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8. Preface

Author

O'Hehir, Robyn E., primary, Holgate, Stephen T., additional, Sheikh, Aziz, additional, and Hershey, Gurjit K. Khurana, additional

Published
2022
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9. Contributors

Author

Akdis, Cezmi A., primary, Akdis, Mübeccel, additional, Baroody, Fuad M., additional, Boguniewicz, Mark, additional, Brown, Simon G.A., additional, Burks, A. Wesley, additional, Chiriac, Anca-Mirela, additional, Corren, Jonathan, additional, Custovic, Adnan, additional, Demoly, Pascal, additional, Fonacier, Luz, additional, Golden, David B.K., additional, Grattan, Clive E.H., additional, Hausmann, Oliver V., additional, Khurana Hershey, Gurjit K., additional, Holgate, Stephen T., additional, Joerg, Lukas, additional, Lemière, Catherine, additional, Leung, Donald Y.M., additional, Mersha, Tesfaye B., additional, Nowak-Węgrzyn, Anna, additional, O'Hehir, Robyn E., additional, Robinson, Clive, additional, Sahiner, Umit, additional, Saini, Sarbjit S., additional, Sampson, Hugh A., additional, Sheikh, Aziz, additional, Sherenian, Michael G., additional, Smith, Helen E., additional, Stewart, Geoffrey A., additional, Suojalehto, Hille, additional, and Turner, Paul J., additional

Published
2022
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12. Phase 1 trial supports safety and mechanism of action of peptide immunotherapy for peanut allergy.

Author

Voskamp, Astrid L., Khosa, Sugandhika, Phan, Tracy, DeBerg, Hannah A., Bingham, Judy, Hew, Mark, Smith, William, Abramovitch, Jodie, Rolland, Jennifer M., Moyle, Matthew, Nadeau, Kari C., Lack, Gideon, Larché, Mark, Wambre, Erik, O'Hehir, Robyn E., Hickey, Pascal, and Prickett, Sara R.

Subjects
PEANUT allergy, PEPTIDES, FOOD allergy, ALLERGIES, IMMUNOTHERAPY, ALLERGENS, IMMUNOGLOBULIN E
Abstract

Background: Food allergy is a leading cause of anaphylaxis worldwide. Allergen‐specific immunotherapy is the only treatment shown to modify the natural history of allergic disease, but application to food allergy has been hindered by risk of severe allergic reactions and short‐lived efficacy. Allergen‐derived peptides could provide a solution. PVX108 comprises seven short peptides representing immunodominant T‐cell epitopes of major peanut allergens for treatment of peanut allergy. Methods: Pre‐clinical safety of PVX108 was assessed using ex vivo basophil activation tests (n = 185). Clinical safety and tolerability of single and repeat PVX108 doses were evaluated in a first‐in‐human, randomized, double‐blind, placebo‐controlled trial in peanut‐allergic adults (46 active, 21 placebo). The repeat‐dose cohort received six doses over 16 weeks with safety monitored to 21 weeks. Exploratory immunological analyses were performed at pre‐dose, Week 21 and Month 18 after treatment. Results: PVX108 induced negligible activation of peanut‐sensitised basophils. PVX108 was safe and well tolerated in peanut‐allergic adults. There were no treatment‐related hypersensitivity events or AEs of clinical concern. The only events occurring more frequently in active than placebo were mild injection site reactions. Exploratory immunological analyses revealed a decrease in the ratio of ST2+ Th2A:CCR6+ Th17‐like cells within the peanut‐reactive Th pool which strengthened following treatment. Conclusion: This study supports the concept that PVX108 could provide a safe alternative to whole peanut immunotherapies and provides evidence of durable peanut‐specific T‐cell modulation. Translation of these findings to clinical efficacy in ongoing Phase 2 trials would provide important proof‐of‐concept for using peptides to treat food allergy. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Third dose COVID-19 mRNA vaccine enhances IgG4 isotype switching and recognition of Omicron subvariants by memory B cells after with mRNA but not adenovirus priming

Author

Hartley, Gemma E., primary, Fryer, Holly A., additional, Gill, Paul A., additional, Boo, Irene, additional, Bornheimer, Scott J., additional, Hogarth, P. Mark, additional, Drummer, Heidi E., additional, O'Hehir, Robyn E., additional, Edwards, Emily S.J., additional, and van Zelm, Menno C., additional

Published
2023
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17. A recent patent in allergy & immunology: Biomarkers on allergen‐specific memory B cells to predict allergen immunotherapy outcome.

Author

Zelm, Menno C., O'Hehir, Robyn E., and McKenzie, Craig I.

Subjects
*ALLERGY desensitization, *IMMUNOLOGIC memory, *BIOMARKERS, *ALLERGIES, *IMMUNOLOGY, *AUTOBIOGRAPHICAL memory, *URTICARIA
Abstract

This article discusses a recent patent in allergy and immunology that focuses on biomarkers on allergen-specific memory B cells to predict the outcome of allergen immunotherapy (AIT). Allergic diseases are common and can have a wide range of symptoms, and AIT is the only disease-modifying treatment available. The patent covers the detection of changes in specific surface proteins on allergen-specific B cells as biomarkers for successful AIT outcome. The study found that the expression of CD23, CD29, and CD124 on allergen-specific B cells can be used as prognostic biomarkers for AIT effects after 2-4 months of treatment. These biomarkers can provide valuable information for treatment optimization and can be used in clinical trials for new treatments or treatment combinations. The article also discusses the functional relevance of these proteins and their potential role in desensitization. [Extracted from the article]

Published
2024
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19. Mobile technology offers novel insights into the control and treatment of allergic rhinitis: The MASK study

Author

Bédard, Annabelle, Basagaña, Xavier, Anto, Josep M., Garcia-Aymerich, Judith, Devillier, Philippe, Arnavielhe, Sylvie, Bedbrook, Anna, Onorato, Gabrielle L., Czarlewski, Wienczyslawa, Murray, Ruth, Almeida, Rute, Fonseca, Joao, Costa, Elisio, Malva, Joao, Morais-Almeida, Mario, Pereira, Ana Margarida, Todo-Bom, Ana, Menditto, Enrica, Stellato, Cristiana, Ventura, Maria Teresa, Cruz, Alvaro A., Stelmach, Rafaël, da Silva, Jane, Larenas-Linnemann, Désirée, Fuentes-Pérez, José M., Huerta-Villalobos, Yunuen R., Emuzyte, Regina, Kvedariene, Violeta, Valiulis, Arunas, Kuna, Piotr, Samolinski, Boleslaw, Klimek, Ludger, Mösges, Ralph, Pfaar, Oliver, Shamai, Sara, Annesi-Maesano, Isabelle, Bosse, Isabelle, Demoly, Pascal, Fontaine, Jean-François, Cardona, Vicky, Mullol, Joaquim, Valero, Antonio, Roller-Wirnsberger, Regina E., Tomazic, Peter Valentin, Chavannes, Niels H., Fokkens, Wytske J., Reitsma, Sietze, Bewick, Mike, Ryan, Dermot, Sheikh, Aziz, Haahtela, Tari, Toppila-Salmi, Sanna, Valovirta, Erkka, Makris, Michael, Papadopoulos, Nikos G., Prokopakis, Emmanuel P., Psarros, Fotis, Cingi, Cemal, Gemicioğlu, Bilun, Yorgancioglu, Arzu, Bosnic-Anticevich, Sinthia, O'Hehir, Robyn E., Bachert, Claus, Hellings, Peter W., Pugin, Benoit, Bindslev-Jensen, Carsten, Eller, Esben, Kull, Ingrid, Melén, Erik, Wickman, Magnus, De Vries, Gert, van Eerd, Michiel, Agache, Ioana, Ansotegui, Ignacio J., Dykewicz, Mark S., Casale, Thomas, Wallace, Dana, Waserman, Susan, Laune, Daniel, and Bousquet, Jean

