256 results on '"O'Connor, Carolyn"'
Search Results
2. Brain-wide correspondence of neuronal epigenomics and distant projections
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Zhou, Jingtian, Zhang, Zhuzhu, Wu, May, Liu, Hanqing, Pang, Yan, Bartlett, Anna, Peng, Zihao, Ding, Wubin, Rivkin, Angeline, Lagos, Will N., Williams, Elora, Lee, Cheng-Ta, Miyazaki, Paula Assakura, Aldridge, Andrew, Zeng, Qiurui, Salinda, J. L. Angelo, Claffey, Naomi, Liem, Michelle, Fitzpatrick, Conor, Boggeman, Lara, Yao, Zizhen, Smith, Kimberly A., Tasic, Bosiljka, Altshul, Jordan, Kenworthy, Mia A., Valadon, Cynthia, Nery, Joseph R., Castanon, Rosa G., Patne, Neelakshi S., Vu, Minh, Rashid, Mohammad, Jacobs, Matthew, Ito, Tony, Osteen, Julia, Emerson, Nora, Lee, Jasper, Cho, Silvia, Rink, Jon, Huang, Hsiang-Hsuan, Pinto-Duartec, António, Dominguez, Bertha, Smith, Jared B., O’Connor, Carolyn, Zeng, Hongkui, Chen, Shengbo, Lee, Kuo-Fen, Mukamel, Eran A., Jin, Xin, Margarita Behrens, M., Ecker, Joseph R., and Callaway, Edward M.
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- 2023
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3. Single-cell DNA methylome and 3D multi-omic atlas of the adult mouse brain
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Liu, Hanqing, Zeng, Qiurui, Zhou, Jingtian, Bartlett, Anna, Wang, Bang-An, Berube, Peter, Tian, Wei, Kenworthy, Mia, Altshul, Jordan, Nery, Joseph R., Chen, Huaming, Castanon, Rosa G., Zu, Songpeng, Li, Yang Eric, Lucero, Jacinta, Osteen, Julia K., Pinto-Duarte, Antonio, Lee, Jasper, Rink, Jon, Cho, Silvia, Emerson, Nora, Nunn, Michael, O’Connor, Carolyn, Wu, Zhanghao, Stoica, Ion, Yao, Zizhen, Smith, Kimberly A., Tasic, Bosiljka, Luo, Chongyuan, Dixon, Jesse R., Zeng, Hongkui, Ren, Bing, Behrens, M. Margarita, and Ecker, Joseph R.
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- 2023
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4. The β1-adrenergic receptor links sympathetic nerves to T cell exhaustion
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Globig, Anna-Maria, Zhao, Steven, Roginsky, Jessica, Maltez, Vivien I., Guiza, Juan, Avina-Ochoa, Natalia, Heeg, Maximilian, Araujo Hoffmann, Filipe, Chaudhary, Omkar, Wang, Jiawei, Senturk, Gokhan, Chen, Dan, O’Connor, Carolyn, Pfaff, Samuel, Germain, Ronald N., Schalper, Kurt A., Emu, Brinda, and Kaech, Susan M.
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- 2023
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5. Cell-type-specific effects of age and sex on human cortical neurons
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Chien, Jo-Fan, Liu, Hanqing, Wang, Bang-An, Luo, Chongyuan, Bartlett, Anna, Castanon, Rosa, Johnson, Nicholas D., Nery, Joseph R., Osteen, Julia, Li, Junhao, Altshul, Jordan, Kenworthy, Mia, Valadon, Cynthia, Liem, Michelle, Claffey, Naomi, O'Connor, Carolyn, Seeker, Luise A., Ecker, Joseph R., Behrens, M. Margarita, and Mukamel, Eran A.
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- 2024
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6. Epigenomic diversity of cortical projection neurons in the mouse brain
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Zhang, Zhuzhu, Zhou, Jingtian, Tan, Pengcheng, Pang, Yan, Rivkin, Angeline C, Kirchgessner, Megan A, Williams, Elora, Lee, Cheng-Ta, Liu, Hanqing, Franklin, Alexis D, Miyazaki, Paula Assakura, Bartlett, Anna, Aldridge, Andrew I, Vu, Minh, Boggeman, Lara, Fitzpatrick, Conor, Nery, Joseph R, Castanon, Rosa G, Rashid, Mohammad, Jacobs, Matthew W, Ito-Cole, Tony, O’Connor, Carolyn, Pinto-Duartec, António, Dominguez, Bertha, Smith, Jared B, Niu, Sheng-Yong, Lee, Kuo-Fen, Jin, Xin, Mukamel, Eran A, Behrens, M Margarita, Ecker, Joseph R, and Callaway, Edward M
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Neurosciences ,Human Genome ,Genetics ,Brain Disorders ,Underpinning research ,1.1 Normal biological development and functioning ,Neurological ,Animals ,Brain Mapping ,Cerebral Cortex ,Epigenome ,Epigenomics ,Female ,Male ,Mice ,Neural Pathways ,Neurons ,General Science & Technology - Abstract
Neuronal cell types are classically defined by their molecular properties, anatomy and functions. Although recent advances in single-cell genomics have led to high-resolution molecular characterization of cell type diversity in the brain1, neuronal cell types are often studied out of the context of their anatomical properties. To improve our understanding of the relationship between molecular and anatomical features that define cortical neurons, here we combined retrograde labelling with single-nucleus DNA methylation sequencing to link neural epigenomic properties to projections. We examined 11,827 single neocortical neurons from 63 cortico-cortical and cortico-subcortical long-distance projections. Our results showed unique epigenetic signatures of projection neurons that correspond to their laminar and regional location and projection patterns. On the basis of their epigenomes, intra-telencephalic cells that project to different cortical targets could be further distinguished, and some layer 5 neurons that project to extra-telencephalic targets (L5 ET) formed separate clusters that aligned with their axonal projections. Such separation varied between cortical areas, which suggests that there are area-specific differences in L5 ET subtypes, which were further validated by anatomical studies. Notably, a population of cortico-cortical projection neurons clustered with L5 ET rather than intra-telencephalic neurons, which suggests that a population of L5 ET cortical neurons projects to both targets. We verified the existence of these neurons by dual retrograde labelling and anterograde tracing of cortico-cortical projection neurons, which revealed axon terminals in extra-telencephalic targets including the thalamus, superior colliculus and pons. These findings highlight the power of single-cell epigenomic approaches to connect the molecular properties of neurons with their anatomical and projection properties.
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- 2021
7. DNA methylation atlas of the mouse brain at single-cell resolution
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Liu, Hanqing, Zhou, Jingtian, Tian, Wei, Luo, Chongyuan, Bartlett, Anna, Aldridge, Andrew, Lucero, Jacinta, Osteen, Julia K, Nery, Joseph R, Chen, Huaming, Rivkin, Angeline, Castanon, Rosa G, Clock, Ben, Li, Yang Eric, Hou, Xiaomeng, Poirion, Olivier B, Preissl, Sebastian, Pinto-Duarte, Antonio, O’Connor, Carolyn, Boggeman, Lara, Fitzpatrick, Conor, Nunn, Michael, Mukamel, Eran A, Zhang, Zhuzhu, Callaway, Edward M, Ren, Bing, Dixon, Jesse R, Behrens, M Margarita, and Ecker, Joseph R
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Neurosciences ,Human Genome ,Genetics ,Underpinning research ,1.1 Normal biological development and functioning ,Neurological ,Animals ,Atlases as Topic ,Brain ,Chromatin ,Cytosine ,DNA Methylation ,Datasets as Topic ,Dentate Gyrus ,Enhancer Elements ,Genetic ,Epigenome ,Epigenomics ,Gene Expression Profiling ,Hippocampus ,Male ,Mice ,Mice ,Inbred C57BL ,Models ,Biological ,Neural Pathways ,Neurons ,Single-Cell Analysis ,General Science & Technology - Abstract
Mammalian brain cells show remarkable diversity in gene expression, anatomy and function, yet the regulatory DNA landscape underlying this extensive heterogeneity is poorly understood. Here we carry out a comprehensive assessment of the epigenomes of mouse brain cell types by applying single-nucleus DNA methylation sequencing1,2 to profile 103,982 nuclei (including 95,815 neurons and 8,167 non-neuronal cells) from 45 regions of the mouse cortex, hippocampus, striatum, pallidum and olfactory areas. We identified 161 cell clusters with distinct spatial locations and projection targets. We constructed taxonomies of these epigenetic types, annotated with signature genes, regulatory elements and transcription factors. These features indicate the potential regulatory landscape supporting the assignment of putative cell types and reveal repetitive usage of regulators in excitatory and inhibitory cells for determining subtypes. The DNA methylation landscape of excitatory neurons in the cortex and hippocampus varied continuously along spatial gradients. Using this deep dataset, we constructed an artificial neural network model that precisely predicts single neuron cell-type identity and brain area spatial location. Integration of high-resolution DNA methylomes with single-nucleus chromatin accessibility data3 enabled prediction of high-confidence enhancer-gene interactions for all identified cell types, which were subsequently validated by cell-type-specific chromatin conformation capture experiments4. By combining multi-omic datasets (DNA methylation, chromatin contacts, and open chromatin) from single nuclei and annotating the regulatory genome of hundreds of cell types in the mouse brain, our DNA methylation atlas establishes the epigenetic basis for neuronal diversity and spatial organization throughout the mouse cerebrum.
