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30 results on '"Novoselova, Marina V."'

1. Evaluation of polymeric submicron microcapsule accumulation in cellular and intercellular space of 3D spheroids

Author

Abalymov, A. A., Lomova, Maria V., Novoselova, Marina V., and Gorin, Dmitriy A.

Subjects
spheroids, fl ow cytometry, microcapsules, drug delivery, theranostics, Biology (General), QH301-705.5
Abstract

Multicellular spheroids are three-dimensional in vitro models of organs and tissues. Multicellular spheroids have gained great interest in the fi eld of biotechnology as they are reproducible and mimic real organs and tissues so can be used as test systems for new forms of drugs, allowing minimizing the use of in vivo animal models. Flow cytometry was used to describe the accumulation of submicron polymeric microcapsules in cellular spheroids, which allowed us to identify the main aspects of drug carrier-cell interactions within the spheroid. Spheroids were generated using 4T1 mouse breast cancer cells and healthy L929 mouse fi broblast cells. The arrangement of microcapsules with 300, 500, 1000 nm diameter with biocompatible shells in cell spheroids was evaluated in their intercellular and intracellular spaces.

Published
2024
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10. Golden Vaterite as a Mesoscopic Metamaterial for Biophotonic Applications

Author

Noskov, Roman E., primary, Machnev, Andrey, additional, Shishkin, Ivan I., additional, Novoselova, Marina V., additional, Gayer, Alexey V., additional, Ezhov, Alexander A., additional, Shirshin, Evgeny A., additional, German, Sergei V., additional, Rukhlenko, Ivan D., additional, Fleming, Simon, additional, Khlebtsov, Boris N., additional, Gorin, Dmitry A., additional, and Ginzburg, Pavel, additional

Published
2021
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12. Multifunctional nanostructured drug delivery carriers for cancer therapy: Multimodal imaging and ultrasound-induced drug release

Author

Novoselova, Marina V., primary, German, Sergei V., additional, Abakumova, Tatiana O., additional, Perevoschikov, Stanislav V., additional, Sergeeva, Olga V., additional, Nesterchuk, Mikhail V., additional, Efimova, Olga I., additional, Petrov, Kirill S., additional, Chernyshev, Vasiliy S., additional, Zatsepin, Timofei S., additional, and Gorin, Dmitry A., additional

Published
2021
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13. Barnase encapsulation into submicron porous CaCO3 particles: studies of loading and enzyme activity

Author

Yashchenok, Alexey M., primary, Gusliakova, Olga I., additional, Konovalova, Elena V., additional, Novoselova, Marina V., additional, Shipunova, Victoria O., additional, Abakumova, Tatiana O., additional, Efimova, Olga I., additional, Kholodenko, Roman, additional, Schulga, Alexey A., additional, Zatsepin, Timofei S., additional, Gorin, Dmitry A., additional, and Deyev, Sergey M., additional

Published
2021
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14. Sentinel lymph node detection by combining nonradioactive techniques with contrast agents: State of the art and prospects.

Author

Kurochkin, Maxim A., German, Sergey V., Abalymov, Anatolii, Vorontsov, Dmitry А., Gorin, Dmitry A., and Novoselova, Marina V.

Abstract

The status of sentinel lymph nodes (SLNs) has a substantial prognostic value because these nodes are the first place where cancer cells accumulate along their spreading route. Routine SLN biopsy ("gold standard") involves peritumoral injections of radiopharmaceuticals, such as technetium‐99m, which has obvious disadvantages. This review examines the methods used as "gold standard" analogs to diagnose SLNs. Nonradioactive preoperative and intraoperative methods of SLN detection are analyzed. Promising photonic tools for SLNs detection are reviewed, including NIR‐I/NIR‐II fluorescence imaging, photoswitching dyes for SLN detection, in vivo photoacoustic detection, imaging and biopsy of SLNs. Also are discussed methods of SLN detection by magnetic resonance imaging, ultrasonic imaging systems including as combined with photoacoustic imaging, and methods based on the magnetometer‐aided detection of superparamagnetic nanoparticles. The advantages and disadvantages of nonradioactive SLN‐detection methods are shown. The review concludes with prospects for the use of conservative diagnostic methods in combination with photonic tools. [ABSTRACT FROM AUTHOR]

Published
2022
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15. Barnase encapsulation into submicron porous CaCO3 particles: studies of loading and enzyme activity.

Author

Yashchenok, Alexey M., Gusliakova, Olga I., Konovalova, Elena V., Novoselova, Marina V., Shipunova, Victoria O., Abakumova, Tatiana O., Efimova, Olga I., Kholodenko, Roman, Schulga, Alexey A., Zatsepin, Timofei S., Gorin, Dmitry A., and Deyev, Sergey M.

