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2. Polygenic liability for antipsychotic dosage and polypharmacy - a real-world registry and biobank study

Author

Koch, Elise, Kämpe, Anders, Alver, Maris, Sigurðarson, Sindri, Einarsson, Guðmundur, Partanen, Juulia, Smith, Robert L., Jaholkowski, Piotr, Taipale, Heidi, Lähteenvuo, Markku, Steen, Nils Eiel, Smeland, Olav B., Djurovic, Srdjan, Molden, Espen, Sigurdsson, Engilbert, Stefánsson, Hreinn, Stefánsson, Kári, Palotie, Aarno, Milani, Lili, O’Connell, Kevin S., and Andreassen, Ole A.

Published
2024
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7. Toxoplasma gondii infection associated with inflammasome activation and neuronal injury

Author

Andreou, Dimitrios, Steen, Nils Eiel, Mørch-Johnsen, Lynn, Jørgensen, Kjetil Nordbø, Wortinger, Laura A., Barth, Claudia, Szabo, Attila, O’Connell, Kevin S., Lekva, Tove, Hjell, Gabriela, Johansen, Ingrid Torp, Ormerod, Monica B. E. G., Haukvik, Unn K., Aukrust, Pål, Djurovic, Srdjan, Yolken, Robert H., Andreassen, Ole A., Ueland, Thor, and Agartz, Ingrid

Published
2024
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8. How Real-World Data Can Facilitate the Development of Precision Medicine Treatment in Psychiatry

Author

Koch, Elise, Pardiñas, Antonio F., O’Connell, Kevin S., Selvaggi, Pierluigi, Camacho Collados, José, Babic, Aleksandar, Marshall, Serena E., Van der Eycken, Erik, Angulo, Cecilia, Lu, Yi, Sullivan, Patrick F., Dale, Anders M., Molden, Espen, Posthuma, Danielle, White, Nathan, Schubert, Alexander, Djurovic, Srdjan, Heimer, Hakon, Stefánsson, Hreinn, Stefánsson, Kári, Werge, Thomas, Sønderby, Ida, O’Donovan, Michael C., Walters, James T.R., Milani, Lili, and Andreassen, Ole A.

Published
2024
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9. Multivariate genetic analysis of personality and cognitive traits reveals abundant pleiotropy

Author

Hindley, Guy, Shadrin, Alexey A., van der Meer, Dennis, Parker, Nadine, Cheng, Weiqiu, O’Connell, Kevin S., Bahrami, Shahram, Lin, Aihua, Karadag, Naz, Holen, Børge, Bjella, Thomas, Deary, Ian J., Davies, Gail, Hill, W. David, Bressler, Jan, Seshadri, Sudha, Fan, Chun Chieh, Ueland, Torill, Djurovic, Srdjan, Smeland, Olav B., Frei, Oleksandr, Dale, Anders M., and Andreassen, Ole A.

Published
2023
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14. Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

Author

Mullins, Niamh, Forstner, Andreas J, O’Connell, Kevin S, Coombes, Brandon, Coleman, Jonathan RI, Qiao, Zhen, Als, Thomas D, Bigdeli, Tim B, Børte, Sigrid, Bryois, Julien, Charney, Alexander W, Drange, Ole Kristian, Gandal, Michael J, Hagenaars, Saskia P, Ikeda, Masashi, Kamitaki, Nolan, Kim, Minsoo, Krebs, Kristi, Panagiotaropoulou, Georgia, Schilder, Brian M, Sloofman, Laura G, Steinberg, Stacy, Trubetskoy, Vassily, Winsvold, Bendik S, Won, Hong-Hee, Abramova, Liliya, Adorjan, Kristina, Agerbo, Esben, Al Eissa, Mariam, Albani, Diego, Alliey-Rodriguez, Ney, Anjorin, Adebayo, Antilla, Verneri, Antoniou, Anastasia, Awasthi, Swapnil, Baek, Ji Hyun, Bækvad-Hansen, Marie, Bass, Nicholas, Bauer, Michael, Beins, Eva C, Bergen, Sarah E, Birner, Armin, Bøcker Pedersen, Carsten, Bøen, Erlend, Boks, Marco P, Bosch, Rosa, Brum, Murielle, Brumpton, Ben M, Brunkhorst-Kanaan, Nathalie, Budde, Monika, Bybjerg-Grauholm, Jonas, Byerley, William, Cairns, Murray, Casas, Miquel, Cervantes, Pablo, Clarke, Toni-Kim, Cruceanu, Cristiana, Cuellar-Barboza, Alfredo, Cunningham, Julie, Curtis, David, Czerski, Piotr M, Dale, Anders M, Dalkner, Nina, David, Friederike S, Degenhardt, Franziska, Djurovic, Srdjan, Dobbyn, Amanda L, Douzenis, Athanassios, Elvsåshagen, Torbjørn, Escott-Price, Valentina, Ferrier, I Nicol, Fiorentino, Alessia, Foroud, Tatiana M, Forty, Liz, Frank, Josef, Frei, Oleksandr, Freimer, Nelson B, Frisén, Louise, Gade, Katrin, Garnham, Julie, Gelernter, Joel, Giørtz Pedersen, Marianne, Gizer, Ian R, Gordon, Scott D, Gordon-Smith, Katherine, Greenwood, Tiffany A, Grove, Jakob, Guzman-Parra, José, Ha, Kyooseob, Haraldsson, Magnus, Hautzinger, Martin, Heilbronner, Urs, Hellgren, Dennis, Herms, Stefan, Hoffmann, Per, Holmans, Peter A, Huckins, Laura, Jamain, Stéphane, Johnson, Jessica S, and Kalman, Janos L

