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African American (AA) women have the highest prevalence of obesity than other groups in the US making them disproportionately at high risk for chronic diseases associated with obesity such type 2 diabetes mellitus. Research has shown that stress may be a risk factor for obesity and that it may be more prevalent within AA women. The aim of this study was to identify if there is an association between psychological stress in AA women in the US and abdominal obesity (AO). A cross sectional study design was employed using secondary data from the 2011-2012 National Health and Nutrition Examination Survey (NHANES). There were 655 AA female participants included in the study sample. The exposure variable was psychological stress assessed by select questions from the NHANES survey. The outcome variable was AO measured by waist circumference. Logistic regression was used to examine the relationship between psychological stress and AO among AA women. The results of this study were that psychological stress was correlated with increased odds of AO upon adjusting for age, BMI, educational level and marital status (OR=1.192 95% CI 0.305 – 4.655). However, the association was not statistically significant. When examining the relationship between other covariates and AO, having a formal education and being a married woman were each found to be associated with decreased odds of AO. The results were not generalizable, but they suggest areas of promise in better understanding the impact of AO among AA women which could lead to targeted interventions to reduce this outcome in the population as well as others.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection elicits an antibody response that targets several viral proteins including spike (S) and nucleocapsid (N); S is the major target of neutralizing antibodies. Here, we assess levels of anti-N binding antibodies and anti-S neutralizing antibodies in unvaccinated children compared with unvaccinated older adults following infection. Specifically, we examine neutralization and anti-N binding by sera collected up to 52 weeks following SARS-CoV-2 infection in children and compare these to a cohort of adults, including older adults, most of whom had mild infections that did not require hospitalization. Neutralizing antibody titers were lower in children than adults early after infection, but by 6 months titers were similar between age groups. The neutralizing activity of the children's sera decreased modestly from one to six months; a pattern that was not significantly different from that observed in adults. However, infection of children induced much lower levels of anti-N antibodies than in adults, and levels of these anti-N antibodies decreased more rapidly in children than in adults, including older adults. These results highlight age-related differences in the antibody responses to SARS-CoV-2 proteins and, as vaccines for children are introduced, may provide comparator data for the longevity of infection-elicited and vaccination-induced neutralizing antibody responses.