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3. Change in Alcohol Use Based on Self-Report and a Quantitative Biomarker, Phosphatidylethanol, in People With HIV

Author

McGinnis, Kathleen A., Tate, Janet P., Bryant, Kendall J., Justice, Amy C., O’Connor, Patrick G., Rodriguez-Barradas, Maria C., Crystal, Stephen, Cutter, Christopher J., Hansen, Nathan B., Maisto, Stephen A., Marconi, Vincent C., Williams, Emily C., Cook, Robert L., Gordon, Adam J., Gordon, Kirsha S., Eyawo, Oghenowede, Edelman, E. Jennifer, and Fiellin, David A.

Published
2022
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6. Emergency department patients with untreated opioid use disorder: A comparison of those seeking versus not seeking referral to substance use treatment

Author

Coupet, Edouard, Jr, D’Onofrio, Gail, Chawarski, Marek, Edelman, E.J., O’Connor, Patrick G., Owens, Patricia, Martel, Shara, Fiellin, David A., Cowan, Ethan, Richardson, Lynne, Huntley, Kristen, Whiteside, Lauren K., Lyons, Michael S., Rothman, Richard E., Pantalon, Michael, and Hawk, Kathryn

Published
2021
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9. Integrated stepped alcohol treatment for patients with HIV and liver disease: A randomized trial

Author

Edelman, E. Jennifer, Maisto, Stephen A., Hansen, Nathan B., Cutter, Christopher J., Dziura, James, Deng, Yanhong, Fiellin, Lynn E., O'Connor, Patrick G., Bedimo, Roger, Gibert, Cynthia L., Marconi, Vincent C., Rimland, David, Rodriguez-Barradas, Maria C., Simberkoff, Michael S., Tate, Janet P., Justice, Amy C., Bryant, Kendall J., and Fiellin, David A.

Published
2019
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10. Predictors of Abstinence from Heavy Drinking During Treatment in COMBINE and External Validation in PREDICT

Author

Gueorguieva, Ralitza, Wu, Ran, O'Connor, Patrick G, Weisner, Constance, Fucito, Lisa M, Hoffmann, Sabine, Mann, Karl, and O'Malley, Stephanie S

Subjects
Prevention, Alcoholism, Alcohol Use and Health, Neurosciences, Substance Misuse, Good Health and Well Being, Acamprosate, Age Factors, Alcohol Abstinence, Alcohol Deterrents, Alcohol Drinking, Behavior Therapy, Combined Modality Therapy, Controlled Clinical Trials as Topic, Decision Trees, Germany, Goals, Humans, Logistic Models, Middle Aged, Naltrexone, Predictive Value of Tests, Randomized Controlled Trials as Topic, Reproducibility of Results, Taurine, Time Factors, Treatment Outcome, United States, gamma-Glutamyltransferase, Alcohol Dependence, Clinical Trial, Classification Tree, Deterministic Forest, Logistic Regression, Clinical Sciences, Psychology, Substance Abuse
Abstract

BackgroundThe goal of the current study was to use tree-based methods (Zhang and Singer, 2010, Recursive Partitioning and Applications, 2nd ed. Springer, New York) to identify predictors of abstinence from heavy drinking in COMBINE (Anton et al. JAMA 2006; 295:2003), the largest study of pharmacotherapy for alcoholism in the United States to date, and to validate these results in PREDICT (Mann et al. Addict Biol 2012; 18:937), a parallel study conducted in Germany.MethodsWe compared a classification tree constructed according to purely statistical criteria to a tree constructed according to a combination of statistical criteria and clinical considerations for prediction of no heavy drinking during treatment in COMBINE. We considered over 100 baseline predictors. The tree approach was compared to logistic regression. The trees and a deterministic forest identified the most important predictors of no heavy drinking for direct testing in PREDICT.ResultsThe tree built using both clinical and statistical considerations consisted of 4 splits based on consecutive days of abstinence (CDA) prior to randomization, age, family history of alcoholism, and confidence to resist drinking in response to withdrawal and urges. The tree based on statistical considerations with 4 splits also split on CDA and age but also on gamma-glutamyl transferase level and drinking goal. Deterministic forest identified CDA, age, and drinking goal as the most important predictors. Backward elimination logistic regression among the top 18 predictors identified in the deterministic forest analyses identified only age and CDA as significant main effects. Longer CDA and goal of complete abstinence were associated with better outcomes in both data sets.ConclusionsThe most reliable predictors of abstinence from heavy drinking were CDA and drinking goal. Trees provide binary decision rules and straightforward graphical representations for identification of subgroups based on response and may be easier to implement in clinical settings.

