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Your search keyword '"O A, Alexeyev"' showing total 6 results
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6 results on '"O A, Alexeyev"'

1. An increased incidence of Propionibacterium acnes biofilms in acne vulgaris: a case-control study

Author

A C, Jahns, B, Lundskog, R, Ganceviciene, R H, Palmer, I, Golovleva, C C, Zouboulis, A, McDowell, S, Patrick, and O A, Alexeyev

Subjects
Adult, Male, Microscopy, Confocal, Adolescent, Biopsy, Middle Aged, Young Adult, Phenotype, Biofilms, Case-Control Studies, Acne Vulgaris, Humans, Female, Propionibacterium acnes, Skin
Abstract

Acne vulgaris is a disorder of the sebaceous follicles. Propionibacterium acnes can be involved in inflammatory acne.This case-control study aimed at investigating the occurrence and localization of P. acnes in facial biopsies in acne and to characterize the P. acnes phylotype in skin compartments.Specific monoclonal and polyclonal antibodies were applied to skin biopsies of 38 patients with acne and matching controls to localize and characterize P. acnes and to determine expression of co-haemolysin CAMP factor, a putative virulence determinant.Follicular P. acnes was demonstrated in 18 (47%) samples from patients with acne and eight (21%) control samples [odds ratio (OR) 3·37, 95% confidence interval (CI) 1·23-9·23; P = 0·017]. In 14 (37%) samples from patients with acne, P. acnes was visualized in large macrocolonies/biofilms in sebaceous follicles compared with only five (13%) control samples (OR 3·85, 95% CI 1·22-12·14; P = 0·021). Macrocolonies/biofilms consisting of mixed P. acnes phylotypes expressing CAMP1 were detected in both case and control samples. Only four samples tested positive for the presence of Staphylococcus spp. and fungi were not observed.We have for the first time visualized different P. acnes phylotypes in macrocolonies/biofilms in sebaceous follicles of skin biopsies. Our results support the hypothesis that P. acnes can play a role in the pathogenesis of acne as acne samples showed a higher prevalence of follicular P. acnes colonization, both in terms of follicles containing P. acnes and the greater numbers of bacteria in macrocolonies/biofilms than in control samples.

Published
2012

2. A major outbreak of hemorrhagic fever with renal syndrome in the Samara region, European Russia

Author

V. I. Roschupkin, V. N. Verkhovtsev, O. A. Alexeyev, A. A. Suzdaltsev, and E. S. Efratova

Subjects
Adult, Microbiology (medical), Orthohantavirus, medicine.medical_specialty, Pediatrics, Adolescent, Antibodies, Viral, Disease Outbreaks, Russia, Seroepidemiologic Studies, Epidemiology, Animals, Humans, Medicine, Child, Aged, Hantavirus, biology, Arvicolinae, business.industry, Outbreak, General Medicine, Middle Aged, biology.organism_classification, Samara, Virology, Infectious Diseases, Child, Preschool, Hemorrhagic Fever with Renal Syndrome, Bunyaviridae, business
Published
1998
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3. A minority of seropositive wild bank voles (<e1>Clethrionomys glareolus</e1>) show evidence of current Puumala virus infection

Author

*, O. A. ALEXEYEV, §, †, C. AHLM, ††, ELGH, F., AAVA, B., PALO, T., SETTERGREN, B., TÄRNVIK, A., and WADELL, G.

Abstract

Bank voles (Clethrionomys glareolus) serve as the reservoir for Puumala (PUU) virus, the aetiologic agent of nephropathia epidemica. The animals are believed to be persistently infected and the occurrence of serum antibodies is usually taken as an evidence of active infection. We found serum antibodies to PUU virus in 42 of 299 wild bank voles captured in a PUU virus endemic area. PUU virus RNA was demonstrated in lung specimens of 11 of these 42 animals and in 2 of them antigen was also found. Thus in the lungs of 31 of 42 seropositive animals neither PUU virus RNA nor antigen was detected. In 2 of 257 seronegative animals, lung specimens showed presence of PUU virus antigen and RNA. Isolation of PUU virus from lung tissue was successful in all 4 antigen-positive bank voles but in none of 16 tested antigen-negative animals. In conclusion, only a minority of bank voles with serum antibodies to PUU virus showed evidence of current infection.

Published
1998

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