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This study aims to investigate the effect of ground tire rubber (GTR) treated by acetone on mechanical and morphological properties of ethylene-vinyl acetate (EVA) matrix. Polymeric EVA/GTR (0, 10, 20, 30, and 40 phr) compounds were achieved through extrusion and batch foaming process. TGA and NMR analysis revealed that oils and additives were removed from the GTR after the acetone treatment. Morphological characterization showed cell sizes below 100 [micro]m in the compounds with treated GTR, which improved the mechanical performance of EVA/GTR compounds. The results indicated that the acetone-treated GTR are a suitable raw material to obtain foam compounds useful in vibrations absorber and isolation applications. KEYWORDS EVA-GTR foam compounds, ground rubber, Trigonox 145-B, 1 | INTRODUCTION Today, over 17 million tons of tires per year are produced around the world. However, the worn tires have become a serious issue as residue accumulation due [...]

A catalytic system for a phosphorus ligand-free Suzuki-Miyaura reaction in water at room temperature was disclosed. Ammonium 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonate) (ABTS) was an efficient promoterand actedboth asa ligand and as a surfactant for the synthesis of biaryl compounds via the Suzuki-Miyaura reaction in water. The targeted biaryl architectures were achieved under mild conditions with high efficiency and good functional group tolerance. Key words: Suzuki-Miyaura reaction, biaryl, ligand free, 22'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid), water. Nous presentons un systeme catalytique sans ligand phosphore pour la reaction de SuzukiMiyaura dans l'eau a temperature ambiante. Le 2,2'azino-bis(3-ethylbenzohiazoline-6-sulfonate) d'ammonium (ABTS) s'est revele etre un promoteur efficace, agissant a la fois comme ligand et comme tensioactif dans la synthese de composes biaryliques par couplage de SuzukiMiyaura dans l'eau. Ce systeme catalytique a permis de former les structures biaryliques ciblees dans des conditions douces avec une grande efficacite et une bonne tolerance aux groupements fonctionnels. [Traduit par la Redaction] Mots-cles: reaction de Suzuki-Miyaura, biaryle, sans ligand, 22'-azino-bis(acide 3ethylbenzohiazoline-6-sulfonique), eau., Introduction As a versatile alternative to the formation of C-C bonds, (1,2) the Suzuki-Miyaura coupling reaction has found extensive use in the synthesis of natural products, pharmaceuticals, and advanced materials [...]

This study was aimed to synthesize novel 2-(2-bromophenyl)-N-phenethylacetamides and benzylisoquinoline (BIQ) derivatives to be evaluated as antidepressant-like agents in mice. The phenethylacetamides derivatives were synthesized by coupling aromatic amides to the backbone of 2-bromophenylacetyl chloride. The synthesis of BIQ was achieved by the reaction between synthesized phenethylacetamides and 2-chloropyridine. The structures of compounds were established mainly by 1D and 2D NMR spectra. Those compounds obtained with moderate to good yields were evaluated as antidepressant-like agents in the forced swim test and the open field paradigms in mice. The possible mechanism of those active derivatives was explored by antagonist experiments in combination with p-chloro-phenylalanine methyl ester, reserpine, sulpiride, and dopamine D1 antagonist SCH3390. Also, MAO A and B inhibition assays were performed. Docking studies between the human dopamine D3 receptor and the higher active compound were performed. The results showed that the (2-bromophenyl)-(3,4-dihydroisoquinoline-1-yl) methanone (4a) presented the most potent antidepressant-like effects without modifying the ambulatory activity of experimental mice. Antagonist experiments showed that 4a acted on the serotonergic and dopaminergic receptors. Docking studies indicated a strong affinity between the human dopamine D3 receptor and 4a. Our results showed that BIQ 4a has an antidepressant-like effect that is possibly mediated by an interaction with the presynaptic serotonin receptors and dopaminergic, D1, D2, and D3, receptors. This study highlights the pharmacological potential of halogenated BIQs in the treatment of some depressive disorders. Keywords: acetamide, antidepressant, benzylisoquinoline, isoquinoline, synthesis. La presente etude visait a synthetiser de nouveaux derives 2-(2-bromophenyl)-N-phenethylacetamide