Published
2014

11. Integrated stepped alcohol treatment for patients with HIV and alcohol use disorder: a randomised controlled trial

Author

Edelman, E Jennifer, Maisto, Stephen A, Hansen, Nathan B, Cutter, Christopher J, Dziura, James, Deng, Yanhong, Fiellin, Lynn E, O'Connor, Patrick G, Bedimo, Roger, Gibert, Cynthia L, Marconi, Vincent C, Rimland, David, Rodriguez-Barradas, Maria C, Simberkoff, Michael S, Tate, Janet P, Justice, Amy C, Bryant, Kendall J, and Fiellin, David A

Published
2019
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14. Perspectives of Clinicians and Staff at Community-Based Opioid Use Disorder Treatment Settings on Linkages With Emergency Department–Initiated Buprenorphine Programs

Author

Sue, Kimberly L., primary, Chawarski, Marek, additional, Curry, Leslie, additional, McNeil, Ryan, additional, Coupet, Edouard, additional, Schwartz, Robert P., additional, Wilder, Christine, additional, Tsui, Judith I., additional, Hawk, Kathryn F., additional, D’Onofrio, Gail, additional, O’Connor, Patrick G., additional, Fiellin, David A., additional, and Edelman, E. Jennifer, additional

Published
2023
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15. Implementation Facilitation to Promote Emergency Department–Initiated Buprenorphine for Opioid Use Disorder

Author

D’Onofrio, Gail, primary, Edelman, E. Jennifer, additional, Hawk, Kathryn F., additional, Chawarski, Marek C., additional, Pantalon, Michael V., additional, Owens, Patricia H., additional, Martel, Shara H., additional, Rothman, Richard, additional, Saheed, Mustapha, additional, Schwartz, Robert P., additional, Cowan, Ethan, additional, Richardson, Lynne, additional, Salsitz, Edwin, additional, Lyons, Michael S., additional, Freiermuth, Caroline, additional, Wilder, Christine, additional, Whiteside, Lauren, additional, Tsui, Judith I., additional, Klein, Jared W., additional, Coupet, Edouard, additional, O’Connor, Patrick G., additional, Matthews, Abigail G., additional, Murphy, Sean M., additional, Huntley, Kristen, additional, and Fiellin, David A., additional

Published
2023
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17. Integrated stepped alcohol treatment for patients with HIV and at-risk alcohol use: a randomized trial

Author

Edelman, E. Jennifer, Maisto, Stephen A., Hansen, Nathan B., Cutter, Christopher J., Dziura, James, Deng, Yanhong, Fiellin, Lynn E., O’Connor, Patrick G., Bedimo, Roger, Gibert, Cynthia L., Marconi, Vincent C., Rimland, David, Rodriguez-Barradas, Maria C., Simberkoff, Michael S., Tate, Janet P., Justice, Amy C., Bryant, Kendall J., and Fiellin, David A.

Published
2020
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22. Implementation facilitation to promote emergency department-initiated buprenorphine for opioid use disorder: protocol for a hybrid type III effectiveness-implementation study (Project ED HEALTH)

Author

D’Onofrio, Gail, Edelman, E. Jennifer, Hawk, Kathryn F., Pantalon, Michael V., Chawarski, Marek C., Owens, Patricia H., Martel, Shara H., VanVeldhuisen, Paul, Oden, Neal, Murphy, Sean M., Huntley, Kristen, O’Connor, Patrick G., and Fiellin, David A.

