Search

Your search keyword '"Nyirády P"' showing total 337 results
Start Over Author "Nyirády P"
337 results on '"Nyirády P"'

14. Magnetresonanztomographie beim Prostatakrebs-Screening: Eine systematische Review und Metaanalyse

Author

Fazekas, T, Shim, SR, Basile, G, Baboudjian, M, Kói, T, Ploussard, G, Kasivisvanathan, V, Rivas, JG, Gandaglia, G, Szarvas, T, Schoots, IG, van den Bergh, RCN, Leapman, MS, Nyirády, P, Shariat, SF, Rajwa, P, Fazekas, T, Shim, SR, Basile, G, Baboudjian, M, Kói, T, Ploussard, G, Kasivisvanathan, V, Rivas, JG, Gandaglia, G, Szarvas, T, Schoots, IG, van den Bergh, RCN, Leapman, MS, Nyirády, P, Shariat, SF, and Rajwa, P

Published
2024

15. Prevalence of APC and PTEN Alterations in Urachal Cancer

Author

Nagy, Nikolett, Reis, Henning, Hadaschik, Boris, Niedworok, Christian, Módos, Orsolya, Szendrői, Attila, Bíró, Krisztina, Hager, Thomas, Herold, Thomas, Ablat, Jason, Black, Peter C., Okon, Krzysztof, Tolkach, Yuri, Csizmarik, Anita, Oláh, Csilla, Keresztes, David, Bremmer, Felix, Gaisa, Nadine T., Kriegsmann, Joerg, Kovalszky, Ilona, Kiss, András, Tímár, József, Szász, Marcell A., Rink, Michael, Fisch, Margit, Nyirády, Péter, and Szarvas, Tibor

Published
2020
Full Text
View/download PDF

20. Adherence to EAU guidelines on penile cancer translates into better outcomes: a multicenter international study

Author

Cindolo, Luca, Spiess, Philippe E., Bada, Maida, Chipollini, Juan J., Nyirády, Peter, Chiodini, Paolo, Varga, Judith, Ditonno, Pasquale, Battaglia, Michele, De Nunzio, Cosimo, Tema, Giorgia, Veccia, Alessandro, Antonelli, Alessandro, Musi, Gennaro, De Cobelli, Ottavio, Conti, Andrea, Micali, Salvatore, Álvarez-Maestro, Mario, Olarte, José Quesada, Diogenes, Erico, Lima, Marcos Venicio Alves, Tracey, Andrew, Guruli, Georgi, Autorino, Riccardo, Sountoulides, Petros, and Schips, Luigi

Published
2019
Full Text
View/download PDF

23. Magnetic Resonance Imaging in Prostate Cancer Screening: A Systematic Review and Meta-Analysis

Author

Fazekas, Tamás, Shim, Sung Ryul, Basile, Giuseppe, Baboudjian, Michael, Kói, Tamás, Przydacz, Mikolaj, Abufaraj, Mohammad, Ploussard, Guillaume, Kasivisvanathan, Veeru, Rivas, Juan Gómez, Gandaglia, Giorgio, Szarvas, Tibor, Schoots, Ivo G., van den Bergh, Roderick C. N., Leapman, Michael S., Nyirády, Péter, Shariat, Shahrokh F., and Rajwa, Pawel

