Search

Your search keyword '"O'Morain, Colm A."' showing total 721 results
Start Over Author "O'Morain, Colm A."
721 results on '"O'Morain, Colm A."'

1. Author Correction: Comparison of the management of Helicobacter pylori infection between the older and younger European populations

Author

Jonaitis, Paulius, Nyssen, Olga P., Saracino, Ilaria Maria, Fiorini, Giulia, Vaira, Dino, Pérez-Aísa, Ángeles, Tepes, Bojan, Castro-Fernandez, Manuel, Pabón-Carrasco, Manuel, Keco-Huerga, Alma, Voynovan, Irina, Lucendo, Alfredo J., Lanas, Ángel, Martínez-Domínguez, Samuel J., Almajano, Enrique Alfaro, Rodrigo, Luis, Vologzanina, Ludmila, Brglez Jurecic, Natasa, Denkovski, Maja, Bujanda, Luis, Mahmudov, Umud, Leja, Mārcis, Lerang, Frode, Babayeva, Gülüstan, Bordin, Dmitry S., Gasbarrini, Antonio, Kupcinskas, Juozas, Gridnyev, Oleksiy, Rokkas, Theodore, Marcos-Pinto, Ricardo, Phull, Perminder S., Smith, Sinead M., Tonkić, Ante, Boltin, Doron, Buzás, György Miklós, Šembera, Štěpán, Şimşek, Halis, Matysiak-Budnik, Tamara, Milivojevic, Vladimir, Marlicz, Wojciech, Venerito, Marino, Boyanova, Lyudmila, Doulberis, Michael, Capelle, Lisette G., Cano-Català, Anna, Moreira, Leticia, Mégraud, Francis, O’Morain, Colm, Gisbert, Javier P., and Jonaitis, Laimas

Published
2023
Full Text
View/download PDF

2. Comparison of the management of Helicobacter pylori infection between the older and younger European populations

Author

Jonaitis, Paulius, Nyssen, Olga P., Saracino, Ilaria Maria, Fiorini, Giulia, Vaira, Dino, Pérez-Aísa, Ángeles, Tepes, Bojan, Castro-Fernandez, Manuel, Pabón-Carrasco, Manuel, Keco-Huerga, Alma, Voynovan, Irina, Lucendo, Alfredo J., Lanas, Ángel, Martínez-Domínguez, Samuel J., Almajano, Enrique Alfaro, Rodrigo, Luis, Vologzanina, Ludmila, Brglez Jurecic, Natasa, Denkovski, Maja, Bujanda, Luis, Mahmudov, Umud, Leja, Mārcis, Lerang, Frode, Babayeva, Gülüstan, Bordin, Dmitry S., Gasbarrini, Antonio, Kupcinskas, Juozas, Gridnyev, Oleksiy, Rokkas, Theodore, Marcos-Pinto, Ricardo, Phull, Perminder S., Smith, Sinead M., Tonkić, Ante, Boltin, Doron, Buzás, György Miklós, Šembera, Štěpán, Şimşek, Halis, Matysiak-Budnik, Tamara, Milivojevic, Vladimir, Marlicz, Wojciech, Venerito, Marino, Boyanova, Lyudmila, Doulberis, Michael, Capelle, Lisette G., Cano-Català, Anna, Moreira, Leticia, Mégraud, Francis, O’Morain, Colm, Gisbert, Javier P., and Jonaitis, Laimas

Published
2023
Full Text
View/download PDF

5. I-CARE, a European Prospective Cohort Study Assessing Safety and Effectiveness of Biologics in Inflammatory Bowel Disease

