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9. Impact of the COVID-19 lockdown on the vitamin D status of people in the West of Ireland.

Author

O'Sullivan, Maria, Moran, Caoimhe, Griffin, Tomás P., Doheny, Helen, McCartney, Daniel MA., and O'Shea, Paula M.

Abstract

Objective: Identify the impact of COVID-19 lockdown restrictions on the vitamin D status of individuals in the west of Ireland. Design: Cross-sectional study. Setting: Adults who had wintertime serum 25(OH)D analysis completed in Galway University Hospital. Participants: A total of 16,725 participants (2015–2020 (n = 13,449) and 2020–2021 (n = 3276)). Baseline demographics; sex, age, origin of the sample and the date of sample collection. Results: Median serum vitamin D and serum vitamin D3 concentrations were higher in the 5-month period from October–February 2020–2021 (61 nmol/L (± 36–85 nmol/L) and 60 nmol/L (± 34–85 nmol/L)) respectively, than for the corresponding 5-month period (October–February) in 2015–2020 (53 nmol/L (± 32–78 nmol/L) and 51 nmol/L (± 30–77 nmol/L)) respectively. These changes coincided with a decline in the prevalence of deficiency. In the 5-month period October–February 2020–2021, 19.2% of the population were vitamin D deficient (< 30 nmol/L) compared to 22.5% in the corresponding 5-month period in 2015–2020, and 38.1% were vitamin D deficient (< 50 nmol/L) in the 5-month period October–February 2020–2021 compared to 46.6% in the corresponding 5-month period in 2015–2020. Males were more likely to be deficient at both thresholds (p < 0.001). For the total cohort, at the < 30 nmol/L threshold, inpatients (25.5%) and nursing home residents (34.1%) had higher prevalence of deficiency. Conclusions: Vitamin D levels were higher in the 5-month period of October–February 2020–2021, and this precipitated a decline in deficiency at both thresholds, indicating that lockdown coincided with enhanced vitamin D status. We postulate that it may be attributable to changes in diet and/or supplementation, or increased sun exposure, but further confirmatory studies are required. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Maintaining glucose integrity ex-vivo: Impact of preanalytical specimen handling.

Author

Islam, Md Nahidul, Lyons, Claire, Griffin, Tomas P, Hamon, Siobhan, Dunne, Fidelma P, and O'Shea, Paula M

Subjects
BLOOD sugar, GLUCOSE, GLUCOKINASE, GLYCOLYSIS
Abstract

Background: Adopting the WHO protocol for glucose analysis is arguably impractical in the routine clinical setting. Deviations may develop due to a lack of understanding regarding the impact of glycolysis on the accuracy of results. Aim: We sought to assess the stability of glucose in two different blood collection tubes (BCT), BD Vacutainer® FX 'Fl-Ox' and Greiner Vacuette® FC-Mix 'FC-Mix' stored at room temperature (RT:18–22°C) and 4°C over 8.5 days. Method: Each participant provided venous whole blood collected into 51 BCTs; 'Fl-Ox' (n = 26) and 'FC-Mix' (n = 25). One Fl-Ox sample from each participant was handled according to the WHO recommended method. The remaining BCTs were stored at 4°C/RT prior to analyses at designated study timepoints. Glucose was measured using the hexokinase assay on the Cobas® 8000 platform. Results: Participants (n = 8, Male = 2) were aged 24–56 years. Plasma glucose measured in FI-Ox BCTs according to the WHO sample-handling method had a median concentration of 5.73 mmol/L (Range: 5.39–10.37 mmol/L). Glucose decreased by greater than minimal difference (>0.26 mmol/L) in blood collected into Fl-Ox and stored @4°C/RT within 24 h of phlebotomy. FC-Mix BCT maintained glucose <0.26 mmol/L @4°C over a period of 8.5 days and up to 4 days @RT when compared to the WHO recommended method. Conclusion: Glucose in FC-Mix BCT stored @4°C demonstrated the best agreement with results determined using the WHO specifications. When FC-Mix tubes were stored @RT, glucose was stable for 4 days. These findings suggest that the FC-Mix BCT effectively inhibits glycolysis and should be introduced into routine clinical practice. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Follow-up at 1 year and beyond of women with gestational diabetes treated with insulin and/or oral glucose-lowering agents: a core outcome set using a Delphi survey