Subjects
Biological Sciences, Genetics, Biotechnology, Serious Mental Illness, Human Genome, Bipolar Disorder, Neurosciences, Brain Disorders, Mental Health, Aetiology, 2.1 Biological and endogenous factors, Neurological, Mental health, Good Health and Well Being, Case-Control Studies, Chromosomes, Human, Genetic Predisposition to Disease, Genome, Human, Genome-Wide Association Study, Humans, Major Histocompatibility Complex, Multifactorial Inheritance, Phenotype, Quantitative Trait Loci, Risk Factors, HUNT All-In Psychiatry, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-wide association study of 41,917 bipolar disorder cases and 371,549 controls of European ancestry, which identified 64 associated genomic loci. Bipolar disorder risk alleles were enriched in genes in synaptic signaling pathways and brain-expressed genes, particularly those with high specificity of expression in neurons of the prefrontal cortex and hippocampus. Significant signal enrichment was found in genes encoding targets of antipsychotics, calcium channel blockers, antiepileptics and anesthetics. Integrating expression quantitative trait locus data implicated 15 genes robustly linked to bipolar disorder via gene expression, encoding druggable targets such as HTR6, MCHR1, DCLK3 and FURIN. Analyses of bipolar disorder subtypes indicated high but imperfect genetic correlation between bipolar disorder type I and II and identified additional associated loci. Together, these results advance our understanding of the biological etiology of bipolar disorder, identify novel therapeutic leads and prioritize genes for functional follow-up studies.

Published
2021

15. Cross-trait genome-wide association analysis of C-reactive protein level and psychiatric disorders

Author

Hindley, Guy, Drange, Ole Kristian, Lin, Aihua, Kutrolli, Gleda, Shadrin, Alexey A., Parker, Nadine, O’Connell, Kevin S., Rødevand, Linn, Cheng, Weiqiu, Bahrami, Shahram, Karadag, Naz, Holen, Børge, Jaholkowski, Piotr, Woldeyohannes, Markos Tesfaye, Djurovic, Srdjan, Dale, Anders M., Frei, Oleksandr, Ueland, Thor, Smeland, Olav B., and Andreassen, Ole A.

Published
2023
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16. Genome-wide Association Analysis of Parkinson’s Disease and Schizophrenia Reveals Shared Genetic Architecture and Identifies Novel Risk Loci

Author

Smeland, Olav B, Shadrin, Alexey, Bahrami, Shahram, Broce, Iris, Tesli, Martin, Frei, Oleksandr, Wirgenes, Katrine V, O'Connell, Kevin S, Krull, Florian, Bettella, Francesco, Steen, Nils Eiel, Sugrue, Leo, Wang, Yunpeng, Svenningsson, Per, Sharma, Manu, Pihlstrøm, Lasse, Toft, Mathias, O'Donovan, Michael, Djurovic, Srdjan, Desikan, Rahul, Dale, Anders M, and Andreassen, Ole A

Subjects
Genetics, Biotechnology, Aging, Parkinson's Disease, Neurodegenerative, Serious Mental Illness, Human Genome, Neurosciences, Prevention, Mental Health, Schizophrenia, Brain Disorders, 2.1 Biological and endogenous factors, Aetiology, Neurological, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Multifactorial Inheritance, Parkinson Disease, Polymorphism, Single Nucleotide, GWAS, Genetic overlap, Parkinson’s disease, RERE, ZDHHC2, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract

BackgroundParkinson's disease (PD) and schizophrenia (SCZ) are heritable brain disorders that involve dysregulation of the dopaminergic system. Epidemiological studies have reported potential comorbidity between the disorders, and movement disturbances are common in patients with SCZ before treatment with antipsychotic drugs. Despite this, little is known about shared genetic etiology between the disorders.MethodsWe analyzed recent large genome-wide association studies on patients with SCZ (N = 77,096) and PD (N = 417,508) using a conditional/conjunctional false discovery rate (FDR) approach to evaluate overlap in common genetic variants and improve statistical power for genetic discovery. Using a variety of biological resources, we functionally characterized the identified genomic loci.ResultsWe observed genetic enrichment in PD conditional on associations with SCZ and vice versa, indicating polygenic overlap. We then leveraged this cross-trait enrichment using conditional FDR analysis and identified 9 novel PD risk loci and 1 novel SCZ locus at conditional FDR < .01. Furthermore, we identified 9 genomic loci jointly associated with PD and SCZ at conjunctional FDR < .05. There was an even distribution of antagonistic and agonistic effect directions among the shared loci, in line with the insignificant genetic correlation between the disorders. Of 67 genes mapped to the shared loci, 65 are expressed in the human brain and show cell type-specific expression profiles.ConclusionsAltogether, the study increases understanding of the genetic architectures underlying SCZ and PD, indicating that common molecular genetic mechanisms may contribute to overlapping pathophysiological and clinical features between the disorders.