Published
2019
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20. Mind the gaps: Clinical trial concepts to address unanswered questions in aeroallergen immunotherapy—An NIAID/AHRQ Workshop

Author

Wheatley, Lisa M., Wood, Robert, Nadeau, Kari, Liu, Andrew, Zoratti, Edward, Bacharier, Leonard, Brittain, Erica, Calderon, Moises, Casale, Thomas, Chipps, Bradley, Cox, Linda, Creticos, Peter S., Desai, Manisha, Dreborg, Sten, Durham, Stephen, Gergen, Peter J., Gruchalla, Rebecca, Nelson, Harold, O'Hehir, Robyn E., Plaut, Marshall, Schwaninger, Julie M., Tilles, Stephen, Vickery, Brian, Wittenberg, Kim M., and Togias, Alkis

Published
2019
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21. Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018): Change management in allergic rhinitis and asthma multimorbidity using mobile technology

Author

Bousquet, J., Hellings, P.W., Aberer, W., Agache, I., Akdis, C.A., Akdis, M., Alberti, M.R., Almeida, R., Amat, F., Angles, R., Annesi-Maesano, I., Ansotegui, I.J., Anto, J.M., Arnavielle, S., Asayag, E., Asarnoj, A., Arshad, H., Avolio, F., Bacci, E., Bachert, C., Baiardini, I., Barbara, C., Barbagallo, M., Baroni, I., Barreto, B.A., Basagana, X., Bateman, E.D., Bedolla-Barajas, M., Bedbrook, A., Bewick, M., Beghé, B., Bel, E.H., Bergmann, K.C., Bennoor, K.S., Benson, M., Bertorello, L., Białoszewski, A.Z., Bieber, T., Bialek, S., Bindslev-Jensen, C., Bjermer, L., Blain, H., Blasi, F., Blua, A., Bochenska Marciniak, M., Bogus-Buczynska, I., Boner, A.L., Bonini, M., Bonini, S., Bosnic-Anticevich, C.S., Bosse, I., Bouchard, J., Boulet, L.P., Bourret, R., Bousquet, P.J., Braido, F., Briedis, V., Brightling, C.E., Brozek, J., Bucca, C., Buhl, R., Buonaiuto, R., Panaitescu, C., Burguete Cabañas, M.T., Burte, E., Bush, A., Caballero-Fonseca, F., Caillot, D., Caimmi, D., Calderon, M.A., Camargos, P.A.M., Camuzat, T., Canfora, G., Canonica, G.W., Cardona, V., Carlsen, K.H., Carreiro-Martins, P., Carriazo, A.M., Carr, W., Cartier, C., Casale, T., Castellano, G., Cecchi, L., Cepeda Sarabia, A.M., Chavannes, N.H., Chen, Y., Chiron, R., Chivato, T., Chkhartishvili, E., Chuchalin, A.G., Chung, K.F., Ciaravolo, M.M., Ciceran, A., Cingi, C., Ciprandi, G., Carvalho Coehlo, A.C., Colas, L., Colgan, E., Coll, J., Conforti, D., Correia de Sousa, J., Cortés-Grimaldo, R.M., Corti, F., Costa, E., Costa-Dominguez, M.C., Courbis, A.L., Cox, L., Crescenzo, M., Cruz, A.A., Custovic, A., Czarlewski, W., Dahlen, S.E., Dario, C., da Silva, J., Dauvilliers, Y., Darsow, U., De Blay, F., De Carlo, G., Dedeu, T., de Fátima Emerson, M., De Feo, G., De Vries, G., De Martino, B., de Paula Motta Rubini, N., Deleanu, D., Demoly, P., Denburg, J.A., Devillier, P., Di Capua Ercolano, S., Di Carluccio, N., Didier, A., Dokic, D., Dominguez-Silva, M.G., Douagui, H., Dray, G., Dubakiene, R., Durham, S.R., Du Toit, G., Dykewicz, M.S., El-Gamal, Y., Eklund, P., Eller, E., Emuzyte, R., Farrell, J., Farsi, A., Ferreira de Mello, J., Jr., Ferrero, J., Fink-Wagner, A., Fiocchi, A., Fokkens, W.J., Fonseca, J.A., Fontaine, J.F., Forti, S., Fuentes-Perez, J.M., Gálvez-Romero, J.L., Gamkrelidze, A., Garcia-Aymerich, J., García-Cobas, C.Y., Garcia-Cruz, M.H., Gemicioğlu, B., Genova, S., George, C., Gereda, J.E., Gerth van Wijk, R., Gomez, R.M., Gómez-Vera, J., González Diaz, S., Gotua, M., Grisle, I., Guidacci, M., Guldemond, N.A., Gutter, Z., Guzmán, M.A., Haahtela, T., Hajjam, J., Hernández, L., Hourihane, J.O.'B., Huerta-Villalobos, Y.R., Humbert, M., Iaccarino, G., Illario, M., Ivancevich, J.C., Jares, E.J., Jassem, E., Johnston, S.L., Joos, G., Jung, K.S., Jutel, M., Kaidashev, I., Kalayci, O., Kalyoncu, A.F., Karjalainen, J., Kardas, P., Keil, T., Keith, P.K., Khaitov, M., Khaltaev, N., Kleine-Tebbe, J., Klimek, L., Kowalski, M.L., Kuitunen, M., Kull, I., Kuna, P., Kupczyk, M., Kvedariene, V., Krzych-Fałta, E., Lacwik, P., Larenas-Linnemann, D., Laune, D., Lauri, D., Lavrut, J., Le, L.T.T., Lessa, M., Levato, G., Li, J., Lieberman, P., Lipiec, A., Lipworth, B., Lodrup Carlsen, K.C., Louis, R., Lourenço, O., Luna-Pech, J.A., Maciej, K., Magnan, A., Mahboub, B., Maier, D., Mair, A., Majer, I., Malva, J., Mandajieva, E., Manning, P., De Manuel Keenoy, E., Marshall, G.D., Masjedi, M.R., Maspero, J.F., Mathieu-Dupas, E., Matta Campos, J.J., Matos, A.L., Maurer, M., Mavale-Manuel, S., Mayora, O., Medina-Avalos, M.A., Melén, E., Melo-Gomes, E., Meltzer, E.O., Menditto, E., Mercier, J., Miculinic, N., Mihaltan, F., Milenkovic, B., Moda, G., Mogica-Martinez, M.D., Mohammad, Y., Momas, I., Montefort, S., Monti, R., Mora