Published
2019
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25. Additional file 1 of Characterizing the social support and functioning of a low-threshold medication for opioid use disorder treatment cohort at intake

Author

Oles, William, Alexander, Marcus, Kumar, Navin, Howell, Benjamin, O’Connor, Patrick G., Madden, Lynn M., and Barry, Declan T.

Abstract

Additional file 1: Supplemental Table 1. Demographic and social support/functioning items chosen from validated instruments. Supplemental Table 2. APT Foundation 2017 cohort demographic characteristics, all categories listed on BASIS-24 included with test statistics for comparison by sex.

Published
2022
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26. Additional file 2 of Characterizing the social support and functioning of a low-threshold medication for opioid use disorder treatment cohort at intake

Author

Oles, William, Alexander, Marcus, Kumar, Navin, Howell, Benjamin, O’Connor, Patrick G., Madden, Lynn M., and Barry, Declan T.

Abstract

Additional file 2: Supplemental Table 3. Multivariate ordinal analysis results of social support and social functioning indicators by demographic characteristics of patients entering low-threshold MOUD treatment. Supplemental Table 4. Multivariate binomial analysis results of social support and social functioning indicators by demographic characteristics of patients entering low-threshold MOUD treatment.

Published
2022
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30. Contributors

Author

Abrams, Charles S., Adler, Ronald S., Agarwal, Anupam, Akin, Cem, Aksamit, Allen J., Jr., Al-Awqati, Qais, Allen, Upton D., Allos, Ban Mishu, Angus, Derek C., Appelbaum, Frederick R., Armitage, James O., Armstrong, April W., Armstrong, Deborah K., Arnaout, M. Amin, Arnold, Robert M., Aronson, Louise, Atkinson, John P., Attia, Evelyn, Auerbach, Andrew D., Ayanian, John Z., Baddour, Larry M., Baden, Lindsey R., Bailey, Thomas C., Bain, Barbara J., Bajorin, Dean F., Baloh, Robert W., Bangham, Charles R.M., Barasch, Jonathan, Barrett, Bruce, Bartholomew, John R., Bartleson, J.D., Barton, Mary B., Basner, Robert C., Bass, Adam J., Bass, Anne R., Bauman, Julie E., Bausch, Daniel G., Bayer, Arnold S., Bazarian, Jeffrey J., Bearman, Gonzalo M., Becker, Richard C., Beckham, J. David, Beckman, Joshua A., Beigel, John H., Bel, Elisabeth H., Belda, Walter, Jr., Benarroch, Eduardo E., Berger, Joseph R., Berliner, Nancy, Bernat, James L., Bessesen, Daniel H., Bibbins-Domingo, Kirsten, Biesecker, Leslie G., Biundo, Joseph J., Blankson, Joel N., Bloch, Karen C., Blom, Henk J., Boden, William E., Boivin, Guy, Bolognia, Jean, Bonomo, Robert A., Booth, Sarah L., Bosaeus, Ingvar G., Brenner, David J., Bridges, S. Louis, Jr., Brochard, Laurent, Brodsky, Robert A., Brook, Itzhak, Brown, Jennifer R., Brunetti, Enrico, Bryant, Amy E., Budge, Philip J., Buffet, Pierre A., Bushinsky, David A., Bykerk, Vivian P., Calabresi, Peter A., Calello, Diane P., Calfee, David P., Callahan, S. Todd, Camilleri, Michael, Canoso, Juan J., Cappellini, Maria