Published
2021

17. Genome-wide association study identifies 48 common genetic variants associated with handedness

Author

Cuellar-Partida, Gabriel, Tung, Joyce Y, Eriksson, Nicholas, Albrecht, Eva, Aliev, Fazil, Andreassen, Ole A, Barroso, Inês, Beckmann, Jacques S, Boks, Marco P, Boomsma, Dorret I, Boyd, Heather A, Breteler, Monique MB, Campbell, Harry, Chasman, Daniel I, Cherkas, Lynn F, Davies, Gail, de Geus, Eco JC, Deary, Ian J, Deloukas, Panos, Dick, Danielle M, Duffy, David L, Eriksson, Johan G, Esko, Tõnu, Feenstra, Bjarke, Geller, Frank, Gieger, Christian, Giegling, Ina, Gordon, Scott D, Han, Jiali, Hansen, Thomas F, Hartmann, Annette M, Hayward, Caroline, Heikkilä, Kauko, Hicks, Andrew A, Hirschhorn, Joel N, Hottenga, Jouke-Jan, Huffman, Jennifer E, Hwang, Liang-Dar, Ikram, M Arfan, Kaprio, Jaakko, Kemp, John P, Khaw, Kay-Tee, Klopp, Norman, Konte, Bettina, Kutalik, Zoltan, Lahti, Jari, Li, Xin, Loos, Ruth JF, Luciano, Michelle, Magnusson, Sigurdur H, Mangino, Massimo, Marques-Vidal, Pedro, Martin, Nicholas G, McArdle, Wendy L, McCarthy, Mark I, Medina-Gomez, Carolina, Melbye, Mads, Melville, Scott A, Metspalu, Andres, Milani, Lili, Mooser, Vincent, Nelis, Mari, Nyholt, Dale R, O’Connell, Kevin S, Ophoff, Roel A, Palmer, Cameron, Palotie, Aarno, Palviainen, Teemu, Pare, Guillaume, Paternoster, Lavinia, Peltonen, Leena, Penninx, Brenda WJH, Polasek, Ozren, Pramstaller, Peter P, Prokopenko, Inga, Raikkonen, Katri, Ripatti, Samuli, Rivadeneira, Fernando, Rudan, Igor, Rujescu, Dan, Smit, Johannes H, Smith, George Davey, Smoller, Jordan W, Soranzo, Nicole, Spector, Tim D, Pourcain, Beate St, Starr, John M, Stefánsson, Hreinn, Steinberg, Stacy, Teder-Laving, Maris, Thorleifsson, Gudmar, Stefánsson, Kári, Timpson, Nicholas J, Uitterlinden, André G, van Duijn, Cornelia M, van Rooij, Frank JA, Vink, Jaqueline M, Vollenweider, Peter, Vuoksimaa, Eero, and Waeber, Gérard

Subjects
Biological Psychology, Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Psychology, Human Genome, Mental Health, Brain Disorders, Neurosciences, Schizophrenia, Genetics, 2.1 Biological and endogenous factors, Aetiology, Mental health, Adult, Aged, Female, Functional Laterality, Gene Frequency, Genetic Loci, Genetic Variation, Genome-Wide Association Study, Humans, Linkage Disequilibrium, Male, Middle Aged, Polymorphism, Single Nucleotide, Quantitative Trait, Heritable, Sex Factors, Biomedical and clinical sciences, Health sciences
Abstract

Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P

Published
2021

18. Shared genetic architecture between schizophrenia and subcortical brain volumes implicates early neurodevelopmental processes and brain development in childhood

Author

Cheng, Weiqiu, van der Meer, Dennis, Parker, Nadine, Hindley, Guy, O’Connell, Kevin S., Wang, Yunpeng, Shadrin, Alexey A., Alnæs, Dag, Bahrami, Shahram, Lin, Aihua, Karadag, Naz, Holen, Børge, Fernandez-Cabello, Sara, Fan, Chun-Chieh, Dale, Anders M., Djurovic, Srdjan, Westlye, Lars T., Frei, Oleksandr, Smeland, Olav B., and Andreassen, Ole A.

Published
2022
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20. The relationship between cannabis use, schizophrenia, and bipolar disorder: a genetically informed study

Author

Cheng, Weiqiu, Parker, Nadine, Karadag, Naz, Koch, Elise, Hindley, Guy, Icick, Romain, Shadrin, Alexey, O’Connell, Kevin S, Bjella, Thomas, Bahrami, Shahram, Rahman, Zillur, Tesfaye, Markos, Jaholkowski, Piotr, Rødevand, Linn, Holen, Børge, Lagerberg, Trine Vik, Steen, Nils Eiel, Djurovic, Srdjan, Dale, Anders M, Frei, Oleksandr, Smeland, Olav B, and Andreassen, Ole A

Published
2023
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21. Quantifying the Polygenic Architecture of the Human Cerebral Cortex: Extensive Genetic Overlap between Cortical Thickness and Surface Area

Author

van der Meer, Dennis, Frei, Oleksandr, Kaufmann, Tobias, Chen, Chi-Hua, Thompson, Wesley K, O’Connell, Kevin S, Sánchez, Jennifer Monereo, Linden, David EJ, Westlye, Lars T, Dale, Anders M, and Andreassen, Ole A

Subjects
Neurosciences, Genetics, Aetiology, 2.1 Biological and endogenous factors, Aged, Cerebral Cortex, Female, Genome-Wide Association Study, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Multifactorial Inheritance, Organ Size, cortical thickness, parcellation, pleiotropy, polygenicity, surface area, Psychology, Cognitive Sciences, Experimental Psychology
Abstract

The thickness of the cerebral cortical sheet and its surface area are highly heritable traits thought to have largely distinct polygenic architectures. Despite large-scale efforts, the majority of their genetic determinants remain unknown. Our ability to identify causal genetic variants can be improved by employing brain measures that better map onto the biology we seek to understand. Such measures may have fewer variants but with larger effects, that is, lower polygenicity and higher discoverability. Using Gaussian mixture modeling, we estimated the number of causal variants shared between mean cortical thickness and total surface area, as well as the polygenicity and discoverability of regional measures. We made use of UK Biobank data from 30 880 healthy White European individuals (mean age 64.3, standard deviation 7.5, 52.1% female). We found large genetic overlap between total surface area and mean thickness, sharing 4016 out of 7941 causal variants. Regional surface area was more discoverable (P = 2.6 × 10-6) and less polygenic (P = 0.004) than regional thickness measures. These findings may serve as a roadmap for improved future GWAS studies; knowledge of which measures are most discoverable may be used to boost identification of genetic predictors and thereby gain a better understanding of brain morphology.