Bogado, D., Morais-Almeida, M., Morato-Castro, F.F., Mösges, R., Mota-Pinto, A., Moura Santo, P., Mullol, J., Münter, L., Muraro, A., Murray, R., Naclerio, R., Nadif, R., Nalin, M., Napoli, L., Namazova-Baranova, L., Neffen, H., Niedeberger, V., Nekam, K., Neou, A., Nieto, A., Nogueira-Silva, L., Nogues, M., Novellino, E., Nyembue, T.D., O'Hehir, R.E., Odzhakova, C., Ohta, K., Okamoto, Y., Okubo, K., Onorato, G.L., Ortega Cisneros, M., Ouedraogo, S., Pali-Schöll, I., Palkonen, S., Panzner, P., Papadopoulos, N.G., Park, H.S., Papi, A., Passalacqua, G., Paulino, E., Pawankar, R., Pedersen, S., Pépin, J.L., Pereira, A.M., Persico, M., Pfaar, O., Phillips, J., Picard, R., Pigearias, B., Pin, I., Pitsios, C., Plavec, D., Pohl, W., Popov, T.A., Portejoie, F., Potter, P., Pozzi, A.C., Price, D., Prokopakis, E.P., Puy, R., Pugin, B., Pulido Ross, R.E., Przemecka, M., Rabe, K.F., Raciborski, F., Rajabian-Soderlund, R., Reitsma, S., Ribeirinho, I., Rimmer, J., Rivero-Yeverino, D., Rizzo, J.A., Rizzo, M.C., Robalo-Cordeiro, C., Rodenas, F., Rodo, X., Rodriguez Gonzalez, M., Rodriguez-Mañas, L., Rolland, C., Rodrigues Valle, S., Roman Rodriguez, M., Romano, A., Rodriguez-Zagal, E., Rolla, G., Roller-Wirnsberger, R.E., Romano, M., Rosado-Pinto, J., Rosario, N., Rottem, M., Ryan, D., Sagara, H., Salimäki, J., Samolinski, B., Sanchez-Borges, M., Sastre-Dominguez, J., Scadding, G.K., Schunemann, H.J., Scichilone, N., Schmid-Grendelmeier, P., Serpa, F.S., Shamai, S., Sheikh, A., Sierra, M., Simons, F.E.R., Siroux, V., Sisul, J.C., Skrindo, I., Solé, D., Somekh, D., Sondermann, M., Sooronbaev, T., Sova, M., Sorensen, M., Sorlini, M., Spranger, O., Stellato, C., Stelmach, R., Stukas, R., Sunyer, J., Strozek, J., Szylling, A., Tebyriçá, J.N., Thibaudon, M., To, T., Todo-Bom, A., Tomazic, P.V., Toppila-Salmi, S., Trama, U., Triggiani, M., Suppli Ulrik, C., Urrutia-Pereira, M., Valenta, R., Valero, A., Valiulis, A., Valovirta, E., van Eerd, M., van Ganse, E., van Hague, M., Vandenplas, O., Ventura, M.T., Vezzani, G., Vasankari, T., Vatrella, A., Verissimo, M.T., Viart, F., Viegi, M., Vicheva, D., Vontetsianos, T., Wagenmann, M., Walker, S., Wallace, D., Wang, D.Y., Waserman, S., Werfel, T., Westman, M., Wickman, M., Williams, D.M., Williams, S., Wilson, N., Wright, J., Wroczynski, P., Yakovliev, P., Yawn, B.P., Yiallouros, P.K., Yorgancioglu, A., Yusuf, O.M., Zar, H.J., Zhang, L., Zhong, N., Zernotti, M.E., Zidarn, M., Zuberbier, T., Zubrinich, C., Zurkuhlen, A., Bousquet, Jean, Hellings, Peter W., Agache, Ioana, Amat, Flore, Annesi-Maesano, Isabella, Ansotegui, Ignacio J., Anto, Josep M., Bachert, Claus, Bateman, Eric D., Bedbrook, Anna, Bennoor, Kazi, Bewick, Mickael, Bindslev-Jensen, Carsten, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Brozek, Jan, Brussino, Luisa, Canonica, Giorgio W., Cardona, Victoria, Casale, Thomas, Cepeda Sarabia, Alfonso M., Chavannes, Niels H., Cecchi, Lorenzo, Correia de Sousa, Jaime, Costa, Elisio, Cruz, Alvaro A., Czarlewski, Wienczyslawa, De Carlo, Giuseppe, De Feo, Giulia, Demoly, Pascal, Devillier, Philippe, Dykewicz, Mark S., El-Gamal, Yehia, Eller, Esben E., Fonseca, Joao A., Fontaine, Jean-François, Fokkens, Wytske J., Guzmán, Maria-Antonieta, Haahtela, Tari, Illario, Maddalena, Ivancevich, Juan-Carlos, Just, Jocelyne, Kaidashev, Igor, Khaitov, Musa, Kalayci, Omer, Keil, Thomas, Klimek, Ludger, Kowalski, Marek L., Kuna, Piotr, Kvedariene, Violeta, Larenas-Linnemann, Desiree, Laune, Daniel, Le, Lan T.T., Carlsen, Karin Lodrup, Lourenço, Olga, Mahboub, Bassam, Mair, Alpana, Menditto, Enrica, Milenkovic, Branislava, Morais-Almeida, Mario, Mösges, Ralph, Mullol, Joaquim, Murray, Ruth, Naclerio, Robert, Namazova-Baranova, Leyla, Novellino, Ettore, O'Hehir, Robyn E., Ohta, Ken, Okamoto, Yoshitaka, Okubo, Kimi, Onorato, Gabrielle L., Palkonen, Susanna, Panzner, Petr, Papadopoulos, Nikos G., Park, Hae-Sim, Paulino, Ema, Pawankar, Ruby, Pfaar, Oliver, Plavec, Davor, Popov, Ted A., Potter, Paul, Prokopakis, Emmanuel P., Rottem, Menachem, Ryan, Dermot, Salimäki, Johanna, Samolinski, Boleslaw, Sanchez-Borges, Mario, Schunemann, Holger J., Sheikh, Aziz, Sisul, Juan-Carlos, Rajabian-Söderlund, Rojin, Sooronbaev, Talant, Stellato, Cristiana, To, Teresa, Todo-Bom, Ana-Maria, Tomazic, Peter-Valentin, Toppila-Salmi, Sanna, Valero, Antonio, Valiulis, Arunas, Valovirta, Erkka, Ventura, Maria-Teresa, Wagenmann, Martin, Wang, De Yun, Wallace, Dana, Waserman, Susan, Wickman, Magnus, Yorgancioglu, Arzu, Zhang, Luo, Zhong, Nanshan, Zidarn, Mihaela, and Zuberbier, Torsten