Author

Gornet, Jean-Marc, Beaugerie, Laurent, Shaji, Sebastian, Peyrin-Biroulet, Laurent, Reimund, Jean-Marie, Hebuterne, Xavier, Amiot, Aurélien, Armelao, Franco, Blanc, Pierre, Papi, Claudio, De Chambrun, Guillaume Pineton, Roblin, Xavier, Chu, Karmiris, Konstantinos, Shariq, Sohail, Viazis, Nikolaos, Limdi, Jimmy, Eder H, Piotr, Michalopoulos, Georgios, Bell, Andrew, Biancone, Livia, Dewitte, Marie, Mazhar, Zia, Franchimont, Denis, Nancey, Stephane, Macaigne, Gilles, Principi, Maria Beatrice, Fumery, Mathurin, Parkes, Gareth, Valats, Jean-Christophe, Doherty, Glen, Bouguen, Guillaume, Molnar, Tamás, Tsai, Hersin, Gangi, Mohsin, Pedersen, Natalia, Heluwaert, Frédéric, Shenderey, Richard, Zeissig, Sebastian, Butterworth, Jeffrey, Castiglione, Fabiana, Corless, Lynsey, Zallot, Camille, Baert, Filip, Singh, Salil, Sonwalkar, Sunil, Clayton, Elizabeth, Rahier, Jean-François, Vani, Deven, Bellaiche, Guy, De Vos, Martine, Kirchgesner, Julien, Kopylov, Uri, Lobaton, Triana, Locher, Christophe, Mantzaris, Gerassimos, Abouda, George, Smith, Katie, Sprakes, Michael, Theodoropoulou, Angeliki, Wesley, Emma, Bonnet, Joëlle, Elphick, David, Gilletta, Cyrielle, Gordon, John, Laharie, David, Nakad, Antoine, Orlando, Ambrogio, Dubois, Patrick, Hasselblatt, Peter, Michiels, Christophe, Preston, Cathryn, Staicu, Anca, Vuitton, Lucine, Kaassis, Mehdi, Speight, Ally, Ghosh, Deb, Löwenberg, Mark, Mathieu, Nicolas, Pelletier, Anne-Laure, Phillips, Anne, Magro, Fernando, Altwegg, Romain, Avni, Irit, biron, Landy, Jonathon, Nachury, Maria, Shenoy, Achuth, Trang, Caroline, Abitbol, Vered, Bamias, Georgios, Farkas, Klaudia, Maaser, Christian, Shitrit, Ariella, Siegmund, Britta, Filippi, Jérôme, O'morain, Colm, Yanai, Henit, Costes, Laurent, Hobday, David, Szepes, Zoltán, Calabrese, Emma, Dallal, Helen, Fung, Michael, Ramadas, Arvind, Baburajan, Bijay, Koss, Konrad, Barberis, Christophe, Buisson, Anthony, Amil, Morgane, Balestrieri, Paola, Johnson, Matthew, Tzouvala, Maria, Viennot, Stéphanie, Nagy, Ferenc, Thompson, Nick, Alric, Laurent, Samuel, Sunil, Bourrier, Anne, Chanteloup, Elise, Del Tedesco, Emilie, Harbord, Marcus, Lobo, Alan, Myers, Sally, Pollok, Richard, Ahmad, Tariq, Chaudhary, Rakesh, Karakoidas, Christos, Soliman, Ashraf, Stefanescu, Carmen, Theocharis, Georgios, Branden, Stijn Vanden, Beltran, Belén, Bouhnik, Yoram, Bourreille, Arnaud, Branco, Joana, Colleypriest, Ben, Eliakim, Rami, Knight, Paul, O'toole, Aoibhlinn, Robles, Virgina, Triantafyllou, Konstantinos, Bosca, Marta Maia, Lambrecht, Guy, Mosquera, Lucia Marquez, Panter, Simon, Pappa, Aikaterini, Simon, Marion, Sivaji, Ganesh, Bellanger, Christophe, Belle, Arthur, Borruel, Natalia, Egan, Laurence, Peeters, Harald, Sharpstone, Daniel, Arasaradnam, Ramesh, Benitez, José Manuel, Dahlerup, Jens Frederik, Giouleme, Olga, Gisbert, Javier P., Helwig, Ulf, Minguez, Miguel, Tsironi, Eftychia, Variola, Angela, Allen, Patrick, Boivineau, Lucille, Cole, Andy, Dib, Nina, Gomollon, Fernando, Johnston, Richard, Katsanos, Konstantinos, Kennedy, Nick, Kiszka-Kanowitz, Marianne, Marin-Jimenez, Ignacio, Miheller, Pál, Nos, Pilar, Saraj, Othman, Vinter-Jensen, Lars, Zittan, Eran, Baudry, Clotilde, Calvet, Xavier, Cazelles-Boudier, Marie-Christine, Coenegrachts, Jean-Louis, Cullen, Garret, Daperno, Marco, Dhar, Anjan, Gerard, Romain, Jensen, Nanna, Maharshak, Nitsan, Mcalindon, Mark, Mcloughlin, Simon, Parkes, Miles, Patel, Kamal, Peixoto, Armando, Polymeros, Dimitrios, Portela, Francisco, Rocca, Rodolfo, Seksik, Philippe, Subramanian, Sreedhar, Tennenbaum, Ruth, Atreya, Raja, Bachmann, Oliver, Berger, Arthur, Bor, Renáta, Buckley, Maire, Carpio, Daniel, Chaparro, María, Costa, Francesco, Domenech, Eugeni, Esteve, Maria, Foley, Stephen, Guardiola, Jordi, Koutroubakis, Ioannis, Kuehbacher, Tanja, Landman, Cécilia, Lavagna, Alessandro, Manceñido, Noemí, Mañosa, Míriam, Martín-Arranz, Maria Dolores, Plastaras, Laurianne, Scribano, Maria Lia, Sengupta, Subhasish, Teich, Nils, Tran-Minh, My-Linh, Zampeli, Evanthia, Amininejad, Leila, Arroyo, Teresa, Attar, Alain, Backman, Ann-Sofie, Bálint, Anita, Beckly, John, Ben Horin, Shomron, Bernardo, Sónia, Caillo, Ludovic, Caron, Bénédicte, Shanika de Silva, María, FábiáN, Anna, Fiorino, Gionata, Gutierrez, Ana, Lahat, Adi, Masmoudi, Mohamed, Mendolaro, Marco, Muls, Vinciane, Poullenot, Florian, Probert, Christopher, Reenaers, Catherine, Rutka, Mariann, Sarwari, Zaman, Sayer, Joanne, Sicilia, Beatriz, Sousa, Helena, van Kemseke, Catherine, Zabana, Yamile, Astegiano, Marco, Banim, Paul, Bettenworth, Dominik, Boualit, Médina, Brodersen, Jacob Broder, Christidou, Angeliki, Cooney, Rachel, Pinto, João Cortez, Cravo, Portugal Marília, Cremer, Anneline, Danese, Silvio, di Sabatino, Antonio, Fallingborg, Jan, Ferronato, Antonio, Planella, Esther Garcia, Gupta, Sanjay, Halfvarson, Jonas, Israeli, Eran, Kestenbaum, Samantha, Larsen, Lone, Macken, Elisabeth, Mathou, Nicoletta, Milassin, Ágnes, Pofelski, Joanna, Ricci, Chiara, Rodriguez-Moranta, Francisco, Schmidt-Lauber, Martin, Shaw, Ian, Soares, Marta, Soliman, Heithem, Triantos, Christos, Zografos, Konstantinos, Agrawal, Anurag, Armuzzi, Alessandro, Aubourg, Alexandre, Acosta, Manuel Barreiro-de, Barrio, Jesús, Bergemalm, Daniel, Bermejo, Fernando, Bodini, Giorgia, Bohr, Johan, Bossuyt, Peter, Christodoulou, Dimitrios, Claessens, Christophe, Collins, Paul, de Francisco, Ruth, Garcia, Santiago, Georgopoulos, Sotirios, Goutorbe, Felix, Kalantzis, Chrisostomos, Kourikou, Anastasia, Mace, Vincent, Malamut, Georgia, Ministro, Paula, Larmurier, Isabelle Nion, Ricart, Elena, Serrero, Mélanie, Sheridan, Juliette, Weimers, Petra, Andersen, Vibeke, Arroja, Bruno, Bokemeyer, Bernd, Bujanda, Luis, Degand, Thibault, Eriksson, Carl, Garceau, Cécile, Glerup, Henning, Goren, Idan, Jackson, Lucina, Koch, Stéphane, Mesonero, Francisco, Ordas, Ingrid, Riviere, Pauline, Saibeni, Simone, Soares, João, Tavernier, Noémie, Theede, Klaus, Ungar, Bella, Bästlein, Elke, Gasbarrini, Antonio, Protopapas, Andreas, Reindl, Wolfgang, Bossa, Fabrizio, Hart, Ailsa, Heil, Franz-Josef, O'Connor, Anthony, Oldenburg, Bas, Pastorelli, Luca, Stephen patchett, Ramakrishnan, Subramaniam, de Caestecker, John, Echarri, Ana, Kevans, David, Büning, Jürgen, Coelho, Rosa, Jansen, Jeroen, Koslowski, Benjamin, Wells, Christopher, Ceballos, Daniel, König, Ingrid, Padmanabhan, Hari, Patani, Timi, Qureshi, Raheel, Zagorowicz, Edyta, Allez, Matthieu, Archavlis, Emmanouil, Bonnet, Delphine, Guidi, Luisa, Mcnamara, Deirdre, Vernia, Piero, Weidenhiller, Michael, Alon, Lang, Boysen, Trine, Delattre, Charlotte, Farrell, Richard, Krüger, Rolf-Achim, Paupard, Thierry, Vind, Ida, Caprioli, Flavio, Gancho, Vladimir, Quentin, Vincent, Avidan, Benjamin, D’Haens, Geert, Mccarthy, Jane, Snook, Jonathon, Soufleris, Konstantinos, Zerbib, Frank, Carter, Dan, Depla, Annekatrien, Eisenbach, Thomas, Fries, Walter, Grammatikos, Nikolaos, Ilegems, Saskia, Lopez-Sanroman, Antonio, Moreau, Jacques, Riegler, Gabriele, Rietdijk, Svend, Rocha, Marta, Rosa, Isabelle, Ryan, Barbara, Yeremenko, Yelena, Boruchowicz, Arnaud, Damião, Filipe, Laoudi, Foteini, Lügering, Andreas, Macarri, Giampiero, Thomopoulos, Konstantinos, Barros, Luísa, Blixt, Thomas, Garros, Aurélien, Khorrami, Sam, Sokol, Harry, Sturm, Andreas, Livovsky, Dan, Maul, Jochen, Miks, Heinrich, Papadopoulos, Vasileios, Schmidt, Carsten, Snir, Yifat, Svenningsen, Lise, Ahmed, Wafaa, Broitman, Yelena, Cuillerier, Emmanuel, Kant, Prashant, Leyden, Jan, Lichtenstein, Lev, Lopes, Susana, Martineau, Chloé, Mulcahy, Hugh, Schweitzer, Axel, Van Schaik, Fiona, Banai, Hagar, Danion, Pauline, Dulery, Charlotte, Fidder, Herma, Gay, Claire, Hagege, Hervé, Harnois, Florence, Jørgensen, Søren Peter, Müller-Ziehm, Jens, Oikonomou, Michail, Palmela, Carolina, Schulze/Röske, Jörg, Smith, Mark, Thurm, Tamar, Bresso, Francesca, Brixi, Hedia, Jones, John, Macmathuna, Padraig, Painchart, Claire, Ron, Yulia, Vester-Andersen, Marianne, Alexandrino, Gonçalo, Börner, Norbert, Cardoso, Mariana, Chagas, Cristina, Dignaß, Axel, Dotan, Iris, Hedin, Charlotte, Karatzas, Pantelis, Kasapidis, Panagiotis, Palatka, Károly, Sakizlis, Georgios, Wilson, Ana, Bosanko, Nick, Caldeira, Paulo, Gagniere, Charlotte, Libier, Louise, Meunier, Camille, Moog, Gero, Pasquion, Audrey, Pica, Roberta, Akbar, Ayesha, Arab, Nadia, Cadiot, Guillaume, Carvalho, João, Charpignon, Claire, Fellermann, Laus, Fishman, Sigal, Fraser, Gerald, Gluck, Nathan, Hoesl, Mark, Kierkus, Jarosław, Klopocka, Maria, Arranz, Eduardo Martin, Menchen, Luis, Nikolaus, Susanna, Petrache, Anca, Ponsioen, Cyriel, Riestra, Sabino, Robledo, Pilar, Rodriguez, Cristina, Samer, Misheal, Tischer, Matthias, Wypych, Joanna, Baudon, Julien, Bezzio, Cristina, Boschetti, Gilles, Burisch, Johan, Creed, Tom, Demarzo, Maria Giulia, Festa, Stefano, Figueroa, Andrés, Julsgaard, Mette, Navarro, Pablo, Perez-Galindo, Pablo, Rouillon, Cléa, Sablich, Emanuele, Tosca, Joan, Vidon, Mathias, Vidon, Marine, Vitte, René-Louis, Wampach, Anne, Baumann, Cédric, Urmes, Isabelle Clerc, Rousseau, Hélène, Borie, Marc, Uzzan, Mathieu, Chatten, Kelly, Peter, Rimmer, Tariq, Iqbal, Cossignani, Marta, Cañete, Fiorella, Holvoet, Tom, Krasz, Susanne, Dias, Sandra, Abalia, Hadas, Abaza, Aziza, Abramovich, Gal, Ackzell, Ingrid, Adams, Carol, Addleton, Catherine, Alfambra, Erika, Algaba, Alicia, Allcock, Clare, Allison, Joanna, Amouriaux, Karine, Anderson, Julie, Anderson, Emma, Appelmans, Saskia, Armstrong, Lisa, Atkins, Stacey, Attaran-Bandarabadi, Masoumeh, Bailey, Yvonne, Bardot, Stephanie, Beck, Natasha, Bennett, Lillie, Bergfeld, Jonathan Phil, Berkane, Ramdane, Boey, Hanne, Bowlas, Louise, Bradley-Potts, Joanne, Brear, Tracy, Bretlander-Peters, Nicole, Brown, Ellen, Brown, Johanna, Buckingham, Elizabeth, Buellens, Katrien, Bull, Rhian, Burke, Maura, Burns, Leighanne, Burton, Julie, Bwalya, Agness, Cabanas, Karine, Callaghan, Muriel, Camou, Océane, Campbell, Debbie, Capoferro, Elvira, Carnahan, Mandy, Carnio, Cornelia, Carter, Anne, Clack, Concetta Casali, Chedouba, Leïla, Cipriano, Bessie, Claeys, Sophie, Closset, Manon, Coban, Dilek, Cococcia, Sara, Coe, Carolann, Cole, Helen, Collet, Emilie, Collins, Kayleigh, Combes, Isabelle, Connor, Emma, Constantin, Kathryn, Cooke, Susan, Cornet, Nathanaëlle, Corrihons, Estelle, Corsino, Pilar, Cortaville, Rosie, Cotterill, Donna, Cowton, Amanda, Cox, Harriet, Cripps, Viktoria, Crowder, Amanda, Cukier, Tzufit, Daniel, Amelia, Dawe, Chris, de Haan, Jose, Croix, Rosanna de la, Dejonckheere, Evva, Villanegro, Juan Delare, Delaval, Guillaume, Delliponti, Mariangela, Delommez, Aude, Detry, Emilie, Dhanaratne, Melanie, Galan, Laura Diez, Dodel, Marie, Dooks, Emma, Du Cheyron, Joseph, Duane, Linda, Vulgo Cochran, Jennifer Dulling, Dyer, Simona, Dymond, Harvey, Ekblad, Charlotte, Elliott, Kerry, Emmerson, Ingrid, Eugene-Jolchine, Irène, Fleming, Lorna, Fletcher, Eve, Ford, Sarah, Forshaw, Greg, Foulds, Angela, Francois, Caroline, Fuge, Nicole, Gafni, Gal, Ganon, Miri, Nuñez, Olga Garcia, Ramirez, Laura Garcia, Gelder, Sophie, Gettkowski, Raimonda, Gilardi, Daniela, Giuffrida, Paolo, Gobert, Vincent, Godden, Jo, Godwin, Nuala, Goulden, Kay, Graham, Sharon, Green, Charlotte, Green, Marie, Gueye, Aboubakar, Guler, Tuba, Gustavsson, Ida, Hadjisavvas, Helena, Hammonds, Fiona, Hantzi, Christina, Hauke, Marion, Haydock, Julie, Hayes, Orla, Nislev, Lizette Helbo, Hochstodter, Jessica, Hogg, Ashleigh, Hölbing, Manuela, Holland, Maureen, Holsbergen, Maartje, Howard, Linda, Hoyda, Aviya, Hull, Robert, Irish, Jane, Jackson, Wendy, Janssen, Wendy, Jeffrey, Lesley, Jourdan, Sofia, Jutrowska, Izabela, Kaniel, Chava, Karezos, Theofilos, Kelly, Niamh, Kelly, Jessica, Kennedy, Mary, Kennedy, Una, Kibaru, Joyce, Kirkman, Gemma, Klaproth, Janine, Kneese, Corinna, Koch, Andrea, Kokke, Kathleen, Koppelow, Martha, Krause, Sabine, Krauspe, Sabine, Kwakkenbos, Petra, Labarile, Nunzia, Lang, Hannah, Lassailly, Marianne, Leconte, Martine, Lepczynski, Linda, Levell, Emma, Levhar, Nina, Lindhort, Kerstin, Lisle, Jessica, Cauce, Beatriz Lopez, Lorenz, Gabriele, Lovati, Ambra, Lowry, Tracey, Lund, Margareta, Vorderbrügge, Anne Lutz, Maansson, Suzanne, Madapathage, Videsheka, Cheviakoff, Maelys, Magness, Alison, Manley, Orla, Manyoni, Catherine, Marg, Ingke, Marra, Antonella, Martins, Carole, Massella, Arianna, Mathias, Aurore, Mervyn, Danielle, Minsart, Charlotte, Mitchell, Sally, Monks, Kathleen, Montero, Mélanie, Moore, Alson, Moser, Maren, Moss, Alison, Mullen, Angela, Murciano, M. Francisca, Naylor, Deanna, Nehus, Ansgar, Nicholson, Anne, Nöding, Sarah, Nolan, Sinead, Nörenberg, Janet, Northcott, Clare, O'Connell, Jim, O’Kelly, Alison, Orbach-Zingboim, Noam, Orobitg, Judit, Otieno, Charlene, Owen, Charlotte, Patch, Sarah, Pauker, Maor, Pauli, Renate, Pearson, Harriet, Peggy, Falgon, Petit, Séverine, Petrissans, Christine, Piergallini, Simona, Pippard, Lucy, Pitt, Laura, Pócsik, Gabriella, Poher, Yoann, Pomes, Chloé, Pritchard, Lucy, Puchades, Laura, Quaid, Sheena, Rana, Aleem, Raynard, Dana, Reilly, Mykla, Reinert, Sonja, Reinknecht, Manuela, Renner, Baerbel, Reynolds, Rob, Rizzuto, Giulia, Robinson, Matthew, Robrechts, Joke, Rodriguez, Eva M., Rosenblum, Efrat, Russel, Tamlyn, Sadare, Ibiyemi, Salama, Noa, Schakel, Toos, Schauer, Anja, Schiavoni, Elisa, Shaw, Caroline, Shelton, Sarah, Sicart, Virginie, Siouville, Elodie, Smith, Orla, Soude, Théo, Stephenson, Sophie, Stephenson, Elaine, Steppe, Marjan, Sterkx, An, Stickley, Jo, Sugrue, Kathleen, Swietec, Natalia, Tasiaux, Charlotte, Thamu, Bhavneet, Thomas, Susane, Tobi, Ogwa, Touabi, Kahina, Tovi, Shifra, Tregonning, Julie, Turchini, Laura, Unkhoff, Julia, Unruh, Olesya, Uzun, Nurcan, Van Aert, Frauke, Bergh, Sandrine Vanden, Vandenbroucke, Louise, Vansteenkiste, Laura, Vardit, Shay, Vergriete, Valentin, Walker, Elaine, Warner, Eleanor, Watchorn, Olivia, Watson, Ekaterina, Wauthier, Marie-Claire, Weetman, Belgium Maria, Weston, Margaret, West-Petroschka, Wiebke, Wienecke, Susann, Wierling, Kerstin, Wiestler, Miriam, Wilcox, Rebecca, Wilhelmsen, Elva, Williams, Angharad, Williamson, Georgina, Wilson, Deborah, Wistance, Kate, Wortmann, Nicolas, Wurie, Subie, Yadgar, Karin, Young, Gail, Young, Megan, Aucouturier, Julien, Bertin, Marie- Jo, Bougrine, Hasnae, Coisnon, Marie, Defrance, Antoine, Gutierrez, Kati, Harouz, Amel, Jerber, Laure, Khlifi, Aida, Kirati, Amina, Liworo, Nasaladjine, Logoltat, Maude, Mailhat, Charlotte, M'Bayi, Chancely, Medane, Yasmina, Merkhoufa, Dalal, Elhad, Saouda Mohamed, Monthe, Bertille, Moyon, Fanny, Rabiega, Pascaline, Sekela, Jennifer, Thilloy, Charlotte, Hamamouche, Naima, Partisotti, Frederic, Blandin, Patrick, Mokhtari, Hocine, Coutard, Laure, and Doherty, Glen A.