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- 2021
8. Gene regulatory networks underlying human microglia maturation
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Han, Claudia, Li, Rick, Hansen, Emily, Bennett, Hunter, Poirion, Olivier, Buchanan, Justin, Challacombe, Jean, Fixsen, Bethany, Trescott, Samantha, Schlachetzki, Johannes CM, Preissl, Sebastian, Wang, Allen, O’Connor, Carolyn, Warden, Anna, Shriram, Shreya, Kim, Roy, Nguyen, Celina, Schafer, Danielle, Ramirez, Gabriela, Anavim, Samuel, Johnson, Avalon, Sajti, Eniko, Gupta, Mihir, Levy, Michael, Ben-Haim, Sharona, Gonda, David, Laurent, Louise, Glass, Christopher, and Coufal, Nicole
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Pediatric ,Biotechnology ,Human Genome ,Neurosciences ,Genetics ,Brain Disorders ,1.1 Normal biological development and functioning ,2.1 Biological and endogenous factors ,Neurological - Abstract
The fetal period is a critical time for brain development, characterized by neurogenesis, neural migration, and synaptogenesis 1-3 . Microglia, the tissue resident macrophages of the brain, are observed as early as the fourth week of gestation 4 and are thought to engage in a variety of processes essential for brain development and homeostasis 5-11 . Conversely, microglia phenotypes are highly regulated by the brain environment 12-14 . Mechanisms by which human brain development influences the maturation of microglia and microglia potential contribution to neurodevelopmental disorders remain poorly understood. Here, we performed transcriptomic analysis of human fetal and postnatal microglia and corresponding cortical tissue to define age-specific brain environmental factors that may drive microglia phenotypes. Comparative analysis of open chromatin profiles using bulk and single-cell methods in conjunction with a new computational approach that integrates epigenomic and single-cell RNA-seq data allowed decoding of cellular heterogeneity with inference of subtype- and development stage-specific transcriptional regulators. Interrogation of in vivo and in vitro iPSC-derived microglia models provides evidence for roles of putative instructive signals and downstream gene regulatory networks which establish human-specific fetal and postnatal microglia gene expression programs and potentially contribute to neurodevelopmental disorders.
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- 2021
9. Canonical BAF complex activity shapes the enhancer landscape that licenses CD8+ T cell effector and memory fates
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McDonald, Bryan, Chick, Brent Y., Ahmed, Nasiha S., Burns, Mannix, Ma, Shixin, Casillas, Eduardo, Chen, Dan, Mann, Thomas H., O’Connor, Carolyn, Hah, Nasun, Hargreaves, Diana C., and Kaech, Susan M.
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- 2023
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10. Brain cell type–specific enhancer–promoter interactome maps and disease-risk association
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Nott, Alexi, Holtman, Inge R, Coufal, Nicole G, Schlachetzki, Johannes CM, Yu, Miao, Hu, Rong, Han, Claudia Z, Pena, Monique, Xiao, Jiayang, Wu, Yin, Keulen, Zahara, Pasillas, Martina P, O'Connor, Carolyn, Nickl, Christian K, Schafer, Simon T, Shen, Zeyang, Rissman, Robert A, Brewer, James B, Gosselin, David, Gonda, David D, Levy, Michael L, Rosenfeld, Michael G, McVicker, Graham, Gage, Fred H, Ren, Bing, and Glass, Christopher K
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Biological Sciences ,Genetics ,Brain Disorders ,Dementia ,Alzheimer's Disease ,Aging ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Neurosciences ,Human Genome ,Stem Cell Research ,Acquired Cognitive Impairment ,Neurodegenerative ,Aetiology ,2.1 Biological and endogenous factors ,Neurological ,Adaptor Proteins ,Signal Transducing ,Alzheimer Disease ,Brain ,Cells ,Cultured ,Chromatin ,Enhancer Elements ,Genetic ,Gene Regulatory Networks ,Genetic Variation ,Genome-Wide Association Study ,Humans ,Microglia ,Nuclear Proteins ,Promoter Regions ,Genetic ,Sequence Deletion ,Tumor Suppressor Proteins ,General Science & Technology - Abstract
Noncoding genetic variation is a major driver of phenotypic diversity, but functional interpretation is challenging. To better understand common genetic variation associated with brain diseases, we defined noncoding regulatory regions for major cell types of the human brain. Whereas psychiatric disorders were primarily associated with variants in transcriptional enhancers and promoters in neurons, sporadic Alzheimer's disease (AD) variants were largely confined to microglia enhancers. Interactome maps connecting disease-risk variants in cell-type-specific enhancers to promoters revealed an extended microglia gene network in AD. Deletion of a microglia-specific enhancer harboring AD-risk variants ablated BIN1 expression in microglia, but not in neurons or astrocytes. These findings revise and expand the list of genes likely to be influenced by noncoding variants in AD and suggest the probable cell types in which they function.
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- 2019
11. Human microglia maturation is underpinned by specific gene regulatory networks
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Han, Claudia Z., Li, Rick Z., Hansen, Emily, Trescott, Samantha, Fixsen, Bethany R., Nguyen, Celina T., Mora, Cristina M., Spann, Nathanael J., Bennett, Hunter R., Poirion, Olivier, Buchanan, Justin, Warden, Anna S., Xia, Bing, Schlachetzki, Johannes C.M., Pasillas, Martina P., Preissl, Sebastian, Wang, Allen, O’Connor, Carolyn, Shriram, Shreya, Kim, Roy, Schafer, Danielle, Ramirez, Gabriela, Challacombe, Jean, Anavim, Samuel A., Johnson, Avalon, Gupta, Mihir, Glass, Ian A., Levy, Michael L., Haim, Sharona Ben, Gonda, David D., Laurent, Louise, Hughes, Jennifer F., Page, David C., Blurton-Jones, Mathew, Glass, Christopher K., and Coufal, Nicole G.
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- 2023
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12. CTLA-4 blockade induces a microglia-Th1 cell partnership that stimulates microglia phagocytosis and anti-tumor function in glioblastoma
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Chen, Dan, Varanasi, Siva Karthik, Hara, Toshiro, Traina, Kacie, Sun, Ming, McDonald, Bryan, Farsakoglu, Yagmur, Clanton, Josh, Xu, Shihao, Garcia-Rivera, Lizmarie, Mann, Thomas H., Du, Victor, Chung, H. Kay, Xu, Ziyan, Tripple, Victoria, Casillas, Eduardo, Ma, Shixin, O’Connor, Carolyn, Yang, Qiyuan, Zheng, Ye, Hunter, Tony, Lemke, Greg, and Kaech, Susan M.