Published
2020

22. Dissecting the Shared Genetic Architecture of Common Epilepsies With Cortical Brain Morphology

Author

Karadag, Naz, primary, Hagen, Espen, additional, Shadrin, Alexey A., additional, van der Meer, Dennis, additional, O'Connell, Kevin S., additional, Rahman, Zillur, additional, Kutrolli, Gleda, additional, Parker, Nadine, additional, Bahrami, Shahram, additional, Fominykh, Vera, additional, Heuser, Kjell, additional, Taubøll, Erik, additional, Steen, Nils Eiel, additional, Djurovic, Srdjan, additional, Dale, Anders M., additional, Frei, Oleksandr, additional, Andreassen, Ole A., additional, and Smeland, Olav B., additional

Published
2024
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23. Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation.

Author

Frei, Oleksandr, Holland, Dominic, Smeland, Olav B, Shadrin, Alexey A, Fan, Chun Chieh, Maeland, Steffen, O'Connell, Kevin S, Wang, Yunpeng, Djurovic, Srdjan, Thompson, Wesley K, Andreassen, Ole A, and Dale, Anders M

Subjects
Humans, Models, Statistical, Bipolar Disorder, Schizophrenia, Gene Frequency, Multifactorial Inheritance, Linkage Disequilibrium, Models, Genetic, Genome-Wide Association Study, Models, Genetic, Statistical
Abstract

Accumulating evidence from genome wide association studies (GWAS) suggests an abundance of shared genetic influences among complex human traits and disorders, such as mental disorders. Here we introduce a statistical tool, MiXeR, which quantifies polygenic overlap irrespective of genetic correlation, using GWAS summary statistics. MiXeR results are presented as a Venn diagram of unique and shared polygenic components across traits. At 90% of SNP-heritability explained for each phenotype, MiXeR estimates that 8.3 K variants causally influence schizophrenia and 6.4 K influence bipolar disorder. Among these variants, 6.2 K are shared between the disorders, which have a high genetic correlation. Further, MiXeR uncovers polygenic overlap between schizophrenia and educational attainment. Despite a genetic correlation close to zero, the phenotypes share 8.3 K causal variants, while 2.5 K additional variants influence only educational attainment. By considering the polygenicity, discoverability and heritability of complex phenotypes, MiXeR analysis may improve our understanding of cross-trait genetic architectures.

Published
2019

25. Increased circulating IL-18 levels in severe mental disorders indicate systemic inflammasome activation

Author

Szabo, Attila, O‘Connell, Kevin S., Ueland, Thor, Sheikh, Mashhood A., Agartz, Ingrid, Andreou, Dimitrios, Aukrust, Pål, Boye, Birgitte, Bøen, Erlend, Drange, Ole Kristian, Elvsåshagen, Torbjørn, Engh, John Abel, Hope, Sigrun, Collier Høegh, Margrethe, Joa, Inge, Johnsen, Erik, Kroken, Rune Andreas, Vik Lagerberg, Trine, Lekva, Tove, Malt, Ulrik Fredrik, Melle, Ingrid, Morken, Gunnar, Nærland, Terje, Steen, Vidar Martin, Sørensen, Kjetil, Wedervang-Resell, Kirsten, Auten Weibell, Melissa, Westlye, Lars T., Steen, Nils Eiel, Andreassen, Ole, and Djurovic, Srdjan

Published
2022
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26. Corrigendum to “Cross-trait genome-wide association analysis of C-reactive protein level and psychiatric disorders” [Psychoneuroendocrinology 157 (2023) 106368]

Author

Hindley, Guy, primary, Drange, Ole Kristian, additional, Lin, Aihua, additional, Kutrolli, Gleda, additional, Shadrin, Alexey A., additional, Parker, Nadine, additional, O’Connell, Kevin S., additional, Rødevand, Linn, additional, Cheng, Weiqiu, additional, Bahrami, Shahram, additional, Karadag, Naz, additional, Holen, Børge, additional, Jaholkowski, Piotr, additional, Woldeyohannes, Markos Tesfaye, additional, Djurovic, Srdjan, additional, Dale, Anders M., additional, Frei, Oleksandr, additional, Ueland, Thor, additional, Smeland, Olav B., additional, and Andreassen, Ole A., additional

Published
2024
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27. Unraveling the shared genetics of common epilepsies and general cognitive ability.