Abstract

IMPORTANCE: Prostate magnetic resonance imaging (MRI) is increasingly integrated within the prostate cancer (PCa) early detection pathway. OBJECTIVE: To systematically evaluate the existing evidence regarding screening pathways incorporating MRI with targeted biopsy and assess their diagnostic value compared with prostate-specific antigen (PSA)–based screening with systematic biopsy strategies. DATA SOURCES: PubMed/MEDLINE, Embase, Cochrane/Central, Scopus, and Web of Science (through May 2023). STUDY SELECTION: Randomized clinical trials and prospective cohort studies were eligible if they reported data on the diagnostic utility of prostate MRI in the setting of PCa screening. DATA EXTRACTION: Number of screened individuals, biopsy indications, biopsies performed, clinically significant PCa (csPCa) defined as International Society of Urological Pathology (ISUP) grade 2 or higher, and insignificant (ISUP1) PCas detected were extracted. MAIN OUTCOMES AND MEASURES: The primary outcome was csPCa detection rate. Secondary outcomes included clinical insignificant PCa detection rate, biopsy indication rates, and the positive predictive value for the detection of csPCa. DATA SYNTHESIS: The generalized mixed-effect approach with pooled odds ratios (ORs) and random-effect models was used to compare the MRI-based and PSA-only screening strategies. Separate analyses were performed based on the timing of MRI (primary/sequential after a PSA test) and cutoff (Prostate Imaging Reporting and Data System [PI-RADS] score ≥3 or ≥4) for biopsy indication. RESULTS: Data were synthesized from 80 114 men from 12 studies. Compared with standard PSA-based screening, the MRI pathway (sequential screening, PI-RADS score ≥3 cutoff for biopsy) was associated with higher odds of csPCa when tests results were positive (OR, 4.15; 95% CI, 2.93-5.88; P ≤ .001), decreased odds of biopsies (OR, 0.28; 95% CI, 0.22-0.36; P ≤ .001), and insignificant cancers detected (OR, 0.34; 95% CI, 0.23-0.49; P = .002) without significant differences in the detection of csPCa (OR, 1.02; 95% CI, 0.75-1.37; P = .86). Implementing a PI-RADS score of 4 or greater threshold for biopsy selection was associated with a further reduction in the odds of detecting insignificant PCa (OR, 0.23; 95% CI, 0.05-0.97; P = .048) and biopsies performed (OR, 0.19; 95% CI, 0.09-0.38; P = .01) without differences in csPCa detection (OR, 0.85; 95% CI, 0.49-1.45; P = .22). CONCLUSION AND RELEVANCE: The results of this systematic review and meta-analysis suggest that integrating MRI in PCa screening pathways is associated with a reduced number of unnecessary biopsies and overdiagnosis of insignificant PCa while maintaining csPCa detection as compared with PSA-only screening.

Published
2024
Full Text
View/download PDF

26. Positive family history as a predictor for disease outcomes after radical prostatectomy for nonmetastatic prostate cancer.

Author

Rajwa, Pawel, Quhal, Fahad, D'Andrea, David, Korn, Stephan, Petrov, Patrik, Yanagisawa, Takafumi, Kawada, Tatsushi, Motlagh, Reza Sari, Mostafaei, Hadi, Laukhtina, Ekaterina, Aydh, Abdulmajeed, König, Frederik, Pallauf, Maximilian, Pradere, Benjamin, Nyirády, Peter, Abufaraj, Mohammad, Marra, Giancarlo, Gandaglia, Giorgio, Briganti, Alberto, and Karakiewicz, Pierre

Abstract

While family history (FHx) of prostate cancer (PCa) increases the risk of PCa, comparably less is known regarding the impact of FHx on pathologic and oncologic outcomes after radical prostatectomy (RP). We retrospectively reviewed our multicenter database comprising 6,041 nonmetastatic PCa patients treated with RP. Patients with a FHx of PCa in one or more first-degree relatives were considered as FHx positive. We examined the association of FHx with pathologic outcomes and biochemical recurrence (BCR) using logistic and Cox regression models, respectively. In total, 1,677 (28%) patients reported a FHx of PCa. Compared to patients without FHx, those with, were younger at RP (median age of 59 vs. 62 years, p < 0.01), and had significantlymore favorable biopsy and RP histopathologic findings. On multivariable logistic regression analysis, positive FHx was associated with extracapsular extension (odds ratio [OR] 0.77, 95% confidence interval [CI] 0.66–0.90, p < 0.01; model AUC 0.73) and upgrading (OR 0.70, 95% CI 0.62–0.80, p < 0.01; model AUC 0.68). Incorporating FHx significantly improved the AUC of the base model for upgrading (p < 0.01). Positive FHx was not associated with BCR in pre- and postoperative multivariable models (p = 0.1 and p = 0.7); c-indexes of Cox multivariable models were: 0.73 and 0.82, respectively. We found that patients with clinically nonmetastatic PCa who have positive FHx of PCa undergo RP at a younger age and have more favorable pathologic outcomes. Nevertheless, FHx of PCa did not confer better BCR rates, suggesting that FHx leads to potentially early detection and treatment without impact on BCR. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

33. P152 - Combined analysis of molecular patterns and clinical factors for the prediction of immune checkpoint inhibitor therapy in advanced urothelial carcinoma

Author

Szarvas, T., Varadi, M., Horvath, O., Soos, E., Fazekas, T., Csizmarik, A., Nemeth, B., Gyorffy, B., Kenessey, I., Reis, H., Koll, F., Olah, C., Hadaschik, B., Krafft, U., Mairinger, F., Wessolly, M., Hoffmann, M., Grunewald, C., Niegisch, G., Maraz, A., Kuthi, L., Furka, A., and Nyirady, P.