et benzyliso-quinoline (BIQ) en vue de les evaluer comme agents pseudoantidepresseurs chez la souris. Nous avons synthetise les derives phenethylacetylamide par couplage d'amides aromatiques au squelette du chlorure de 2-bromophenylacetyle. Nous avons obtenu les derives BIQ par reaction entre les derives phenethylacetamide que nous avons synthetises et la 2-chloropyridine. Les structures de ces composes ont ete determinees principalement a l'aide des spectres RMN1D et 2D. Les composes obtenus avec des rendements moderes a bons ont ete evalues comme agents pseudoantidepresseurs chez la souri sdans le cadre du test de la nage forcee et du test de l'open field. Nous avons explore le mecanisme d'action possible de ces derives actifs par des experiences sur des antagonistes administres en association, dont l'ester methylique de la p-chlorophenylalanine, la reserpine, le sulpiride et l'antagoniste dopaminergique D1 SCH23390. De plus, nous avons effectue des tests d'inhibi-tion de la monoamine oxydase (MAO) A et B. Nous avons egalement realise des etudes d'amarrage entre le recepteur dopaminergique D3 humain et le compose le plus actif. Les resultats ont montre que la (2-bromophenyl)-(3,4-dihydroisoquinoline-1-yl) methanone (4a) presentait les effets pseudoantidepresseurs les plus puissants sans modifier l'activite locomotrice des souris de laboratoire. Les experiences sur les antagonistes ont montre que le compose 4a agissait sur les recepteurs serotoni-nergiques et dopaminergiques. Les etudes d'amarrage ont quant a elles indique une forte affinite entre le recepteur dopaminergique D3 humain et le compose 4a. Nos resultats ont montre que le derive benzylisoquinoline 4a a un effet pseu-doantidepresseur qui repose possiblement sur une interaction avec les recepteurs presynaptiques de la serotonine et les recepteurs dopaminergiques D1, D2 et D3. Cette etude souligne le potentiel pharmacologique des BIQ halogenees dans le traitement de certains troubles depressifs. [Traduit par la Redaction] Mots-cles: acetamide, antidepresseur, benzylisoquinoline, isoquinoline, synthese., Introduction Depression is a common complex mental disorder, characterized by changes in the emotional state. (1) Although it is well known that several causes can lead to a depressive state, [...]

A novel tripod-chromogenic sensor based on a s-triazine and thiazolidine-2,4-dione ring (TCST)was designed, synthesized, and applied as a colorimetric probe in aqueous solutions of dimethyl sulfoxide (DMSO). The probe showed a highly sensitive and selective colorimetric sensor for naked-eye detection of L[i.sup.+], changing from colourless to yellow. The probe's detection limit toward L[i.sup.+] was found to be 1.2 [micro]M. The result of the Job plot analysis showed 1:1 stoichiometry for the interaction between the tripod chemosensor and L[i.sup.+] and this result was confirmed by [.sup.1.H] NMR titration experiments. The probe can also be used for biological activities depending on the results of microbial tests. Key words: chemosensor, colorimetric, naked-eye detection, L[i.sup.+] sensing, s-triazine, thiazolidine-24-dione. Nous avons concu et synthetise un nouveau capteur chromogene de type tripode contenant un noyau central striazine et des cycles thiazolidine-2,4dione (TCST)et nous l'avons employe comme sonde colorimetrique dans des solutions aqueuses de dimethylsulfoxyde (DMSO). Nous avons observe que cette sonde agit comme capteur colorimetrique haute-ment sensible et selectif pour la detection a l'ceil nu de l'ion L[i.sup.+], qui se caracterise par un changement de couleur passant d'incolore a jaune. La limite de detection de la sonde a l'egard de l'ion L[i.sup.+] etait de 1,2 [micro]M. L'analyse de la courbe de Job a montre que l'interaction entre le capteur chimique de type tripode et l'ion L[i.sup.+] presentait une stc chiometrie de 1:1. Ce resul-tat a ete confirme au moyen d'experiences de titrage par RMN [.sup.1.H]. La sonde peut egalement etre utilisee comme molecule bioactive selon les resultats de tests microbiens. [Traduit par la Redaction] Mots-cles: capteur chimique, colorimetrique, detection a l'ceil nu, detection d'ions L[i.sup.+], striazine, thiazolidine-24dione., Introduction Lithium (Li) is an important metal with natural sources in the Earth's crustal rocks, seawater, and mammals. (1,2) Among the metal ions, this soft metal has an undeniable industrial [...]