Domenica, Carabello, Blase A., Carucci, Laura R., Castells, Mariana, Catherino, William H., Cederholm, Tommy E., Chalasani, Naga P., Chambers, Henry F., Chang, Larry W., Chang, Lin, Chao, Nelson J., Chatterjee, Mitali, Chaturvedi, Seemant, Chen, Lin H., C-A Chen, Sharon, Chon, Susan Y., Christiani, David C., Chu, Edward, Cieslak, Theodore J., Cioffi, George A., Clancy, Carolyn M., Clauss, Heather, Clauw, Daniel J., Clemmons, David R., Coffman, Thomas M., Cohen, David, Cohen, Jeffrey, Cohen, Myron S., Cohen, Steven P., Connors, Joseph M., Cook, Deborah J., Cook, Lucy B.M., Cooney, Kathleen A., Craigen, William J., Crandall, Jill P., Croft, Simon L., Crow, Mary K., Crump, John A., Cudkowicz, Merit E., Cunningham-Rundles, Charlotte, Dahir, Kathryn M., Damon, Inger K., Daras, Michael, Dart, Richard C., Davidson, Nancy E., Deane, Kevin D., DeAngelis, Lisa M., DeCamp, Malcolm M., DeLoughery, Thomas G., Rio, Carlos del, De Luca, Gabriele C., Denning, David W., Deuster, Patricia A., DeZern, Amy E., Dhatariya, Ketan K., Diasio, Robert B., Diemert, David J., Digre, Kathleen B., Dilsizian, Vasken, Dionne, Jodie A., Di Paola, Jorge, Dispenzieri, Angela, Dogra, Sunil, Doroshow, James H., Douglas, John M., Jr., Drazen, Jeffrey M., Drekonja, Dimitri, Dubberke, Erik R., DuBeau, Catherine E., Dumler, J. Stephen, Duvic, Madeleine, Ebi, Kristie, Edwards, Kathryn M., Edwards, N. Lawrence, Eikelboom, John W., Einhorn, Lawrence H., Elliott, Perry M., Emanuel, Ezekiel J., Falagas, Matthew E., Falk, Gary W., Fang, James C., Farley, Monica M., Feder, Gene, Feller-Kopman, David J., McDonald File, Thomas, Jr., Fishman, Glenn I., Flack, John M., Fleckenstein, James M., Fleisher, Lee A., Flint, Paul W., Fogel, Evan L., Fontana, Robert J., Forsmark, Chris E., Fournier, Pierre-Edouard, Fowler, Vance G., Jr., Franco, Manuel A., Fraser, Victoria J., Freeman, Roy, Freund, Karen M., Froberg, Blake A., Gallagher, Patrick G., Gandhi, Monica, Gandhi, Rajesh T., Ganz, Leonard, Garan, Hasan, Garcia-Tsao, Guadalupe, Geisler, William M., Gelfand, Joel M., George, Tony P., Gepstein, Lior, Gertz, Morie A., Ghanem, Khalil G., Gharavi, Ali G., Ghossein, Cybele, Gill, Christopher J., Ginsburg, Geoffrey S., Glesby, Marshall J., Gnann, John W., Jr., Goldman, David L., Goldman, Lee, Goldstein, Larry B., Gordon, Anthony C., Gotlib, Jason, Gotuzzo, Eduardo, Grasemann, Hartmut, Green-McKenzie, Judith, Greenberg, Harry B., Greenberg, Steven A., Greer, David M., Greysen, S. Ryan, Griffin, Marie R., Griggs, Robert C., Grossman, Daniel, Guay-Woodford, Lisa M., Gulick, Roy M., Haake, David A., Hagman, Melissa M., Hagspiel, Klaus D., Harris, Raymond C., Havers, Fiona P., Heath, Elisabeth I., Hecht, Frederick M., Hensrud, Donald D., Hess, Jeremy, Hewlett, Erik L., Hift, Richard J., Hill, David R., Hill, Nicholas S., Hillyer, Christopher D., Hirsch, Hans H., Hoeper, Marius M., Hoit, Brian D., Holers, V. Michael, Holland, Steven M., Hollenberg, Anthony N., Hollenberg, Steven M., Howard, Jo, Hunter, David J., Hussain, Khalid, Iannuzzi, Michael C., Inman, Robert D., Inouye, Sharon