Author

Bogdanet, Delia, Reddin, Catriona, Macken, Esther, Griffin, Tomas P., Fhelelboom, Narjes, Biesty, Linda, Thangaratinam, Shakila, Dempsey, Eugene, Crowther, Caroline, Galjaard, Sander, Maresh, Michael, Loeken, Mary R., Napoli, Angela, Anastasiou, Eleni, Noctor, Eoin, de Valk, Harold W., van Poppel, Mireille N. M., Agostini, Andrea, Clarson, Cheril, Egan, Aoife M., O’Shea, Paula M., Devane, Declan, and Dunne, Fidelma P.

Published
2019
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15. The Role of Early Pregnancy Maternal pGCD59 Levels in Predicting Neonatal Hypoglycemia—Subanalysis of the DALI Study

Author

Bogdanet, Delia, Luque-Fernandez, Miguel Angel, Toth-Castillo, Michelle, Desoye, Gernot, O'Shea, Paula M, Dunne, Fidelma P, Halperin, Jose, A, Lapolla, A, and DALI Core Investigator Group

Subjects
Blood Glucose, Glycation, Epidemiology, Endocrinology, Diabetes and Metabolism, Biochemistry (medical), Clinical Biochemistry, Infant, Newborn, Infant, Glucose Tolerance Test, Biochemistry, Hypoglycemia, Infant, Newborn, Diseases, Biomarkers, Neonatal hypoglycaemia, Prediction, Diabetes, Gestational, Fetal Diseases, Endocrinology, Pregnancy, Humans, Female
Abstract

Context Neonatal hypoglycaemia (NH) is the most common metabolic problem in infants born of mothers with gestational diabetes. Plasma glycated CD59 (pGCD59) is an emerging biomarker that has shown potential in identifying women at risk of developing gestational diabetes. The aim of this study was to assess the association between early maternal levels of pGCD59 and NH. Objective The aim of this study was to assess the association between early pregnancy maternal levels of plasma glycated CD59 (pGCD59) and neonatal hypoglycemia (NH). Methods This is an observational study of pregnant women with a prepregnancy body mass index (BMI) greater than or equal to 29 screened for eligibility to participate in the Vitamin D and Lifestyle Intervention for Gestational Diabetes (DALI) trial. This analysis included 399 pregnancies. Levels of pGCD59 were measured in fasting maternal samples taken at the time of a 75-g, 2-hour oral glucose tolerance test performed in early pregnancy ( Results We identified 30 infants with NH. Maternal levels of pGCD59 in early pregnancy were positively associated with the prevalence of NH (one-way analysis of variance, P Conclusion Although pGCD59 levels in early pregnancy in women with BMI greater than or equal to 29 are associated with NH, our results indicate that this biomarker by itself is only a fair predictor of NH.

Published
2022

17. Sublethal Hyperthermia Transiently Disrupts Cortisol Steroidogenesis in Adrenocortical Cells

Author

Mullen, Nathan, primary, Donlon, Padraig T, additional, Sebek, Jan, additional, Duffy, Katen, additional, Cappiello, Grazia, additional, Feely, Sarah, additional, Warde, Kate M, additional, Harhen, Brendan, additional, Finn, David P, additional, O'Shea, Paula M, additional, Prakash, Punit, additional, O’Halloran, Martin, additional, and Dennedy, Michael C, additional

Published
2023
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19. Major disparities in patient‐reported adherence compared to objective assessment of adherence using mass spectrometry: A prospective study in a tertiary‐referral hypertension clinic.

