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9 results on '"Nyman, T.A."'

5. G.P.271

Author

Marttila, M., primary, Lehtokari, V.L., additional, Marston, S.B., additional, Nyman, T.A., additional, Barnerias, C., additional, Beggs, A.H., additional, Bertin, E., additional, Ceyhan-Birsoy, Ö., additional, Cintas, P., additional, Gerard, M., additional, Gilbert-Dussardier, B., additional, Hogue, J.S., additional, Longman, C., additional, Eymard, B., additional, Frydman, M., additional, Kang, P.B., additional, Klinge, L., additional, Kolski, H., additional, Lochmüller, H., additional, Magy, L., additional, Manel, V., additional, Mayer, M., additional, North, K.N., additional, Peudenier-Robert, S., additional, Pihko, H., additional, Probst, F.J., additional, Reisin, R., additional, Stewart, W., additional, Taratuto, A.L., additional, de Visser, M., additional, Wilichowski, E., additional, Winer, J., additional, Nowak, K., additional, Lain, N.G., additional, Winder, T.L., additional, Monnier, N., additional, Clarke, N.F., additional, Pelin, K., additional, Grönholm, M., additional, and Wallgren-Pettersson, C., additional

Published
2014
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7. G.P.271: Mutation update and genotype-phenotype correlations of novel and previously described mutations in TPM2 and TPM3 causing congenital myopathies

Author

Marttila, M., Lehtokari, V.L., Marston, S.B., Nyman, T.A., Barnerias, C., Beggs, A.H., Bertin, E., Ceyhan-Birsoy, Ö., Cintas, P., Gerard, M., Gilbert-Dussardier, B., Hogue, J.S., Longman, C., Eymard, B., Frydman, M., Kang, P.B., Klinge, L., Kolski, H., Lochmüller, H., Magy, L., Manel, V., Mayer, M., North, K.N., Peudenier-Robert, S., Pihko, H., Probst, F.J., Reisin, R., Stewart, W., Taratuto, A.L., de Visser, M., Wilichowski, E., Winer, J., Nowak, K., Lain, N.G., Winder, T.L., Monnier, N., Clarke, N.F., Pelin, K., Grönholm, M., and Wallgren-Pettersson, C.

Published
2014
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8. A Streptococcus uberis transposon mutant screen reveals a negative role for LiaR homologue in biofilm formation.

Author

Salomäki, T., Karonen, T., Siljamäki, P., Savijoki, K., Nyman, T.A., Varmanen, P., and Iivanainen, A.

Subjects
BIOFILMS, BOVINE mastitis, STREPTOCOCCUS uberis, TRANSPOSONS, MUTAGENESIS, PHOSPHORYLATION
Abstract

Aims The environmental pathogen Streptococcus uberis causes intramammary infections in dairy cows. Because biofilm growth might contribute to Strep. uberis mastitis, we conducted a biological screen to identify genes potentially involved in the regulation of biofilm growth. Methods and Results By screening a transposon mutant library of Strep. uberis, we determined that the disruption of 13 genes (including hasA, coaC, clpP, miaA, nox and uidA) led to increased biofilm formation. One of the genes ( SUB1382) encoded a homologue of the LiaR response regulator ( RR) of the Bacillus subtilis two-component signalling system ( TCS). Electrophoretic mobility shift assays revealed that DNA binding by LiaR was greatly enhanced by phosphorylation. Two-dimensional differential in-gel electrophoresis analyses of the liaR mutant and the parental Strep. uberis strain revealed five differentially produced proteins with at least a 1·5-fold change in relative abundance ( P < 0·05). Conclusions The DNA-binding protein LiaR is a potential regulator of biofilm formation by Strep. uberis. Significance and Impact of the Study Several molecular primary and downstream targets involved in biofilm formation by Strep. uberis were identified. This provides a solid foundation for further studies on the regulation of biofilm formation in this important pathogen. [ABSTRACT FROM AUTHOR]

Published
2015
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9. Biological properties of extracellular vesicles and their physiological functions