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- 2023
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13. Giving Voice to Women and Children Killed in the Context of Domestic Homicide: Lessons Learned from Death Review Committees
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Jaffe, Peter, primary, Sinclair, Deborah, additional, Olszowy, Laura, additional, Saxton, Michael, additional, Reif, Katherine, additional, and O’Connor, Carolyn, additional
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- 2022
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14. “Change your number”: When Technology Intersects with Coercive Control, Intimate Partner Violence, and Legal Systems
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Alaggia, Ramona, primary, O’Connor, Carolyn, additional, and Scott, Marsha, additional
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- 2022
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15. The inactive X chromosome drives sex differences in microglial inflammatory activity in human glioblastoma
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Tharp, Marla E., primary, Han, Claudia Z., additional, Balak, Chris D., additional, Fitzpatrick, Conor, additional, O’Connor, Carolyn, additional, Preissl, Sebastian, additional, Buchanan, Justin, additional, Nott, Alexi, additional, Escoubet, Laure, additional, Mavrommatis, Konstantinos, additional, Gupta, Mihir, additional, Schwartz, Marc S., additional, Hoi Sang, U, additional, Jones, Pamela S., additional, Levy, Michael L., additional, Gonda, David D., additional, Ben-Haim, Sharona, additional, Ciacci, Joseph, additional, Barba, David, additional, Khalessi, Alexander, additional, Coufal, Nicole G., additional, Chen, Clark C., additional, Glass, Christopher K., additional, and Page, David C., additional
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- 2024
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16. Associations between receiving non-consensual image and video sexts and average sleep duration among adolescents and young adults
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Ganson, Kyle T., primary, O’Connor, Carolyn, additional, Nagata, Jason M., additional, Testa, Alexander, additional, Jackson, Dylan B., additional, Pang, Nelson, additional, and Mishna, Faye, additional
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- 2024
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17. An environment-dependent transcriptional network specifies human microglia identity
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Gosselin, David, Skola, Dylan, Coufal, Nicole G, Holtman, Inge R, Schlachetzki, Johannes CM, Sajti, Eniko, Jaeger, Baptiste N, O'Connor, Carolyn, Fitzpatrick, Conor, Pasillas, Martina P, Pena, Monique, Adair, Amy, Gonda, David D, Levy, Michael L, Ransohoff, Richard M, Gage, Fred H, and Glass, Christopher K
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Biological Sciences ,Biomedical and Clinical Sciences ,Genetics ,Neurodegenerative ,Biotechnology ,Neurosciences ,2.1 Biological and endogenous factors ,Underpinning research ,Aetiology ,1.1 Normal biological development and functioning ,Neurological ,Animals ,Brain Neoplasms ,Cells ,Cultured ,Environment ,Epilepsy ,Female ,Gene Expression Profiling ,Gene Expression Regulation ,Gene Regulatory Networks ,Humans ,Male ,Mice ,Mice ,Inbred C57BL ,Microglia ,General Science & Technology - Abstract
Microglia play essential roles in central nervous system (CNS) homeostasis and influence diverse aspects of neuronal function. However, the transcriptional mechanisms that specify human microglia phenotypes are largely unknown. We examined the transcriptomes and epigenetic landscapes of human microglia isolated from surgically resected brain tissue ex vivo and after transition to an in vitro environment. Transfer to a tissue culture environment resulted in rapid and extensive down-regulation of microglia-specific genes that were induced in primitive mouse macrophages after migration into the fetal brain. Substantial subsets of these genes exhibited altered expression in neurodegenerative and behavioral diseases and were associated with noncoding risk variants. These findings reveal an environment-dependent transcriptional network specifying microglia-specific programs of gene expression and facilitate efforts to understand the roles of microglia in human brain diseases.
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- 2017
18. Microglia use TAM receptors to detect and engulf amyloid β plaques
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Huang, Youtong, Happonen, Kaisa E., Burrola, Patrick G., O’Connor, Carolyn, Hah, Nasun, Huang, Ling, Nimmerjahn, Axel, and Lemke, Greg
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- 2021
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19. Social support and pregnancy attitudes among youth experiencing homelessness
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Begun, Stephanie, Barman-Adhikari, Anamika, O'Connor, Carolyn, and Rice, Eric
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- 2020
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20. Immune-evasive human islet-like organoids ameliorate diabetes
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Yoshihara, Eiji, O'Connor, Carolyn, Gasser, Emanuel, Wei, Zong, Oh, Tae Gyu, Tseng, Tiffany W., and Wang, Dan
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Organs, Culture of -- Methods ,Diabetes -- Care and treatment ,Stem cells -- Usage ,Islet cell transplantation -- Methods ,Immune recognition -- Prevention ,Environmental issues ,Science and technology ,Zoology and wildlife conservation - Abstract
Islets derived from stem cells hold promise as a therapy for insulin-dependent diabetes, but there remain challenges towards achieving this goal.sup.1-6. Here we generate human islet-like organoids (HILOs) from induced pluripotent stem cells and show that non-canonical WNT4 signalling drives the metabolic maturation necessary for robust ex vivo glucose-stimulated insulin secretion. These functionally mature HILOs contain endocrine-like cell types that, upon transplantation, rapidly re-establish glucose homeostasis in diabetic NOD/SCID mice. Overexpression of the immune checkpoint protein programmed death-ligand 1 (PD-L1) protected HILO xenografts such that they were able to restore glucose homeostasis in immune-competent diabetic mice for 50 days. Furthermore, ex vivo stimulation with interferon-[gamma] induced endogenous PD-L1 expression and restricted T cell activation and graft rejection. The generation of glucose-responsive islet-like organoids that are able to avoid immune detection provides a promising alternative to cadaveric and device-dependent therapies in the treatment of diabetes. Metabolically-mature human islet-like organoids generated from induced pluripotent stem cells are able to recapitulate insulin-responsive pancreatic islet function and avoid immunologic cell death in diabetic mouse transplantation models., Author(s): Eiji Yoshihara [sup.1] [sup.5] [sup.6] , Carolyn O'Connor [sup.2] , Emanuel Gasser [sup.1] , Zong Wei [sup.1] [sup.7] , Tae Gyu Oh [sup.1] , Tiffany W. Tseng [sup.1] , [...]
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- 2020
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21. Cell type-specific effects of age and sex on human cortical neurons
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Chien, Jo-Fan, primary, Liu, Hanqing, additional, Wang, Bang-An, additional, Luo, Chongyuan, additional, Bartlett, Anna, additional, Castanon, Rosa, additional, Johnson, Nicholas D., additional, Nery, Joseph R., additional, Osteen, Julia, additional, Li, Junhao, additional, Altshul, Jordan, additional, Kenworthy, Mia, additional, Valadon, Cynthia, additional, Liem, Michelle, additional, Claffey, Naomi, additional, O'Connor, Carolyn, additional, Seeker, Luise A., additional, Ecker, Joseph R., additional, Behrens, M. Margarita, additional, and Mukamel, Eran A., additional
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- 2023
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22. 1014 Adrenergic receptors regulate T cell differentiation in viral infection and cancer
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Globig, Anna-Maria, primary, Zhao, Steven, additional, Roginsky, Jessica, additional, Avina-Ochoa, Natalia, additional, Heeg, Maximilian, additional, Chaudhary, Omkar, additional, Hoffmann, Filipe Araujo, additional, Chen, Dan, additional, O’Connor, Carolyn, additional, Emu, Brinda, additional, and Kaech, Susan, additional
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- 2023
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23. Epigenome erosion in Alzheimer's disease brain cells and induced neurons
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Ecker, Joseph R., primary, Gage, Fred H., additional, Wang, Bangan, additional, Jones, Jeffrey, additional, Zhou, Jingtian, additional, Tian, Wei, additional, Wu, Yue, additional, Wang, Wenliang, additional, Berube, Peter, additional, Bartlett, Anna, additional, Castanon, Rosa Gomez, additional, Nery, Joseph R, additional, Chen, Huaming, additional, Kenworthy, Mia, additional, Altshul, Jordan, additional, Valadon, Cynthia, additional, Wang, Yichen, additional, Kang, Austin, additional, Goodman, Ryan, additional, Liem, Michelle, additional, Claffey, Naomi, additional, O'Connor, Carolyn, additional, Metcalf, Jeffrey, additional, and Luo, Chongyuan, additional
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- 2023
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24. Single-cell DNA methylation and 3D genome architecture in the human brain
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Tian, Wei, primary, Zhou, Jingtian, additional, Bartlett, Anna, additional, Zeng, Qiurui, additional, Liu, Hanqing, additional, Castanon, Rosa G., additional, Kenworthy, Mia, additional, Altshul, Jordan, additional, Valadon, Cynthia, additional, Aldridge, Andrew, additional, Nery, Joseph R., additional, Chen, Huaming, additional, Xu, Jiaying, additional, Johnson, Nicholas D., additional, Lucero, Jacinta, additional, Osteen, Julia K., additional, Emerson, Nora, additional, Rink, Jon, additional, Lee, Jasper, additional, Li, Yang E., additional, Siletti, Kimberly, additional, Liem, Michelle, additional, Claffey, Naomi, additional, O’Connor, Carolyn, additional, Yanny, Anna Marie, additional, Nyhus, Julie, additional, Dee, Nick, additional, Casper, Tamara, additional, Shapovalova, Nadiya, additional, Hirschstein, Daniel, additional, Ding, Song-Lin, additional, Hodge, Rebecca, additional, Levi, Boaz P., additional, Keene, C. Dirk, additional, Linnarsson, Sten, additional, Lein, Ed, additional, Ren, Bing, additional, Behrens, M. Margarita, additional, and Ecker, Joseph R., additional
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- 2023
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25. Simultaneous profiling of 3D genome structure and DNA methylation in single human cells
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Lee, Dong-Sung, Luo, Chongyuan, Zhou, Jingtian, Chandran, Sahaana, Rivkin, Angeline, Bartlett, Anna, Nery, Joseph R., Fitzpatrick, Conor, O’Connor, Carolyn, Dixon, Jesse R., and Ecker, Joseph R.