Author

Curneen, James M. G., Rabbitt, Louise, Browne, Darragh, O'Donoghue, Darragh F., Alansari, Yousef, Harhen, Brendan, Ní Ghríofa, Ailbhe, Ferguson, John, McEvoy, John William, Lappin, David, Finn, David P., O'Shea, Paula M., and Dennedy, Michael Conall

Subjects
LIQUID chromatography-mass spectrometry, MASS spectrometry, ANGIOTENSIN-receptor blockers, ELECTRONIC surveillance, PATIENT compliance, LONGITUDINAL method
Abstract

Aim: Many challenges exist in determining true rates of adherence to antihypertensive medications among individuals in a clinic setting. For the first time, we aimed to compare patient‐reported antihypertensive adherence with objective evidence using mass spectrometry spot urinalysis in a tertiary referral clinic setting. Methods: A prospective observational single‐centre cohort study was performed in a tertiary referral hypertension clinic, encompassing antihypertensive initiation and persistence. Patients were referred with apparent treatment‐resistant hypertension or for suspected secondary causes. Participants completed a self‐reported assessment of antihypertensive adherence and provided a spot urine sample. The presence of antihypertensive medications and/or their respective metabolites was evaluated using high‐performance liquid chromatography tandem mass spectrometry. Patients were determined to be adherent if they demonstrated both self‐reported adherence and objective mass spectrometry evidence. Results: Of all 105 eligible participants initially recruited, 73 (69.5%) met the eligibility criteria. Only 27.4% (95% confidence interval 0.2‐0.4) of participants demonstrated true adherence to their self‐reported antihypertensives, despite 75.3% (0.6‐0.8) reporting adherence. Greatest medication adherence was achieved with angiotensin II receptor blockers (61%), with calcium‐channel blockers and mineralocorticoid antagonists demonstrating least adherence (38%). Conclusion: In patients attending a tertiary hypertension clinic, the combined use of spot urine mass spectrometry and self‐reporting identifies higher rates of nonadherence when compared to either modality alone. Both techniques should be combined for more accurate detection of medication adherence. [ABSTRACT FROM AUTHOR]

Published
2023
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21. Reference intervals for clinical biochemistry and haematology tests during normal pregnancy

Author

Groenendijk, Wendy, primary, Bogdanet, Delia, additional, Dervan, Louise, additional, Finn, Oisin, additional, Islam, Md Nahidul, additional, Doheny, Helen, additional, Griffin, Tomás P., additional, Blake, Liam, additional, Lyons, Mark, additional, Kilcooley, Mary, additional, Krawczyk, Janusz, additional, Gilmore, Ruth, additional, Griffin, Damian G., additional, Gaffney, Geraldine, additional, Dunne, Fidelma P., additional, and O’Shea, Paula M., additional

Published
2022
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22. The Diagnostic Accuracy of Second Trimester Plasma Glycated CD59 (pGCD59) to Identify Women with Gestational Diabetes Mellitus Based on the 75 g OGTT Using the WHO Criteria: A Prospective Study of Non-Diabetic Pregnant Women in Ireland

Author

Bogdanet, Delia, primary, Toth Castillo, Michelle, additional, Doheny, Helen, additional, Dervan, Louise, additional, Luque-Fernandez, Miguel-Angel, additional, Halperin, Jose A., additional, O’Shea, Paula M., additional, and Dunne, Fidelma P., additional

Published
2022
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24. Major disparities in patient‐reported adherence compared to objective assessment of adherence using mass spectrometry: A prospective study in a tertiary‐referral hypertension clinic

Author

Curneen, James M. G., primary, Rabbitt, Louise, additional, Browne, Darragh, additional, O'Donoghue, Darragh F., additional, Alansari, Yousef, additional, Harhen, Brendan, additional, Ní Ghríofa, Ailbhe, additional, Ferguson, John, additional, McEvoy, John William, additional, Lappin, David, additional, Finn, David P., additional, O'Shea, Paula M., additional, and Dennedy, Michael Conall, additional