Author

Juan M. Falcón-Pérez, Irene M. Ghobrial, Aija Linē, Eva Rohde, Francesco Cappello, Irina Nazarenko, María Yáñez-Mó, Saara Laitinen, Mayda Gursel, María Mittelbrunn, Krisztina Buzas, Mario Gimona, Erzsébet Ligeti, An Hendrix, Ihsan Gursel, Marie Stampe Ostenfeld, Antonio Marcilla, Joana Carvalho, Eva-Maria Krämer-Albers, Georg Lipps, Francisco Sánchez-Madrid, Thomas Lener, Carla Oliveira, Éva Pállinger, Francesc E. Borràs, Susanne G. van der Grein, Olivier De Wever, Veronika Kralj-Iglič, Bernd Giebel, Anabela Cordeiro da Silva, Esther N. M. Nolte-‘t Hoen, Nuno Santarém, Willem Stoorvogel, Marina Rigau, Hernando A. del Portillo, Katsutoshi Kokubun, Marca H. M. Wauben, Alicia Llorente, Apolonija Bedina Zavec, Eva Colas, Katharina Schallmoser, Maja Kosanović, Peter Kierulf, Jaume Reventós, Mireia Olivan, Jan Lötvall, Edit I. Buzás, Enriqueta Casal, Michael W. Graner, Pia Siljander, Stefano Fais, Cecilia Lässer, Marei Sammar, Niels H. H. Heegaard, Lorraine O'Driscoll, Roman Štukelj, Tuula A. Nyman, Zoraida Andreu, Mateja Manček-Keber, M. Helena Vasconcelos, Infection & Immunity, Fertility & Reproduction, dB&C I&I, LS Celbiologie-Algemeen, Yanez-Mo M., Siljander P.R.-M., Andreu Z., Zavec A.B., Borras F.E., Buzas E.I., Buzas K., Casal E., Cappello F., Carvalho J., Colas E., Cordeiro-Da Silva A., Fais S., Falcon-Perez J.M., Ghobrial I.M., Giebel B., Gimona M., Graner M., Gursel I., Gursel M., Heegaard N.H.H., Hendrix A., Kierulf P., Kokubun K., Kosanovic M., Kralj-Iglic V., Kramer-Albers E.-M., Laitinen S., Lasser C., Lener T., Ligeti E., Line A., Lipps G., Llorente A., Lotvall J., Mancek-Keber M., Marcilla A., Mittelbrunn M., Nazarenko I., Nolte-'t Hoen E.N.M., Nyman T.A., O'Driscoll L., Olivan M., Oliveira C., Pallinger E., Del Portillo H.A., Reventos J., Rigau M., Rohde E., Sammar M., Sanchez-Madrid F., Santarem N., Schallmoser K., Ostenfeld M.S., Stoorvogel W., Stukelj R., Van Der Grein S.G., Helena Vasconcelos M., Wauben M.H.M., and De Wever O.

Subjects
Proteomics, Cellular distribution, MATURE DENDRITIC CELLS, Review, Review Article, Urine, Embryo development, Monocyte, Protein processing, Vascular biology, Feces, Vesícules seminals, SYNCYTIOTROPHOBLAST MICROVILLOUS MEMBRANES, Cell selection, Pregnancy, T lymphocyte, Bile, CELL-DERIVED EXOSOMES, Biogenesis, Lung lavage, Uterus fluid, Innate immunity, Male genital system, lcsh:Cytology, Microvesicle, OUTER-MEMBRANE VESICLES, Blood clotting, prokaryote, Eukaryota, Extracellular vesicle, RNA analysis, Cell biology, Blood, Cerebrospinal fluid, Liver metabolism, microvesicle, Morphogen, Human, Nervous system, Cell signaling, Breast milk, Natural killer cell, Fisiologia, Extracellular vesicles, Exosome, lcsh:QH573-671, Saliva, Biology, Biology and Life Sciences, DNA, Plant, RNA transport, Cell function, Macrophage, Molecular biology, Physiology, Medizin, FACTOR PATHWAY INHIBITOR, eukaryote, Protein glycosylation, Extracellular space, Tissue repair, Espai extracel·lular, Reticulocyte, Seminal plasma, Mesenchymal stem cell, Antigen presenting cell, Seminal vesicles, Nose mucus, Biofilm, Neutrophil, MicroRNA, PLANT-MICROBE INTERACTIONS, Lipid, Amnion fluid, Prokaryota, microparticle, Cell interaction, Cell transport, eukaryote, exosome, extracellular vesicle, microparticle, microvesicle, physiology, prokaryote, Bone mineralization, Microorganism, Histology, Adaptive immunity, Membrane vesicle, Computational biology, Membrane receptor, Stress, Cell communication, Mast cell, MESENCHYMAL STEM-CELLS, HUMAN ENDOTHELIAL-CELLS, exosome, Cytokine, Synovial fluid, Cell Biology, Nonhuman, IMMUNE-MODULATORY FEATURES, Review article, DNA content, physiology, RNA, INTESTINAL EPITHELIAL-CELLS, extracellular vesicle, Body fluid, Lectin
Abstract

The authors wish to thank Dr R Simpson and Dr D Taylor for critical reading of the manuscript and acknowledge the Horizon 2020 European Cooperation in Science and Technology programme and its support of our European Network on Microvesicles and Exosomes in Health & Disease (ME-HaD; BM1202 www.cost.eu/COST_Actions/bmbs/Actions/BM1202). In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity to transfer proteins, lipids and nucleic acids, thereby influencing various physiological and pathological functions of both recipient and parent cells. While intensive investigation has targeted the role of EVs in different pathological processes, for example, in cancer and autoimmune diseases, the EV-mediated maintenance of homeostasis and the regulation of physiological functions have remained less explored. Here, we provide a comprehensive overview of the current understanding of the physiological roles of EVs, which has been written by crowd-sourcing, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia. This review is intended to be of relevance to both researchers already working on EV biology and to newcomers who will encounter this universal cell biological system. Therefore, here we address the molecular contents and functions of EVs in various tissues and body fluids from cell systems to organs. We also review the physiological mechanisms of EVs in bacteria, lower eukaryotes and plants to highlight the functional uniformity of this emerging communication system.

Published
2015
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