K., Ison, Michael G., Jen, Joanna C., Jensen, Dennis M., Jensen, Michael D., Jensen, Robert T., Johnston, S. Claiborne, Jones, Robin L., Jordan, Richard C., Kahi, Charles J., Kaiser, Laurent, Kaminski, Henry J., Kamya, Moses R., Kao, Louise W., Kaplan, Steven A., Kastner, Daniel L., Katzka, David A., Katzman, Debra K., Kaushansky, Kenneth, Kaye, Keith S., Keating, Armand, Kelley, Robin K., Kennedy, Richard B., Khuri, Fadlo R., Kim, Rose, Kirchhoff, Louis V., Kirking, Hannah, Kirtane, Ajay J., Kishnani, Priya S., Klausner, Jeffrey D., Klion, Amy D., Klompas, Michael, Knopman, David S., Ko, Christine J., Kodali, Susheel, Kontoyiannis, Dimitrios P., Koppel, Barbara S., Korenblat, Kevin M., Korf, Bruce R., Kortepeter, Mark G., Koshy, Anita A., Kottilil, Shyamasundaran, Kovacs, Joseph A., Kovacs, Thomas O., Kowdley, Kris V., Kraft, Monica, Kramer, Christopher M., Krasnewich, Donna M., Kraus, William E., Krause, Peter J., Kroger, Andrew T., Kroshinsky, Daniela, Kuemmerle, John F., Kuipers, Ernst J., Kutner, Jean S., Laheru, Daniel, Lampert, Rachel, Landefeld, C. Seth, Landovitz, Raphael J., Landry, Donald W., Lange, Richard A., Lee, Hochang B., Lee, Nelson, Levey, Andrew S., Levine, Stephanie M., Lichtenstein, Gary R., Liebmann, Jeffrey M., Liebschutz, Jane M., Lim, Henry W., Lima, Aldo A.M., Limaye, Ajit P., Limdi, Nita A., Link, Mark S., Liu, Catherine, Lloyd-Jones, Donald M., Lopez, Fred A., Louie, Arnold, Lyness, Jeffrey M., MacKenzie, C. Ronald, MacLennan, Calman A., MacMillan, Harriet L., Madoff, Robert D., Maher, Jacquelyn, Maier, Lisa A., Maldarelli, Frank, Malhotra, Atul, Manary, Mark J., Marcos, Luis A., Marelli, Ariane J., Marks, Andrew R., Marschall, Jonas, Martin, Paul, Martinez, Fernando J., Mason, Joel B., Masur, Henry, Mathers, Amy J., Matthay, Michael A., McCool, F. Dennis, McInnes, Iain B., McLaughlin, Vallerie, McMichael, Amy, McMurray, John J.V., McQuaid, Kenneth R., Mead, Paul S., Means, Robert T., Jr., Melia, Michael T., Mellinghoff, Ingo K., Melton, Genevieve B., Merrick, Samuel T., Miceli, Marisa H., Michel, Marc, Mokdad, Ali H., Moy, Ernest, Mukherjee, Debabrata, Murr, Andrew H., Myerburg, Robert J., Nadeau, Kari C., Nath, Avindra, Neal-Perry, Genevieve, Neilson, Eric G., Nelson, Christina A., Nelson, David B., Nelson, Lewis S., Nestler, Eric J., Neuzil, Kathleen M., Nieman, Lynnette K., Niven, Alexander S., O’Connor, Christopher M., O’Connor, Francis G., O’Connor, Patrick G., O’Donnell, Anne E., O’Donnell, James S., Oh, Jae K., Okun, Michael S., O’Leary, Sean T., Olgin, Jeffrey E., Olivier, Kenneth N., Olivotto, Iacopo, Olsen, Nancy J., Orenstein, Walter A., Ortel, Thomas L., O’Shea, John J., Osmon, Douglas R., Ostrem, Jill L., Ostrosky-Zeichner, Luis, Otto, Catherine M., Ottolini, Martin G., Ovsyannikova, Inna G., Pappas, Peter G., Park, Ben Ho, Patel, Robin, Patterson, Thomas F., Pawlotsky, Jean-Michel, Payne, Thomas H., Pearce, Elizabeth N., Pearson, Richard D., Perl, Trish M., Petersen, Brett W., Petri, William A., Jr., Pfeffer, Marc A., Philips, Jennifer A., Pisetsky, David S., Pletcher, Steven D., Plumb, Ian