Published
2022
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27. Effects of a Milk-Based Meal Replacement Program on Weight and Metabolic Characteristics in Adults with Severe Obesity

Author

Rafey, Mohammed F, Murphy, Conor F, Abdalgwad, Razk, Kilkelly, Katriona, Griffin, Helena, Beatty, Niamh, O’Shea, Paula M, Collins, Chris, McGrath, Robert, Hynes, Mary, Davenport, Colin, O’Donnell, Martin, and Finucane, Francis M

Subjects
obesity treatment, milk, lifestyle modification, type 2 diabetes, hypocaloric diet, Targets and Therapy [Diabetes, Metabolic Syndrome and Obesity], Original Research
Abstract

Mohammed F Rafey,1,2,* Conor F Murphy,1,2,* Razk Abdalgwad,1,2 Katriona Kilkelly,1 Helena Griffin,1 Niamh Beatty,1 Paula M O’Shea,3 Chris Collins,2,4 Robert McGrath,1 Mary Hynes,1 Colin Davenport,1,2 Martin O’Donnell,2 Francis M Finucane1,2 1Bariatric Medicine Service, Centre for Diabetes, Endocrinology and Metabolism, Galway University Hospitals, Galway, Ireland; 2HRB Clinical Research Facility, National University of Ireland, Galway, Ireland; 3Department of Clinical Biochemistry, Galway University Hospitals, Galway, Ireland; 4Department of Surgery, Galway University Hospitals, Galway, Ireland*These authors contributed equally to this workCorrespondence: Francis M FinucaneBariatric Medicine Service, Centre for Diabetes, Endocrinology and Metabolism, Galway University Hospital, Galway, IrelandTel +353 91 542711Email francis.finucane@hse.ieObjective: Low energy meal replacement regimens can induce short-term weight loss in patients with severe obesity, but usually require specially formulated dietary supplements. We sought to determine the effects of a milk-based meal replacement program on anthropometric and metabolic characteristics in adults with severe obesity.Methods: We conducted a retrospective cohort study of patients attending our hospital-based bariatric medicine service who completed a 24-week program consisting of eight weeks of milk-based meal replacement followed by weight stabilisation and maintenance phases. Patients were seen fortnightly by the bariatric physician, nurse and dietitian. We assessed changes in anthropometric and metabolic outcomes in completers at 0, 8, 16 and 24 weeks.Results: Of 105 program completers available for follow-up, 53.3% were female. Mean age was 51.1± 11.2 years. Body weight decreased from 144.0± 27.6 kg at baseline to 121.1± 25.0 kg at 24 weeks (P< 0.001), a mean total body weight loss of 15.9± 6.0%, with a reduction in body mass index from 50.6± 8.0 to 42.6± 7.6 kg m− 2 (P< 0.001). In patients with diabetes, haemoglobin A1c decreased from 66.3± 13.0 to 48.3± 13.5 mmol/mol (P< 0.001) and diabetes medication use decreased significantly. There were significant improvements also in lipid profiles and reductions in antihypertensive medication use.Conclusion: These preliminary findings suggest that completion of a 24-week milk-based meal replacement program has large effects on important outcomes in adults with severe obesity. However, attrition was high. Prospective assessment of the efficacy, safety, durability and cost-effectiveness of this intervention seems warranted.Keywords: hypocaloric diet, milk, lifestyle modification, obesity treatment, type 2 diabetes

Published
2020

31. Burden of chronic kidney disease and rapid decline in renal function among adults attending a hospital-based diabetes center in Northern Europe

Author

Griffin, Tomás P, primary, O'Shea, Paula M, additional, Smyth, Andrew, additional, Islam, Md Nahidul, additional, Wall, Deirdre, additional, Ferguson, John, additional, O'Sullivan, Esther, additional, Finucane, Francis M, additional, Dinneen, Sean F, additional, Dunne, Fidelma P, additional, Lappin, David W, additional, Reddan, Donal N, additional, Bell, Marcia, additional, O'Brien, Timothy, additional, Griffin, Damian G, additional, and Griffin, Matthew D, additional

Published
2021
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32. Remote capillary blood collection for HbA1c measurement during the COVID‐19 pandemic: A laboratory and patient perspective.