Published
2019
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23. Trait profiles in difficult‐to‐treat asthma: Clinical impact and response to systematic assessment

Author

Lin, Tiffany, primary, Pham, Jonathan, additional, Denton, Eve, additional, Lee, Joy, additional, Hore‐Lacy, Fiona, additional, Sverrild, Asger, additional, Stojanovic, Stephanie, additional, Tay, Tunn Ren, additional, Murthee, Kavitha Garuna, additional, Radhakrishna, Naghmeh, additional, Dols, Monique, additional, Bondarenko, Janet, additional, Mahoney, Janine, additional, O'Hehir, Robyn E., additional, Dabscheck, Eli, additional, and Hew, Mark, additional

Published
2023
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25. COVID-19 adenoviral vector vaccination elicits a robust memory B cell response with the capacity to recognize Omicron BA.2 and BA.5 variants

Author

Fryer, Holly A., primary, Hartley, Gemma E., additional, Edwards, Emily S.J., additional, Varese, Nirupama, additional, Boo, Irene, additional, Bornheimer, Scott J., additional, Hogarth, P. Mark, additional, Drummer, Heidi E., additional, O’Hehir, Robyn E., additional, and van Zelm, Menno C., additional

Published
2023
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31. RNA sequencing of single allergen‐specific memory B cells after grass pollen immunotherapy: Two unique cell fates and CD29 as a biomarker for treatment effect

Author

McKenzie, Craig I., primary, Varese, Nirupama, additional, Aui, Pei Mun, additional, Reinwald, Simone, additional, Wines, Bruce D., additional, Hogarth, P. Mark, additional, Thien, Francis, additional, Hew, Mark, additional, Rolland, Jennifer M., additional, O'Hehir, Robyn E., additional, and van Zelm, Menno C., additional

Published
2022
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35. Dedication

Author

O'Hehir, Robyn E., primary, Holgate, Stephen T., additional, and Sheikh, Aziz, additional

Published
2017
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36. Preface

Author

O'Hehir, Robyn E., primary, Holgate, Stephen T., additional, and Sheikh, Aziz, additional

Published
2017
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37. The second COVID‐19 mRNA vaccine dose enhances the capacity of Spike‐specific memory B cells to bind Omicron BA.2.

Author

Hartley, Gemma E., Edwards, Emily S. J., Varese, Nirupama, Boo, Irene, Aui, Pei M., Bornheimer, Scott J., Hogarth, P. Mark, Drummer, Heidi E., O'Hehir, Robyn E., and van Zelm, Menno C.

Subjects
IMMUNOLOGIC memory, SARS-CoV-2 Omicron variant, COVID-19 vaccines, BOOSTER vaccines, SARS-CoV-2
Abstract

RBD-specific Bmem were detected in all donors after first and second doses, with significantly higher numbers (1.7-fold) post-dose 2 (Figure 1F, Figure S1A-D). The second COVID-19 mRNA vaccine dose enhances the capacity of Spike-specific memory B cells to bind Omicron BA.2 (A) Participants were sampled pre-BNT162b2 vaccination, 3 weeks post-dose 1, and 4 weeks post-dose 2 with a median of 23 days (range: 21-39 days) between doses. [Extracted from the article]

Published
2023
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38. RNA sequencing of single allergen‐specific memory B cells after grass pollen immunotherapy: Two unique cell fates and CD29 as a biomarker for treatment effect.

Author

McKenzie, Craig I., Varese, Nirupama, Aui, Pei Mun, Reinwald, Simone, Wines, Bruce D., Hogarth, P. Mark, Thien, Francis, Hew, Mark, Rolland, Jennifer M., O'Hehir, Robyn E., and van Zelm, Menno C.

Subjects
IMMUNOLOGIC memory, RNA sequencing, TREATMENT effectiveness, ALLERGIC rhinitis, POLLEN, SEASONAL affective disorder, AUTOBIOGRAPHICAL memory
Abstract

Background: Sublingual immunotherapy (SLIT) for grass pollen allergy can modify the natural history of allergic rhinitis and is associated with increased allergen‐specific IgG4. IgG4 competitively inhibits functional IgE on the surface of effector cells, such as mast cells and basophils, from binding to allergens. To further understand the important role memory B‐cell (Bmem) responses play in mediating the beneficial effects of SLIT, we assessed changes in allergen‐specific Bmem subsets induced by SLIT for grass pollen allergy. Methods: Blood samples were collected twice outside the pollen season from twenty‐seven patients with sensitization to ryegrass pollen (RGP; Lolium perenne) and seasonal rhinoconjunctivitis. Thirteen received 4‐month pre‐seasonal SLIT for grass pollen allergy, and 14 received standard pharmacotherapy only. Single‐cell RNA sequencing was performed on FACS‐purified Lol p 1‐specific Bmem before and after SLIT from four patients, and significant genes were validated by flow cytometry on the total cohort. Results: Four months of SLIT increased RGP‐specific IgE and IgG4 in serum and induced two Lol p 1‐specific Bmem subsets with unique transcriptional profiles. Both subsets had upregulated expression of beta 1 integrin ITGB1 (CD29), whereas IGHE (IgE), IGHG4 (IgG4), FCER2 (CD23), and IL13RA1 were upregulated in one subset. There was an increase in the proportion of Lol p 1+ Bmem expressing surface IgG4, CD23, and CD29 after SLIT. Conclusions: A clinically successful 4 months course of SLIT for grass pollen allergy induces two transcriptionally unique Bmem fates. Associated changes in surface‐expressed proteins on these Bmem subsets can be used as early biomarkers for treatment effects. [ABSTRACT FROM AUTHOR]

Published
2023
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42. Validity, reliability, and responsiveness of daily monitoring visual analog scales in MASK-air (R)

