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631 results on '"O'Connell, Jeffrey R."'

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1. Epigenetic and proteomic signatures associate with clonal hematopoiesis expansion rate

2. Epigenetic and proteomic signatures associate with clonal hematopoiesis expansion rate

3. Genome-wide association meta-analysis identifies 17 loci associated with nonalcoholic fatty liver disease

4. The genetic determinants of recurrent somatic mutations in 43,693 blood genomes

5. Powerful, scalable and resource-efficient meta-analysis of rare variant associations in large whole genome sequencing studies

6. A framework for detecting noncoding rare-variant associations of large-scale whole-genome sequencing studies

7. Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension

8. Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data

9. A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels

10. Whole genome sequence analysis of platelet traits in the NHLBI Trans-Omics for Precision Medicine (TOPMed) initiative

11. Whole genome sequence analysis of blood lipid levels in >66,000 individuals

12. Whole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program

13. Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis

14. Whole-genome sequencing in diverse subjects identifies genetic correlates of leukocyte traits: The NHLBI TOPMed program

15. Allele-specific variation at APOE increases nonalcoholic fatty liver disease and obesity but decreases risk of Alzheimer’s disease and myocardial infarction

16. BinomiRare: A robust test for association of a rare genetic variant with a binary outcome for mixed models and any case-control proportion

17. Genome sequencing unveils a regulatory landscape of platelet reactivity.

18. Variant-specific inflation factors for assessing population stratification at the phenotypic variance level.

19. Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program

20. Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices.

21. Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale.

22. De novo mutations across 1,465 diverse genomes reveal mutational insights and reductions in the Amish founder population

23. Impact of Rare and Common Genetic Variants on Diabetes Diagnosis by Hemoglobin A1c in Multi-Ancestry Cohorts: The Trans-Omics for Precision Medicine Program

24. Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways

27. Insulin Resistance Exacerbates Genetic Predisposition to Nonalcoholic Fatty Liver Disease in Individuals Without Diabetes

28. Efficient Variant Set Mixed Model Association Tests for Continuous and Binary Traits in Large-Scale Whole-Genome Sequencing Studies

29. Deep-coverage whole genome sequences and blood lipids among 16,324 individuals.

30. DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation.

31. Analysis commons, a team approach to discovery in a big-data environment for genetic epidemiology

32. A genetic association study of circulating coagulation Factor VIII and von Willebrand Factor levels

33. Whole genome sequence analysis of apparent treatment resistant hypertension status in participants from the Trans-Omics for Precision Medicine program

34. De novo mutations across 1,465 diverse genomes reveal mutational insights and reductions in the Amish founder population

35. Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation

36. Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis

37. Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

38. Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci

39. Rare variants in long non-coding RNAs are associated with blood lipid levels in the TOPMed whole-genome sequencing study

40. Interactions between genes involved in physiological dysregulation and axon guidance: role in Alzheimer’s disease

41. Discovery and refinement of loci associated with lipid levels

42. Common variants associated with plasma triglycerides and risk for coronary artery disease

43. Whole genome analysis of plasma fibrinogen reveals population-differentiated genetic regulators with putative liver roles

44. Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

45. Supplementary Methods, Figures S1-S2, Table S1-S2 from Identification of a Variant in KDR Associated with Serum VEGFR2 and Pharmacodynamics of Pazopanib

46. Data from Identification of a Variant in KDR Associated with Serum VEGFR2 and Pharmacodynamics of Pazopanib

49. Mapping Genes in Isolated Populations: Lessons from the Old Order Amish

50. Candidate Gene Association Study of Coronary Artery Calcification in Chronic Kidney Disease: Findings From the CRIC Study (Chronic Renal Insufficiency Cohort)

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