Published
2023
Full Text
View/download PDF

7. IOIBD Recommendations for Clinical Trials in Ulcerative Proctitis: The PROCTRIAL Consensus

Author

Caron, Bénédicte, Abreu, Maria T., Siegel, Corey A., Panaccione, Remo, Sands, Bruce E., Dignass, Axel, Turner, Dan, Dotan, Iris, Hart, Ailsa L., Ahuja, Vineet, Allez, Matthieu, Ananthakrishnan, Ashwin N., Ghosh, Subrata, Griffiths, Anne M., Halfvarson, Jonas, Kaser, Arthur, Kotze, Paulo G., Koutroubakis, Ioannis E., Lakatos, Peter L., Levine, Arie, Lewis, James D., Magro, Fernando, Mantzaris, Gerassimos J., O’Morain, Colm, Ran, Zhihua, Reinisch, Walter, Rogler, Gerhard, Sachar, David B., Siegmund, Britta, Silverberg, Mark S., Sood, Ajit, Spinelli, Antonino, Steinwurz, Flavio, Tysk, Curt, Yamamoto-Furusho, Jesus K., Schreiber, Stefan, Rubin, David T., Sandborn, William J., Danese, Silvio, and Peyrin-Biroulet, Laurent

Published
2022
Full Text
View/download PDF

8. Endpoints for extraintestinal manifestations in inflammatory bowel disease trials: the EXTRA consensus from the International Organization for the Study of Inflammatory Bowel Diseases

Author

Guillo, Lucas, Abreu, Maria, Panaccione, Remo, Sandborn, William J, Azevedo, Valderilio F, Gensler, Lianne, Moghaddam, Bahar, Ahuja, Vineet, Ali, Sabrina A, Allez, Matthieu, Ananthakrishnan, Ashwin N, Bhattacharya, Abhik, Dubinsky, Marla, Griffiths, Anne, Hart, Ailsa, Korelitz, Burton, Kotze, Paulo G, Koutroubakis, Ioannis E, Lakatos, Peter L, Lindsay, James O, Magro, Fernando, Mantzaris, Gerassimos J, Ng, Siew C, O'Morain, Colm, Panés, Julian, Parigi, Tommaso, Ran, Zhihua, Rogler, Gerhard, Rubin, David T, Sachar, David B, Siegmund, Britta, Steinwurz, Flavio, Tysk, Curt, Vavricka, Stephan, Verstraete, Sofia G, Brezin, Antoine P, Haemel, Anna K, Dignass, Axel, Sands, Bruce E, Danese, Silvio, and Peyrin-Biroulet, Laurent

Published
2022
Full Text
View/download PDF

12. Outcomes and Endpoints of Postoperative Recurrence in Crohn's Disease: Systematic Review and Consensus Conference.

Author

Hammoudi, Nassim, Sachar, David, D'Haens, Geert, Reinisch, Walter, Kotze, Paulo Gustavo, Vermeire, Severine, Schölmerich, Jürgen, Kamm, Michael A, Griffiths, Anne, Panes, Julian, Ghosh, Subrata, Siegel, Corey A, Bemelman, Willem, O'Morain, Colm, Steinwurz, Flavio, Fleshner, Phillip, Mantzaris, Gerassimos J, Sands, Bruce, Abreu, Maria T, and Dotan, Iris

Abstract

Background Outcomes after ileocolonic resection in Crohn's disease [CD] are heterogeneous, and a clear definition of postoperative recurrence remains to be determined. Our Endpoints Working Group of the International Organization for the study of Inflammatory Bowel Disease [IOIBD] aimed to standardise postoperative outcomes, to discuss which endpoints should be used for postoperative clinical trials, and to define those which could be used in trials or registries. Methods Based on a systematic review of the literature, recommendations and statements were drafted and sent to all IOIBD members for a first round of voting. Recommendations and statements were revised based on the voters' comments during a consensus hybrid conference open to all IOIBD members. If no agreement was reached after two rounds of voting, the statement was excluded. Results In the systematic review, 3071 manuscripts were screened of which 434 were included. Sixteen recommendations were identified, of which 11 were endorsed. Recommendations and statements include that endoscopy remains the gold standard and should be used as a short-term primary endpoint in both observational cohorts and randomised controlled trials. Clinical symptoms classically used in clinical trials for luminal CD are not reliable in this specific situation. For that reason, longer-term endpoints should be based on the evidence of macroscopic inflammation assessed by imaging techniques, endoscopy, or as reflected by the presence of complications. Conclusions Agencies recommend the use of clinical evaluations, as in the case of luminal CD, and do not recognise primary endpoints based solely on endoscopy. This consensus has led to agreement on the need to define postoperative endoscopy-based and/or imaging-based endpoints. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

13. Combination of Bismuth and Standard Triple Therapy Eradicates Helicobacter pylori Infection in More than 90% of Patients

Author

McNicholl, Adrian G., Bordin, Dmitry S., Lucendo, Alfredo, Fadeenko, Galina, Fernandez, Manuel Castro, Voynovan, Irina, Zakharova, Natalia Valerievna, Sarsenbaeva, Aiman Silkanovna, Bujanda, Luis, Perez-Aisa, Ángeles, Vologzhanina, Liudmila, Zaytsev, Oleg, Ilchishina, Tatiana, Coba, Cristobal de la, Lasala, Jorge Perez, Alekseenko, Sergey, Modolell, Ines, Molina-Infante, Javier, Ruiz-Zorrilla Lopez, Rafael, Alonso-Galan, Horacio, Moreno, Nuria Fernandez, Hinojosa, Jen, Santaella, Inmaculada, Varela, Pilar, Gonzalez-Cordero, Pedro Luis, Barrio, Jesus, Dominguez-Jimenez, Jose Luis, Nuñez, Oscar, Alcedo, Javier, Nyssen, Olga P., Caldas, Maria, Donday, Maria G., Shvetz, Oleg, Megraud, Francis, O'Morain, Colm, and Gisbert, Javier P.

Published
2020
Full Text
View/download PDF

16. Room for Improvement in the Treatment of Helicobacter pylori Infection: Lessons from the European Registry on H. pylori Management (Hp-EuReg)

Author

Nyssen, Olga P., Vaira, Dino, Tepes, Bojan, Kupcinskas, Limas, Bordin, Dmitry, Pérez-Aisa, Ángeles, Gasbarrini, Antonio, Castro-Fernández, Manuel, Bujanda, Luis, Garre, Ana, Lucendo, Alfredo, Vologzhanina, Liudmila, Jurecic, Natasa B., Rodrigo-Sáez, Luis, Huguet, Jose M., Voynovan, Irina, Perez-Lasala, Jorge, Romero, Pilar Mata, Vujasinovic, Miroslav, Abdulkhakov, Rustam, Barrio, Jesús, Fernandez-Salazar, Luis, Mégraud, Francis, O’Morain, Colm, and Gisbert, Javier P.

Published
2022
Full Text
View/download PDF

18. Role of compliance in Helicobacter pylorieradication treatment: Results of the European Registry on H. pylorimanagement

Author

Huguet, Jose M., Ferrer‐Barceló, Luis, Suárez, Patrícia, Barcelo‐Cerda, Susana, Sempere, Javier, Saracino, Ilaria Maria, Fiorini, Giulia, Vaira, Dino, Pérez‐Aísa, Ángeles, Jonaitis, Laimas, Tepes, Bojan, Castro‐Fernandez, M., Pabón‐Carrasco, Manuel, Keco‐Huerga, Alma, Voynovan, Irina, Lucendo, Alfredo J., Lanas, Ángel, Martínez‐Domínguez, Samuel J., Alfaro Almajano, Enrique, Rodrigo, Luis, Vologzanina, Ludmila, Bordin, Dmitry S., Gasbarrini, Antonio, Babayeva, Gülüstan, Lerang, Frode, Leja, Mārcis, Kupčinskas, Juozas, Rokkas, Theodore, Marcos‐Pinto, Ricardo, Meštrović, Antonio, Gridnyev, Oleksiy, Phull, Perminder S., Smith, Sinead M., Boltin, Doron, Buzás, György Miklós, Kral, Jan, Şimşek, Halis, Matysiak‐Budnik, Tamara, Milivojevic, Vladimir, Marlicz, Wojciech, Venerito, Marino, Boyanova, Lyudmila, Doulberis, Michael, Capelle, Lisette G., Cano‐Català, Anna, Moreira, Leticia, Nyssen, Olga P., Mégraud, Francis, O’Morain, Colm, and Gisbert, Javier P.