Author

Sousa-Pinto, Bernardo, Eklund, Patrik, Pfaar, Oliver, Klimek, Ludger, Zuberbier, Torsten, Czarlewski, Wienczyslawa, Bedard, Annabelle, Bindslev-Jensen, Carsten, Bedbrook, Anna, Bosnic-Anticevich, Sinthia, Brussino, Luisa, Cardona, Victoria, Cruz, Alvaro A., de Vries, Govert, Devillier, Philippe, Fokkens, Wytske J., Miguel Fuentes-Perez, Jose, Gemicioglu, Bilun, Haahtela, Tari, Rocio Huerta-Villalobos, Yunen, Carlos Ivancevich, Juan, Kull, Inger, Kuna, Piotr, Kvedariene, Violeta, Larenas Linnemann, Desiree E., Laune, Daniel, Makris, Michael, Melen, Erik, Morais-Almeida, Mario, Moesges, Ralph, Mullol, Joaquim, O'Hehir, Robyn E., Papadopoulos, Nikolaos G., Pereira, Ana Margarida, Prokopakis, Emmanuel P., Psarros, Fotis, Regateiro, Frederico S., Reitsma, Sietze, Samolinski, Boleslaw, Scichilone, Nicola, da Silva, Jane, Stellato, Cristiana, Todo-Bom, Ana, Tomazic, Peter Valentin, Salmi, Sanna Toppila, Valero, Antonio, Valiulis, Arunas, Valovirta, Erkka, van Eerd, Michiel, Ventura, Maria Teresa, Yorgancioglu, Arzu, Basagana, Xavier, Anto, Josep M., Bousquet, Jean, Fonseca, Joao Almeida, HUS Inflammation Center, and Department of Dermatology, Allergology and Venereology

Subjects
INTRACLASS CORRELATION-COEFFICIENTS, allergic rhinitis, reliability, responsiveness, 3121 General medicine, internal medicine and other clinical medicine, ASTHMA, SLEEPINESS, visual analog scales, INSTRUMENTS, CARE, mobile health, WORK PRODUCTIVITY, VALIDATION
Abstract

Background MASK-air (R) is an app that supports allergic rhinitis patients in disease control. Users register daily allergy symptoms and their impact on activities using visual analog scales (VASs). We aimed to assess the concurrent validity, reliability, and responsiveness of these daily VASs. Methods Daily monitoring VAS data were assessed in MASK-air (R) users with allergic rhinitis. Concurrent validity was assessed by correlating daily VAS values with those of the EuroQol-5 Dimensions (EQ-5D) VAS, the Control of Allergic Rhinitis and Asthma Test (CARAT) score, and the Work Productivity and Activity Impairment Allergic Specific (WPAI-AS) Questionnaire (work and activity impairment scores). Intra-rater reliability was assessed in users providing multiple daily VASs within the same day. Test-retest reliability was tested in clinically stable users, as defined by the EQ-5D VAS, CARAT, or "VAS Work" (i.e., VAS assessing the impact of allergy on work). Responsiveness was determined in users with two consecutive measurements of EQ-5D-VAS or "VAS Work" indicating clinical change. Results A total of 17,780 MASK-air (R) users, with 317,176 VAS days, were assessed. Concurrent validity was moderate-high (Spearman correlation coefficient range: 0.437-0.716). Intra-rater reliability intraclass correlation coefficients (ICCs) ranged between 0.870 (VAS assessing global allergy symptoms) and 0.937 (VAS assessing allergy symptoms on sleep). Test-retest reliability ICCs ranged between 0.604 and 0.878-"VAS Work" and "VAS asthma" presented the highest ICCs. Moderate/large responsiveness effect sizes were observed-the sleep VAS was associated with lower responsiveness, while the global allergy symptoms VAS demonstrated higher responsiveness. Conclusion In MASK-air (R), daily monitoring VASs have high intra-rater reliability and moderate-high validity, reliability, and responsiveness, pointing to a reliable measure of symptom loads.

Published
2021

47. Management of anaphylaxis due to COVID‐19 vaccines in the elderly

Author

Bousquet, Jean, primary, Agache, Ioana, additional, Blain, Hubert, additional, Jutel, Marek, additional, Ventura, Maria Teresa, additional, Worm, Margitta, additional, Del Giacco, Stefano, additional, Benetos, Athanasios, additional, Bilo, Beatrice Maria, additional, Czarlewski, Wienczyslawa, additional, Abdul Latiff, Amir Hamzah, additional, Al‐Ahmad, Mona, additional, Angier, Elizabeth, additional, Annesi‐Maesano, Isabella, additional, Atanaskovic‐Markovic, Marina, additional, Bachert, Claus, additional, Barbaud, Annick, additional, Bedbrook, Anna, additional, Bennoor, Kazi S., additional, Berghea, Elena Camelia, additional, Bindslev‐Jensen, Carsten, additional, Bonini, Sergio, additional, Bosnic‐Anticevich, Sinthia, additional, Brockow, Knut, additional, Brussino, Luisa, additional, Camargos, Paulo, additional, Canonica, G. Walter, additional, Cardona, Victoria, additional, Carreiro‐Martins, Pedro, additional, Carriazo, Ana, additional, Casale, Thomas, additional, Caubet, Jean‐Christoph, additional, Cecchi, Lorenzo, additional, Cherubini, Antonio, additional, Christoff, George, additional, Chu, Derek K., additional, Cruz, Alvaro A., additional, Dokic, Dejan, additional, El‐Gamal†, Yehia, additional, Ebisawa, Motohiro, additional, Eberlein, Bernadette, additional, Farrell, John, additional, Fernandez‐Rivas, Montserrat, additional, Fokkens, Wytske J., additional, Fonseca, Joao A., additional, Gao, Yadong, additional, Gavazzi, Gaëtan, additional, Gawlik, Radoslaw, additional, Gelincik, Asli, additional, Gemicioğlu, Bilun, additional, Gotua, Maia, additional, Guérin, Olivier, additional, Haahtela, Tari, additional, Hoffmann‐Sommergruber, Karin, additional, Hoffmann, Hans Jürgen, additional, Hofmann, Maja, additional, Hrubisko, Martin, additional, Illario, Maddalena, additional, Irani, Carla, additional, Ispayeva, Zhanat, additional, Ivancevich, Juan Carlos, additional, Julge, Kaja, additional, Kaidashev, Igor, additional, Khaitov, Musa, additional, Knol, Edward, additional, Kraxner, Helga, additional, Kuna, Piotr, additional, Kvedariene, Violeta, additional, Lauerma, Antti, additional, Le, Lan T. T., additional, Le Moing, Vincent, additional, Levin, Michael, additional, Louis, Renaud, additional, Lourenco, Olga, additional, Mahler, Vera, additional, Martin, Finbarr C., additional, Matucci, Andrea, additional, Milenkovic, Branislava, additional, Miot, Stéphanie, additional, Montella, Emma, additional, Morais‐Almeida, Mario, additional, Mortz, Charlotte G., additional, Mullol, Joaquim, additional, Namazova‐Baranova, Leyla, additional, Neffen, Hugo, additional, Nekam, Kristof, additional, Niedoszytko, Marek, additional, Odemyr, Mikaëla, additional, O’Hehir, Robyn E., additional, Okamoto, Yoshitaka, additional, Ollert, Markus, additional, Palomares, Oscar, additional, Papadopoulos, Nikolaos G., additional, Panzner, Petr, additional, Passalacqua, Giovanni, additional, Patella, Vincenzo, additional, Petrovic, Mirko, additional, Pfaar, Oliver, additional, Pham‐Thi, Nhân, additional, Plavec, Davor, additional, Popov, Todor A., additional, Recto, Marysia T., additional, Regateiro, Frederico S., additional, Reynes, Jacques, additional, Roller‐Winsberger, Regina E., additional, Rolland, Yves, additional, Romano, Antonino, additional, Rondon, Carmen, additional, Rottem, Menachem, additional, Rouadi, Philip W., additional, Salles, Nathalie, additional, Samolinski, Boleslaw, additional, Santos, Alexandra F., additional, S Sarquis, Faradiba, additional, Sastre, Joaquin, additional, M. G. A. Schols, Jos, additional, Scichilone, Nicola, additional, Sediva, Anna, additional, Shamji, Mohamed H., additional, Sheikh, Aziz, additional, Skypala, Isabel, additional, Smolinska, Sylwia, additional, Sokolowska, Milena, additional, Sousa‐Pinto, Bernardo, additional, Sova, Milan, additional, Stelmach, Rafael, additional, Sturm, Gunter, additional, Suppli Ulrik, Charlotte, additional, Todo‐Bom, Ana Maria, additional, Toppila‐Salmi, Sanna, additional, Tsiligianni, Ioanna, additional, Torres, Maria, additional, Untersmayr, Eva, additional, Urrutia Pereira, Marilyn, additional, Valiulis, Arunas, additional, Vitte, Joana, additional, Vultaggio, Alessandra, additional, Wallace, Dana, additional, Walusiak‐Skorupa, Jolanta, additional, Wang, De‐Yun, additional, Waserman, Susan, additional, Yorgancioglu, Arzu, additional, Yusuf, Osman M., additional, Zernotti, Mario, additional, Zidarn, Mihaela, additional, Chivato, Tomas, additional, Akdis, Cezmi A., additional, Zuberbier, Torsten, additional, and Klimek, Ludger, additional