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- 2019
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26. Troubled times: Canadian social workers' early adversities, mental health, and resilience during the COVID-19 pandemic.
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Alaggia, Ramona, O'Connor, Carolyn, Fuller-Thomson, Esme, and West, Keri
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ADVERSE childhood experiences , *STATISTICS , *CONFIDENCE intervals , *SOCIAL workers , *EFFECT sizes (Statistics) , *MENTAL health , *HEALTH status indicators , *POST-traumatic stress disorder , *DESCRIPTIVE statistics , *QUESTIONNAIRES , *MENTAL depression , *CHI-squared test , *LOGISTIC regression analysis , *ANXIETY , *ODDS ratio , *COVID-19 pandemic , *PSYCHOLOGICAL resilience , *PSYCHOLOGICAL stress - Abstract
Canadian social workers were surveyed about early adversities, mental health, and resilience. Bivariate analysis (n = 236) was conducted to understand relationships between predictor and outcome variables; and logistic regression analyses were conducted for depression, post-traumatic stress disorder, anxiety, and resilience. The impact of pandemic-related factors was also investigated. The results indicate that social workers are experiencing concerning levels of mental health issues, with significantly lower levels of resilience in younger social workers. A trauma and resilience informed approach to workplace policies and practices is urgently required to support social workers' mental health needs. [ABSTRACT FROM AUTHOR]
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- 2024
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27. Female pubertal development in the United Kingdom : trends in onset, progress and duration from 1948 to the present
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O'Connor, Carolyn Elizabeth
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301 - Abstract
Female pubertal development is the process of physical changes from the child to adult female bodies. The nature of human adaptation creates huge inter and intra-population variation in female pubertal development in response to both heritable and environmental determinants. Age at menarche has been declining globally in response to urbanisation and industrialisation. In the USA and other developed countries age at pubertal onset, specifically age at thelarche, appears to be declining with the concurrent rise in overweight and obesity. Longitudinal cohort datasets from the UK were analysed to replicate these findings in the UK population from 1948-2005. These data show evidence for a continued downward secular trend in age at menarche, and show a downward secular trend in age at pubertal onset, in response to increased weight status. Over the period 1948-2005, age at menarche decreased by 0.30 years, and age at thelarche decreased by one year. The average interval between pubertal onset and age at menarche increased from 2.3 years to 2.7 years. More than half of the total decrease in age at thelarche took place between 1980 and 2001. Some of the variance in pubertal development, and specifically the large decrease in age at thelarche, may to be the result of increasing exposure to endocrine disrupting chemicals over the last 50-60 years. Lipophilic endocrine disruptors have the potential to accelerate pubertal development in overweight girls who have the capacity to store dangerous levels of these toxic substances in their high fat mass. The changes in timing and tempo of female pubertal development in the UK should be considered on a continuum of adaptive plasticity that is evident in the population variation of female pubertal development, rather than measuring recent changes as pathology. Earlier age at puberty has a number of implications for negative health outcomes, specifically increased risk of reproductive cancers. Moreover, the interaction between increased weight status and increased exposure to endocrine disruptors may exacerbate these negative effects.
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- 2013
28. Troubled teens and challenged caregivers: Characteristics associated with the decision to provide child welfare services to adolescents in Ontario, Canada
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King, Bryn, Fallon, Barbara, Filippelli, Joanne, Black, Tara, and O'Connor, Carolyn
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- 2018
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29. Factors associated with racial differences in child welfare investigative decision-making in Ontario, Canada
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King, Bryn, Fallon, Barbara, Boyd, Reiko, Black, Tara, Antwi-Boasiako, Kofi, and O’Connor, Carolyn
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- 2017
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30. Adrenergic receptors regulate T cell differentiation in viral infection and cancer
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Globig, Anna-Maria, primary, Zhao, Steven, additional, Roginsky, Jessica, additional, Avina-Ochoa, Natalia, additional, Heeg, Maximilian, additional, Chaudhary, Omkar, additional, Hoffmann, Filipe Araujo, additional, Chen, Dan, additional, O’Connor, Carolyn, additional, Emu, Brinda, additional, and Kaech, Susan, additional
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- 2023
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31. Brain-wide Correspondence Between Neuronal Epigenomics and Long-Distance Projections
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Zhou, Jingtian, primary, Zhang, Zhuzhu, additional, Wu, May, additional, Liu, Hanqing, additional, Pang, Yan, additional, Bartlett, Anna, additional, Rivkin, Angeline C., additional, Lagos, Will N., additional, Williams, Elora, additional, Lee, Cheng-Ta, additional, Miyazaki, Paula Assakura, additional, Aldridge, Andrew I., additional, Zeng, Qiurui, additional, Salinda, J.L. Angelo, additional, Claffey, Naomi, additional, Liem, Michelle, additional, Fitzpatrick, Conor, additional, Boggeman, Lara, additional, Yao, Zizhen, additional, Smith, Kimberly A., additional, Tasic, Bosiljka, additional, Altshul, Jordan, additional, Kenworthy, Mia A., additional, Valadon, Cynthia, additional, Nery, Joseph R., additional, Castanon, Rosa G., additional, Patne, Neelakshi S., additional, Vu, Minh, additional, Rashid, Mohammad, additional, Jacobs, Matthew W., additional, Ito-Cole, Tony, additional, Osteen, Julia, additional, Emerson, Nora, additional, Lee, Jasper, additional, Cho, Silvia, additional, Rink, Jon, additional, Huang, Hsiang-Hsuan, additional, Pinto-Duartec, Antonio, additional, Dominguez, Bertha, additional, Smith, Jared B., additional, O'Connor, Carolyn, additional, Zeng, Hongkui, additional, Lee, Kuo-Fen, additional, Mukamel, Eran A., additional, Jin, Xin, additional, Behrens, M. Margarita, additional, Ecker, Joseph R., additional, and Callaway, Edward M., additional
- Published
- 2023
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32. Single-cell DNA Methylome and 3D Multi-omic Atlas of the Adult Mouse Brain
- Author
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Liu, Hanqing, primary, Zeng, Qiurui, additional, Zhou, Jingtian, additional, Bartlett, Anna, additional, Wang, Bang-An, additional, Berube, Peter, additional, Tian, Wei, additional, Kenworthy, Mia, additional, Altshul, Jordan, additional, Nery, Joseph R., additional, Chen, Huaming, additional, Castanon, Rosa G., additional, Zu, Songpeng, additional, Li, Yang Eric, additional, Lucero, Jacinta, additional, Osteen, Julia K., additional, Pinto-Duarte, Antonio, additional, Lee, Jasper, additional, Rink, Jon, additional, Cho, Silvia, additional, Emerson, Nora, additional, Nunn, Michael, additional, O’Connor, Carolyn, additional, Yao, Zizhen, additional, Smith, Kimberly A., additional, Tasic, Bosiljka, additional, Zeng, Hongkui, additional, Luo, Chongyuan, additional, Dixon, Jesse R., additional, Ren, Bing, additional, Behrens, M. Margarita, additional, and Ecker, Joseph R, additional
- Published
- 2023
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33. Deletion mapping of regulatory elements for GATA3 in T cells reveals a distal enhancer involved in allergic diseases
- Author
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Chen, Hsiuyi V., primary, Lorenzini, Michael H., additional, Lavalle, Shanna N., additional, Sajeev, Karthyayani, additional, Fonseca, Ariana, additional, Fiaux, Patrick C., additional, Sen, Arko, additional, Luthra, Ishika, additional, Ho, Aaron J., additional, Chen, Aaron R., additional, Guruvayurappan, Karthik, additional, O’Connor, Carolyn, additional, and McVicker, Graham, additional
- Published
- 2023
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34. The β1-adrenergic receptor links sympathetic nerves to T cell exhaustion.
