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Your search keyword '"Nunn, M.A."' showing total 13 results
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13 results on '"Nunn, M.A."'

2. Successful treatment of a PNH patient non-responsive to eculizumab with the novel complement C5 inhibitor coversin (nomacopan)

Author

Schols, S.E.M., Nunn, M.A., Mackie, I., Weston-Davies, W., Nishimura, J.I., Kanakura, Y., Blijlevens, N.M., Muus, P., Langemeijer, S., Schols, S.E.M., Nunn, M.A., Mackie, I., Weston-Davies, W., Nishimura, J.I., Kanakura, Y., Blijlevens, N.M., Muus, P., and Langemeijer, S.

Abstract

Contains fulltext : 218318.pdf (Publisher’s version ) (Closed access)

Published
2020

5. Crystal structure and functional characterization of an immunomodulatory salivary cystatin from the soft tick Ornithodoros moubata.

Author

Salát, J., Paesen, G.C., Rezácová, P., Kotsyfakis, M., Kovárová, Z., Sanda, M., Majtán, J., Grunclová, L., Horká, H., Andersen, J.F., Brynda, J., Horn, M., Nunn, M.A., Kopácek, P., Kopecký, J., Mares, M., Salát, J., Paesen, G.C., Rezácová, P., Kotsyfakis, M., Kovárová, Z., Sanda, M., Majtán, J., Grunclová, L., Horká, H., Andersen, J.F., Brynda, J., Horn, M., Nunn, M.A., Kopácek, P., Kopecký, J., and Mares, M.

Abstract

The saliva of blood-feeding parasites is a rich source of peptidase inhibitors that help to overcome the host's defence during host–parasite interactions. Using proteomic analysis, the cystatin OmC2 was demonstrated in the saliva of the soft tick Ornithodoros moubata, an important disease vector transmitting African swine fever virus and the spirochaete Borrelia duttoni. A structural, biochemical and biological characterization of this peptidase inhibitor was undertaken in the present study. Recombinant OmC2 was screened against a panel of physiologically relevant peptidases and was found to be an effective broad-specificity inhibitor of cysteine cathepsins, including endopeptidases (cathepsins L and S) and exopeptidases (cathepsins B, C and H). The crystal structure of OmC2 was determined at a resolution of 2.45 Å (1 Å=0.1 nm) and was used to describe the structure–inhibitory activity relationship. The biological impact of OmC2 was demonstrated both in vitro and in vivo. OmC2 affected the function of antigen-presenting mouse dendritic cells by reducing the production of the pro-inflammatory cytokines tumour necrosis factor α and interleukin-12, and proliferation of antigen-specific CD4+ T-cells. This suggests that OmC2 may suppress the host's adaptive immune response. Immunization of mice with OmC2 significantly suppressed the survival of O. moubata in infestation experiments. We conclude that OmC2 is a promising target for the development of a novel anti-tick vaccine to control O. moubata populations and combat the spread of associated diseases

Published
2010

6. Description of a novel tick-derived dendritic cell modulator

Author

Preston, S.G., Paesen, G.C., Majtan, J., Rysnik, O., Kouremenou, C., Becker, P., Nunn, M.A., Nuttall, P.A., Preston, S.G., Paesen, G.C., Majtan, J., Rysnik, O., Kouremenou, C., Becker, P., Nunn, M.A., and Nuttall, P.A.

Published
2010

7. OMCI in complex with palmitoleic acid

Author

Roversi, P., primary, Maillet, I., additional, Togbe, D., additional, Couillin, I., additional, Quesniaux, V.F.J., additional, Teixeira, M., additional, Ahmat, N., additional, Lissina, O., additional, Boland, W., additional, Ploss, K., additional, Caesar, J.J.E., additional, Leonhartsberger, S., additional, Ryffel, B., additional, Lea, S.M., additional, and Nunn, M.A., additional

Published
2012
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8. OMCI in complex with leukotriene B4

Author

Roversi, P., primary, Maillet, I., additional, Togbe, D., additional, Couillin, I., additional, Quesniaux, V.F.J., additional, Teixeira, M., additional, Ahmat, N., additional, Lissina, O., additional, Boland, W., additional, Ploss, K., additional, Caesar, J.J.E., additional, Leonhartsberger, S., additional, Ryffel, B., additional, Lea, S.M., additional, and Nunn, M.A., additional

Published
2012
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13. Meeting Report: Risk Assessment of Tamiflu® use under Pandemic Conditions—Report from an Interdisciplinary Workshop

Author

Singer A. C., Howard B. M., Johnson A. C., Knowles C. J., Jackman S., ACCINELLI, CESARE, Barra Caracciolo A., Bernard I, Bird S., Boucard T., Boxall A., Brian J. V., Cartmell E., Chubb C., Churchley J., Costigan S., Crane M., Dempsey M. J., Dorrington B., Fick J., Holmes J., Hutchinson T., Karcher F., Kelleher S. L., Marsden P., Noone G., Nunn M. A., Oxford J., Rachwal T., Roberts N., Roberts M., Saccà M. L., Sanders M., Straub J. O., Terry A., Thomas D., Toovey S., Townsend R., Voulvoulis N., Watts C., Wells U., Singer A.C., Howard B.M., Johnson A.C., Knowles C.J., Jackman S., Accinelli C., Barra Caracciolo A., Bernard I, Bird S., Boucard T., Boxall A., Brian J.V., Cartmell E., Chubb C., Churchley J., Costigan S., Crane M., Dempsey M.J., Dorrington B., Fick J., Holmes J., Hutchinson T., Karcher F., Kelleher S.L., Marsden P., Noone G., Nunn M.A., Oxford J., Rachwal T., Roberts N., Roberts M., Saccà M.L., Sanders M., Straub J.O., Terry A., Thomas D., Toovey S., Townsend R., Voulvoulis N., Watts C., and Wells U.

Subjects
POLLUTION, ANTIVIRAL, SEWAGE TREATMENT PLANT, TAMIFLU, DRUG, ECOTOXICOLOGY
Abstract

On 3 October 2007, 40 participants with diverse expertise attended the workshop Tamiflu and the Environment: Implications of Use under Pandemic Conditions to assess the potential human health impact and environmental hazards associated with use of Tamiflu during an influenza pandemic. Based on the identification and risk-ranking of knowledge gaps, the consensus was that oseltamivir ethylester-phosphate (OE-P) and oseltamivir carboxylate (OC) were unlikely to pose an ecotoxicologic hazard to freshwater organisms. OC in river water might hasten the generation of OCresistance in wildfowl, but this possibility seems less likely than the potential disruption that could be posed by OC and other pharmaceuticals to the operation of sewage treatment plants. The workgroup members agreed on the following research priorities: a) available data on the ecotoxicology of OE-P and OC should be published; b) risk should be assessed for OC-contaminated river water generating OC-resistant viruses in wildfowl; c) sewage treatment plant functioning due to microbial inhibition by neuraminidase inhibitors and other antimicrobials used during a pandemic should be investigated; and d) realistic worst-case exposure scenarios should be developed. Additional modeling would be useful to identify localized areas within river catchments that might be prone to high pharmaceutical concentrations in sewage treatment plant effluent. Ongoing seasonal use of Tamiflu in Japan offers opportunities for researchers to assess how much OC enters and persists in the aquatic environment.

Published
2008

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