Abstract

The present study focuses on the immobilization of the bacterial ribonuclease barnase (Bn) into submicron porous calcium carbonate (CaCO3) particles. For encapsulation, we apply adsorption, freezing-induced loading and co-precipitation methods and study the effects of adsorption time, enzyme concentration and anionic polyelectrolytes on the encapsulation efficiency of Bn. We show that the use of negatively charged dextran sulfate (DS) and ribonucleic acid from yeast (RNA) increases the loading capacity (LC) of the enzyme on CaCO3 particles by about 3-fold as compared to the particles with Bn itself. The ribonuclease (RNase) activity of encapsulated enzyme depends on the LC of the particles and transformation of metastable vaterite to stable calcite, as studied by the assessment of enzyme activities in particles. [ABSTRACT FROM AUTHOR]

Published
2021
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16. Biodegradable Polymeric Multilayer Capsules for Therapy of Lung Cancer

Author

Novoselova, Marina V., primary, Loh, Hui Mun, additional, Trushina, Daria B., additional, Ketkar, Avanee, additional, Abakumova, Tatiana O., additional, Zatsepin, Timofei S., additional, Kakran, Mitali, additional, Brzozowska, Agata Maria, additional, Lau, Hooi Hong, additional, Gorin, Dmitry A., additional, Antipina, Maria N., additional, and Brichkina, Anna I., additional

Published
2020
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19. Amplification of photoacoustic effect in bimodal polymer particles by self-quenching of indocyanine green

Author

Mokrousov, Maksim D., primary, Novoselova, Marina V., additional, Nolan, Jackie, additional, Harrington, Walter, additional, Rudakovskaya, Polina, additional, Bratashov, Daniil N., additional, Galanzha, Ekaterina I., additional, Fuenzalida-Werner, Juan Pablo, additional, Yakimov, Boris P., additional, Nazarikov, Gleb, additional, Drachev, Vladimir P., additional, Shirshin, Evgeny A., additional, Ntziachristos, Vasilis, additional, Stiel, Andre C., additional, Zharov, Vladimir P., additional, and Gorin, Dmitry A., additional

Published
2019
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20. Label-free characterization of white blood cells using fluorescence lifetime imaging and flow-cytometry: molecular heterogeneity and erythrophagocytosis [Invited]

Author

Yakimov, Boris P., primary, Gogoleva, Maria A., additional, Semenov, Alexey N., additional, Rodionov, Sergey A., additional, Novoselova, Marina V., additional, Gayer, Alexey V., additional, Kovalev, Alexey V., additional, Bernakevich, Alexey I., additional, Fadeev, Victor V., additional, Armaganov, Artashes G., additional, Drachev, Vladimir P., additional, Gorin, Dmitry A., additional, Darvin, Maxim E., additional, Shcheslavskiy, Vladislav I., additional, Budylin, Gleb S., additional, Priezzhev, Alexander V., additional, and Shirshin, Evgeny A., additional

Published
2019
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21. Submicron-Sized Nanocomposite Magnetic-Sensitive Carriers: Controllable Organ Distribution and Biological Effects

Author

Novoselova, Marina V., primary, German, Sergey V., additional, Sindeeva, Olga A., additional, Kulikov, Oleg A., additional, Minaeva, Olga V., additional, Brodovskaya, Ekaterina P., additional, Ageev, Valentin P., additional, Zharkov, Mikhail N., additional, Pyataev, Nikolay A., additional, Sukhorukov, Gleb B., additional, and Gorin, Dmitry A., additional

Published
2019
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22. Photoacoustic and fluorescent effects in multilayer plasmon‐dye interfaces

Author

Novoselova, Marina V., primary, Bratashov, Daniil N., additional, Sarimollaoglu, Mustafa, additional, Nedosekin, Dmitry A., additional, Harrington, Walter, additional, Watts, Alex, additional, Han, Mikyung, additional, Khlebtsov, Boris N., additional, Galanzha, Ekaterina I., additional, Gorin, Dmitry A., additional, and Zharov, Vladimir P., additional

Published
2019
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23. High-efficiency freezing-induced loading of inorganic nanoparticles and proteins into micron- and submicron-sized porous particles

Author

German, Sergei V., primary, Novoselova, Marina V., additional, Bratashov, Daniil N., additional, Demina, Polina A., additional, Atkin, Vsevolod S., additional, Voronin, Denis V., additional, Khlebtsov, Boris N., additional, Parakhonskiy, Bogdan V., additional, Sukhorukov, Gleb B., additional, and Gorin, Dmitry A., additional