- Author
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Globig, Anna-Maria, Zhao, Steven, Roginsky, Jessica, Maltez, Vivien I., Guiza, Juan, Avina-Ochoa, Natalia, Heeg, Maximilian, Araujo Hoffmann, Filipe, Chaudhary, Omkar, Wang, Jiawei, Senturk, Gokhan, Chen, Dan, O'Connor, Carolyn, Pfaff, Samuel, Germain, Ronald N., Schalper, Kurt A., Emu, Brinda, and Kaech, Susan M.
- Abstract
CD8
+ T cells are essential components of the immune response against viral infections and tumours, and are capable of eliminating infected and cancerous cells. However, when the antigen cannot be cleared, T cells enter a state known as exhaustion1. Although it is clear that chronic antigen contributes to CD8+ T cell exhaustion, less is known about how stress responses in tissues regulate T cell function. Here we show a new link between the stress-associated catecholamines and the progression of T cell exhaustion through the β1 -adrenergic receptor ADRB1. We identify that exhausted CD8+ T cells increase ADRB1 expression and that exposure of ADRB1+ T cells to catecholamines suppresses their cytokine production and proliferation. Exhausted CD8+ T cells cluster around sympathetic nerves in an ADRB1-dependent manner. Ablation of β1 -adrenergic signalling limits the progression of T cells towards the exhausted state in chronic infection and improves effector functions when combined with immune checkpoint blockade (ICB) in melanoma. In a pancreatic cancer model resistant to ICB, β-blockers and ICB synergize to boost CD8+ T cell responses and induce the development of tissue-resident memory-like T cells. Malignant disease is associated with increased catecholamine levels in patients2,3, and our results establish a connection between the sympathetic stress response, tissue innervation and T cell exhaustion. Here, we uncover a new mechanism by which blocking β-adrenergic signalling in CD8+ T cells rejuvenates anti-tumour functions.Stress-associated catecholamines promote CD8+ T cell exhaustion through the β1 -adrenergic receptor, and blocking β-adrenergic signalling may help restore anti-tumour functions. [ABSTRACT FROM AUTHOR]- Published
- 2023
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35. Troubled times: Canadian social workers’ early adversities, mental health, and resilience during the COVID-19 pandemic
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Alaggia, Ramona, primary, O’Connor, Carolyn, additional, Fuller-Thomson, Esme, additional, and West, Keri, additional
- Published
- 2023
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36. Publisher Correction: Immune-evasive human islet-like organoids ameliorate diabetes
- Author
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Yoshihara, Eiji, O’Connor, Carolyn, Gasser, Emanuel, Wei, Zong, Oh, Tae Gyu, Tseng, Tiffany W., Wang, Dan, Cayabyab, Fritz, Dai, Yang, Yu, Ruth T., Liddle, Christopher, Atkins, Annette R., Downes, Michael, and Evans, Ronald M.
- Published
- 2021
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37. The Lawyer's Baggage: Engaging the Oppressor Within
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O'Connor, Carolyn
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Lawyers -- Evaluation -- Psychological aspects -- Social aspects ,Oppression (Politics) -- Analysis -- Management -- Research ,Engagement (Philosophy) -- Analysis -- Psychological aspects -- Research ,Social movements -- Analysis -- Psychological aspects -- Research ,Company business management ,Law ,Social sciences - Abstract
For at least fifty years, lawyers have examined what professional role to play in movements to end oppression. First, lawyers criticized the impact litigator: ducking in and out of movements, [...]
- Published
- 2019
38. A microglia-CD4+ T cell partnership generates protective anti-tumor immunity to glioblastoma
- Author
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Chen, Dan, primary, Varanasi, Siva Karthik, additional, Hara, Toshiro, additional, Traina, Kacie, additional, McDonald, Bryan, additional, Farsakoglu, Yagmur, additional, Clanton, Josh, additional, Xu, Shihao, additional, Mann, Thomas H., additional, Du, Victor, additional, Chung, H. Kay, additional, Xu, Ziyan, additional, Tripple, Victoria, additional, Casillas, Eduardo, additional, Ma, Shixin, additional, O’Connor, Carolyn, additional, Yang, Qiyuan, additional, Zheng, Ye, additional, Hunter, Tony, additional, Lemke, Greg, additional, and Kaech, Susan M., additional
- Published
- 2022
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- View/download PDF
39. Robust single-cell DNA methylome profiling with snmC-seq2
- Author
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Luo, Chongyuan, Rivkin, Angeline, Zhou, Jingtian, Sandoval, Justin P., Kurihara, Laurie, Lucero, Jacinta, Castanon, Rosa, Nery, Joseph R., Pinto-Duarte, António, Bui, Brian, Fitzpatrick, Conor, O’Connor, Carolyn, Ruga, Seth, Van Eden, Marc E., Davis, David A., Mash, Deborah C., Behrens, M. Margarita, and Ecker, Joseph R.
- Published
- 2018
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40. Leaf cell-specific and single-cell transcriptional profiling reveals a role for the palisade layer in UV light protection
- Author
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Procko, Carl, primary, Lee, Travis, additional, Borsuk, Aleca, additional, Bargmann, Bastiaan O R, additional, Dabi, Tsegaye, additional, Nery, Joseph R, additional, Estelle, Mark, additional, Baird, Lisa, additional, O’Connor, Carolyn, additional, Brodersen, Craig, additional, Ecker, Joseph R, additional, and Chory, Joanne, additional
- Published
- 2022
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- View/download PDF
41. Deletion mapping of regulatory elements for GATA3 reveals a distal T helper 2 cell enhancer involved in allergic diseases
- Author
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Chen, Hsiuyi V, primary, Fiaux, Patrick C, additional, Sen, Arko, additional, Luthra, Ishika, additional, Ho, Aaron J, additional, Chen, Aaron R, additional, Guruvayurappan, Karthik, additional, Lorenzini, Michael H, additional, O'Connor, Carolyn, additional, and McVicker, Graham, additional
- Published
- 2022
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- View/download PDF
42. Conceptualizing anti-Asian racism in Canada during the COVID-19 pandemic: A call for action to social workers
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Zhao, Kedi, primary, O’Connor, Carolyn, additional, Lenz, Trish, additional, and Fang, Lin, additional
- Published
- 2022
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43. Understanding Sexual Consent Among Adolescents
- Author
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O'Connor, Carolyn, primary and Begun, Stephanie, primary
- Published
- 2022
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44. Correction: Corrigendum: Nuclear RNA-seq of single neurons reveals molecular signatures of activation
- Author
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Lacar, Benjamin, Linker, Sara B., Jaeger, Baptiste N., Krishnaswami, Suguna Rani, Barron, Jerika J., Kelder, Martijn J. E., Parylak, Sarah L, Paquola, Apuã C. M., Venepally, Pratap, Novotny, Mark, O’Connor, Carolyn, Fitzpatrick, Conor, Erwin, Jennifer A., Hsu, Jonathan Y., Husband, David, McConnell, Michael J., Lasken, Roger, and Gage, Fred H.