Author

Karadag, Naz, primary, Hagen, Espen, additional, Shadrin, Alexey A., additional, Van Der Meer, Dennis, additional, O'Connell, Kevin S., additional, Rahman, Zillur, additional, Kutrolli, Gleda, additional, Parker, Nadine, additional, Bahrami, Shahram, additional, Fominykh, Vera, additional, Heuser, Kjell, additional, Tauboll, Erik, additional, Ueland, Torill, additional, Steen, Nils Eiel, additional, Djurovic, Srdjan, additional, Dale, Anders M., additional, Frei, Oleksandr, additional, Andreassen, Ole A., additional, and Smeland, Olav B., additional

Published
2024
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28. Dissecting the genetic overlap between three complex phenotypes with trivariate MiXeR

Author

Shadrin, Alexey A, primary, Hindley, Guy, additional, Hagen, Espen, additional, Parker, Nadine, additional, Tesfaye, Markos, additional, Jaholkowski, Piotr, additional, Rahman, Zillur, additional, Kutrolli, Gleda, additional, Fominykh, Vera, additional, Djurovic, Srdjan, additional, Smeland, Olav B, additional, O'Connell, Kevin S, additional, van der Meer, Dennis, additional, Frei, Oleksandr, additional, Andreassen, Ole A, additional, and Dale, Anders M, additional

Published
2024
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29. Fine-mapping genomic loci refines bipolar disorder risk genes

Author

Koromina, Maria, primary, Ravi, Ashvin, additional, Panagiotaropoulou, Georgia, additional, Schilder, Brian M., additional, Humphrey, Jack, additional, Braun, Alice, additional, Bidgeli, Tim, additional, Chatzinakos, Chris, additional, Coombes, Brandon, additional, Kim, Jaeyoung, additional, Liu, Xiaoxi, additional, Terao, Chikashi, additional, O'Connell, Kevin S., additional, Adams, Mark, additional, Adolfsson, Rolf, additional, Alda, Martin, additional, Alfredsson, Lars, additional, Andlauer, Till F.M., additional, Andreassen, Ole A., additional, Antoniou, Anastasia, additional, Baune, Bernhard T., additional, Bengesser, Susanne, additional, Biernacka, Joanna, additional, Boehnke, Michael, additional, Bosch, Rosa, additional, Cairns, Murray, additional, Carr, Vaughan J., additional, Casas, Miquel, additional, Catts, Stanley, additional, Cichon, Sven, additional, Corvin, Aiden, additional, Craddock, Nicholas, additional, Dafnas, Konstantinos, additional, Dalkner, Nina, additional, Dannlowski, Udo, additional, Degenhardt, Franziska, additional, Di Florio, Arianna, additional, Dikeos, Dimitris, additional, Fellendorf, Frederike Tabea, additional, Ferentinos, Panagiotis, additional, Forstner, Andreas J., additional, Forty, Liz, additional, Frye, Mark, additional, Fullerton, Janice M., additional, Gawlik, Micha, additional, Gizer, Ian R., additional, Gordon-Smith, Katherine, additional, Green, Melissa J., additional, Grigoroiu-Serbanescu, Maria, additional, Guzman-Parra, Josep, additional, Hahn, Tim, additional, Henskens, Frans, additional, Hillert, Jan, additional, Jablensky, Assen V., additional, Jones, Lisa, additional, Jones, Ian, additional, Jonsson, Lina, additional, Kelsoe, John R., additional, Kircher, Tilo, additional, Kirov, George, additional, Kittel-Schneider, Sarah, additional, Kogevinas, Manolis, additional, Landen, Mikael, additional, Leboyer, Marion, additional, Lenger, Melanie, additional, Lissowska, Jolanta, additional, Lochner, Christine, additional, Loughland, Carmel, additional, MacIntyre, Donald, additional, Martin, Nicholas G., additional, Maratou, Eirini, additional, Mathews, Carol A., additional, Mayoral, Fermin, additional, McElroy, Susan L., additional, McGregor, Nathaniel W., additional, McIntosh, Andrew, additional, McQuillin, Andrew, additional, Michie, Patricia, additional, Mitchell, Philip B., additional, Moutsatsou, Paraskevi, additional, Mowry, Bryan, additional, Mueller-Myhsok, Bertram, additional, Myers, Richard, additional, Nenadic, Igor, additional, Noethen, Markus M., additional, O'Donovan, Michael, additional, O'Donovan, Claire, additional, Ophoff, Roel A., additional, Owen, Michael J., additional, Pantelis, Chris, additional, Pato, Carlos, additional, Pato, Michele T., additional, Patrinos, George P., additional, Pawlak, Joanna M., additional, Perlis, Roy H., additional, Porichi, Evgenia, additional, Posthuma, Danielle, additional, Ramos-Quiroga, Josep Antoni, additional, Reif, Andreas, additional, Reininghaus, Eva Z., additional, Ribases, Marta, additional, Rietschel, Marcella, additional, Schall, Ulrich, additional, Schulze, Thomas G., additional, Scott, Laura, additional, Scott, Rodney J., additional, Serretti, Alessandro, additional, Shannon Weickert, Cynthia, additional, Smoller, Jordan W., additional, Soler Artigas, Maria Soler, additional, Stein, Dan J., additional, Streit, Fabian, additional, Toma, Claudio, additional, Tooney, Paul, additional, Vieta, Eduard, additional, Vincent, John B., additional, Waldman, Irwin D., additional, Weickert, Thomas, additional, Witt, Stephanie H., additional, Swiatkowska, Beata, additional, Hong, Kyung Sue Sue, additional, Ikeda, Masashi, additional, Iwata, Nakao, additional, Won, Hong-Hee, additional, Edenberg, Howard J., additional, Ripke, Stephan, additional, Raj, Towfique, additional, Coleman, Jonathan R. I., additional, and Mullins, Niamh, additional

Published
2024
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32. Identification of genetic overlap and novel risk loci for attention-deficit/hyperactivity disorder and bipolar disorder

Author

O’Connell, Kevin S., Shadrin, Alexey, Bahrami, Shahram, Smeland, Olav B., Bettella, Francesco, Frei, Oleksandr, Krull, Florian, Askeland, Ragna B., Walters, G. Bragi, Davíðsdóttir, Katrín, Haraldsdóttir, Gyða S., Guðmundsson, Ólafur Ó., Stefánsson, Hreinn, Fan, Chun C., Steen, Nils Eiel, Reichborn-Kjennerud, Ted, Dale, Anders M., Stefánsson, Kári, Djurovic, Srdjan, and Andreassen, Ole A.