Published
2018
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26. Formulation for Oral Delivery of Lactoferrin Based on Bovine Serum Albumin and Tannic Acid Multilayer Microcapsules

Author

Kilic, Ece, primary, Novoselova, Marina V., additional, Lim, Su Hui, additional, Pyataev, Nikolay A., additional, Pinyaev, Sergey I., additional, Kulikov, Oleg A., additional, Sindeeva, Olga A., additional, Mayorova, Oksana A., additional, Murney, Regan, additional, Antipina, Maria N., additional, Haigh, Brendan, additional, Sukhorukov, Gleb B., additional, and Kiryukhin, Maxim V., additional

Published
2017
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27. In vitro and in vivo MRI visualization of nanocomposite biodegradable microcapsules with tunable contrast

Author

German, Sergey V., primary, Bratashov, Daniil N., additional, Navolokin, Nikita A., additional, Kozlova, Anastasia A., additional, Lomova, Maria V., additional, Novoselova, Marina V., additional, Burilova, Evgeniya A., additional, Zyev, Victor V., additional, Khlebtsov, Boris N., additional, Bucharskaya, Alla B., additional, Terentyuk, Georgy S., additional, Amirov, Rustem R., additional, Maslyakova, Galina N., additional, Sukhorukov, Gleb B., additional, and Gorin, Dmitry A., additional

Published
2016
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29. Fabrication and photoluminescent properties of Tb3+ doped carbon nanodots.

Author

Vostrikova, Anna M., Kokorina, Alina A., Demina, Polina A., German, Sergei V., Novoselova, Marina V., Tarakina, Nadezda V., Sukhorukov, Gleb B., and Goryacheva, Irina Y.

Abstract

Carbon nanodots (CNDs) doped with Tb ions were synthesized using different synthetic routes: hydrothermal treatment of a solution containing carbon source (sodium dextran sulfate) and TbCl3; mixing of CNDs and TbCl3 solutions; freezing-induced loading of Tb and carbon-containing source into pores of CaCO3 microparticles followed by hydrothermal treatment. Binding of Tb ions to CNDs (Tb-CND coupling) was confirmed using size-exclusion chromatography and manifested itself through a decrease of the Tb photoluminescence lifetime signal. The shortest Tb photoluminescence lifetime was observed for samples obtained by hydrothermal synthesis of CaCO3 microparticles where Tb and carbon source were loaded into pores via the freezing-induced process. The same system displays an increase of Tb photoluminescence via energy transfer with excitation at 320-340 nm. Based on the obtained results, freezing-induced loading of cations into CNDs using porous CaCO3 microparticles as reactors is proposed to be a versatile route for the introduction of active components into CNDs. The obtained CNDs with long-lived emission may be used for time-resolved imaging and visualization in living biological samples where time-resolved and long-lived luminescence microscopy is required. [ABSTRACT FROM AUTHOR]

Published
2018
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30. Barnase encapsulation into submicron porous CaCO 3 particles: studies of loading and enzyme activity.

Author

Yashchenok AM, Gusliakova OI, Konovalova EV, Novoselova MV, Shipunova VO, Abakumova TO, Efimova OI, Kholodenko R, Schulga AA, Zatsepin TS, Gorin DA, and Deyev SM

Subjects
Adsorption, Bacterial Proteins biosynthesis, Bacterial Proteins metabolism, Calcium Carbonate metabolism, Dextran Sulfate chemistry, Dextran Sulfate metabolism, Escherichia coli enzymology, Particle Size, Polyelectrolytes metabolism, Porosity, RNA chemistry, RNA metabolism, Ribonucleases biosynthesis, Ribonucleases metabolism, Saccharomyces cerevisiae chemistry, Saccharomyces cerevisiae metabolism, Surface Properties, Bacterial Proteins chemistry, Calcium Carbonate chemistry, Polyelectrolytes chemistry, Ribonucleases chemistry
Abstract

The present study focuses on the immobilization of the bacterial ribonuclease barnase (Bn) into submicron porous calcium carbonate (CaCO 3 ) particles. For encapsulation, we apply adsorption, freezing-induced loading and co-precipitation methods and study the effects of adsorption time, enzyme concentration and anionic polyelectrolytes on the encapsulation efficiency of Bn. We show that the use of negatively charged dextran sulfate (DS) and ribonucleic acid from yeast (RNA) increases the loading capacity (LC) of the enzyme on CaCO 3 particles by about 3-fold as compared to the particles with Bn itself. The ribonuclease (RNase) activity of encapsulated enzyme depends on the LC of the particles and transformation of metastable vaterite to stable calcite, as studied by the assessment of enzyme activities in particles.

Published
2021
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