- Published
- 2017
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45. A multimodal cell census and atlas of the mammalian primary motor cortex
- Author
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Callaway, Edward M., Dong, Hong-Wei, Ecker, Joseph R., Hawrylycz, Michael J., Huang, Z. Josh, Lein, Ed S., Ngai, John, Osten, Pavel, Ren, Bing, Tolias, Andreas Savas, White, Owen, Zeng, Hongkui, Zhuang, Xiaowei, Ascoli, Giorgio A., Behrens, M. Margarita, Chun, Jerold, Feng, Guoping, Gee, James C., Ghosh, Satrajit S., Halchenko, Yaroslav O., Hertzano, Ronna, Lim, Byung Kook, Martone, Maryann E., Ng, Lydia, Pachter, Lior, Ropelewski, Alexander J., Tickle, Timothy L., Yang, X. William, Zhang, Kun, Bakken, Trygve E., Berens, Philipp, Daigle, Tanya L., Harris, Julie A., Jorstad, Nikolas L., Kalmbach, Brian E., Kobak, Dmitry, Li, Yang Eric, Liu, Hanqing, Matho, Katherine S., Mukamel, Eran A., Naeemi, Maitham, Scala, Federico, Tan, Pengcheng, Ting, Jonathan T., Xie, Fangming, Zhang, Meng, Zhang, Zhuzhu, Zhou, Jingtian, Zingg, Brian, Armand, Ethan, Yao, Zizhen, Bertagnolli, Darren, Casper, Tamara, Crichton, Kirsten, Dee, Nick, Diep, Dinh, Ding, Song-Lin, Dong, Weixiu, Dougherty, Elizabeth L., Fong, Olivia, Goldman, Melissa, Goldy, Jeff, Hodge, Rebecca D., Hu, Lijuan, Keene, C. Dirk, Krienen, Fenna M., Kroll, Matthew, Lake, Blue B., Lathia, Kanan, Linnarsson, Sten, Liu, Christine S., Macosko, Evan Z., McCarroll, Steven A., McMillen, Delissa, Nadaf, Naeem M., Nguyen, Thuc Nghi, Palmer, Carter R., Pham, Thanh, Plongthongkum, Nongluk, Reed, Nora M., Regev, Aviv, Rimorin, Christine, Romanow, William J., Savoia, Steven, Siletti, Kimberly, Smith, Kimberly, Sulc, Josef, Tasic, Bosiljka, Tieu, Michael, Torkelson, Amy, Tung, Herman, van Velthoven, Cindy T. J., Vanderburg, Charles R., Yanny, Anna Marie, Fang, Rongxin, Hou, Xiaomeng, Lucero, Jacinta D., Osteen, Julia K., Pinto-Duarte, Antonio, Poirion, Olivier, Preissl, Sebastian, Wang, Xinxin, Aldridge, Andrew I., Bartlett, Anna, Boggeman, Lara, O’Connor, Carolyn, Castanon, Rosa G., Chen, Huaming, Fitzpatrick, Conor, Luo, Chongyuan, Nery, Joseph R., Nunn, Michael, Rivkin, Angeline C., Tian, Wei, Dominguez, Bertha, Ito-Cole, Tony, Jacobs, Matthew, Jin, Xin, Lee, Cheng-Ta, Lee, Kuo-Fen, Miyazaki, Paula Assakura, Pang, Yan, Rashid, Mohammad, Smith, Jared B., Vu, Minh, Williams, Elora, Biancalani, Tommaso, Booeshaghi, A. Sina, Crow, Megan, Dudoit, Sandrine, Fischer, Stephan, Gillis, Jesse, Hu, Qiwen, Kharchenko, Peter V., Niu, Sheng-Yong, Ntranos, Vasilis, Purdom, Elizabeth, Risso, Davide, de Bézieux, Hector Roux, Somasundaram, Saroja, Street, Kelly, Svensson, Valentine, Vaishnav, Eeshit Dhaval, Van den Berge, Koen, Welch, Joshua D., An, Xu, Bateup, Helen S., Bowman, Ian, Chance, Rebecca K., Foster, Nicholas N., Galbavy, William, Gong, Hui, Gou, Lin, Hatfield, Joshua T., Hintiryan, Houri, Hirokawa, Karla E., Kim, Gukhan, Kramer, Daniel J., Li, Anan, Li, Xiangning, Luo, Qingming, Muñoz-Castañeda, Rodrigo, Stafford, David A., Feng, Zhao, Jia, Xueyan, Jiang, Shengdian, Jiang, Tao, Kuang, Xiuli, Larsen, Rachael, Lesnar, Phil, Li, Yaoyao, Li, Yuanyuan, Liu, Lijuan, Peng, Hanchuan, Qu, Lei, Ren, Miao, Ruan, Zongcai, Shen, Elise, Song, Yuanyuan, Wakeman, Wayne, Wang, Peng, Wang, Yimin, Wang, Yun, Yin, Lulu, Yuan, Jing, Zhao, Sujun, Zhao, Xuan, Narasimhan, Arun, Palaniswamy, Ramesh, Banerjee, Samik, Ding, Liya, Huilgol, Dhananjay, Huo, Bingxing, Kuo, Hsien-Chi, Laturnus, Sophie, Li, Xu, Mitra, Partha P., Mizrachi, Judith, Wang, Quanxin, Xie, Peng, Xiong, Feng, Yu, Yang, Eichhorn, Stephen W., Berg, Jim, Bernabucci, Matteo, Bernaerts, Yves, Cadwell, Cathryn René, Castro, Jesus Ramon, Dalley, Rachel, Hartmanis, Leonard, Horwitz, Gregory D., Jiang, Xiaolong, Ko, Andrew L., Miranda, Elanine, Mulherkar, Shalaka, Nicovich, Philip R., Owen, Scott F., Sandberg, Rickard, Sorensen, Staci A., Tan, Zheng Huan, Allen, Shona, Hockemeyer, Dirk, Lee, Angus Y., Veldman, Matthew B., Adkins, Ricky S., Ament, Seth A., Bravo, Héctor Corrada, Carter, Robert, Chatterjee, Apaala, Colantuoni, Carlo, Crabtree, Jonathan, Creasy, Heather, Felix, Victor, Giglio, Michelle, Herb, Brian R., Kancherla, Jayaram, Mahurkar, Anup, McCracken, Carrie, Nickel, Lance, Olley, Dustin, Orvis, Joshua, Schor, Michael, Hood, Greg, Dichter, Benjamin, Grauer, Michael, Helba, Brian, Bandrowski, Anita, Barkas, Nikolaos, Carlin, Benjamin, D’Orazi, Florence D., Degatano, Kylee, Gillespie, Thomas H., Khajouei, Farzaneh, Konwar, Kishori, Thompson, Carol, Kelly, Kathleen, Mok, Stephanie, Sunkin, Susan, BRAIN Initiative Cell Census Network (BICCN) Corresponding authors, [missing], BICCN contributing principal investigators, [missing], Principal manuscript editors, [missing], Manuscript writing and figure generation, [missing], Analysis coordination, [missing], Integrated data analysis, [missing], scRNA-seq and snRNA-seq data generation and processing, [missing], ATAC-seq data generation and processing, [missing], Methylcytosine data production and analysis, [missing], Epi-retro-seq data generation and processing, [missing], ‘Omics data analysis, [missing], Tracing and connectivity data generation, [missing], Morphology data generation and reconstruction, [missing], OLST/STPT and other data generation, [missing], Morphology, connectivity and imaging analysis, [missing], Spatially resolved single-cell transcriptomics (MERFISH), [missing], Multimodal profiling (Patch-seq), [missing], Transgenic tools, [missing], NeMO archive and analytics, [missing], Brain Image Library (BIL) archive, [missing], DANDI archive, [missing], Brain Cell Data Center (BCDC), [missing], Project management, [missing], and BRAIN Initiative Cell Census Network (BICCN), [missing]
- Subjects
Epigenomics ,Male ,INTERNEURONS ,ORGANIZATION ,MOUSE ,Molecular neuroscience ,Neural circuits ,CLASSIFICATION ,Article ,Mice ,Atlases as Topic ,Glutamates ,Species Specificity ,Animals ,Humans ,TRANSCRIPTOMICS ,SPECIFICATION ,NEURONS ,In Situ Hybridization, Fluorescence ,Phylogeny ,Neurons ,Multidisciplinary ,Gene Expression Profiling ,Biology and Life Sciences ,PATHWAYS ,Brain ,Callithrix ,Censuses ,Cellular neuroscience ,Mathematics and Statistics ,SINGLE ,Organ Specificity ,MORPHOLOGY ,Motor cortex ,Female ,Single-Cell Analysis ,Transcriptome - Abstract
Here we report the generation of a multimodal cell census and atlas of the mammalian primary motor cortex as the initial product of the BRAIN Initiative Cell Census Network (BICCN). This was achieved by coordinated large-scale analyses of single-cell transcriptomes, chromatin accessibility, DNA methylomes, spatially resolved single-cell transcriptomes, morphological and electrophysiological properties and cellular resolution input–output mapping, integrated through cross-modal computational analysis. Our results advance the collective knowledge and understanding of brain cell-type organization1–5. First, our study reveals a unified molecular genetic landscape of cortical cell types that integrates their transcriptome, open chromatin and DNA methylation maps. Second, cross-species analysis achieves a consensus taxonomy of transcriptomic types and their hierarchical organization that is conserved from mouse to marmoset and human. Third, in situ single-cell transcriptomics provides a spatially resolved cell-type atlas of the motor cortex. Fourth, cross-modal analysis provides compelling evidence for the transcriptomic, epigenomic and gene regulatory basis of neuronal phenotypes such as their physiological and anatomical properties, demonstrating the biological validity and genomic underpinning of neuron types. We further present an extensive genetic toolset for targeting glutamatergic neuron types towards linking their molecular and developmental identity to their circuit function. Together, our results establish a unifying and mechanistic framework of neuronal cell-type organization that integrates multi-layered molecular genetic and spatial information with multi-faceted phenotypic properties., The BRAIN Initiative Cell Census Network has constructed a multimodal cell census and atlas of the mammalian primary motor cortex in a landmark effort towards understanding brain cell-type diversity, neural circuit organization and brain function.