Abstract

Adherence to Helicobacter pylori (H. pylori)eradication treatment is a cornerstone for achieving adequate treatment efficacy. To determine which factors influence compliance with treatment. A systematic prospective non‐interventional registry (Hp‐EuReg) of the clinical practice of European gastroenterologists. Compliance was considered adequate if ≥90% drug intake. Data were collected until September 2021 using the AEG‐REDCap e‐CRF and were subjected to quality control. Modified intention‐to‐treat analyses were performed. Multivariate analysis carried out the factors associated with the effectiveness of treatment and compliance. Compliance was inadequate in 646 (1.7%) of 38,698 patients. The non‐compliance rate was higher in patients prescribed longer regimens (10‐, 14‐days) and rescue treatments, patients with uninvestigated dyspepsia/functional dyspepsia, and patients reporting adverse effects. Prevalence of non‐adherence was lower for first‐line treatment than for rescue treatment (1.5% vs. 2.2%; p< 0.001). Differences in non‐adherence in the three most frequent first‐line treatments were shown: 1.1% with proton pump inhibitor + clarithromycin + amoxicillin; 2.3% with proton pump inhibitor clarithromycin amoxicillin metronidazole; and 1.8% with bismuth quadruple therapy. These treatments were significantly more effective in compliant than in non‐compliant patients: 86% versus 44%, 90% versus 71%, and 93% versus 64%, respectively (p< 0.001). In the multivariate analysis, the variable most significantly associated with higher effectiveness was adequate compliance (odds ratio, 6.3 [95%CI, 5.2–7.7]; p< 0.001). Compliance with Helicobacter pylorieradication treatment is very good. Factors associated with poor compliance include uninvestigated/functional dyspepsia, rescue‐treatment, prolonged treatment regimens, the presence of adverse events, and the use of non‐bismuth sequential and concomitant treatment. Adequate treatment compliance was the variable most closely associated with successful eradication.

Published
2024
Full Text
View/download PDF

20. Helicobacter pylori treatment results in Slovenia in the period 2013-2015 as a part of European Registry on Helicobacter pylori Management

Author

Tepes Bojan, Kastelic Marko, Vujasinovic Miroslav, Lampic Polona, Seruga Maja, Jurecic Natasa Brglez, Nyssen Olga P., Donday Maria G., O’Morain Colm, Megraud Francis, McNicholl Adrian G, and Gisbert Javier P.

Subjects
helicobacter pylori, eradication treatment, european registry on helicobacter pylori management, slovenian results, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Helicobacter pylori (H. pylori) is the most common chronic bacterial infection in the world affecting over 50% of the world’s population. H. pylori is a grade I carcinogen, responsible for the development of 89 % of noncardia gastric cancers. In the present study we analyzed the data for H. pylori eradication treatments in Slovenia.

Published
2017
Full Text
View/download PDF

21. An efficient strategy for evaluating new non-invasive screening tests for colorectal cancer: the guiding principles

Author

Bresalier, Robert S, primary, Senore, Carlo, additional, Young, Graeme P, additional, Allison, James, additional, Benamouzig, Robert, additional, Benton, Sally, additional, Bossuyt, Patrick M M, additional, Caro, Luis, additional, Carvalho, Beatriz, additional, Chiu, Han-Mo, additional, Coupé, Veerle M H, additional, de Klaver, Willemijn, additional, de Klerk, Clasine Maria, additional, Dekker, Evelien, additional, Dolwani, Sunil, additional, Fraser, Callum G, additional, Grady, William, additional, Guittet, Lydia, additional, Gupta, Samir, additional, Halloran, Stephen P, additional, Haug, Ulrike, additional, Hoff, Geir, additional, Itzkowitz, Steven, additional, Kortlever, Tim, additional, Koulaouzidis, Anastasios, additional, Ladabaum, Uri, additional, Lauby-Secretan, Beatrice, additional, Leja, Mārcis, additional, Levin, Bernard, additional, Levin, Theodore Robert, additional, Macrae, Finlay, additional, Meijer, Gerrit A, additional, Melson, Joshua, additional, O'Morain, Colm, additional, Parry, Susan, additional, Rabeneck, Linda, additional, Ransohoff, David F, additional, Sáenz, Roque, additional, Saito, Hiroshi, additional, Sanduleanu-Dascalescu, Silvia, additional, Schoen, Robert E, additional, Selby, Kevin, additional, Singh, Harminder, additional, Steele, Robert J C, additional, Sung, Joseph J Y, additional, Symonds, Erin Leigh, additional, and Winawer, Sidney J, additional

Published
2023
Full Text
View/download PDF

22. Management of Helicobacter pylori infection

Author

Malfertheiner, Peter, Megraud, Francis, Rokkas, Theodore, Gisbert, Javier P., Liou, Jyh-Ming, Schulz, Christian, Gasbarrini, Antonio, Hunt, Richard H., Leja, Marcis, O’Morain, Colm, Rugge, Massimo, Suerbaum, Sebastian, Tilg, Herbert, Sugano, Kentaro, El-Omar, Emad M., Agreus, L., Bazzoli, F, Bordin, D, Loginov, A.S., Mario, F. D., Dinis-Ribeiro, M., Engstrand, Lars, Fallone, C, Goh, K.L., Graham, David, Kuipers, E.J., Kupcinskas, J., Lanas, A., Machado, Jose C., Mahachai, V., Marshall, B.J., Milosavljevic, Tomica, Moss, S.F., Park, J.Y., Niv, Y., Rajilić-Stojanović, Mirjana, Ristimaki, A, Smith, S., Tepeš, Bojan, Wu, C.Y., Zhou, L., and Gastroenterology & Hepatology

Subjects
SDG 3 - Good Health and Well-being, gastric cancer, Settore MED/12 - GASTROENTEROLOGIA, Gastroenterology, helicobacter pylori, helicobacter pylori - treatment, helicobacter pylori - gastritis
Abstract

Helicobacter pyloriInfection is formally recognised as an infectious disease, an entity that is now included in the International Classification of Diseases 11th Revision. This in principle leads to the recommendation that all infected patients should receive treatment. In the context of the wide clinical spectrum associated with Helicobacter pylori gastritis, specific issues persist and require regular updates for optimised management.The identification of distinct clinical scenarios, proper testing and adoption of effective strategies for prevention of gastric cancer and other complications are addressed. H. pylori treatment is challenged by the continuously rising antibiotic resistance and demands for susceptibility testing with consideration of novel molecular technologies and careful selection of first line and rescue therapies. The role of H. pylori and antibiotic therapies and their impact on the gut microbiota are also considered.Progress made in the management of H. pylori infection is covered in the present sixth edition of the Maastricht/Florence 2021 Consensus Report, key aspects related to the clinical role of H. pylori infection were re-evaluated and updated. Forty-one experts from 29 countries representing a global community, examined the new data related to H. pylori infection in five working groups: (1) indications/associations, (2) diagnosis, (3) treatment, (4) prevention/gastric cancer and (5) H. pylori and the gut microbiota. The results of the individual working groups were presented for a final consensus voting that included all participants. Recommendations are provided on the basis of the best available evidence and relevance to the management of H. pylori infection in various clinical fields.

Published
2022

25. 131 - PAUTAS Y EFECTIVIDAD DE LAS TERAPIAS CUÁDRUPLES CON BISMUTO EN EUROPA: RESULTADOS DEL REGISTRO EUROPEO SOBRE EL MANEJO DE LA INFECCIÓN POR HELICOBACTER PYLORI (HP-EUREG)

Author

Calvet, Xavier, primary, Gené, Emili, additional, Olmedo, Llum, additional, Bordin, Dmitry, additional, García-Morales, Natalia, additional, Hernández, Luis, additional, Gridnyev, Oleksiy, additional, Kupinskas, Juozas, additional, Gasbarrini, Antonio, additional, Boltin, Doron, additional, Babayeva, Gulustan, additional, Pinto, Ricardo Marcos, additional, Tepes, Bojan, additional, Buzas, Gyorgy M, additional, Papp, Veronika, additional, Simsek, Halis, additional, Cano-Català, Anna, additional, Moreira, Leticia, additional, Puig, Ignasi, additional, Nyssen, Olga P., additional, Mégraud, Francis, additional, O’Morain, Colm, additional, and Gisbert, Javier P., additional

Published
2023
Full Text
View/download PDF

26. 138 - EFECTIVIDAD EN PRIMERA LÍNEA DE TRATAMIENTO FRENTE A HELICOBACTER PYLORI: SUBANÁLISIS DE LOS DATOS ESPAÑOLES DEL REGISTRO EUROPEO SOBRE EL MANEJO DE LA INFECCIÓN POR H. PYLORI (HPEUREG)

Author

Hernández, Luis, primary, Pérez-Aisa, Maria Ángeles, additional, Domínguez, Samuel Jesús Martínez-, additional, Pabón-Carrasco, Manuel, additional, Bujanda, Luis, additional, Lucendo, Alfredo, additional, Rodrigo, Luis, additional, Garre, Ana, additional, Huguet, Jose María, additional, Alcaide, Noelia, additional, Perona, Mónica, additional, Barrio, Jesús, additional, Núñez, Óscar, additional, Tejada, Javier Tejedor, additional, Mata, Pilar, additional, Ledro, Diego, additional, Ortuño, Juan, additional, Cajal, Manuel Domínguez, additional, Ladrón, Gema, additional, Camarero, Judith Gómez, additional, Rodríguez, Blas José Gómez, additional, Nyssen, Olga P., additional, Megraud, Francis, additional, O’Morain, Colm, additional, and Gisbert, Javier P., additional

Published
2023
Full Text
View/download PDF

27. 139 - EFECTIVIDAD EN SEGUNDA LÍNEA DE TRATAMIENTO FRENTE A HELICOBACTER PYLORI: SUBANÁLISIS DE LOS DATOS ESPAÑOLES DEL REGISTRO EUROPEO SOBRE EL MANEJO DE LA INFECCIÓN POR H. PYLORI (HPEUREG)

Author

Hernández, Luis, primary, Pérez-Aisa, Maria Ángeles, additional, Domínguez, Samuel Jesús Martínez-, additional, Pabón-Carrasco, Manuel, additional, Bujanda, Luis, additional, Lucendo, Alfredo, additional, Rodrigo, Luis, additional, Garre, Ana, additional, Huguet, Jose María, additional, Alcaide, Noelia, additional, Perona, Mónica, additional, Barrio, Jesús, additional, Núñez, Óscar, additional, Tejada, Javier Tejedor, additional, Mata, Pilar, additional, Ledro, Diego, additional, Ortuño, Juan, additional, Cajal, Manuel Domínguez, additional, Ladrón, Gema, additional, Camarero, Judith Gómez, additional, Rodríguez, Blas José Gómez, additional, Nyssen, Olga P., additional, Megraud, Francis, additional, O’Morain, Colm, additional, and Gisbert, Javier P., additional

