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Additional file 1. Animal procedure schematic. Animals under anaesthesia received intratracheally an E.Coli culture dose establishing the lung injury. One hour later and still under anaesthesia, animals were ventilated using a Flexivent ventilator and EVs or vehicle were delivered using an Aerogen nebuliser connected to the ventilator by a specific module. The system was controlled by a computer allowing to control the delivery internal, and nebulising EVs only in the inspiratory phase to the experimental animals. After this procedure, animals were allowed to recover for the following 48 hours. Finally, animals under anaesthesia were cannulated gaining arterial access and mechanically ventilated to collect different samples such as blood and measure physiological parameters before animals were euthanized.

This dissertation provides a comprehensive interpretation of the Greater Hippias, Plato’s dialogue on nobility and beauty. It helps shed light on a crucial dimension of Plato’s political philosophy, for according to him, nobility and beauty are among the most important yet contentious aspects of moral, political, and religious life. In the course of interpreting the Greater Hippias, the dissertation seeks to clarify how Plato understands the nature and character of nobility and beauty and the various ways in which they hold meaning and relevance for our individual and political lives. This requires tracing his analysis of what all is implied in the conventional conception of nobility and beauty and the natural basis of our attachment to it. The dissertation concludes, first of all, that the Greater Hippias shows that the kind of nobility that seems most impressive to us serves the common good and is rooted in what conventional and lawful political orders honor and praise most highly. Second, it shows how nobility and beauty promise to satisfy the soul’s longing for the transcendent and the divine. Third, it shows that nobility must ultimately be understood in terms of the good, and especially in terms of the beneficial and the pleasant, but that men resist understanding nobility in those terms. Hence the dissertation uncovers the core of the tension between the conventional understanding of nobility and a rational understanding of nobility—or between what seems noblest to us and what’s actually good for us.

The turtle Angolachelys mbaxi Mateus et al., 2009, is an enigmatic turtle from the Late Cretaceous of Angola which in its description it was erected a new clade, the Angolachelonia Mateus et al., 2009. The phylogenetic position of Angolachelys and Angolachelonia has been questioned and reviewed multiple times since their definition. The new specimen of Angolachelys mbaxi, collected from the same locality as the holotype, consists of postcranial material and a skull, which will not be described in this thesis. The postcranial material is described and studied in this thesis, with the objective of reviewing and ascribing the phylogenetic position of Angolachelys and confirming the validity of Angolachelonia as a clade, to confirm if Angolachelys and the Angolachelonia were in fact of the marine ecology, and therefore suggesting the existence of an evolutionary transition to the marine habit by the Angolachelonia. The paleoecology of Angolachelys mbaxi is studied, namely in respect to the adaptations of its feeding habits. Angolachelys and the Angolachelonia were found in multiple phylogenetic positions, the most prevalent being found as the sister taxon of the Chelonioidea. Angolachelys has been defined as a marine turtle, with features indicative of a more pelagic lifestyle A tartaruga Angolachelys mbaxi Mateus et al., 2009, é uma tartaruga enigmática do Cretáceo Superior de Angola que na sua descrição foi erigida um novo clado, a Angolachelonia. A posição filogenética de Angolachelys e Angolachelonia foi questionada e revista várias vezes desde a sua definição. O novo espécime de Angolachelys mbaxi, recolhido na mesma localidade do holótipo, constituído por material pós-craniano é descrito e estudado nesta tese, com o objetivo de rever e atribuir a posição filogenética de Angolachelys e confirmar a validade de Angolachelonia como clado, confirmar se Angolachelys e a Angolachelonia eram de facto da ecologia marinha, sugerindo assim a existência de uma transição evolutiva para o hábito marinho pela Angolachelonia. É estudada a paleoecologia de Angolachelys mbaxi, nomeadamente no que diz respeito às adaptações dos seus hábitos alimentares. Angolachelys e Angolachelonia foram encontrados em várias posições filogenéticas, a mais prevalente sendo encontrada como o táxon irmão de Chelonioidea. Angolachelys foi definida como uma tartaruga marinha, com características indicativas de um estilo de vida mais pelágico.

This manuscript aims to outline the pertinent epidemiology, presentation, diagnosis, and treatment of patients who present with breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) as it pertains to primary care, such that the primary care physician (PCP) is able to appropriately care for patients with breast implants and counsel on risks of BIA-ALCL.