Published
2024
Full Text
View/download PDF

44. Galactomannans are the most effective soluble dietary fibers in type 2 diabetes: a systematic review and network meta-analysis

Author

Juhász, Anna E., Greff, Dorina, Teutsch, Brigitta, Gede, Noémi, Hegyi, Péter, Horváth, Eszter M., Deák, Pál Á., Nyirády, Péter, Ács, Nándor, and Juhász, Réka

Abstract

Soluble dietary fibers are known to reduce the levels of blood glucose and lipids in patients with type 2 diabetes mellitus (type 2 diabetes). Although several different dietary fiber supplements are utilized, to our knowledge, no previous study has ranked their efficacy yet.

Published
2023
Full Text
View/download PDF

45. Robot-assisted laparoscopy does not have demonstrable advantages over conventional laparoscopy in endometriosis surgery: a systematic review and meta-analysis

Author

Csirzó, Ádám, Kovács, Dénes Péter, Szabó, Anett, Fehérvári, Péter, Jankó, Árpád, Hegyi, Péter, Nyirády, Péter, Sipos, Zoltán, Sára, Levente, Ács, Nándor, Szabó, István, and Valent, Sándor

Abstract

Background: Endometriosis is a chronic condition affecting 6–10% of women of reproductive age, with endometriosis-related pain and infertility being the leading symptoms. Currently, the gold standard treatment approach to surgery is conventional laparoscopy (CL); however, the increasing availability of robot-assisted surgery is projected as a competitor of CL. This study aimed to compare the perioperative outcomes of robot-assisted laparoscopy (RAL) and CL in endometriosis surgery. Objectives: We aimed to compare the effectiveness and safety of these two procedures. Methods: A systematic search was conducted in three medical databases. Studies investigating different perioperative outcomes of endometriosis-related surgeries were included. Results are presented as odds ratios (OR) or mean differences (MD) with 95% confidence intervals (CI). Results: Our search yielded 2,014 records, of which 13 were eligible for data extraction. No significant differences were detected between the CL and RAL groups in terms of intraoperative complications (OR = 1.07, CI 0.43–2.63), postoperative complications (OR = 1.3, CI 0.73–2.32), number of conversions to open surgery (OR = 1.34, CI 0.76–2.37), length of hospital stays (MD = 0.12, CI 0.33–0.57), blood loss (MD = 16.73, CI 4.18–37.63) or number of rehospitalizations (OR = 0.95, CI 0.13–6.75). In terms of operative times (MD = 28.09 min, CI 11.59–44.59) and operating room times (MD = 51.39 min, CI 15.07–87.72;), the RAL technique remained inferior. Conclusion: RAL does not have statistically demonstrable advantages over CL in terms of perioperative outcomes for endometriosis-related surgery. Graphical abstract:

Published
2023
Full Text
View/download PDF

48. Next-generation sequencing-based molecular analysis of urachal adenocarcinomas

Author

Nagy, N., primary, Kubik, A., additional, Szendrői, A., additional, Módos, O., additional, Csizmarik, A., additional, Oláh, C., additional, Keresztes, D., additional, Kenessey, I., additional, Szász, M., additional, Oroszi, M., additional, Nagy, Z., additional, Francz, M., additional, Korodi-Gál, B., additional, Nizar, J., additional, Hadaschik, B., additional, Nyirády, P., additional, and Szarvas, T., additional

Published
2019
Full Text
View/download PDF

50. Comparative proteome analysis identified NAMPT as a potential serum marker for the prediction of docetaxel-resistance in prostate cancer

Author

Keresztes, D., primary, Módos, O., additional, Szűcs, M., additional, Hüttl, A., additional, Csizmarik, A., additional, Nagy, N., additional, Kretz, V., additional, Bracht, T., additional, Sitek, B., additional, Witzke, K., additional, Puhr, M., additional, Sevcenko, S., additional, Kramer, G., additional, Shariat, S., additional, Nyirády, P., additional, and Szarvas, T., additional

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results