- Published
- 2021
46. Correction: Corrigendum: Nuclear RNA-seq of single neurons reveals molecular signatures of activation
- Author
-
Lacar, Benjamin, Linker, Sara B., Jaeger, Baptiste N., Krishnaswami, Suguna Rani, Barron, Jerika J., Kelder, Martijn J. E., Parylak, Sarah L., Paquola, Apuã C. M., Venepally, Pratap, Novotny, Mark, O’Connor, Carolyn, Fitzpatrick, Conor, Erwin, Jennifer A., Hsu, Jonathan Y., Husband, David, McConnell, Michael J., Lasken, Roger, and Gage, Fred H.
- Published
- 2016
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- View/download PDF
47. Gene regulatory networks underlying human microglia maturation
- Author
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Han, Claudia Z., primary, Li, Rick Z., additional, Hansen, Emily, additional, Bennett, Hunter R., additional, Poirion, Olivier, additional, Buchanan, Justin, additional, Challacombe, Jean F., additional, Fixsen, Bethany R., additional, Trescott, Samantha, additional, Schlachetzki, Johannes C.M., additional, Preissl, Sebastian, additional, Wang, Allen, additional, O’Connor, Carolyn, additional, Warden, Anna S., additional, Shriram, Shreya, additional, Kim, Roy, additional, Nguyen, Celina T., additional, Schafer, Danielle M., additional, Ramirez, Gabriela, additional, Anavim, Samuel A., additional, Johnson, Avalon, additional, Sajti, Eniko, additional, Gupta, Mihir, additional, Levy, Michael L., additional, Ben-Haim, Sharona, additional, Gonda, David D., additional, Laurent, Louise, additional, Glass, Christopher K., additional, and Coufal, Nicole G., additional
- Published
- 2021
- Full Text
- View/download PDF
48. Sonographic Assessment of the Carpal Tunnel Syndrome Secondary to a Tenosynovitis of the Flexor Digitorum Superficialis in a Patient With Rheumatoid Arthritis
- Author
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Panahi, Eric, O’Connor, Carolyn R., and Checa, Angel
- Published
- 2014
- Full Text
- View/download PDF
49. Contributors
- Author
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ABDEL-RAZEQ, SONYA S., primary, ABDULBAKI, ABDULRAHMAN, additional, AFRIDI, WAFFIYAH, additional, AL MALKI, MONZR M., additional, ALI, TANYA, additional, ALIOTTA, PHILIP J., additional, ALVERO, RUBEN, additional, ANANDAN, SRIVIDYA, additional, ANDERSON, MEL L., additional, ANILOWSKI, KATHRYN TAYLOR, additional, ANVAR, MICHELLE STOZEK, additional, AOKI, ETSUKO, additional, APPELLE, NICOLE, additional, ASFAHANI, WISSAM S.Z., additional, ASIEDU, DANIEL K., additional, AULAKH, SUDEEP KAUR, additional, BALIOG, CRISOSTOMO R., additional, BANSAL, PRIYA, additional, BARADHI, KRISHNA, additional, BARRETT, ROWLAND P., additional, BATRA, KERRI, additional, BEHERA, VIKRAM, additional, BERGER, OMRI, additional, BERGES, ARNALDO A., additional, BERKOWITZ, SETH A., additional, BHAT, JAYDEEP, additional, BHATT, HARIKRASHNA, additional, BILODEAU, COURTNEY CLARK, additional, BISHOP, KENNETH D., additional, BLUNDIN, MICHAEL, additional, BODKIN, SHEENAGH M., additional, BORA, NIRALI, additional, BORKAN, JEFFREY M., additional, BOSKE, ALEXANDRA, additional, BOWLBY, LYNN, additional, BRADY, MARK F., additional, BRAR, MANDEEP K., additional, BROWN, ELIZABETH J., additional, BROWN, GAVIN, additional, BUCKLEY, JENNIFER, additional, BURNS, JONATHAN, additional, BURTIS, D. BRANDON, additional, BURTT, DOUGLAS, additional, BUSSELEN, STEVEN, additional, RODRIGUEZ CABRERA, CLAUDIA, additional, CHAUDHARY, NIDA, additional, CHENG, VICKY, additional, CHOUDHARY, GAURAV, additional, CHOW, STEPHANIE W., additional, COHEN, LISA, additional, COHEN, SCOTT, additional, COMPTON, KAILA, additional, CORIGLIANO, MARIA A., additional, COWLES, BRIAN J., additional, CRISTESCU, DAN A., additional, CRISTOFARO, PATRICIA, additional, CURTIN, ALICIA J., additional, DALRYMPLE, KRISTY L., additional, DANAKAS, GEORGE T., additional, DEGENHARDT, ALEXANDRA, additional, DIAZ, JOSEPH A., additional, DIEP, JIMMY, additional, DOBBS, MICHAEL R., additional, DOOBAY, NATHALIA, additional, DOTSON, WILLIAM F., additional, DUKER, ANDREW, additional, EISENDRATH, STUART J., additional, ELLSWORTH, PAMELA, additional, ELTOMI, HODA, additional, ESPINOSA, PATRICIO SEBASTIAN, additional, FABRE, VALERIA, additional, FAGAN, MARK J., additional, FARKASH, GIL M., additional, FARRELL, TIMOTHY W., additional, FELDMAN, MITCHELL D., additional, FERRI, FRED F., additional, FINNEY, GLEN, additional, FISCHER, STACI A., additional, FISHMAN, MARLENE, additional, FONG, TAMARA G., additional, FORMICA, PHILIP, additional, FORT, FRANK G., additional, FORT, GLENN G., additional, FORTUNATO, DAVID J., additional, FRITZ, GREGORY K., additional, GADDAM, SAINATH, additional, GEKHT, GENNA, additional, GEORGE, PAUL F., additional, GIUSTOZZI, ANNGENE A., additional, GLEIT, CINDY, additional, GOLDBERG, RICHARD J., additional, GOLDBURT, ALLA, additional, GOPALAKRISHNAN, GEETHA, additional, GORDON, PAUL, additional, GRAFF, NANCY R., additional, GRAY, JOHN A., additional, GROVES, ELLIOTT M., additional, GUPTA, PAVAN, additional, GUPTA, PRIYA SARIN, additional, HACK, NAWAZ, additional, HAHN, WILLIAM O., additional, HALL, HARALD ALEXANDER, additional, HALPERN, MICHELE, additional, HANDA, SAJEEV, additional, HARRISON, TAYLOR, additional, HAYES, DON, additional, HOLLAND, N. WILSON, additional, HU, SUSIE L., additional, HUME, ANNE L., additional, HUNDAL, HARKAWAL S., additional, HUTSON, SHARLISA, additional, HYDER, SARAH M., additional, ISAACSON, RICHARD S., additional, ISMAIL, AHMAD M., additional, JANKOWICH, MATTHEW D., additional, JAVIER, NOEL S.C., additional, JEREMIAH, JENNIFER, additional, JOHNSON, MICHAEL P., additional, JOHNSTON, BREE, additional, JONES, KIMBERLY, additional, JONES, KOHAR, additional, KALANITHI, LUCY, additional, KATZ, EMILY R., additional, KAZIM, ALI, additional, KEELEY, BROOKE