Published
2023
Full Text
View/download PDF

28. 134 - EFECTIVIDAD DE LA TERAPIA DE ERRADICACIÓN EMPÍRICA CON FURAZOLIDONA: RESULTADOS DEL REGISTRO EUROPEO SOBRE EL MANEJO DE LA INFECCIÓN POR HELICOBACTER PYLORI (HP- EUREG)

Author

Bordin, D.S., primary, Voynovan, I.N., additional, Sarsenbaeva, A.S., additional, Zaitsev, O.V., additional, Abdulkhakov, R.A., additional, Bakulina, N.V., additional, Bakulin, I.G., additional, Osipenko, M.F., additional, Livzan, M.A., additional, Alekseenko, S.A., additional, Tarasova, L.V., additional, Tarasova, G.N., additional, Bogomolov, P.O., additional, Maev, I.V., additional, Andreev, D.N., additional, Abdulhakov, S.R., additional, Starostin, B.D., additional, Bakanova, N.V., additional, Kononova, A.G., additional, Kolbasnikov, S.V., additional, E.L, Bueverova, additional, Cano-Català, Anna, additional, Moreira, Leticia, additional, Mégraud, Francis, additional, O’Morain, Colm, additional, Nyssen, Olga P., additional, and Gisbert, Javier P., additional

Published
2023
Full Text
View/download PDF

29. 128 - TENDENCIAS TEMPORALES DE PRESCRIPCIÓN DE TRATAMIENTOS ERRADICADORES Y DE SU EFECTIVIDAD EN PACIENTES NAÏVE EN ESPAÑA ENTRE 2013 Y 2022: 10 AÑOS DE EXPERIENCIA DEL REGISTRO EUROPEO SOBRE EL MANEJO DE LA INFECCIÓN POR H. PYLORI (HP-EUREG)

Author

Hernández, Luis, primary, Pérez-Aisa, Maria Ángeles, additional, Domínguez, Samuel Jesús Martínez-, additional, Pabón-Carrasco, Manuel, additional, Bujanda, Luis, additional, Lucendo, Alfredo, additional, Rodrigo, Luis, additional, Garre, Ana, additional, Huguet, Jose María, additional, Alcaide, Noelia, additional, Perona, Mónica, additional, Barrio, Jesús, additional, Núñez, Óscar, additional, Tejada, Javier Tejedor, additional, Mata, Pilar, additional, Ledro, Diego, additional, Ortuño, Juan, additional, Cajal, Manuel Dominguez, additional, Ladrón, Gema, additional, Camarero, Judith Gómez, additional, Rodríguez, Blas José Gómez, additional, Nyssen, Olga P., additional, Megraud, Francis, additional, O’Morain, Colm, additional, and Gisbert, Javier P., additional

Published
2023
Full Text
View/download PDF

30. Effectiveness of first and second-line empirical treatment in Italy: Results of the European registry on Helicobacter pylori management

Author

Gatta, Gian Luigi, Nyssen, Olga P, Fiorini, Giulia, Saracino, Ilaria Maria, Pavoni, Matteo, Romano, Marco, Gravina, Antonietta Gerarda, Granata, Lucia, Pellicano, Rinaldo, Gasbarrini, Antonio, Di Leo, Alfredo, Losurdo, Giuseppe, Franceschi, Francesco, Nardone, Gerardo, Rocco, Alba, Dore, Maria Pina, Farinati, Fabio, Ghisa, Matteo, Bellini, Massimo, Holton, John, Puig, Ignasi, Vaira, Dino, Borghi, Claudio, Mégraud, Franci, O'Morain, Colm, Gisbert, Javier P, Gatta, Luigi, Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Franceschi, Francesco (ORCID:0000-0001-6266-445X), Gatta, Gian Luigi, Nyssen, Olga P, Fiorini, Giulia, Saracino, Ilaria Maria, Pavoni, Matteo, Romano, Marco, Gravina, Antonietta Gerarda, Granata, Lucia, Pellicano, Rinaldo, Gasbarrini, Antonio, Di Leo, Alfredo, Losurdo, Giuseppe, Franceschi, Francesco, Nardone, Gerardo, Rocco, Alba, Dore, Maria Pina, Farinati, Fabio, Ghisa, Matteo, Bellini, Massimo, Holton, John, Puig, Ignasi, Vaira, Dino, Borghi, Claudio, Mégraud, Franci, O'Morain, Colm, Gisbert, Javier P, Gatta, Luigi, Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), and Franceschi, Francesco (ORCID:0000-0001-6266-445X)

Abstract

Background and AimsThe optimal management of naive and not naive Helicobacter pylori patients remains unclear. Therefore, it is essential to evaluate whether the actual clinical practice mirrors the indications suggested by the guidelines. This study aimed to assess the effectiveness and the safety of the empirical first- and second-line treatments prescribed to patients enroled at Italian centres participating in the European Registry on H. pylori Management (Hp-EuReg). MethodsThe Hp-EuReg is an international multicentre prospective non-interventional registry starting in 2013 aiming to evaluate the management of H. pylori infection by European gastroenterologists. Patients were registered in an e-CRF by AEG-REDCap. Variables assessed included demographics, previous eradication attempts, treatment regimen, effectiveness, and tolerance. ResultsOverall, 3723 patients from 2013 to February 2021 were included: 2996 and 727 received an empirical first- and second-line treatment, respectively. According to the modified ITT analysis, among the first-line regimens, only the bismuth quadruple therapy with three-in-one-single capsule (BQT-TSC), the concomitant, and the sequential treatment - all lasting 10 days - achieved an eradication rate >90%. Among the second-line regimens, only the 10-day BQT-TSC reported an effectiveness >90%. High-dose PPI twice daily also significantly increased the effectiveness of some therapies. The BQT-TSC was the regimen with the highest incidence of adverse events. ConclusionsOnly quadruple therapies lasting at least 10 days achieved over 90% eradication rates among the empirical first- and second-line regimens. It remains unclear whether high-dose PPI twice daily can improve the efficacy of quadruple treatment.

Published
2023

31. Vitamin D deficiency in a European inflammatory bowel disease inception cohort: an Epi-IBD study

Author

Chetcuti Zammit, Stefania, Ellul, Pierre, Girardin, Giulia, Valpiani, Daniela, Nielsen, Kári R., Olsen, Jóngerð, Goldis, Adrian, Lazar, Daniela, Shonová, Olga, Nováková, Marie, Sebastian, Shaji, Whitehead, Emma, Carmona, Amalia, Martinez-Cadilla, Jesus, Dahlerup, Jens F., Kievit, Adriana L.H., Thorsgaard, Niels, Katsanos, Konstantinos H., Christodoulou, Dimitrios K., Magro, Fernando, Salupere, Riina, Pedersen, Natalia, Kjeldsen, Jens, Carlsen, Katrine, Ioannis, Kaimaklioti, Bergemalm, Daniel, Halfvarson, Jonas, Duricova, Dana, Bortlik, Martin, Collin, Pekka, Oksanen, Pia, Kiudelis, Gediminas, Kupcinskas, Limas, Kudsk, Karen, Andersen, Vibeke, O’Morain, Colm, Bailey, Yvonne, Doron, Schwartz, Shmuel, Odes, Almer, Sven, Arebi, Naila, Misra, Ravi, Čuković-Čavka, Silvija, Brinar, Marko, Munkholm, Pia, Vegh, Zsuzsanna, and Burisch, Johan

Published
2018
Full Text
View/download PDF

32. Role of proton pump inhibitors dosage and duration in Helicobacter pylorieradication treatment: Results from the European Registry on H. pylorimanagement

Author

Pabón‐Carrasco, Manuel, Keco‐Huerga, Alma, Castro‐Fernández, Manuel, Saracino, Ilaria Maria, Fiorini, Giulia, Vaira, Dino, Pérez‐Aísa, Ángeles, Tepes, Bojan, Jonaitis, Laimas, Voynovan, Irina, Lucendo, Alfredo J., Lanas, Ángel, Martínez‐Domínguez, Samuel J., Almajano, Enrique Alfaro, Rodrigo, Luis, Vologzanina, Ludmila, Brglez Jurecic, Natasa, Denkovski, Maja, Bujanda, Luis, Abdulkhakov, Rustam A., Huguet, Jose M., Fernández‐Salazar, Luis, Alcaide, Noelia, Velayos, Benito, Silkanovna Sarsenbaeva, Aiman, Zaytsev, Oleg, Ilchishina, Tatiana, Barrio, Jesús, Bakulin, Igor, Perona, Monica, Alekseenko, Sergey, Romano, Marco, Gravina, Antonietta G., Núñez, Óscar, Gómez Rodríguez, Blas José, Ledro‐Cano, Diego, Pellicano, Rinaldo, Bogomolov, Pavel, Domínguez‐Cajal, Manuel, Almela, Pedro, Gomez‐Camarero, Judith, Bordin, Dmitry S., Gasbarrini, Antonio, Kupčinskas, Juozas, Cano‐Català, Anna, Moreira, Leticia, Nyssen, Olga P., Mégraud, Francis, O’Morain, Colm, Gisbert, Javier P., Tejedor‐Tejada, Javier, Tarasova, Galina, Dekhnich, Natalia Nikolaevna, Di Leo, Alfredo, Losurdo, Giuseppe, Fernández‐Bermejo, Miguel, Iyo, Eduardo, Bermejo, Fernando, Algaba, Alicia, Grigorieva, Ludmila, Lamuela Calvo, Luis Javier, Jiménez, Itxaso, Starostin, Boris D., Baryshnikova, Natalia, Peña‐Negro, Luisa C., Planella, Montserrat, Ramirez, Consuelo, Bakanova, Natalia V., Farinati, Fabio, Ghisa, Matteo, Angueira, Teresa, Kononova, Alla, Campillo, Ana, Villarroya, Ramón Pajares, Gomez, Barbara, Belousova, Liya Nikolaevna, Compare, Debora, Alcedo, Javier, Burgos‐Santamaría, Diego, Rancel‐Medina, Francisco‐José, Pérez‐Martínez, Isabel, Maev, Igor, Andreev, Dmitrii, González‐Santiago, Jesús M., Segarra Ortega, José Xavier, Flores, Virginia, Cuadrado‐Lavín, Antonio, and Hernández, Luis