Author

Groenendijk, Wendy N., Griffin, Tomás P., Islam, Md N., Blake, Liam, Wall, Deirdre, Bell, Marcia, and O'Shea, Paula M.

Subjects
GLYCOSYLATED hemoglobin, STATISTICS, PATHOLOGY, CAPILLARIES, CROSS-sectional method, BLOOD collection, REGRESSION analysis, PATIENTS' attitudes, QUESTIONNAIRES, DESCRIPTIVE statistics, DATA analysis, COVID-19 pandemic, TELEMEDICINE
Abstract

Aims: The purpose of this study was to assess the clinical performance and user acceptance of capillary blood samples prepared remotely using the MiniCollect® capillary blood collection device as an alternative to blood collection by venepuncture for glycated haemoglobin (HbA1c) analysis. Methods: Following written informed consent, a cross‐sectional study was conducted in individuals aged ≥18 years with any type of diabetes who routinely self‐monitor their blood glucose. Eligible participants recruited whilst attending their routine clinical appointments were required to provide a venous blood sample, prepare a capillary blood sample at home (remotely) and complete a bespoke questionnaire. HbA1c in whole blood collected in ethylenediaminetetraacetic acid was determined by capillary electrophoresis on the Sebia Capillary's 3 Tera analyser following standard operating procedure. Results: HbA1c results from both venous and capillary collection demonstrated good agreement. Passing‐Bablok regression: y = 0 + 1x (p = 0.18), Spearman correlation r = 0.986, p < 0.0001. The Bland–Altman difference plot provided a mean difference of 0.3 mmol/mol (2.2%). Over half of the participants found the MiniCollect device easy to use. The majority of participants were in favour of the remote capillary blood collection service and would use it if routinely available. Conclusion: The home collection of capillary blood for HbA1c determination is a valuable and convenient alternative to standard venous blood collection as it provides an opportunity to support routine HbA1c monitoring, whilst mitigating the transmission of SARS‐CoV‐2. This service would additionally allow individuals to attend clinic visits with a HbA1c value, ensuring optimal continuance of patient care for individuals with diabetes. [ABSTRACT FROM AUTHOR]

Published
2022
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45. Biallelic CYP24A1 variants presenting during pregnancy: clinical and biochemical phenotypes

Author

Griffin, Tomás P, primary, Joyce, Caroline M, additional, Alkanderi, Sumaya, additional, Blake, Liam M, additional, O’Keeffe, Derek T, additional, Bogdanet, Delia, additional, Islam, Md Nahidul, additional, Dennedy, Michael C, additional, Gillan, John E, additional, Morrison, John J, additional, O’Brien, Timothy, additional, Sayer, John A, additional, Bell, Marcia, additional, and O’Shea, Paula M, additional

Published
2020
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50. Senescence marker activin A is increased in human diabetic kidney disease: association with kidney function and potential implications for therapy

Author

Bian, Xiaohui, primary, Griffin, Tomás P, additional, Zhu, Xiangyang, additional, Islam, Md Nahidul, additional, Conley, Sabena M, additional, Eirin, Alfonso, additional, Tang, Hui, additional, O’Shea, Paula M, additional, Palmer, Allyson K, additional, McCoy, Rozalina G, additional, Herrmann, Sandra M, additional, Mehta, Ramila A, additional, Woollard, John R, additional, Rule, Andrew D, additional, Kirkland, James L, additional, Tchkonia, Tamar, additional, Textor, Stephen C, additional, Griffin, Matthew D, additional, Lerman, Lilach O, additional, and Hickson, LaTonya J, additional

Published
2019
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