D., Poland, Gregory A., Powell, Frank, Pyeritz, Reed E., Quinn, Thomas C., Racaniello, Vincent, Radhakrishnan, Jai, Radich, Jerald, Rafailidis, Petros I., Raghu, Ganesh, Ragni, Margaret V., Rahman, Proton, Rajkumar, S. Vincent, Ralston, Stuart H., Raoult, Didier, Reboli, Annette C., Reddy, K. Rajender, Redelmeier, Donald A., Redlich, Carrie A., Reilly, John, Reller, Megan E., Reno, Hilary E.L., Resnick, Neil M., Rice, Louis B., Roach, E. Steve, Robinson, Jennifer G., Rogatsky, Inez, Rogers, Joseph G., Rolain, Jean-Marc, Rollins, Barrett J., Romero, José R., Rosen, Jennifer B., Rosenthal, Philip J., Russell, James A., Rustgi, Anil K., Safer, Joshua D., Saini, Sarbjit S., Salmon, Jane E., Salvana, Edsel Maurice T., Santoro, Nanette, Santucci, Peter A., Sarnak, Mark J., Savage, Kerry J., Savard, Patrice, Sawka, Michael N., Scanlon, Paul D., Schafer, Andrew I., Schiff, Manuel, Schilsky, Michael L., Schneider, Thomas Rudolf, Schooley, Robert T., Schriger, David L., Schuchter, Lynn M., Schwartz, Lawrence B., Seas, Carlos, Seifert, Steven A., Seifter, Julian Lawrence, Selcen, Duygu, Selim, Magdy, Semrad, Carol E., Sepulveda, Jorge, Shaw, Pamela J., Shaz, Beth H., Sheridan, Robert L., Sherman, Stuart, Shojania, Kaveh G., Shopsin, Bo, Shy, Michael E., Sidransky, Ellen, Sifri, Costi D., Siliciano, Robert F., Simel, David L., Skorecki, Karl, Slawski, Barbara A., Slutsky, Arthur S., Smetana, Gerald W., Smith, A. Gordon, Smith, Stephen R., Southwick, Frederick S., Spiegel, Allen M., Spiera, Robert, Spinola, Stanley M., Spong, Catherine Y., Stabler, Sally P., Stark, Paul, St. Clair, E. William, Steiner, Theodore S., Stephens, David S., Stevens, David A., Stevens, Dennis L., Stokes, M. Barry, Stoller, James K., Stone, John H., Stone, Richard M., Su, Edwin P., Swerdloff, Ronald S., Swygard, Heidi, Sykes, Megan, Talbot, H. Keipp, Tamimi, Rulla M., Tanofsky-Kraff, Marian, Tarlo, Susan M., Taylor, Stephanie N., Teirstein, Paul S., Telford, Sam R., III, Thakker, Rajesh V., Therrien, Judith, Thompson, George R., III, Tormoehlen, Laura, Tosti, Antonella, Trehan, Indi, Umpierrez, Guillermo E., Valeri, Anthony Michael, Varga, John, Vaughn, Bradley V., Venook, Alan P., Verbalis, Joseph G., Vose, Julie M., Wachter, Robert M., Walsh, B. Timothy, Walsh, Edward E., Walsh, Thomas J., Walston, Jeremy D., Walter, Roland B., Wang, Christina, Wang, Kenneth K., Ware, Lorraine B., Warren, Cirle A., Watkins, Paul B., Weber, Thomas J., Weimer, Louis H., Weinberg, Geoffrey A., Weinstein, Robert S., Weiss, Roger D., Weiss, Roy E., Weitz, Jeffrey I., Welt, Frederick G.P., Wenzel, Richard P., Werth, Victoria P., West, Sterling G., White, A. Clinton, Jr., White, Christopher J., White, Julian, White, Perrin C., Whitley, Richard J., Whyte, Michael P., Wiebe, Samuel, Wiener-Kronish, Jeanine P., Wilber, David J., Wilcox, Mark H., Winikoff, Beverly, Winter, Jane N., Wittink, Marsha N., Wolff, Tracy A., Wolin, Edward M., Wormser, Gary P., Yancy, Clyde W., Young, Neal S., Young, Vincent B., Young, William F., Jr., Yu, Alan S.L., Zimetbaum, Peter, and Zucker, Jane R.