Abstract

Management of Helicobacter pylori(H. pylori) infection requires co‐treatment with proton pump inhibitors (PPIs) and the use of antibiotics to achieve successful eradication. To evaluate the role of dosage of PPIs and the duration of therapy in the effectiveness of H. pylorieradication treatments based on the ‘European Registry on Helicobacter pylorimanagement’ (Hp‐EuReg). Hp‐EuReg is a multicentre, prospective, non‐interventionist, international registry on the routine clinical practice of H. pylorimanagement by European gastroenterologists. All infected adult patients were systematically registered from 2013 to 2022. Overall, 36,579 patients from five countries with more than 1000 patients were analysed. Optimal (≥90%) first‐line‐modified intention‐to‐treat effectiveness was achieved with the following treatments: (1) 14‐day therapies with clarithromycin‐amoxicillin‐bismuth and metronidazole‐tetracycline‐bismuth, both independently of the PPI dose prescribed; (2) All 10‐day (except 10‐day standard triple therapy) and 14‐day therapies with high‐dose PPIs; and (3) 10‐day quadruple therapies with clarithromycin‐amoxicillin‐bismuth, metronidazole‐tetracycline‐bismuth, and clarithromycin‐amoxicillin‐metronidazole (sequential), all with standard‐dose PPIs. In first‐line treatment, optimal effectiveness was obtained with high‐dose PPIs in all 14‐day treatments, in 10‐ and 14‐day bismuth quadruple therapies and in 10‐day sequential with standard‐dose PPIs. Optimal second‐line effectiveness was achieved with (1) metronidazole‐tetracycline‐bismuth quadruple therapy for 14‐ and 10 days with standard and high‐dose PPIs, respectively; and (2) levofloxacin‐amoxicillin triple therapy for 14 days with high‐dose PPIs. None of the 7‐day therapies in both treatment lines achieved optimal effectiveness. We recommend, in first‐line treatment, the use of high‐dose PPIs in 14‐day triple therapy and in 10‐or 14‐day quadruple concomitant therapy in first‐line treatment, while standard‐dose PPIs would be sufficient in 10‐day bismuth quadruple therapies. On the other hand, in second‐line treatment, high‐dose PPIs would be more beneficial in 14‐day triple therapy with levofloxacin and amoxicillin or in 10‐day bismuth quadruple therapy either as a three‐in‐one single capsule or in the traditional scheme.

Published
2024
Full Text
View/download PDF

35. 135 - TENDENCIAS DE PRESCRIPCIÓN DE TRATAMIENTOS ERRADICADORES Y DE SU EFECTIVIDAD EN PACIENTES NAÏVE A LO LARGO DE 10 AÑOS (2013-2022) EN EUROPA: DATOS DEL REGISTRO EUROPEO SOBRE EL MANEJO DE LA INFECCIÓN POR HELICOBACTER PYLORI (HP-EUREG)

Author

Nyssen, Olga P., primary, Jonaitis, Laimas, additional, Pérez-Aísa, Ángeles, additional, Vaira, Dino, additional, Fiorini, Giulia, additional, Saracino, Ilaria Maria, additional, Tepes, Bojan, additional, Bordin, Dmitry, additional, Huerga, Alma Keco-, additional, Castro-Fernández, Manuel, additional, Lucendo, Alfredo, additional, Vologzhanina, Liudmila, additional, Bujanda, Luis, additional, Jurecic, Natasa Brglez, additional, Denkovski, Maja, additional, Lanas, Angel, additional, Martínez-Dominguez, Samuel, additional, Alfaro, Enrique, additional, Leja, Marcis, additional, Bumane, Renate, additional, Mammadov, Emin, additional, Babayeva, Gulustan, additional, Mahmudov, Umud, additional, Caldas, María, additional, Rodrigo, Luis, additional, Lerang, Frode, additional, Fadieienko, Galyna, additional, Abdulkhakov, Rustam, additional, Malavés, Jose María Huguet, additional, Zaytsev, Oleg, additional, Ilchishina, Tatiana, additional, Fernández-Salazar, Luis, additional, Alcaide, Noelia, additional, Velayos, Benito, additional, Sarsenbaeva, Aiman Silkanovna, additional, Bakulin, Igor, additional, Gravina, Antonietta G., additional, Romano, Marco, additional, Perona, Mónica, additional, Alekseenko, Sergey, additional, Barrio, Jesús, additional, Areia, Miguel, additional, Nuñez, Óscar, additional, Bogomolov, Pavel, additional, Rodríguez, Blas José Gómez, additional, Cajal, Manuel Dominguez-, additional, Camarero, Judith Gomez, additional, Moreno, Manuel Jiménez, additional, Georgopoulos, Sotirios, additional, Notari, Pedro Almela, additional, Tonkic, Ante, additional, Pellicano, Rinaldo, additional, Simsek, Halis, additional, Kunovský, Lumír, additional, Gasbarrini, Antonio, additional, Bote, Jose Maria Botargues, additional, Buzas, Gyorgy M, additional, Fernández-Bermejo, Miguel, additional, Phull, Perminder, additional, Venerito, Marino, additional, Malfertheiner, Peter, additional, Rosania, Rosa, additional, Link, Alexander, additional, Iyo, Eduardo, additional, Kupinskas, Juozas, additional, Shvets, Oleg, additional, Pinto, Ricardo Marcos, additional, Rokkas, Theodore, additional, Simsek, Ilkay, additional, Smith, Sinead, additional, Boltin, Doron, additional, Lamarque, Dominique, additional, Dobru, Daniela, additional, Marlicz, Wojciech, additional, Milivojevic, Vladimir, additional, Boyanova, Lyudmila, additional, Lamy, Vincent, additional, Doulberis, Michael, additional, Bytzer, Peter, additional, Capelle, Lisette, additional, Gridnyev, Oleksiy, additional, Ristimaki, Ari, additional, Cano-Català, Anna, additional, Puig, Ignasi, additional, Mégraud, Francis, additional, O’Morain, Colm, additional, and Gisbert, Javier P., additional

Published
2023
Full Text
View/download PDF

36. 130 - COMPARACIÓN DE LA EFECTIVIDAD DE LOS TRATAMIENTOS ERRADICADORES MÁS FRECUENTES ENTRE LAS POBLACIONES MÁS MAYORES Y MÁS JÓVENES DE EUROPA: DATOS DEL REGISTRO EUROPEO SOBRE EL MANEJO DE LA INFECCIÓN POR HELICOBACTER PYLORI (HP-EUREG)

Author

Jonaitis, Paulius, primary, Nyssen, Olga P., additional, Saracino, Ilaria Maria, additional, Fiorini, Giulia, additional, Vaira, Dino, additional, Pérez-Aísa, Ángeles, additional, Tepes, Bojan, additional, Castro-Fernández, M., additional, Pabón-Carrasco, Manuel, additional, Keco-Huerga, Alma, additional, Voynovan, Irina, additional, Lucendo, Alfredo J, additional, Lanas, Ángel, additional, Martínez-Domínguez, Samuel J, additional, Almajano, Enrique Alfaro, additional, Rodrigo, Luis, additional, Vologzanina, Ludmila, additional, Jurecic, Natasa Brglez, additional, Denkovski, Maja, additional, Bujanda, Luis, additional, Mahmudov, Umud, additional, Leja, Mrcis, additional, Lerang, Frode, additional, Babayeva, Gülüstan, additional, Bordin, Dmitry S., additional, Gasbarrini, Antonio, additional, Kupcinskas, Juozas, additional, Gridnyev, Oleksiy, additional, Rokkas, Theodore, additional, Marcos-Pinto, Ricardo, additional, Phull, Perminder S., additional, Smith, Sinead M., additional, Tonki, Ante, additional, Boltin, Doron, additional, Buzás, György Miklós, additional, Kunovský, Lumír, additional, imek, Halis, additional, Matysiak-Budnik, Tamara, additional, Milivojevic, Vladimir, additional, Marlicz, Wojciech, additional, Venerito, Marino, additional, Boyanova, Lyudmila, additional, Doulberis, Michael, additional, Capelle, Lisette G., additional, Cano-Català, Anna, additional, Moreira, Leticia, additional, Mégraud, Francis, additional, O’Morain, Colm, additional, Gisbert, Javier P., additional, and Jonaitis, Laimas, additional

Published
2023
Full Text
View/download PDF

37. 140 - TRATAMIENTO ERRADICADOR DE SEXTA LÍNEA FRENTE A HELICOBACTER PYLORI: DATOS PRELIMINARES DEL REGISTRO EUROPEO SOBRE EL MANEJO DE LA INFECCIÓN POR HELICOBACTER PYLORI (HP-EUREG)

Author

Nyssen, Olga P., primary, Garre, Ana, additional, Fiorini, Giulia, additional, Saracino, Ilaria Maria, additional, Pavoni, Matteo, additional, Vaira, Dino, additional, Phull, Perminder, additional, Beales, Ian, additional, Gasbarrini, Antonio, additional, Cano-Català, Anna, additional, Moreira, Leticia, additional, Mégraud, Francis, additional, O’Morain, Colm, additional, and Gisbert, Javier P., additional

Published
2023
Full Text
View/download PDF

38. 123 - OPTIMIZACIÓN DE LA DOSIS DE LOS INHIBIDORES DE LA BOMBA DE PROTONES EN LOS TRATAMIENTOS ERRADICADORES DE PRIMERA Y SEGUNDA LÍNEA FRENTE A HELICOBACTER PYLORI: RESULTADOS DEL REGISTRO EUROPEO SOBRE EL MANEJO DE LA INFECCIÓN POR HELICOBACTER PYLORI (HP-EUREG)

Author

Keco-Huerga, Alma, primary, Pabón-Carrasco, Manuel, additional, Castro-Fernández, Manuel, additional, Saracino, Ilaria Maria, additional, Fiorini, Giulia, additional, Vaira, Dino, additional, Pérez-Aísa, Ángeles, additional, Tepes, Bojan, additional, Jonaitis, Laimas, additional, Voynovan, Irina, additional, Lucendo, Alfredo J, additional, Lanas, Ángel, additional, Martínez-Domínguez, Samuel J, additional, Almajano, Enrique Alfaro, additional, Rodrigo, Luis, additional, Vologzanina, Ludmila, additional, Jurecic, Natasa Brglez, additional, Denkovski, Maja, additional, Bujanda, Luis, additional, Abdulkhakov, Rustam A, additional, Huguet, José M., additional, Salazar, L. Fernández, additional, Alcaide, Noelia, additional, Velayos, Benito, additional, Sarsenbaeva, Aiman Silkanovna, additional, Zaytsev, Oleg, additional, Ilchishina, Tatiana, additional, Barrio, Jesús, additional, Bakulin, Igor, additional, Perona, Monica, additional, Alekseenko, Sergey, additional, Romano, Marco, additional, Gravina, Antonietta G., additional, Núñez, Óscar, additional, Rodríguez, Blas José Gómez, additional, Ledro-Cano, Diego, additional, Pellicano, Rinaldo, additional, Bogomolov, Pavel, additional, Domínguez-Cajal, Manuel, additional, Almela, Pedro, additional, Gomez-Camarero, Judith, additional, Bordin, Dmitry S., additional, Gasbarrini, Antonio, additional, Kupinskas, Juozas, additional, Cano-Català, Anna, additional, Moreira, Leticia, additional, Nyssen, Olga P., additional, Mégraud, Francis, additional, O’Morain, Colm, additional, and Gisbert, Javier P., additional