Published
2021
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48. Validity, reliability, and responsiveness of daily monitoring visual analog scales in MASK‐air®

Author

Sousa‐Pinto, Bernardo, primary, Eklund, Patrik, additional, Pfaar, Oliver, additional, Klimek, Ludger, additional, Zuberbier, Torsten, additional, Czarlewski, Wienczyslawa, additional, Bédard, Annabelle, additional, Bindslev‐Jensen, Carsten, additional, Bedbrook, Anna, additional, Bosnic‐Anticevich, Sinthia, additional, Brussino, Luisa, additional, Cardona, Victoria, additional, Cruz, Alvaro A., additional, Vries, Govert, additional, Devillier, Philippe, additional, Fokkens, Wytske J., additional, Fuentes‐Pérez, José Miguel, additional, Gemicioğlu, Bilun, additional, Haahtela, Tari, additional, Huerta‐Villalobos, Yunen Rocío, additional, Ivancevich, Juan Carlos, additional, Kull, Inger, additional, Kuna, Piotr, additional, Kvedariene, Violeta, additional, Larenas Linnemann, Désirée E., additional, Laune, Daniel, additional, Makris, Michael, additional, Melén, Erik, additional, Morais‐Almeida, Mário, additional, Mösges, Ralph, additional, Mullol, Joaquim, additional, O'Hehir, Robyn E., additional, Papadopoulos, Nikolaos G., additional, Pereira, Ana Margarida, additional, Prokopakis, Emmanuel P., additional, Psarros, Fotis, additional, Regateiro, Frederico S., additional, Reitsma, Sietze, additional, Samolinski, Boleslaw, additional, Scichilone, Nicola, additional, Silva, Jane, additional, Stellato, Cristiana, additional, Todo‐Bom, Ana, additional, Tomazic, Peter Valentin, additional, Salmi, Sanna Toppila, additional, Valero, Antonio, additional, Valiulis, Arunas, additional, Valovirta, Erkka, additional, Eerd, Michiel, additional, Ventura, Maria Teresa, additional, Yorgancioglu, Arzu, additional, Basagaña, Xavier, additional, Antó, Josep M., additional, Bousquet, Jean, additional, and Fonseca, João Almeida, additional

Published
2021
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50. ARIA‐EAACI care pathways for allergen immunotherapy in respiratory allergy