Published
2024
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33. Change in Alcohol Use Based on Self-Report and a Quantitative Biomarker, Phosphatidylethanol, in People With HIV

Author

McGinnis, Kathleen A., primary, Tate, Janet P., additional, Bryant, Kendall J., additional, Justice, Amy C., additional, O’Connor, Patrick G., additional, Rodriguez-Barradas, Maria C., additional, Crystal, Stephen, additional, Cutter, Christopher J., additional, Hansen, Nathan B., additional, Maisto, Stephen A., additional, Marconi, Vincent C., additional, Williams, Emily C., additional, Cook, Robert L., additional, Gordon, Adam J., additional, Gordon, Kirsha S., additional, Eyawo, Oghenowede, additional, Edelman, E. Jennifer, additional, and Fiellin, David A., additional

Published
2021
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39. The design and conduct of a randomized clinical trial comparing emergency department initiation of sublingual versus a 7-day extended-release injection formulation of buprenorphine for opioid use disorder: Project ED Innovation

Author

D'Onofrio, Gail, primary, Hawk, Kathryn F., additional, Herring, Andrew A., additional, Perrone, Jeanmarie, additional, Cowan, Ethan, additional, McCormack, Ryan P., additional, Dziura, James, additional, Taylor, R. Andrew, additional, Coupet, Edouard, additional, Edelman, E. Jennifer, additional, Pantalon, Michael V., additional, Owens, Patricia H., additional, Martel, Shara H., additional, O'Connor, Patrick G., additional, Van Veldhuisen, Paul, additional, DeVogel, Nicholas, additional, Huntley, Kristen, additional, Murphy, Sean M., additional, Lofwall, Michelle R., additional, Walsh, Sharon L., additional, and Fiellin, David A., additional

Published
2021
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42. Medications for unhealthy alcohol use: across the spectrum

Author

O'Malley, Stephanie S. and O'Connor, Patrick G.

Subjects
Naltrexone -- Dosage and administration, Patient compliance -- Management, Alcoholism -- Care and treatment, Acamprosate -- Dosage and administration, Company business management, Health
Abstract

Unhealthy alcohol use, which includes the spectrum of drinking behaviors and consequences ranging from risky use to problem drinking, along with alcohol abuse and alcohol dependence (Saitz 2005), has been [...]

Published
2011

45. The impact of access to addiction specialist on attitudes, beliefs and hospital-based opioid use disorder related care: A survey of hospitalist physicians

Author

Calcaterra, Susan L., Binswanger, Ingrid A., Edelman, E. Jennifer, McNair, Bryan K., Wakeman, Sarah E., and O’Connor, Patrick G.