Published
2023
Full Text
View/download PDF

39. LA ADMINISTRACIÓN DE LA TERAPIA CUÁDRUPLE CON BISMUTO EN CÁPSULA ÚNICA TRES VECES AL DÍA AUMENTA LA EFICACIA EN COMPARACIÓN CON LA PAUTA CONVENCIONAL DE CUATRO DOSIS DIARIAS: RESULTADOS DEL REGISTRO EUROPEO SOBRE EL MANEJO DE LA INFECCIÓN POR HELICOBACTER PYLORI (HP-EUREG)

Author

Pérez-Aísa, Ángeles, primary, Nyssen, Olga P., additional, Keco-Huerga, Alma, additional, Rodrigo, Luis, additional, Lucendo, Alfredo J, additional, Rodríguez, Blas José Gómez, additional, Ortuño, Juan, additional, Perona, Mónica, additional, Huguet, José M., additional, Núñez, Óscar, additional, Fernández-Salazar, Luis, additional, Barrio, Jesús, additional, Lanas, Ángel, additional, Iyo, Eduardo, additional, Romero, Pilar Mata, additional, Bermejo, Miguel Fernández-, additional, Gomez, Barbara, additional, Garre, Ana, additional, Gomez-Camarero, Judith, additional, Lamuela, Luis Javier, additional, Campillo, Ana, additional, de la Peña-Negro, Luisa C, additional, Dominguez-Cajal, Manuel, additional, Bujanda, Luis, additional, Burgos-Santamaria, Diego, additional, Bermejo, Fernando, additional, González-Carrera, Víctor, additional, Pajares, Ramón, additional, Notari, Pedro Almela, additional, Tejedor-Tejada, Javier, additional, Planella, Montserrat, additional, Jiménez, Itxaso, additional, Lázaro, Yolanda Arguedas, additional, Cuadrado-Lavín, Antonio, additional, Pérez-Martínez, Isabel, additional, Amorena, Edurne, additional, Santiago, Jesús M González-, additional, Angueira, Teresa, additional, Flores, Virginia, additional, Martínez-Domínguez, Samuel Jesús, additional, Pabón-Carrasco, Manuel, additional, Velayos, Benito, additional, Algaba, Alicia, additional, Ramírez, Consuelo, additional, Almajano, Enrique Alfaro, additional, Castro-Fernández, Manuel, additional, Alcaide, Noelia, additional, Segura, Patricia Sanz, additional, Cano-Català, Anna, additional, Morales, Natalia García-, additional, Moreira, Leticia, additional, Mégraud, Francis, additional, O’Morain, Colm, additional, Calvet, Xavier, additional, and Gisbert, Javier P., additional

Published
2023
Full Text
View/download PDF

40. Effectiveness of first and second‐line empirical treatment in Italy: Results of the European registry on Helicobacter pylori management

Author

Gatta, Luigi, primary, Nyssen, Olga P., additional, Fiorini, Giulia, additional, Saracino, Ilaria Maria, additional, Pavoni, Matteo, additional, Romano, Marco, additional, Gravina, Antonietta Gerarda, additional, Granata, Lucia, additional, Pellicano, Rinaldo, additional, Gasbarrini, Antonio, additional, Di Leo, Alfredo, additional, Losurdo, Giuseppe, additional, Franceschi, Francesco, additional, Nardone, Gerardo, additional, Rocco, Alba, additional, Dore, Maria Pina, additional, Farinati, Fabio, additional, Ghisa, Matteo, additional, Bellini, Massimo, additional, Holton, John, additional, Puig, Ignasi, additional, Vaira, Dino, additional, Borghi, Claudio, additional, Mégraud, Francis, additional, O'Morain, Colm, additional, and Gisbert, Javier P., additional

Published
2022
Full Text
View/download PDF

41. Empirical rescue treatment ofHelicobacter pyloriinfection in third and subsequent lines: 8-year experience in 2144 patients from the European Registry onH. pylorimanagement (Hp-EuReg)

Author

Burgos-Santamaría, Diego, primary, Nyssen, Olga P, additional, Gasbarrini, Antonio, additional, Vaira, Dino, additional, Pérez-Aisa, Ángeles, additional, Rodrigo, Luís, additional, Pellicano, Rinaldo, additional, Keco-Huerga, Alma, additional, Pabón-Carrasco, Manuel, additional, Castro-Fernandez, Manuel, additional, Boltin, Doron, additional, Barrio, Jesus, additional, Phull, Perminder, additional, Kupcinskas, Juozas, additional, Jonaitis, Laimas, additional, Ortiz-Polo, Inmaculada, additional, Tepes, Bojan, additional, Lucendo, Alfredo J, additional, Huguet, José María, additional, Areia, Miguel, additional, Jurecic, Natasa Brglez, additional, Denkovski, Maja, additional, Bujanda, Luís, additional, Ramos-San Román, June, additional, Cuadrado-Lavín, Antonio, additional, Gomez-Camarero, Judith, additional, Jiménez Moreno, Manuel Alfonso, additional, Lanas, Angel, additional, Martinez-Dominguez, Samuel Jesús, additional, Alfaro, Enrique, additional, Marcos-Pinto, Ricardo, additional, Milivojevic, Vladimir, additional, Rokkas, Theodore, additional, Leja, Marcis, additional, Smith, Sinead, additional, Tonkić, Ante, additional, Buzás, György Miklós, additional, Doulberis, Michael, additional, Venerito, Marino, additional, Lerang, Frode, additional, Bordin, Dmitry S, additional, Lamy, Vincent, additional, Capelle, Lisette G, additional, Marlicz, Wojciech, additional, Dobru, Daniela, additional, Gridnyev, Oleksiy, additional, Puig, Ignasi, additional, Mégraud, Francis, additional, O'Morain, Colm, additional, and Gisbert, Javier P, additional

Published
2022
Full Text
View/download PDF

42. Occurrence of Anaemia in the First Year of Inflammatory Bowel Disease in a European Population-based Inception Cohort—An ECCO-EpiCom Study

Author

Burisch, Johan, Vegh, Zsuzsanna, Katsanos, Konstantinnos H, Christodoulou, Dimitrios K, Lazar, Daniela, Goldis, Adrian, O’Morain, Colm, Fernandez, Alberto, Pereira, Santos, Myers, Sally, Sebastian, Shaji, Pedersen, Natalia, Olse, Jóngerð, Rubek Nielsen, Kári, Schwartz, Doron, Odes, Selwyn, Almer, Sven, Halfvarson, Jonas, Turk, Niksa, Cukovic-Cavka, Silvja, Nikulina, Inna, Belousova, Elena, Duricova, Dana, Bortlik, Martin, Shonová, Olga, Salupere, Riina, Barros, Louisa, Magro, Fernando, Jonaitis, Laimas, Kupcinskas, Limas, Turcan, Svetlana, Kaimakliotis, Ioannis, Ladefoged, Karin, Kudsk, Karen, Andersen, Vibeke, Vind, Ida, Thorsgaard, Niels, Oksanen, Pia, Collin, Pekka, Dal Piaz, Giulia, Santini, Alessia, Niewiadomski, Ola, Bell, Sally, Moum, Bjørn, Arebi, Naila, Kjeldsen, Jens, Carlsen, Katrine, Langholz, Ebbe, Lakatos, Peter Laszlo, Munkholm, Pia, Gerdes, Lars Ulrik, Dahlerup, Jens Frederik, Niewiadomski, Ola, Bell, Sally, Turk, Niksa, Cukovic-Cavka, Silvija, Kaimakliotis, Ioannis, Nicolaou, Anastasia, Duricova, Dana, Lukas, Milan, Bortlík, Martin, Shonová, Olga, Burisch, Johan, Munkholm, Pia, Langholz, Ebbe, Blichfeldt, Birgitte, Marker, Dorte, Carlsen, Katrine, Weimers, Petra, Pedersen, Natalia, Kjeldsen, Jens, Aalykke, Clays, Dahlerup, Jens Frederik, Kudsk, Karen, Andersen, Vibeke, Vind, Ida, Thorsgaard, Niels, Salupere, Riina, Olsen, Jóngerð, Nielsen, Kári Rubek, Oksanen, Pia, Collin, Pekka, Katsanos, Konstantinnos H, Christodoulou, Dimitrios K, Skamnelos, Alexandros, Politis, Dimitrios, Ladefoged, Karin, Lakatos, Peter Laszlo, Vegh, Zsuzsanna, Lakatos, Laszlo, Demenyi, Peterne, Kramli, Szabina Nemethne, O’Morain, Colm, Dal Piaz, Giualia, Santini, Alessia, Girardin, Giulia, D’Inca, Renata, Schwartz, Doron, Odes, Selwyn, Kupcinskas, Limas, Jonaitis, Laimas, Kiudelis, Gediminas, Valantiene, Irena, Zykus, Romanas, Kucinskiene, Ruta, Turcan, Svetlana, Barros, Louisa, Magro, Fernando, Lazar, Daniela, Goldis, Adrian, Nikulina, Inna, Belousova, Elena, Hernandez, Vicent, de Castro, Luisa, Pineda, Juan-Ramon, Pereira, Santos, Martinez-Cadilla, Jesus, Sanroman, Luciano, Figueira, Montserrat, Ares, David Martinez, Rodriguez-Prada, Jose-Ignacio, Fernandez, Alberto, Carmona, Amalia, Gonzalez-Portela, Carlos, Almer, Sven, Granberg, Lotta, Almer, Benoît, Halfvarson, Jonas, Widen, Ulla-Britt, Sebastian, Shaji, Myers, Sally, Ashton, Katherine, whitehead, Emma, and Arebi, Naila

Published
2017
Full Text
View/download PDF

44. Effectiveness and Safety of High-Dose Dual Therapy: Results of the European Registry on the Management of Helicobacterpylori Infection (Hp-EuReg)

Author

Fernández-Salazar, Luis, primary, Campillo, Ana, additional, Rodrigo, Luis, additional, Pérez-Aisa, Ángeles, additional, González-Santiago, Jesús, additional, Segarra Ortega, Xavier, additional, Denkovski, Maja, additional, Brglez Jurecic, Natasa, additional, Bujanda, Luis, additional, Gómez Rodríguez, Blas, additional, Ortuño, Juan, additional, Georgopoulos, Sotirios, additional, Jonaitis, Laimas, additional, Puig, Ignasi, additional, Nyssen, Olga P., additional, Megraud, Francis, additional, O’Morain, Colm, additional, and Gisbert, Javier P., additional

Published
2022
Full Text
View/download PDF

46. Experience with Rifabutin-Containing Therapy in 500 Patients from the European Registry on Helicobacter pylori Management (Hp-EuReg)