E., additional, KENNEDY, KARA A., additional, KENNEY, BEVIN, additional, KFOURY, LARA, additional, KIM, JIWON, additional, KIM, WAN J., additional, KIRCHNER, ROBERT M., additional, KLEIN, MICHAEL, additional, KOBY, MELVYN, additional, KOHN, ROBERT, additional, KOKKIRALA, ARAVIND RAO, additional, KORR, KENNETH, additional, KRAMER, KRISTINA, additional, KURSS, DAVID, additional, LAI, CINDY, additional, LALLY, EDWARD V., additional, LE, QUANG P., additional, LEE, KACHIU, additional, LEKANDER, MARGARET, additional, LEVINE, MATTHEW A., additional, LIGHTNER, DONITA DILLON, additional, LIM, CHUN, additional, LIN, CUI LI, additional, LONG, RICHARD, additional, LOWENHAUPT, ELIZABETH A., additional, MAANI, ZEINA W., additional, MAGEE, SUSANNA R., additional, MAKKI, ACHRAF A., additional, MANSOOR, ATIZAZUL H., additional, MARTIN, DOUGLAS W., additional, MATSON, ELISABETH B., additional, MATTSON, DANIEL T., additional, MAVRICH, KATE, additional, MAY, ALISON C., additional, MAY, LAUREN, additional, MAZUMDAR, MAITREYI, additional, McCLEAN, JEFFREY C., additional, McGARRY, KELLY A., additional, McNICOLL, LYNN, additional, McPEAKE, LAURA H., additional, MEHTA, AKANKSHA, additional, MENDEZ-ALLWOOD, DANIEL E., additional, MERCIER, LONNIE R., additional, MIKOLICH, DENNIS J., additional, MORGAN, THERESA A., additional, MUJAHID, NADIA, additional, MUKKADA, VINCENT A., additional, NAQVI, BILAL H., additional, NASSAU, JACK H., additional, NEE, JUDY, additional, NEMOTO, TAKUMA, additional, NG, JAMES J., additional, NOTHNAGLE, MELISSA, additional, NOWAK, BETH, additional, O’BRIEN, GAIL M., additional, O’CONNOR, CAROLYN J., additional, OLAWAIYE, ALEXANDER B., additional, ONG, MICHAEL K., additional, OPAL, STEVEN M., additional, OWENS, JOSEPH R., additional, PACHECO, CHRISTINA ANTONIO, additional, PACHECO, ROBERTO, additional, PATACSIL-TRULL, JANICE, additional, PATEL, BIRJU B., additional, PATEL, PRANAV M., additional, PATROZOU, ELENI, additional, PATTERSON, ALISON, additional, PELIGIAN, STEVEN, additional, PETERSON, HEIDI H., additional, PHILLIPS, KATHARINE A., additional, PIRRAGLIA, PAUL A., additional, PLANTE, WENDY A., additional, PLETTE, ANGELA M., additional, HARTMAN POLENSEK, SHARON S., additional, POON, SAMUEL H., additional, POSNER, DONN, additional, PRASAD, ARUNDATHI G., additional, PRESSMAN, AMANDA, additional, PROMRAT, KITTICHAI, additional, PUNJANI, SHAHNAZ, additional, RAHMAN, IFAD U., additional, RAMANAN, RADHIKA A., additional, RAMSEY, CHRISTIAN N., additional, RASHID, WASIM, additional, REGNANTE, RICHARD, additional, REUS, VICTOR I., additional, RICH, HARLAN G., additional, RISSER, JESSICA, additional, ROACH, RACHEL, additional, ROBINSON, LUTHER K., additional, ROGERS, JAMISON, additional, ROLLE, ANISHKA S., additional, ROTH, JULIE L., additional, ROTH, LAUREN, additional, RUBEOR, AMITY, additional, SADIQ, IMMAD, additional, SAID, NUHA R., additional, SATHYA, BHARATH, additional, SATPATHY, HEMANT K., additional, SATPATHY, RUBY K., additional, SATTERFIELD, JASON M., additional, SAVITZ, SEAN I., additional, SAYEED, SYEDA M., additional, SELL, PETER J., additional, SHAFTS, CATHERINE, additional, SHAH, MADHAVI, additional, SHIH, GRACE, additional, SHRESTHA, ASHA, additional, SIGMAN, MARK, additional, SILVIA, JOANNE M., additional, SINGHAL, DIVYA, additional, SLADKY, JOHN, additional, SMITH, JEANETTE G., additional, SOHUR, U. SHIVRAJ, additional, SOOCH, DIVJOT, additional, SUNTER, HEATHER, additional, SUTTER, MARY BETH, additional, SZUMIGALA, JULIE ANNE, additional, TAMMARO, DOMINICK, additional, TAPYRIK, SARAH, additional, TELANG, GLADYS, additional, TELLIOGLU, TAHIR, additional, TONG, IRIS L., additional, TRUESDELL, ALEXANDER G., additional, TRYFOROS, MARGARET, additional, TUCCI, JOSEPH RALPH, additional, UBOGU, EROBOGHENE E., additional, UITERWYK, SEAN H., additional, ULLRICH, NICOLE J., additional, VAN POZNAK, MARISA E., additional, VANGALA, NITANTH R., additional, VILLAFUERTE, JORGE A., additional, WAYT, TARA M., additional, WEPPNER, DENNIS M., additional, WHITE, JORDAN, additional, WHITE, LAUREL M., additional, WHITLACH, HILARY B., additional, WICKLUND, MATTHEW P., additional, WOJTUSIK, AMANDA, additional, WOLFF, CHARLES, additional, WONG, MARIE ELIZABETH, additional, WU, WEN-CHIH, additional, WU-CHEN, WEN Y. (HELENA), additional, WUTZ, BETH J., additional, XAVIER, SARAH L., additional, YIP, AUGUSTIN G., additional, YOUNG, JOHN Q., additional, YUVIENCO, CANDICE, additional, ZADIKOFF, CINDY, additional, ZAHEER, FARIHA, additional, ZIMMERMAN, MARK, additional, ZIMMERMANN, BERNARD, additional, ZUCCALA, SCOTT J., additional, and ZUZEK, RYAN W., additional
- Published
- 2013
- Full Text
- View/download PDF
50. Tuft Cells Inhibit Pancreatic Tumorigenesis in Mice by Producing Prostaglandin D2
- Author
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DelGiorno, Kathleen E., primary, Chung, Chi-Yeh, additional, Vavinskaya, Vera, additional, Maurer, H. Carlo, additional, Novak, Sammy Weiser, additional, Lytle, Nikki K., additional, Ma, Zhibo, additional, Giraddi, Rajshekhar R., additional, Wang, Dezhen, additional, Fang, Linjing, additional, Naeem, Razia F., additional, Andrade, Leonardo R., additional, Ali, Wahida H., additional, Tseng, Hubert, additional, Tsui, Crystal, additional, Gubbala, Vikas B., additional, Ridinger-Saison, Maya, additional, Ohmoto, Makoto, additional, Erikson, Galina A., additional, O’Connor, Carolyn, additional, Shokhirev, Maxim Nikolaievich, additional, Hah, Nasun, additional, Urade, Yoshihiro, additional, Matsumoto, Ichiro, additional, Kaech, Susan M., additional, Singh, Pankaj K., additional, Manor, Uri, additional, Olive, Kenneth P., additional, and Wahl, Geoffrey M., additional
- Published
- 2020
- Full Text
- View/download PDF
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