Published
2021
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33. List of contributors

Author

Al-Chalabi, Nzaar, primary, Andreassen, Ole A., additional, Baron, David, additional, Blum, Kenneth, additional, Bowirrat, Abdalla, additional, Brady, Philip, additional, Brewer, Raymond, additional, Cadet, Jean Lud, additional, Corvin, Aiden, additional, Cote, Alanna, additional, De Luca, Vincenzo, additional, Deckert, Jürgen, additional, Diehl, Caroline K., additional, Dolžan, Vita, additional, Erhardt, Angelika, additional, Fatemi, Ali Bani, additional, Febo, Marcelo, additional, Ferrera, Alessandra G., additional, Frei, Oleksandr, additional, Gold, Mark S., additional, Goldberg, Joseph F., additional, Heron, Elizabeth A., additional, Hindley, Guy, additional, Huckins, Laura M., additional, Igblom, Amarachukwu, additional, Juki, Marin M., additional, K. Davis, Lea, additional, Kiri Dennis, Jessica, additional, Kong, Camillia, additional, Kores Plesničar, Blanka, additional, Mattheisen, Manuel, additional, Miller, Gregory A., additional, Mishrekar, Asmita, additional, Nemeroff, Charles B., additional, Nurnberger, John I., additional, Ormond, Cathal, additional, O’Connell, Kevin S., additional, Pisanu, Claudia, additional, Qian, Jessica, additional, Ramoz, Nicolas, additional, Rockstroh, Brigitte, additional, Ryan, Niamh M., additional, Samsom, James N., additional, Shadrin, Alexey, additional, Smeland, Olav B., additional, Squassina, Alessio, additional, Terzi, Tea, additional, Thanos, Panayotis K., additional, Tsermpini, Evangelia Eirini, additional, Wang, Yin, additional, Wang, Yunpeng, additional, Wong, Albert H.C., additional, Yee, Cindy M., additional, Young, Hannah, additional, and Zhou, Young, additional

Published
2022
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37. Fine-mapping genomic loci refines bipolar disorder risk genes