Using the branch data from 90 sample trees, we developed novel models of outer- and inner-crown profiles for the northern, eastern, southern, and western sides of planted Larix kaempferi (Lam.) Carriere trees in northeastern China via the integration of competition indices (CIs) based on nonlinear marginal regression (NMR). We also used nonparametric boundary regression (NBR) to model the crown-profile boundary. The largest crown radius and inflection points of sample trees were calculated using NBR and NMR. We determined that the CIs of the ratio of the diameter of the subject tree to the quadratic mean diameter (CI3) and ratio of the basal area of the subject tree to the mean basal area of the stand ([CI.sub.5]) were the best distance-independent CIs for incorporation into the models of outer- and inner-crown profiles, respectively. The CIs showed a significant effect on the outer-crown profile in all four directions for dominant, intermediate, and suppressed trees but did not show a significant effect on inner-crown profile. The outer-crown radius increased and inner-crown radius decreased with increasing [CI.sub.3] and [CI.sub.5], respectively. The crown profile on the northern side was the largest, which conformed to the regularity in the mean current increment of the sampled branches. Key words: crown profile, competition index, nonlinear marginal regression, nonparametric boundary regression, Larix kaempferi. En utilisant les donnees qui caracterisent les branches de 90 arbres echantillons, nous avons mis au point de nouveaux modeles de profils de cime externe et interne pour les faces nord, est, sud et ouest de Larix kaempferi (Lam.) Carriere plante dans le nord-est de la Chine, en integrant des indices de competition a l'aide de la regression marginale non lineaire (RMNL). Nous avons egalement utilise la regression a limites non parametriques (RLNP) pour modeliser la limite du profil de la cime. Le plus grand rayon de la cime et les points d'inflexion des arbres echantillons ont ete calcules a l'aide de la RLNP et de la RMNL. De plus, nous avons determine que les indices de competition du rapport entre le diametre de l'arbre sujet et le diametre moyen quadratique ([CI.sub.3]), ainsi que le rapport entre la surface terriere de l'arbre sujet et la surface terriere moyenne du peuplement ([CI.sub.5]) etaient respectivement les meilleurs indices de competition independants de la distance a incorporer dans les modeles de profils de cime externe et interne. Les indices de competition avaient un effet significatif sur le profil de cime externe dans les quatre directions pour les arbres dominants, intermediaires et opprimes, mais pas sur le profil de cime interne. Les rayons de cime externe et interne augmentaient et diminuaient respectivement avec une augmentation de [CI.sub.3] et de [CI.sub.5]. Le profil de la cime du cote nord etait le plus grand, ce qui est conforme a la regularite de l'accroissement courant moyen des branches echantillonnees. [Traduit par la Redaction] Mots-cles : profil de cime, indice de competition, regression marginale non lineaire, regression a limites non parametriques, Larix kaempferi., Introduction The crown development of an individual tree is determined by a combination of multiple factors, including intertree competition, growing-site conditions, and intrinsic genetics (Attocchi and Skovsgaard 2015; Sharma et [...]