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Introduction Endovascular treatment (ET) is a beneficial treatment for M1–2 occlusions of the middle cerebral artery. Mortality and disability rates are high if large vessel occlusions are not treated. While these rates are lower in M3 occlusions, important branch blockages can lead to disability. Endovascular treatment of small vessel occlusions is difficult, and there are no studies on the effectiveness of endovascular treatment for M3 occlusions. Accordingly, in this study, our aim was to assess the feasibility, safety, and preliminary efficacy of endovascular therapy for M3 occlusions. Methods This study involved a retrospective analysis of a prospectively collected from two centres for acute ischemic stroke of the anterior system between July 2015 and April 2020. Demographic, radiologic, procedural and outcome variables were collected for patients who underwent endovascular therapy for acute ischemic stroke of the anterior system. Results Complete or near complete reperfusion (mTICI 2b-3) of the M3 occlusion was achieved in 15 cases (38.5%). Complete (mTICI 3) reperfusion was achieved in 24 cases (61.5%). Twenty-six patients were treated for primary M3 occlusion, while 13 patients with M3 occlusion were treated as a rescue strategy after successful treatment of a proximal greater vascular occlusion. Complete or near complete reperfusion (mTICI 2b-3) of primary occlusion was achieved in eight cases (30.8%), and complete (mTICI 3) reperfusion was achieved in 18 cases (69.2%). In addition, complete or near complete reperfusion (mTICI 2b-3) of rescue M3 occlusion was achieved in seven cases (%53.8), while complete (mTICI 3) reperfusion was achieved in six cases (46.2%). Only one patient with primary M3 occlusion had ICH due to extravasation. The patient's neurological examination one month later was normal. Conclusions This retrospective study demonstrates that endovascular treatment of M3 occlusions is safe, effective and reliable.

Background We sought to examine the feasibility, safety and preliminary efficacy of anterior cerebral artery (ACA) occlusions in patients undergoing endovascular treatment. Methods Four hundred five consecutive patients with large-vessel occlusion treated with endovascular treatment were analysed to identify all patients with acute ACA occlusion who underwent endovascular treatment. Results Twenty had ACA occlusion (primary ACA occlusion: 9, rescue ACA occlusion: 11), 395 patients had other occlusions (internal carotid artery and MCA). The median [IQR] mRS score in the third month was significantly higher in the ACA-rescue occlusion group versus the ACA-primary occlusion group. The rate of haematoma in patients with ACA-occlusions was significantly higher compared with the ACA-primary occlusion group. Moreover, the three-month mortality rate was higher in patients with ACA-rescue than the patients with ACA-primary. Conclusions Although endovascular treatment can be considered in patients with primary ACA occlusions, our data suggest that future clinical trials are needed to determine the efficacy of endovascular treatment for ACA occlusions. Unfavourable outcomes in our study were considered to occur in the rescue ACA occlusions.

Cheques a reliable negotiable instrument and has a widespread use in Turkey, however, from past to today, dud cheques become a serious problem for the markets and legal practitioners. This problem should be deal with an approach regarding fair trial principle and the neccessities of commercial life. Normal 0 21 false false false TR X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Normal Tablo"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin-top:0cm; mso-para-margin-right:0cm; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0cm; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri",sans-serif; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi; mso-fareast-language:EN-US;} This paper focuses on criminal and administrative sanctions when a cheque is to be marked as a “dud cheque”. Considering historical development, doctrine, court decisions and scholarly works, the study aims to provide the most appropriate solution related to the concerned criminal and administrative sanctions, for legal practitioners and commercial actors.

Introduction: Endovascular treatment (ET) has become most well-proven beneficial treatment for the M1-2 occlusions of the middle cerebral artery. Mortality and disability rates are high if large vessel occlusions are not treated. Even if these rates are lower in M3 occlusions, the important branch blockages can end with disability. Small vessels occlusions are difficult to detect and treatment for endovascular interventions. There are few studies on the effectiveness of endovascular treatment for M3 occlusions. In this study, our aim to assess the feasibility, safety, and preliminary efficacy of endovascular therapy for M3 occlusions. Methods: This study was conducted a retrospective analysis of a prospectively collected database in two-centers for acute ischemic stroke of anterior system between July 2015 and April 2020. Demographic, radiologic, procedural variables and outcome variables were collected in patients with who were taken endovascular therapy for acute ischemic stroke of anterior system. Middle cerebral artery is divided into the sections according to the course and angle of the middle cerebral artery. M3 (opercular) segment of the middle cerebral artery is after the circular sulcus of the insula. Results: The complete or near complete reperfusion (mTICI 2b-3) of m3 occlusion was achieved in 15 cases (38.5%). The complete (mTICI 3) reperfusion was achieved in 24 cases (61.5%). The complete or near complete reperfusion (mTICI 2b-3) of the other anterior circulation occlusion was achieved in 129 cases (65.9%) while the complete (mTICI 3) reperfusion was achieved in 50 cases (27%). Conclusions: This retrospective study demonstrates the ability of endovascularly treatment of M3 occlusions as effective, reliable and cost-effective. Funding Information: None. Declaration of Interests: None. Ethics Approval Statement: This study was approved by the local Institutional Review Board with a waiver of informed consent.

The reproductive biology of the domestic dog is unique among mammalian species; because of this, in vitro maturation (IVM) rate is still very low compared with other domestic animals in spite of attempts at improvement. The aim of this study was to consider the use of recombinant human gonadotropins as a replacement for pituitary gonadotropins for IVM of dog oocytes. A total of 845 cumulus-oocyte complexes were used in this study. To determine the effects of human recombinant gonadotropins, maturation medium was supplemented with two different concentrations (0.05 or 0.1 IU/mL) of pituitary (pFSH, pLH) and human recombinant (rhFSH and rhLH) gonadotropins. After the IVM period, the maturation rate of the oocytes was investigated under an epifluorescence microscope. Our findings showed no significant difference in maturation rate using either pituitary or human recombinant gonadotropin groups (P > 0.05). Applying 1.0 IU human recombinant gonadotropin caused the lowest maturation rate (34.57%; P < 0.05). In conclusion, recombinant human gonadotropins could be applied for IVM of dog oocytes. Moreover, 0.05 IU/mL rhFSH and rhLH can be successfully used in place of biologically derived hormones., Scientific Research Projects Coordination Unit of Istanbul University