Author

Bousquet, Jean, Pfaar, Oliver, Agache, Ioana, Bedbrook, Anna, Akdis, Cezmi A, Canonica, Giorgio Walter, Chivato, Tomas, Al-Ahmad, Mona, Rasib, A. H. Abdul, Ansotegui, Ignacio J, Bachert, Claus, Soto-Martinez, Manuel, Laune, Daniel, Casale, Tomas, Levin, Michael, Larenas-Linnemann, Désirée, Samolinski, Boleslaw, Lodrup Carlsen, Karin C, O'Mahony, Liam, Lombardi, Carlo, Riggioni, Carmen, Hossny, Elham, Barata, Luís Taborda, Lourenço, Olga, Devillier, Philippe, Mahboub, Bassam, Malling, Hans-Jørgen, Sheikh, Aziz, Manning, Patrick, Passalacqua, Giovanni, Marshall, Gailen D, Sanchez-Borges, Mario, Toppila-Salmi, Sanna, Melén, Erik, Fokkens, Wytske J, Meltzer, Eli O, Miculinic, Neven, Soto-Quiros, Manuel, Milenkovic, Branislava, Roberts, Graham, Ohta, Ken, Scichilone, Nicola, Moin, Mostafa, Odemyr, Mikaëla, Montefort, Stephen, Almeida, Mário Morais, Bom, Ana Todo, Mortz, Charlotte G, Serpa, Faradiba S, Patella, Vincenzo, Sova, Milan, Mösges, Ralph, Mullol, Joaquim, Namazova Baranova, Leyla, Tsiligianni, Ioanna, Neffen, Hugo, Bjermer, Leif, Rodriguez-Gonzales, Monica, Torres, Maria J, Okamoto, Yoshitaka, Okubo, Kimi, Pajno, Giovanni B, Baharuddin, Abdullah, Cecchi, Lorenzo, Sastre, Joaquin, Untersmayr, Eva, Pawankar, Ruby, Pham-Thi, Nhân, Plavec, Davor, Cardona, Victoria, Dokic, Dejan, Sisul, Juan Carlos, Rosario, Nelson, Rottem, Menachem, Rouadi, Philip W, Del Giacco, Stefano, Fonseca, Joao A, Schwarze, Jürgen, Scadding, Glenis K, Shamji, Mohamed H, Schmid-Grendelmeier, Peter, Niedoszytko, Marek, Valentin-Rostan, Marylin, Sofiev, Mikhail, Solé, Dirceu, Sooronbaev, Talant, Palkonen, Susanna, Urrutia-Pereira, Marilyn, Skypala, Isabel, Suppli-Ulrik, Charlotte, Bonini, Matteo, Popov, Todor A, Tomazic, Peter-Valentin, Valero, Antonio, Cepeda Sarabia, Alfonso M, Ryan, Dermot, Bosnic-Anticevich, Sinthia, Valiulis, Arunas, Durham, Stephen L, Schünemann, Holger, Kalayci, Omer, Valovirta, Erkka, Panzner, Petr, Vandenplas, Olivier, Ventura, Maria Teresa, Gotua, Maia, Vichyanond, Pakit, Chkhartishvili, Ekaterine, Wagenmann, Martin, Fontaine, Jean-François, Kull, Inger, Wallace, Dana, Recto, Marysia, Walusiak-Skorupa, Jolanta, Wang, De Yun, Hrubiško, Martin, Waserman, Susan, Ebisawa, Motohiro, Bosse, Isabelle, Grisle, Ineta, Wong, Gary Wk, Bindslev-Jensen, Carsten, Yorgancioglu, Arzu, Yusuf, Osman M, Khaitov, Musa, Zernotti, Mario, Gawlik, Radoslaw, Chu, Derek K, Irani, Carla, Zhang, Luo, Zidarn, Mihaela, Zuberbier, Torsten, Kuna, Piotr, Jutel, Marek, Guzmán, Maria Antonieta, El-Gamal, Yehia, Klimek, Ludger, Brough, Helen A, Brussino, Luisa, Calderon, Moises A, Caraballo, Luis, O'Hehir, Robyn E, Gelincik, Asli, Kvedariene, Violeta, Cirule, Ieva, Cruz, Alvaro A, Czarlewski, Wienczyslawa, Nekam, Kristof, Papadopoulos, Nikolaos G., Haahtela, Tari, Emuzyte, Regina, Gamkrelidze, Amiran, Fauquert, Jean Luc, Palomares, Oscar, Regateiro, Frederico S, Ivancevich, Juan Carlos, Gemicioglu, Bilun, Gereda, Jose E, Gerth van Wijk, Roy, Bergmann, Karl-Christian, Knol, Edward, Halken, Susanne, Heffler, Enrico, Hoffmann-Sommergruber, Karin, Martins, Pedro Carreiro, Kritikos, Vicky, Ispayeva, Zhanat, Julge, Kaja, Kaidashev, Igor, Demoly, Pascal, Kowalski, Marek, Kraxner, Helga, Ollert, Markus, Fiocchi, Alessandro, Lauerma, Antti, Lau, Susanne, Park, Hae-Sim, Gomez, R Maximiliano, Comprehensive Health Research Centre (CHRC) - pólo NMS, Centro de Estudos de Doenças Crónicas (CEDOC), NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), uBibliorum, Bousquet J., Pfaar O., Agache I., Bedbrook A., Akdis C.A., Canonica G.W., Chivato T., Al-Ahmad M., Abdul Latiff A.H., Ansotegui I.J., Bachert C., Baharuddin A., Bergmann K.-C., Bindslev-Jensen C., Bjermer L., Bonini M., Bosnic-Anticevich S., Bosse I., Brough H.A., Brussino L., Calderon M.A., Caraballo L., Cardona V., Carreiro-Martins P., Casale T., Cecchi L., Cepeda Sarabia A.M., Chkhartishvili E., Chu D.K., Cirule I., Cruz A.A., Czarlewski W., del Giacco S., Demoly P., Devillier P., Dokic D., Durham S.L., Ebisawa M., El-Gamal✝ Y., Emuzyte R., Gamkrelidze A., Fauquert J.L., Fiocchi A., Fokkens W.J., Fonseca J.A., Fontaine J.-F., Gawlik R., Gelincik A., Gemicioglu B., Gereda J.E., Gerth van Wijk R., Gomez R.M., Gotua M., Grisle I., Guzman M.-A., Haahtela T., Halken S., Heffler E., Hoffmann-Sommergruber K., Hossny E., Hrubisko M., Irani C., Ivancevich J.C., Ispayeva Z., Julge K., Kaidashev I., Kalayci O., Khaitov M., Klimek L., Knol E., Kowalski M.L., Kraxner H., Kull I., Kuna P., Kvedariene V., Kritikos V., Lauerma A., Lau S., Laune D., Levin M., Larenas-Linnemann D.E., Lodrup Carlsen K.C., Lombardi C., Lourenco O.M., Mahboub B., Malling H.-J., Manning P., Marshall G.D., Melen E., Meltzer E.O., Miculinic N., Milenkovic B., Moin M., Montefort S., Morais-Almeida M., Mortz C.G., Mosges R., Mullol J., Namazova Baranova L., Neffen H., Nekam K., Niedoszytko M., Odemyr M., O'Hehir R.E., Ollert M., O'Mahony L., Ohta K., Okamoto Y., Okubo K., Pajno G.B., Palomares O., Palkonen S., Panzner P., G Papadopoulos N., Park H.-S., Passalacqua G., Patella V., Pawankar R., Pham-Thi N., Plavec D., Popov T.A., Recto M., Regateiro F.S., Riggioni C., Roberts G., Rodriguez-Gonzales M., Rosario N., Rottem M., Rouadi P.W., Ryan D., Samolinski B., Sanchez-Borges✝ M., Serpa F.S., Sastre J., Scadding G.K., Shamji M.H., Schmid-Grendelmeier P., Schunemann H.J., Sheikh A., Scichilone N., Sisul J.C., Sofiev M., Sole D., Sooronbaev T., Soto-Martinez M., Soto-Quiros M., Sova M., Schwarze J., Skypala I., Suppli-Ulrik C., Taborda-Barata L., Todo-Bom A., Torres M.J., Valentin-Rostan M., Tomazic P.-V., Valero A., Toppila-Salmi S., Tsiligianni I., Untersmayr E., Urrutia-Pereira M., Valiulis A., Valovirta E., Vandenplas O., Ventura M.T., Vichyanond P., Wagenmann M., Wallace D., Walusiak-Skorupa J., Wang D.Y., Waserman S., Wong G.W.K., Yorgancioglu A., Yusuf O.M., Zernotti M., Zhang L., Zidarn M., Zuberbier T., Jutel M., HUS Inflammation Center, Department of Dermatology, Allergology and Venereology, University of Helsinki, Department of Pathology, Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Philipps Universität Marburg = Philipps University of Marburg, Transilvania University of Brasov, Universität Zürich [Zürich] = University of Zurich (UZH), Humanitas University [Milan] (Hunimed), Universidad San Pablo CEU, Kuwait University, Al-Rashed Allergy Center [Kuwait City], Pantai Hospital [Kuala Lumpur], Hospital Quirónsalud Bizkaia [Bilbao], Ghent University Hospital, Karolinska Institutet [Stockholm], Karolinska University Hospital [Stockholm], Sun Yat-Sen University [Guangzhou] (SYSU), Universiti Sains Malaysia (USM), Humboldt University Of Berlin, Berlin Institute of Health (BIH), Odense University Hospital (OUH), Skane University Hospital [Lund], Fondazione Policlinico Universitario Agostino Gemelli IRCCS, National Heart and Lung Institute [London] (NHLI), Imperial College London-Royal Brompton and Harefield NHS Foundation Trust, Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] (Unicatt), Woolcock Institute of Medical Research [Sydney], The University of Sydney, Guy's and St Thomas' Hospital [London], King‘s College London, Università degli studi di Torino = University of Turin (UNITO), University of Cartagena, Vall d'Hebron University Hospital [Barcelona], Centro Hospitalar de Lisboa Central E.P.E, NOVA Medical School - Faculdade de Ciências Médicas (NMS), Universidade Nova de Lisboa = NOVA University Lisbon (NOVA)-Universidade Nova de Lisboa = NOVA University Lisbon (NOVA), University of South Florida [Tampa] (USF), Azienda Usl Toscana centro [Firenze], Universidad Simon Bolivar (USB), David Tvildiani Medical University (DTMU), McMaster University [Hamilton, Ontario], Children's Clinical University Hospital [Riga, Latvia] (CCUH), Universidade Federal da Bahia (UFBA), Università degli Studi di Cagliari = University of Cagliari (UniCa), Epidemiology of Allergic and Respiratory Diseases Department [iPlesp] (EPAR), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Institut Desbrest de santé publique (IDESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Hôpital Foch [Suresnes], Sagamihara National Hospital [Kanagawa, Japan], Université Ain Shams, Vilnius University [Vilnius], CHU Clermont-Ferrand, IRCCS Ospedale Pediatrico Bambino Gesù [Roma], Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA), European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA), Universidade do Porto = University of Porto, Silesian Medical University, Katowice, Poland, Cerrahpasa Faculty of Medicine, Istanbul University, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Universidad de Chile = University of Chile [Santiago] (UCHILE), Humanitas Clinical and Research Center [Rozzano, Milan, Italy], Medizinische Universität Wien = Medical University of Vienna, Hôtel-Dieu de France (HDF), Université Saint-Joseph de Beyrouth (USJ), Tartu University Hospital [Tartu, Estonia], Ukrainina Medical Stomatological Academy [Poltava, Ukraine], Hacettepe University = Hacettepe Üniversitesi, Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro (UNIBA), Siriraj Hospital, Mahidol University, Mahidol University [Bangkok], Nova Southeastern University (NSU), Nofer Institute of Occupational Medicine (NIOM), National University of Singapore (NUS), Yong Loo Lin School of Medicine [Singapore], The Chinese University of Hong Kong [Hong Kong], Manisa Celal Bayar University, Universidad Nacional de Villa María, Universidad Católica de Córdoba, Beijing Tongren Hospital, Herrada, Anthony, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, and UCL - (MGD) Service de pneumologie