Author

Medicina, Medikuntza, Nyssen, Olga P., Vaira, Dino, Saracino, Ilaria Maria, Fiorini, Giulia, Caldas, María, Bujanda Fernández de Pierola, Luis, Pellicano, Rinaldo, Keco-Huerga, Alma, Pabón-Carrasco, Manuel, Oblitas Susanibar, Elida, Di Leo, Alfredo, Losurdo, Giuseppe, Pérez-Aísa, Ángeles, Gasbarrini, Antonio, Boltin, Doron, Smith, Sinead, Phull, Perminder, Rokkas, Theodore, Lamarque, Dominique, Cano-Català, Anna, Puig, Ignasi, Mégraud, Francis, O’Morain, Colm, Gisbert, Javier P, Medicina, Medikuntza, Nyssen, Olga P., Vaira, Dino, Saracino, Ilaria Maria, Fiorini, Giulia, Caldas, María, Bujanda Fernández de Pierola, Luis, Pellicano, Rinaldo, Keco-Huerga, Alma, Pabón-Carrasco, Manuel, Oblitas Susanibar, Elida, Di Leo, Alfredo, Losurdo, Giuseppe, Pérez-Aísa, Ángeles, Gasbarrini, Antonio, Boltin, Doron, Smith, Sinead, Phull, Perminder, Rokkas, Theodore, Lamarque, Dominique, Cano-Català, Anna, Puig, Ignasi, Mégraud, Francis, O’Morain, Colm, and Gisbert, Javier P

Abstract

Background: First-line Helicobacter pylori (H. pylori) treatments have been relatively well evaluated; however, it remains necessary to identify the most effective rescue treatments. Our aim was to assess the effectiveness and safety of H. pylori regimens containing rifabutin. METHODS: International multicentre prospective non-interventional European Registry on H. pylori Management (Hp-EuReg). Patients treated with rifabutin were registered in AEG-REDCap e-CRF from 2013 to 2021. Modified intention-to-treat and per-protocol analyses were performed. Data were subject to quality control. Results: Overall, 500 patients included in the Hp-EuReg were treated with rifabutin (mean age 52 years, 72% female, 63% with dyspepsia, 4% with peptic ulcer). Culture was performed in 63% of cases: dual resistance (to both clarithromycin and metronidazole) was reported in 46% of the cases, and triple resistance (to clarithromycin, metronidazole, and levofloxacin) in 39%. In 87% of cases rifabutin was utilised as part of a triple therapy together with amoxicillin and a proton-pump-inhibitor, and in an additional 6% of the patients, bismuth was added to this triple regimen. Rifabutin was mainly used in second-line (32%), third-line (25%), and fourth-line (27%) regimens, achieving overall 78%, 80% and 66% effectiveness by modified intention-to-treat, respectively. Compliance with treatment was 89%. At least one adverse event was registered in 26% of the patients (most frequently nausea), and one serious adverse event (0.2%) was reported in one patient with leukopenia and thrombocytopenia with fever requiring hospitalisation. Conclusion: Rifabutin-containing therapy represents an effective and safe strategy after one or even several failures of H. pylori eradication treatment.

Published
2022

47. Management of Helicobacter pylori infection: the Maastricht VI/Florence consensus report

Author

Malfertheiner, Peter, Megraud, Francis, Rokkas, Theodore, Gisbert, Javier P., Liou, Jyh-Ming, Schulz, Christian, Gasbarrini, Antonio, Hunt, Richard H., Leja, Marcis, O’Morain, Colm, Rugge, Massimo, Suerbaum, Sebastian, Tilg, Herbert, Sugano, Kentaro, El-Omar, Emad M., Agreus, L., Bazzoli, F, Bordin, D, Loginov, A.S., Mario, F. D., Dinis-Ribeiro, M., Engstrand, Lars, Fallone, C, Goh, K.L., Graham, David, Kuipers, E.J., Kupcinskas, J., Lanas, A., Machado, Jose C., Mahachai, V., Marshall, B.J., Milosavljevic, Tomica, Moss, S.F., Park, J.Y., Niv, Y., Rajilić-Stojanović, Mirjana, Ristimaki, A, Smith, S., Tepeš, Bojan, Wu, C.Y., Zhou, L., Malfertheiner, Peter, Megraud, Francis, Rokkas, Theodore, Gisbert, Javier P., Liou, Jyh-Ming, Schulz, Christian, Gasbarrini, Antonio, Hunt, Richard H., Leja, Marcis, O’Morain, Colm, Rugge, Massimo, Suerbaum, Sebastian, Tilg, Herbert, Sugano, Kentaro, El-Omar, Emad M., Agreus, L., Bazzoli, F, Bordin, D, Loginov, A.S., Mario, F. D., Dinis-Ribeiro, M., Engstrand, Lars, Fallone, C, Goh, K.L., Graham, David, Kuipers, E.J., Kupcinskas, J., Lanas, A., Machado, Jose C., Mahachai, V., Marshall, B.J., Milosavljevic, Tomica, Moss, S.F., Park, J.Y., Niv, Y., Rajilić-Stojanović, Mirjana, Ristimaki, A, Smith, S., Tepeš, Bojan, Wu, C.Y., and Zhou, L.

Abstract

elicobacter pylori Infection is formally recognised as an infectious disease, an entity that is now included in the International Classification of Diseases 11th Revision. This in principle leads to the recommendation that all infected patients should receive treatment. In the context of the wide clinical spectrum associated with Helicobacter pylori gastritis, specific issues persist and require regular updates for optimised management. The identification of distinct clinical scenarios, proper testing and adoption of effective strategies for prevention of gastric cancer and other complications are addressed. H. pylori treatment is challenged by the continuously rising antibiotic resistance and demands for susceptibility testing with consideration of novel molecular technologies and careful selection of first line and rescue therapies. The role of H. pylori and antibiotic therapies and their impact on the gut microbiota are also considered. Progress made in the management of H. pylori infection is covered in the present sixth edition of the Maastricht/ Florence 2021 Consensus Report, key aspects related to the clinical role of H. pylori infection were re-evaluated and updated. Forty-one experts from 29 countries representing a global community, examined the new data related to H. pylori infection in five working groups: (1) indications/associations, (2) diagnosis, (3) treatment, (4) prevention/gastric cancer and (5) H. pylori and the gut microbiota. The results of the individual working groups were presented for a final consensus voting that included all participants. Recommendations are provided on the basis of the best available evidence and relevance to the management of H. pylori infection in various clinical fields.

Published
2022

48. Empirical rescue treatment of Helicobacter pylori infection in third and subsequent lines: 8-year experience in 2144 patients from the European Registry on H. pylori management (Hp-EuReg)

Author

Burgos-Santamaría, Diego, Nyssen, Olga P, Gasbarrini, Antonio, Vaira, Dino, Pérez-Aisa, Ángele, Rodrigo, Luí, Pellicano, Rinaldo, Keco-Huerga, Alma, Pabón-Carrasco, Manuel, Castro-Fernandez, Manuel, Boltin, Doron, Barrio, Jesu, Phull, Perminder, Kupcinskas, Juoza, Jonaitis, Laima, Ortiz-Polo, Inmaculada, Tepes, Bojan, Lucendo, Alfredo J, Huguet, José María, Areia, Miguel, Jurecic, Natasa Brglez, Denkovski, Maja, Bujanda, Luí, Ramos-San Román, June, Cuadrado-Lavín, Antonio, Gomez-Camarero, Judith, Jiménez Moreno, Manuel Alfonso, Lanas, Angel, Martinez-Dominguez, Samuel Jesú, Alfaro, Enrique, Marcos-Pinto, Ricardo, Milivojevic, Vladimir, Rokkas, Theodore, Leja, Marci, Smith, Sinead, Tonkić, Ante, Buzás, György Mikló, Doulberis, Michael, Venerito, Marino, Lerang, Frode, Bordin, Dmitry S, Lamy, Vincent, Capelle, Lisette G, Marlicz, Wojciech, Dobru, Daniela, Gridnyev, Oleksiy, Puig, Ignasi, Mégraud, Franci, O'Morain, Colm, Gisbert, Javier P, Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Burgos-Santamaría, Diego, Nyssen, Olga P, Gasbarrini, Antonio, Vaira, Dino, Pérez-Aisa, Ángele, Rodrigo, Luí, Pellicano, Rinaldo, Keco-Huerga, Alma, Pabón-Carrasco, Manuel, Castro-Fernandez, Manuel, Boltin, Doron, Barrio, Jesu, Phull, Perminder, Kupcinskas, Juoza, Jonaitis, Laima, Ortiz-Polo, Inmaculada, Tepes, Bojan, Lucendo, Alfredo J, Huguet, José María, Areia, Miguel, Jurecic, Natasa Brglez, Denkovski, Maja, Bujanda, Luí, Ramos-San Román, June, Cuadrado-Lavín, Antonio, Gomez-Camarero, Judith, Jiménez Moreno, Manuel Alfonso, Lanas, Angel, Martinez-Dominguez, Samuel Jesú, Alfaro, Enrique, Marcos-Pinto, Ricardo, Milivojevic, Vladimir, Rokkas, Theodore, Leja, Marci, Smith, Sinead, Tonkić, Ante, Buzás, György Mikló, Doulberis, Michael, Venerito, Marino, Lerang, Frode, Bordin, Dmitry S, Lamy, Vincent, Capelle, Lisette G, Marlicz, Wojciech, Dobru, Daniela, Gridnyev, Oleksiy, Puig, Ignasi, Mégraud, Franci, O'Morain, Colm, Gisbert, Javier P, and Gasbarrini, Antonio (ORCID:0000-0002-7278-4823)

Abstract

Objective To evaluate the use, effectiveness and safety of Helicobacter pylori empirical rescue therapy in third and subsequent treatment lines in Europe. Design International, prospective, non-interventional registry of the clinical practice of European gastroenterologists. Data were collected and quality reviewed until October 2021 at Asociacion Espanola de Gastroenterologia-Research Electronic Data Capture. All cases with three or more empirical eradication attempts were assessed for effectiveness by modified intention-to-treat and per-protocol analysis. Results Overall, 2144 treatments were included: 1519, 439, 145 and 41 cases from third, fourth, fifth and sixth treatment lines, respectively. Sixty different therapies were used; the 15 most frequently prescribed encompassed > 90% of cases. Overall effectiveness remained < 90% in all therapies. Optimised treatments achieved a higher eradication rate than non-optimised (78% vs 67%, p < 0.0001). From 2017 to 2021, only 44% of treatments other than 10-day single-capsule therapy used high proton-pump inhibitor doses and lasted & GE;14 days. Quadruple therapy containing metronidazole, tetracycline and bismuth achieved optimal eradication rates only when prescribed as third-line treatment, either as 10-day single-capsule therapy (87%) or as 14-day traditional therapy with tetracycline hydrochloride (95%). Triple amoxicillin-levofloxacin therapy achieved 90% effectiveness in Eastern Europe only or when optimised. The overall incidence of adverse events was 31%. Conclusion Empirical rescue treatment in third and subsequent lines achieved suboptimal effectiveness in most European regions. Only quadruple bismuth-metronidazole-tetracycline (10-day single-capsule or 14-day traditional scheme) and triple amoxicillin-levofloxacin therapies reached acceptable outcomes in some settings. Compliance with empirical therapy optimisation principles is still poor 5 years after clinical practice guidelines update.

Published
2022

Catalog

Books, media, physical & digital resources
See catalog results