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Your search keyword '"Nunes, Paulo H. M."' showing total 5 results
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5 results on '"Nunes, Paulo H. M."'

2. Terminalia fagifolia Mart. & Zucc. elicits vasorelaxation of rat thoracic aorta through nitric oxide and K+ channels dependent mechanism

Author

de Carvalho, Emanuella F., Nunes, André F., Silva, Náiguel C. B., da Silva Gomes, João Paulo, de Sousa, Renato P., Silva, Valdelânia G., Nunes, Paulo H. M., Santos, Rosimeire F., Chaves, Mariana H., Oliveira, Aldeidia P., and Oliveira, Rita C. M.

Subjects
Endothelium, QH301-705.5, Science, Pharmacology, Nitric Oxide, General Biochemistry, Genetics and Molecular Biology, Potassium channels, Nitric oxide, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Combretaceae, medicine.artery, medicine, Thoracic aorta, Biology (General), 030304 developmental biology, K channels, 0303 health sciences, Aorta, Óxido Nítrico, biology, Vasorelaxation, Terminalia, biology.organism_classification, Potassium channel, medicine.anatomical_structure, chemistry, Terminalia fagifolia, General Agricultural and Biological Sciences, 030217 neurology & neurosurgery, Research Article
Abstract

Terminalia fagifolia Mart. & Zucc. (Combretaceae) is a plant commonly found in the regions of the Brazilian cerrado, popularly used for the treatment of gastrointestinal disorders. There are no reports in the literature on the use of T. fagifolia for the treatment of the cardiovascular system conditions. Nevertheless, plants of the same genus, such as Terminalia arjuna (Roxb.) Wight & Arn and Terminalia superba Engler & Diels, present cardioprotective, hypotensive and vasodilatating effects. In light of this, the aim of the study was to investigate the effect of the ethanolic extract (Tf-EE) and of its aqueous (Tf-AQF), hexanic (Tf-HEXF) and hydroethanolic (Tf-HAF) partition fractions obtained from the stem bark of T. fagifolia Mart. & Zucc. The effects of the extract and partition fractions of T. fagifolia were evaluated on isometric tensions in the thoracic aorta rings of Wistar rats (250–300 g). Tf-EE, Tf-HEXF and Tf-HAF presented a concentration-dependent vasorelaxant effect, and Tf-AQF presented a vasorelaxant effect that was more potent in the presence of endothelium. The relaxation curves of the aorta promoted by the fraction investigated were attenuated in the presence of the following pharmacological tools: L-NAME, ODQ or PTIO. The vasorelaxant effect of the aorta promoted by Tf-AQF was attenuated in the presence of TEA and 4-AP. Tf-EE induced a concentration-dependent and endothelium-independent vasorelaxation. Tf-HAF and Tf-HEXF presented concentration-dependent and vascular-endothelium-independent vasorelaxation, but did not obtain 100% of relaxation. On the other hand, Tf-AQF presented concentration-dependent vasorelaxation that was more potent in aorta rings with vascular endothelium. The relaxant mechanism induced by the Tf-AQF involves the NO/sGC/cGMP pathway and channels Kv., Summary: The investigation of the relaxing effect of extract and fractions of the stem bark partition of Terminalia fagifolia on aortic rings is a pioneering study involving the participation of K+ channels, which demonstrates a potential alternative therapeutic method for the treatment of cardiovascular diseases.

Published
2019
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4. Evaluation of oil-resin activity of Copaifera sp. on gastric emptying in Rattus novergicus.

Author

Vilanova, Camila M. A., Ribeiro, Sahâmia M., Machado, Rodolfo C. S., Vieira, Salatiel M., De Lima, Sidney G., Nunes, Paulo H. M., and Martins, Maria C. C.

Subjects
COPAIBA, TRADITIONAL medicine, ANTI-inflammatory agents, ANTISEPTICS, GASTROINTESTINAL system, GASTRIC emptying, HEALING
Abstract

The Copaiba oil-resin (Copaifera sp.) is widely used in folk medicine, especially as a healing, antiinflammatory, antiseptic, to treat ulcers and skin diseases. Increased gastric emptying was observed with oilresin of Copaifera langsdorfii, highlighting those others species from the genus of Copaifera can act over the gastrointestinal tract. This study evaluated the activity of the Copaifera sp oil-resin on gastric emptying in Rattus novergicus. Eighteen male rats were fasted for 24h and orally received Tween-80 and Copaiba oil-resin 100 and 200 mg/kg; one hour later they all received phenol red (PR) 0.5 mg/mL. Then, the parts of gastrointestinal tract (stomach and intestine) were analyzed. The results showed that Copaifera sp oil-resin at 200 mg/kg increased the gastric emptying in Rattus novergicus. [ABSTRACT FROM AUTHOR]

Published
2013
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5. Antidiarrheal effect of extract from the bark of Combretum leprosum in mice.

Author

Cavalcanti PMS, Martins MDCC, Nunes PHM, Alves Filho FC, Silva JDP, and Cavalcanti SMG

Subjects
Animals, Antidiarrheals pharmacology, Castor Oil, Diarrhea etiology, Female, Gastrointestinal Transit drug effects, Intestinal Secretions drug effects, Mice, Plant Extracts pharmacology, Random Allocation, Rats, Wistar, Receptors, Adrenergic, alpha drug effects, Receptors, Opioid drug effects, Reproducibility of Results, Time Factors, Treatment Outcome, Antidiarrheals therapeutic use, Combretum chemistry, Diarrhea drug therapy, Plant Extracts therapeutic use
Abstract

This study investigated the effects of the ethanolic extract from the bark of Combretum leprosum (ECL) on intestinal transit and castor-oil induced diarrhea in mice. The oral administration of ECL (750 and 1000 mg/kg) slowed intestinal transit (ID50 of 455 mg/kg). The ECL (250-1000 mg/kg) reduced castor-oil induced diarrhea, in a time- and dose-dependent manner (p < 0.05). To determine if antidiarrheal effect of ECL involves α2-adrenergic or opioid receptor activation, the mice were pretreated with antagonists of these receptors, yohimbine or naloxone respectively. None of these drugs inhibited the antidiarrheal effect of ECL. To test if antidiarrheal effect of ECL is due to an antisecretory action, we realized the enteropooling assay on rats. The ECL increased bowel content and did not inhibit intestinal fluid secretion increase induced by misoprostol (100 µg/kg, s.c.). To determine if antimotility effect of ECL is due to a reduction on gastric motility, we realized the organ bath assay in the rat fundus stomach. Isotonic recordings show that the carbachol /KCl - induced contraction was not reversed by the addition of ECL. In conclusion, our results suggest that ECL contains antidiarrheal compounds and these compounds could induce a reduction of intestinal tract motility.

Published
2019
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