna, additional, Karjalainen-Lindsberg, Marja-Liisa, additional, Lehtinen, Tuula, additional, Eray, Mine, additional, Vornanen, Martine, additional, Haapasalo, Hannu, additional, Soini, Ylermi, additional, Jantunen, Esa, additional, Nousiainen, Tapio, additional, Vasala, Kaija, additional, and Kuittinen, Outi, additional

Published
2015
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27. Stem Cell Graft Cellular Composition, Hematological and Immune Recovery in NHL Patients Mobilized with or without Plerixafor: A Prospective Comparison

Author

Valtola, Jaakko, primary, Varmavuo, Ville, additional, Ropponen, Antti, additional, Pyörälä, Marja, additional, Nihtinen, Anne, additional, Kutila, Anu, additional, Vasala, Kaija, additional, Lehtonen, Päivi, additional, Penttilä, Karri, additional, Kuittinen, Taru, additional, Nousiainen, Tapio, additional, Pelkonen, Jukka, additional, Mäntymaa, Pekka, additional, and Jantunen, Esa, additional

Published
2014
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28. Old enemies in new disguises: emergence of Enterococcus faecium as a significant clinical problem at an adult haematology ward.

Author

Hämäläinen, Sari, Pentikäinen, Jaana, Reijula, Jori, Mauranen, Ella, Koivula, Irma, Lindholm, Laura, Juutilainen, Auni, Nousiainen, Tapio, Pyörälä, Marja, Vuopio, Jaana, and Jantunen, Esa

Subjects
EPIDEMICS, HEMATOLOGY, HOSPITAL wards, ENTEROCOCCUS faecium
Abstract

The article reports that since 1991, Enterococcus faecium have been listed as the second leading nosocomial pathogen and are among the five most common causative agents of bloodstream infections.The issue of the emergence of Enterococcus faecium as a significant clinical problem at an adult haematology ward is discussed.

Published
2017
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29. Engraftment and outcome after autologous stem cell transplantation in plerixafor-mobilized non-Hodgkin's lymphoma patients

Author

Varmavuo, Ville, primary, Rimpiläinen, Johanna, additional, Kuitunen, Hanne, additional, Nihtinen, Anne, additional, Vasala, Kaija, additional, Mikkola, Maija, additional, Kutila, Anu, additional, Lehtonen, Päivi, additional, Kuittinen, Taru, additional, Mäntymaa, Pentti, additional, Nousiainen, Tapio, additional, Kuittinen, Outi, additional, and Jantunen, Esa, additional

Published
2013
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30. Comparison of Post-Transplant Outcomes in Non-Hodgkin Lymphoma (NHL) Patients Mobilized with or without Plerixafor Added to Chemomobilization

Author

Varmavuo, Ville, primary, Rimpiläinen, Johanna, additional, Nihtinen, Anne, additional, Vasala, Kaija, additional, Mikkola, Maija, additional, Lehtonen, Päivi, additional, Kuittinen, Taru, additional, Mäntymaa, Pentti, additional, Nousiainen, Tapio, additional, Kuittinen, Outi, additional, and Jantunen, Esa, additional

Published
2012
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42. Intensive chemotherapy of poor prognosis myelodysplastic syndromes (MDS) and acute myeloid leukemia following MDS with idarubicin and cytarabine

Author

Ruutu, Tapani, primary, Hänninen, Auli, additional, Järventie, Greta, additional, Koistinen, Pirjo, additional, Koivunen, Elli, additional, Kätkä, Kalevi, additional, Nousiainen, Tapio, additional, Oksanen, Kalevi, additional, Pelliniemi, Tarja-Terttu, additional, Remes, Kari, additional, Timonen, Timo, additional, Volin, Liisa, additional, and Elonen, Erkki, additional

Published
1997
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46. Serial plasma lactate measurements in haematological patients with neutropenic fever.

Author

Juutilainen, Auni, Hämäläinen, Sari, Matinlauri, Irma, Kuittinen, Taru, Nousiainen, Tapio, Pulkki, Kari, Koivula, Irma, and Jantunen, Esa

Subjects
NEUTROPENIA, BLOOD lactate, SEPSIS, MORTALITY, HEMATOLOGY, PATIENTS
Abstract

Elevated plasma lactate and impaired lactate clearance have been associated with poor outcome in patients with severe sepsis. No data are available on the kinetics or prognostic value of plasma lactate in haematological patients with neutropenic fever. A total of 70 haematological patients with 94 episodes of neutropenic fever were included into this prospective study during the period 2006–2008. The median age of the patients was 56 (range 18–70) y. Nineteen patients received therapy for acute myeloid leukaemia and 51 patients received autologous stem cell transplantation. At the onset and on days 1, 2, and 3 of each neutropenic fever episode, plasma lactate and serum C-reactive protein were determined. Criteria for severe sepsis were fulfilled in 13 neutropenic episodes. An elevated plasma lactate level was infrequent at the start of neutropenic fever (5%). There was no association of lactate level with the development of severe sepsis. Two patients died of septic shock, 1 patient with an exceptionally high and increasing level of lactate and the other patient with a normal lactate level. An elevated plasma lactate level at the start of neutropenic fever is not common and does not indicate severe sepsis, but high lactate and an impaired lactate decrease may signify a fatal course in neutropenic fever. [ABSTRACT FROM AUTHOR]

Published
2010
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49. Hospital Water Supply as a Source of Disseminated Mycobacterium fortuitumInfection in a Leukemia Patient

Author

Kauppinen, Juha, Nousiainen, Tapio, Jantunen, Esa, Mattila, Rauni, and Katila, Marja-Leena

Abstract

AbstractNosocomial acquisition of Mycobacterium fortuitumled to a disseminated infection in a leukemia patient. A linkage to shower-head water was supported by molecular typing of clinical and environmental isolates. Contamination of the hospital water system with microbes that are relatively resistant to common sanitation processes poses an increased risk of infection to neutropenic patients.

Published
1999
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50. Autologous peripheral blood stem cell transplantation in a patient with severe mixed connective tissue disease.

Author

Myllykangas-Luosujärvi, Riitta, Jantunen, Esa, Kaipiainen-Seppänen, Oili, Mahlamäki, Eija, Nousiainen, Tapio, Myllykangas-Luosujärvi, R, Jantunen, E, Kaipiainen-Seppänen, O, Mahlamäki, E, and Nousiainen, T

Subjects
AUTOTRANSPLANTATION, MIXED connective tissue disease, STEM cell treatment, IMMUNOSUPPRESSIVE agents, THERAPEUTICS
Abstract

A 65-year old man with mixed connective tissue disease (MCTD) and severe therapy resistant polymyositis was considered for high-dose cyclophosphamide (200 mg/kg) supported by autologous stem cell transplantation (ASCT). During a 21 months follow-up there has been a significant subjective, but objectively only a slight improvement in muscle strength. Initially the levels of serum creatine kinase and serum aldolase normalised, but are at 21 months at about the same level as before ASCT. Based on histopathological examination there is still active myositis. Our case would suggests that this treatment may have some efficacy in MCTD with severe polymyositis although longer follow-up is needed. [ABSTRACT FROM AUTHOR]

Published
2000
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