Author

Koromina, Maria, Ravi, Ashvin, Panagiotaropoulou, Georgia, Schilder, Brian M., Humphrey, Jack, Braun, Alice, Bidgeli, Tim, Chatzinakos, Chris, Coombes, Brandon, Kim, Jaeyoung, Liu, Xiaoxi, Terao, Chikashi, O'Connell, Kevin S., Adams, Mark, Adolfsson, Rolf, Alda, Martin, Alfredsson, Lars, Andlauer, Till, Andreassen, Ole A., Antoniou, Anastasia, Baune, Bernhard T., Bengesser, Susanne, Biernacka, Joanna, Boehnke, Michael, Bosch, Rosa, Cairns, Murray, Carr, Vaughan J., Casas Brugué, Miquel, Catts, Stanley, Cichon, Sven, Corvin, Aiden, Craddock, Nicholas, Dafnas, Konstantinos, Dalkner, Nina, Dannlowski, Udo, Degenhardt, Franziska, Di Florio, Arianna, Dikeos, Dimitris, Fellendorf, Frederike Tabea, Ferentinos, Panagiotis, Forstner, Andreas Josef, Forty, Liz, Frye, Mark, Fullerton, Janice M., Gawlik, Micha, Gizer, Ian R., Gordon-Smith, Katherine, Green, Melissa J., Grigoroiu-Serbanescu, Maria, Guzman-Parra, José, Hahn, Tim, Henskens, Frans, Hillert, Jan, Jablensky, Assen V., Jones, Lisa, Jones, Ian, Jonsson, Lina, Kelsoe, John R., Kircher, Tilo, Kirov, George, Kittel-Schneider, Sarah, Kogevinas, Manolis, Landén, Mikael, Leboyer, Marion, Lenger, Melanie, Lissowska, Jolanta, Lochner, Christine, Loughland, Carmel, MacIntyre, Donald, Martin, Nicholas G., Maratou, Eirini, Mathews, Carol A., Mayoral, Fermı́n, McElroy, Susan L., McGregor, Nathaniel W., McIntosh, Andrew M., McQuillin, Andrew, Michie, Patricia, Milanova, Vihra, Mitchell, Philip B., Moutsatsou, Paraskevi, Mowry, Bryan, Müller-Myhsok, Bertram, Myers, Richard M., Nenadić, Igor, Nöthen, Markus Maria, O'Donovan, Claire, O'Donovan, Michael, Ophoff, Roel André, Owen, Michael J., Pantelis, Christos, Pato, Carlos, Pato, Michele T., Patrinos, George P., Pawlak, Joanna M., Perlis, Roy H., Porichi, Evgenia, Posthuma, Danielle, Ramos-Quiroga, Josep Antoni, Reif, Andreas, Reininghaus, Eva Z., Ribasés, Marta, Rietschel, Marcella, Schall, Ulrich, Schulze, Thomas Gerd, Scott, Laura J., Scott, Rodney J., Serretti, Alessandro, Shannon Weickert, Cynthia, Smoller, Jordan W., Soler Artigas, Marı́a, Stein, Dan J., Streit, Fabian, Toma, Claudio, Tooney, Paul, Vieta, Eduard, Vincent, John B., Waldman, Irwin D., Weickert, Thomas, Witt, Stephanie H., Hong, Kyung Sue, Ikeda, Masashi, Iwata, Nakao, Świątkowska, Beata, Won, Hong-Hee, Edenberg, Howard J., Ripke, Stephan, Raj, Towfique, Coleman, Jonathan R. I., Mullins, Niamh, Koromina, Maria, Ravi, Ashvin, Panagiotaropoulou, Georgia, Schilder, Brian M., Humphrey, Jack, Braun, Alice, Bidgeli, Tim, Chatzinakos, Chris, Coombes, Brandon, Kim, Jaeyoung, Liu, Xiaoxi, Terao, Chikashi, O'Connell, Kevin S., Adams, Mark, Adolfsson, Rolf, Alda, Martin, Alfredsson, Lars, Andlauer, Till, Andreassen, Ole A., Antoniou, Anastasia, Baune, Bernhard T., Bengesser, Susanne, Biernacka, Joanna, Boehnke, Michael, Bosch, Rosa, Cairns, Murray, Carr, Vaughan J., Casas Brugué, Miquel, Catts, Stanley, Cichon, Sven, Corvin, Aiden, Craddock, Nicholas, Dafnas, Konstantinos, Dalkner, Nina, Dannlowski, Udo, Degenhardt, Franziska, Di Florio, Arianna, Dikeos, Dimitris, Fellendorf, Frederike Tabea, Ferentinos, Panagiotis, Forstner, Andreas Josef, Forty, Liz, Frye, Mark, Fullerton, Janice M., Gawlik, Micha, Gizer, Ian R., Gordon-Smith, Katherine, Green, Melissa J., Grigoroiu-Serbanescu, Maria, Guzman-Parra, José, Hahn, Tim, Henskens, Frans, Hillert, Jan, Jablensky, Assen V., Jones, Lisa, Jones, Ian, Jonsson, Lina, Kelsoe, John R., Kircher, Tilo, Kirov, George, Kittel-Schneider, Sarah, Kogevinas, Manolis, Landén, Mikael, Leboyer, Marion, Lenger, Melanie, Lissowska, Jolanta, Lochner, Christine, Loughland, Carmel, MacIntyre, Donald, Martin, Nicholas G., Maratou, Eirini, Mathews, Carol A., Mayoral, Fermı́n, McElroy, Susan L., McGregor, Nathaniel W., McIntosh, Andrew M., McQuillin, Andrew, Michie, Patricia, Milanova, Vihra, Mitchell, Philip B., Moutsatsou, Paraskevi, Mowry, Bryan, Müller-Myhsok, Bertram, Myers, Richard M., Nenadić, Igor, Nöthen, Markus Maria, O'Donovan, Claire, O'Donovan, Michael, Ophoff, Roel André, Owen, Michael J., Pantelis, Christos, Pato, Carlos, Pato, Michele T., Patrinos, George P., Pawlak, Joanna M., Perlis, Roy H., Porichi, Evgenia, Posthuma, Danielle, Ramos-Quiroga, Josep Antoni, Reif, Andreas, Reininghaus, Eva Z., Ribasés, Marta, Rietschel, Marcella, Schall, Ulrich, Schulze, Thomas Gerd, Scott, Laura J., Scott, Rodney J., Serretti, Alessandro, Shannon Weickert, Cynthia, Smoller, Jordan W., Soler Artigas, Marı́a, Stein, Dan J., Streit, Fabian, Toma, Claudio, Tooney, Paul, Vieta, Eduard, Vincent, John B., Waldman, Irwin D., Weickert, Thomas, Witt, Stephanie H., Hong, Kyung Sue, Ikeda, Masashi, Iwata, Nakao, Świątkowska, Beata, Won, Hong-Hee, Edenberg, Howard J., Ripke, Stephan, Raj, Towfique, Coleman, Jonathan R. I., and Mullins, Niamh

Abstract

Bipolar disorder (BD) is a heritable mental illness with complex etiology. While the largest published genome-wide association study identified 64 BD risk loci, the causal SNPs and genes within these loci remain unknown. We applied a suite of statistical and functional fine-mapping methods to these loci, and prioritized 22 likely causal SNPs for BD. We mapped these SNPs to genes, and investigated their likely functional consequences by integrating variant annotations, brain cell-type epigenomic annotations, brain quantitative trait loci, and results from rare variant exome sequencing in BD. Convergent lines of evidence supported the roles of SCN2A, TRANK1, DCLK3, INSYN2B, SYNE1, THSD7A, CACNA1B, TUBBP5, PLCB3, PRDX5, KCNK4, AP001453.3, TRPT1, FKBP2, DNAJC4, RASGRP1, FURIN, FES, YWHAE, DPH1, GSDMB, MED24, THRA, EEF1A2, and KCNQ2 in BD. These represent promising candidates for functional experiments to understand biological mechanisms and therapeutic potential. Additionally, we demonstrated that fine-mapping effect sizes can improve performance and transferability of BD polygenic risk scores across ancestrally diverse populations, and present a high-throughput fine-mapping pipeline (https://github.com/mkoromina/SAFFARI).

Published
2024

38. Identification of Genetic Loci Shared Between Attention-Deficit/Hyperactivity Disorder, Intelligence, and Educational Attainment

Author

O’Connell, Kevin S., Shadrin, Alexey, Smeland, Olav B., Bahrami, Shahram, Frei, Oleksandr, Bettella, Francesco, Krull, Florian, Fan, Chun C., Askeland, Ragna B., Knudsen, Gun Peggy S., Halmøy, Anne, Steen, Nils Eiel, Ueland, Torill, Walters, G. Bragi, Davíðsdóttir, Katrín, Haraldsdóttir, Gyða S., Guðmundsson, Ólafur Ó., Stefánsson, Hreinn, Reichborn-Kjennerud, Ted, Haavik, Jan, Dale, Anders M., Stefánsson, Kári, Djurovic, Srdjan, and Andreassen, Ole A.