Subjects
Pulmonary and Respiratory Medicine, precision medicine, education, Immunology, Review, Settore MED/10 - Malattie Dell'Apparato Respiratorio, immune system diseases, HDE ALER, allergic rhinitis, asthma, immunotherapy, Medicine and Health Sciences, Immunology and Allergy, [SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology, ComputingMilieux_MISCELLANEOUS, Rhinitis, RC581-607, respiratory tract diseases, 3121 General medicine, internal medicine and other clinical medicine, Immunologic diseases. Allergy, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit, [SDV.IMM.ALL] Life Sciences [q-bio]/Immunology/Allergology, allergic rhinitis, asthma, immunotherapy, precision medicine
Abstract

Funding Information: BSreports personal fees from Allergopharma, during the conduct of the study; grants from National Health Programm, grant, personal fees from Polpharma, ASTRA, personal fees from Mylan, Adamed, patient ombudsman, national Centre for Research and Development, Polish Allergology Society. Funding Information: NGP reports personal fees from Novartis, Nutricia, HAL, MENARINI/FAES FARMA, SANOFI, MYLAN/MEDA, BIOMAY, AstraZeneca, GSK, MSD, ASIT BIOTECH, Boehringer Ingelheim, grants from Gerolymatos International SA, Capricare. Funding Information: CA reports grants from Allergopharma, grants from Idorsia, Swiss National Science Foundation, Christine Kühne‐Center for Allergy Research and Education, European Commission's Horison's 2020 Framework Programme, Cure, Novartis Research Institutes, Astra Zeneca, scibase, advisory role in Sanofi/Regeneron, grants from Glakso Smith‐Kline, advisory role in scibase. Funding Information: MJTreports grants from European Commission, SEAIC, ISCIII, personal fees from Diater laboratory, Leti laboratory, Aimmune Therapeutics. Funding Information: LK reports grants and personal fees from Allergopharma, MEDA/Mylan, LETI Pharma, Sanofi, grants from Stallergenes, Quintiles, ASIT biotech, grants from ALK Abelló, Lofarma, AstraZeneca, GSK, Inmunotk, personal fees from Allergy Therapeut., HAL Allergie, Cassella med; and Membership: AeDA, DGHNO, Deutsche Akademie für Allergologie und klinische Immunologie, HNO‐BV, GPA, EAACI. Funding Information: DPreports grants and personal fees from GlaxoSmithKline, personal fees from Menarini, Pliva, Belupo, AbbVie, Novartis, MSD, Chiesi, Revenio, personal fees and non‐financial support from Boehringer Ingelheim, non‐financial support from Philips. Funding Information: OP reports grants and personal fees from ALK‐Abelló, Allergopharma, Stallergenes Greer, HAL Allergy Holding B.V./HAL Allergie GmbH, Bencard Allergie GmbH/Allergy Therapeutics, Lofarma, ASIT Biotech Tools S.A., Laboratorios LETI/LETI Pharma, Anergis S.A., Glaxo Smith Kline, grants from Biomay, Circassia, Pohl‐Boskamp, Inmunotek S.L., personal fees from MEDA Pharma/MYLAN, Mobile Chamber Experts (a GA2LEN Partner), Indoor Biotechnologies, Astellas Pharma Global, EUFOREA, ROXALL Medizin, Novartis, Sanofi‐Aventis and Sanofi‐Genzyme, Med Update Europe GmbH, streamedup! GmbH, John Wiley and Sons, AS. Copyright: Copyright 2021 Elsevier B.V., All rights reserved. publishersversion published

Published
2021

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