Abstract

AbstractBackgroundHospitalizations for complications related to opioid use disorder (OUD) are increasing. Hospitalists care for most hospitalized patients in the United States, yet little is known about their attitudes, beliefs, and clinical practices regarding OUD-related care.Methods:We distributed an online survey to hospitalists in the United States to measure how access to addiction specialists affected attitudes and beliefs regarding hospital-based OUD care, OUD screening practices, naloxone prescribing, and buprenorphine initiation.Results:Among 262 respondents, 67.9% (n = 178) reported having access to addiction specialists. While 84.5% (n = 221) reported often or always caring for patients with OUD, 48.2% (n = 126) rarely or never screened for OUD, 57.1% (n = 149) rarely or never prescribed or recommended naloxone as harm reduction, and 88.9% (n = 233) rarely or never initiated buprenorphine. In multivariable analyses, compared to hospitalists without access to addiction specialists, hospitalist with access to addiction specialists were more likely to feel supported to screen and refer patients to treatment (aOR = 4.4, 95% CI 2.1 − 9.1; ρ < 0.001), to be aware of local treatment resources (aOR = 3.4, 95% CI 1.8 − 6.3; ρ < 0.001), and refer patients to treatment (aOR = 3.0, 95% CI 1.7 − 5.6; ρ < 0.001).Conclusions:Many hospitalists do not provide life-saving treatment to patients with OUD. Access to addiction specialists may increase provision of OUD-related care by hospitalists.

Published
2022
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47. Buprenorphine/naloxone treatment in primary care is associated with decreased human immunodeficiency virus risk behaviors

Author

Sullivan, Lynn E., Moore, Brent A., Chawarski, Marek C., Pantalon, Michael V., Barry, Declan, O'Connor, Patrick G., Schottenfeld, Richard S., and Fiellin, David A.

Subjects
Behavioral health care -- Research, Naloxone -- Dosage and administration, Buprenorphine -- Dosage and administration, HIV (Viruses) -- Risk factors, HIV (Viruses) -- Prevention, Family medicine -- Methods, Intravenous drug abuse -- Care and treatment, Drug therapy, Combination -- Usage, Health
Abstract

Methadone treatment reduces human immunodeficiency virus (HIV) risk, but the effects of primary-care-based buprenorphine/naloxone on HIV risk are unknown. The purpose of this study was to determine whether primary-care-based buprenorphine/naloxone was associated with decreased HIV risk behavior. We conducted a longitudinal analysis of 166 opioid-dependent persons (129 men and 37 women) receiving buprenorphine/naloxone treatment in a primary care clinic. We compared baseline and 12- and 24-week overall, drug-related, and sex-related HIV risk behaviors using the AIDS/HIV Risk Inventory (ARI). Buprenorphine/naloxone treatment was associated with significant reductions in overall and drug-related ARI scores from baseline to 12 and 24 weeks. Intravenous drug use in the past 3 months was endorsed by 37%, 12%, and 7% of patients at baseline and at 12 and 24 weeks, respectively (p < .001). Sex while you or your partner were 'high' was endorsed by 64%, 13%, and 15% of patients at baseline and at 12 and 24 weeks, respectively (p < .001). Inconsistent condom use during sex with a steady partner was high at baseline and did not change over time. We conclude that primary-care-based buprenorphine/naloxone treatment is associated with decreased drug-related HIV risk, but additional efforts may be needed to address sex-related HIV risk when present (ClinicalTrials.gov number, NCT00023283). Keywords: Buprenorphine; HIV/AIDS; Risk-reduction behavior; Treatment; Prevention

Published
2008

50. Additional file 1 of Integrated stepped alcohol treatment for patients with HIV and at-risk alcohol use: a randomized trial

Author

Edelman, E. Jennifer, Maisto, Stephen A., Hansen, Nathan B., Cutter, Christopher J., Dziura, James, Yanhong Deng, Fiellin, Lynn E., O’Connor, Patrick G., Bedimo, Roger, Gibert, Cynthia L., Marconi, Vincent C., Rimland, David, Rodriguez-Barradas, Maria C., Simberkoff, Michael S., Tate, Janet P., Justice, Amy C., Bryant, Kendall J., and Fiellin, David A.

Abstract

Additional file 1: Table S1 Drinking and HIV-related outcomes by treatment group. Table S2 Participant baseline demographic and clinical characteristics associated with treatment response.

Published
2020
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