Published
2020
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39. Regional Genetic Architecture of the Corpus Callosum and its Overlap with Psychiatric and Substance Use Phenotypes

Author

Campbell, Megan L, primary, Shadrin, Alexey, additional, van der Meer, Dennisa, additional, Tesfaye, Markos, additional, Smeland, Olav Bjerkehagen, additional, O'Connell, Kevin S, additional, Parker, Nadine, additional, Frei, Oleksandr, additional, Andreassen, Ole, additional, Stein, Dan, additional, Dalvie, Shareefa, additional, and Rokicki, Jaroslav, additional

Published
2023
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40. Genome-wide analyses reveal shared genetic architecture and novel risk loci between opioid use disorder and general cognitive ability

Author

Holen, Børge, primary, Kutrolli, Gleda, additional, Shadrin, Alexey A., additional, Icick, Romain, additional, Hindley, Guy, additional, Rødevand, Linn, additional, O’Connell, Kevin S., additional, Frei, Oleksandr, additional, Parker, Nadine, additional, Tesfaye, Markos, additional, Deak, Joseph D., additional, Gelernter, Joel, additional, Jahołkowski, Piotr, additional, Dale, Anders M., additional, Djurovic, Srdjan, additional, Andreassen, Ole A., additional, and Smeland, Olav B., additional

Published
2023
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42. Elevated levels of peripheral and central nervous system immune markers reflect innate immune dysregulation in Autism spectrum disorders

Author

Szabo, Attila, primary, O'Connell, Kevin S., additional, Akkouh, Ibrahim A., additional, Ueland, Thor, additional, Steen, Nils Eiel, additional, Ueland, Torill, additional, Sæther, Linn Sofie, additional, Osete, Jordi Requena, additional, Andreassen, Ole A., additional, Nærland, Terje, additional, and Djurovic, Srdjan, additional

Published
2023
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47. Shared Genetic Loci Between Schizophrenia and White Blood Cell Counts Suggest Genetically Determined Systemic Immune Abnormalities

Author

Steen, Nils Eiel, primary, Rahman, Zillur, additional, Szabo, Attila, additional, Hindley, Guy F L, additional, Parker, Nadine, additional, Cheng, Weiqiu, additional, Lin, Aihua, additional, O’Connell, Kevin S, additional, Sheikh, Mashhood A, additional, Shadrin, Alexey, additional, Bahrami, Shahram, additional, Karthikeyan, Sandeep, additional, Hoseth, Eva Z, additional, Dale, Anders M, additional, Aukrust, Pål, additional, Smeland, Olav B, additional, Ueland, Thor, additional, Frei, Oleksandr, additional, Djurovic, Srdjan, additional, and Andreassen, Ole A, additional

Published
2023
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48. Genome-wide Association Analysis of Schizophrenia and Vitamin D Levels Shows Shared Genetic Architecture and Identifies Novel Risk Loci

Author

Jaholkowski, Piotr, primary, Hindley, Guy F L, additional, Shadrin, Alexey A, additional, Tesfaye, Markos, additional, Bahrami, Shahram, additional, Nerhus, Mari, additional, Rahman, Zillur, additional, O’Connell, Kevin S, additional, Holen, Børge, additional, Parker, Nadine, additional, Cheng, Weiqiu, additional, Lin, Aihua, additional, Rødevand, Linn, additional, Karadag, Naz, additional, Frei, Oleksandr, additional, Djurovic, Srdjan, additional, Dale, Anders M, additional, Smeland, Olav B, additional, and Andreassen, Ole A, additional

Published
2023
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49. Associations Between Symptoms of Premenstrual Disorders and Polygenic Liability for Major Psychiatric Disorders

Author

Jaholkowski, Piotr, primary, Shadrin, Alexey A., additional, Jangmo, Andreas, additional, Frei, Evgeniia, additional, Tesfaye, Markos, additional, Hindley, Guy F. L., additional, Haram, Marit, additional, Rahman, Zillur, additional, Athanasiu, Lavinia, additional, Bakken, Nora Refsum, additional, Holen, Børge, additional, Fominykh, Vera, additional, Kutrolli, Gleda, additional, Parekh, Pravesh, additional, Parker, Nadine, additional, Rødevand, Linn, additional, Birkenæs, Viktoria, additional, Djurovic, Srdjan, additional, Frei, Oleksandr, additional, O’Connell, Kevin S., additional, Smeland, Olav B., additional, Tesli, Martin, additional, and Andreassen, Ole A., additional

Published
2023
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50. Identification of novel genomic risk loci shared between common epilepsies and psychiatric disorders

Author

Karadag, Naz, primary, Shadrin, Alexey A, additional, O’Connell, Kevin S, additional, Hindley, Guy F L, additional, Rahman, Zillur, additional, Parker, Nadine, additional, Bahrami, Shahram, additional, Fominykh, Vera, additional, Cheng, Weiqiu, additional, Holen, Børge, additional, Alvestad, Silje, additional, Taubøll, Erik, additional, Steen, Nils Eiel, additional, Djurovic, Srdjan, additional, Dale, Anders M, additional, Frei, Oleksandr, additional, Andreassen, Ole A, additional, and Smeland, Olav B, additional

Published
2023
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