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This paper presents the measurements on first very thin Ultra-Fast Silicon Detectors (UFSDs) produced by Fondazione Bruno Kessler; the data have been collected in a beam test setup at the CERN PS, using beam with a momentum of 12 GeV/c. UFSDs with a nominal thickness of 25 and 35 $$\mu$$ μ m and an area of 1 $$\times$$ × 1 $$\text {mm}^2$$ mm 2 have been considered, together with an additional HPK 50-$$\mu$$ μ m thick sensor, taken as reference. Their timing performances have been studied as a function of the applied voltage and gain. A time resolution of about 25 ps and of 22 ps at a voltage of 120 and 240 V has been obtained for the 25 and 35 $$\mu$$ μ m thick UFSDs, respectively.

The University and the National Institute for Nuclear Physics of Torino are developing LGAD-based prototypes for beam monitoring in proton therapy. The direct measurement of single beam particles could overcome some features of currently used ionization chambers, such as slow charge collection and reduced sensitivity, which limit the implementation of advanced delivery techniques (e.g. rescanning). LGAD strip sensors have been designed and produced by Bruno Kessler Foundation (FBK, Trento) specifically for this project. A counter prototype to directly count individual protons at clinical fluence rates (106–1010 protons/cm2·s) and a telescope system to measure the beam energy with time-of-flight (TOF) techniques are described. Tests of LGAD silicon strip sensors performed on synchrotron and cyclotron beams of therapeutic centers, using a pin-hole ionization chamber for the independent measurement of the particle flux, already showed the possibility to keep the counting error 8 protons/cm2·s. The ongoing tests of counting sensors readout by a dedicated fast charge sensitive amplifier chip are reported. The telescope system, made of two sensors at a distance up to 95 cm, allows measuring the beam energy in the clinical range (70–230 MeV) with a maximum deviation of 310 keV in respect to the nominal one, with an uncertainty of 500 keV, thus achieving the prescribed clinical accuracy of 1 mm in the range in water.

In the framework of the development of future advanced treatment modalities in charged particle therapy, the use of silicon sensors is an appealing alternative to gas ionization chambers commonly used for beam monitoring. A prototype of a device, based on Low-Gain Avalanche Diode (LGAD) sensors with 50 μ m thickness, is being developed to discriminate and count single beam particles. This paper describes the design and characterization of ABACUS, an innovative multi-channel ASIC prototype for LGAD readout, based on a fast amplifier with self-reset capabilities. The design goals aim at detecting charge pulses in a wide range, from 4 fC to 150 fC, up to 70 MHz instantaneous rates, with a dead time of about 10 ns or less and efficiency larger than 98%. The characterization results indicate that even at the lowest input charge the signal-to-noise ratio is 15, high enough to keep full efficiency and preventing fake counts from the electronics noise. The dead time was found to be in the range between 5 ns and 10 ns, allowing to reach a full counting efficiency up to instantaneous rates of 70 MHz or larger, depending on the input charge.

Beam monitoring in particle therapy is a critical task that, because of the high flux and the time structure of the beam, can be challenging for the instrumentation. Recent developments in thin silicon detectors with moderate internal gain, optimized for timing applications (Ultra Fast Silicon Detectors, UFSD), offer a favourable technological option to conventional ionization chambers. Thanks to their fast collection time and good signal-to-noise ratio, properly segmented sensors allow discriminating and counting single protons up to the high fluxes of a therapeutic beam, while the excellent time resolution can be exploited for measuring the proton beam energy using time-of-flight techniques. We report here the results of the first tests performed with UFSD detector pads on a therapeutic beam. It is found that the signal of protons can be easily discriminated from the noise, and that the very good time resolution is confirmed. However, a careful design is necessary to limit large pile-up inefficiencies and early performance degradation due to radiation damage.

Fast procedures for the beam quality assessment and for the monitoring of beam energy modulations during the irradiation are among the most urgent improvements in particle therapy. Indeed, the online measurement of the particle beam energy could allow assessing the range of penetration during treatments, encouraging the development of new dose delivery techniques for moving targets. Towards this end, the proof of concept of a new device, able to measure in a few seconds the energy of clinical proton beams (from 60 to 230 MeV) from the Time of Flight (ToF) of protons, is presented. The prototype consists of two Ultra Fast Silicon Detector (UFSD) pads, featuring an active thickness of 80 um and a sensitive area of 3 x 3 mm2, aligned along the beam direction in a telescope configuration, connected to a broadband amplifier and readout by a digitizer. Measurements were performed at the Centro Nazionale di Adroterapia Oncologica (CNAO, Pavia, Italy), at five different clinical beam energies and four distances between the sensors (from 7 to 97 cm) for each energy. In order to derive the beam energy from the measured average ToF, several systematic effects were considered, Monte Carlo simulations were developed to validate the method and a global fit approach was adopted to calibrate the system. The results were benchmarked against the energy values obtained from the water equivalent depths provided by CNAO. Deviations of few hundreds of keV have been achieved for all considered proton beam energies for both 67 and 97 cm distances between the sensors and few seconds of irradiation were necessary to collect the required statistics. These preliminary results indicate that a telescope of UFSDs could achieve in a few seconds the accuracy required for the clinical application and therefore encourage further investigations towards the improvement and the optimization of the present prototype.

The University of Torino (UniTO) and the National Institute for Nuclear Physics (INFN-TO) are investigating the use of Ultra Fast Silicon Detectors (UFSD) for beam monitoring in radiobiological experiments with therapeutic proton beams. The single particle identification approach of solid state detectors aims at increasing the sensitivity and reducing the response time of the conventional monitoring devices, based on gas detectors. Two prototype systems are being developed to count the number of beam particles and to measure the beam energy with time-of-flight (ToF) techniques. The clinically driven precision (< 1%) in the number of particles delivered and the uncertainty < 1 mm in the depth of penetration (range) in radiobiological experiments (up to 108 protons/s fluxes) are the goals to be pursued. The future translation into clinics would allow the implementation of faster and more accurate treatment modalities, nowadays prevented by the limits of state-of-the-art beam monitors. The experimental results performed with clinical proton beams at CNAO (Centro Nazionale di Adroterapia Oncologica, Pavia) and CPT (Centro di Protonterapia, Trento) showed a counting inefficiency 2, and a deviation of few hundreds of keV of measured beam energies with respect to nominal ones. The progresses of the project are reported.

To fully exploit the physics potentials of particle therapy in delivering dose with high accuracy and selectivity, charged particle therapy needs further improvement. To this scope, a multidisciplinary project (MoVeIT) of the Italian National Institute for Nuclear Physics (INFN) aims at translating research in charged particle therapy into clinical outcome. New models in the treatment planning system are being developed and validated, using dedicated devices for beam characterization and monitoring in radiobiological and clinical irradiations. Innovative silicon detectors with internal gain layer (LGAD) represent a promising option, overcoming the limits of currently used ionization chambers. Two devices are being developed: one to directly count individual protons at high rates, exploiting the large signal-to-noise ratio and fast collection time in small thicknesses (1 ns in 50 μm) of LGADs, the second to measure the beam energy with time-of-flight techniques, using LGADs optimized for excellent time resolutions (Ultra Fast Silicon Detectors, UFSDs). The preliminary results of first beam tests with therapeutic beam will be presented and discussed.