17 results on '"O. Cantin"'
Search Results
2. Devenir cartilagineux à 12ans de recul après reconstruction du ligament croisé antérieur
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D. Saragaglia, Nicolas Lefevre, O. Cantin, F. Rongieras, Christophe Hulet, Nicolas Graveleau, and Sébastien Lustig
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030222 orthopedics ,03 medical and health sciences ,0302 clinical medicine ,Orthopedics and Sports Medicine ,Surgery ,030229 sport sciences - Abstract
Resume Introduction En cas de laxite anterieure chronique, la reconstruction du ligament croise anterieur (LCA) pourrait ralentir le developpement de l’arthrose. Cette etude a ete menee afin de determiner la prevalence globale de l’arthrose et d’identifier les facteurs de risque apres reconstruction du LCA. Hypothese Les lesions meniscales, le delai traumatisme–chirurgie, l’index de masse corporelle (IMC), la laxite residuelle et les lesions cartilagineuses influencent l’evolution vers l’arthrose. Materiels et methodes Cette etude multicentrique retrospective sur le devenir des ligaments croises a 12 ans de recul a ete realisee dans le cadre du symposium de la Sofcot 2014. La cohorte comprenait 675 reconstructions sous arthroscopie du LCA de janvier 2002 a decembre 2003. L’evaluation clinique comprenait le score IKDC objectif et subjectif. L’analyse de l’arthrose a ete realisee sur 589 radiographies du genou selon la classification IKDC. Les facteurs predictifs de developpement d’arthrose etudies etaient l’âge, le sexe, l’IMC, le delai traumatisme–chirurgie, le niveau d’activite, les meniscectomies mediales ou laterales, le type de greffe, les chondropathies mediales ou laterales, le positionnement des tunnels, la laxite residuelle. Une analyse univariee et multivariee avec regression logistique a ete realisee. Resultats Le recul moyen etait de 11,9 ± 0,8 ans. Le score IKDC subjectif etait de 83,7 ± 13. A 12 ans, le taux d’arthrose moderee a severe (C ou D IKDC) etait de 19 % (16 % d’arthrose femoro-tibiale mediale, 4 % d’arthrose femoro-tibiale laterale et 2 % d’arthrose femoro-patellaire). Les facteurs pronostiques etaient l’âge a la chirurgie superieur a 34 ans (p Conclusions Cette etude a grande echelle a identifie des facteurs de risque arthrosique qui devraient permettre d’ameliorer l’information des patients sur l’evolution a long terme apres reconstruction du LCA. Niveau de preuve Etude retrospective de cohorte de niveau IV.
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- 2016
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3. The role of high tibial osteotomy in the treatment of knee laxity: a comprehensive review
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Elvire Servien, Robert A. Magnussen, Ph Neyret, O Cantin, F Corbi, Sébastien Lustig, Centre Albert Trillat [Hôpital de la Croix-Rousse - HCL], Hôpital de la Croix-Rousse [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Orthopaedic Surgery, Ohio State University [Columbus] (OSU), Laboratoire de Biomécanique et Mécanique des Chocs (LBMC UMR T9406), Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR)
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Joint Instability ,Reoperation ,musculoskeletal diseases ,Ligamentous laxity ,medicine.medical_specialty ,COMBINED SURGERY ,Knee Joint ,medicine.medical_treatment ,Osteoarthritis ,Osteotomy ,KNEE LAXITY ,BIOMECANIQUE ,03 medical and health sciences ,0302 clinical medicine ,High tibial osteotomy ,medicine ,Humans ,Orthopedics and Sports Medicine ,GENOU ,Tibia ,030222 orthopedics ,business.industry ,030229 sport sciences ,musculoskeletal system ,medicine.disease ,Surgery ,Knee laxity ,CHIRURGIE ,Orthopedic surgery ,[SDV.IB]Life Sciences [q-bio]/Bioengineering ,HIGH TIBIAL OSTEOTOMY ,business - Abstract
PURPOSE: The purpose of this study is to review the indications for and outcomes of high tibial osteotomy in the treatment of patients with chronic knee laxity. METHODS: A comprehensive literature review was performed to identify surgical indications and results of high tibial osteotomy for the treatment of chronic knee laxity. RESULTS: Four distinct situations were identified in which a high tibial osteotomy may be advantageous: (1) anterior laxity with varus osteoarthritis, (2) chronic anterior laxity in the setting of varus with lateral ligamentous laxity, (3) chronic anterior laxity in the setting of a high tibial slope, and (4) chronic posterior laxity or posterolateral corner injury. A total of 24 studies were included in this report, including reports of the treatment of 410 knees as well as several review articles. The most frequently reported indication for that addition of HTO was anterior laxity in the setting of varus OA, which was noted to have good results, minimizing anterior knee laxity and allowing return to sports, while reducing the progression of osteoarthritis. More advanced cases in which lateral structures have also become stretched and incompetent are an excellent indication for HTO, with the need for subsequent lateral procedures dependent on the degree of varus laxity and especially hyperextension that is present. Excessive tibial slope has been identified as a cause of ACL reconstruction failure, and some authors have recommended addressing very high slope in revision cases. In knees with chronic posterior or posterolateral instability, correction of alignment first is generally recommended, with subsequent ligamentous procedures performed when instability persists. CONCLUSIONS: Knees with chronic instability pose a difficult treatment challenge. In all cases, the contribution of coronal plane alignment to varus-valgus knee stability must be carefully considered and addressed prior to ligament surgery. Sagittal plane alignment is also key and must not be overlooked. Such considerations drive the indication for osteotomy as well as the type of osteotomy that is chosen. Level of evidence IV.
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- 2015
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4. Cementless lateralized stems in primary THA: Mid-term survival and risk factors for failure in 172 stems
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O. Cantin, Fabien Subtil, Romain Desmarchelier, C. Courtin, Michel-Henry Fessy, A. Viste, service de chirurgie orthopédique et traumatologique, Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Laboratoire de Biomécanique et Mécanique des Chocs (LBMC UMR T9406), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR), Biostatistiques santé, Département biostatistiques et modélisation pour la santé et l'environnement [LBBE], Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), and Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)
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Male ,Arthroplasty, Replacement, Hip ,Radiography ,Kaplan-Meier Estimate ,NON-INTEGRATION ,0302 clinical medicine ,Risk Factors ,Medicine ,HANCHE ,Orthopedics and Sports Medicine ,Femur ,Aged, 80 and over ,030222 orthopedics ,Incidence (epidemiology) ,Age Factors ,Femoral canal ,[SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph] ,Middle Aged ,Prosthesis Failure ,medicine.anatomical_structure ,Radiological weapon ,Female ,Hip Joint ,Adult ,Reoperation ,medicine.medical_specialty ,SURVIVAL RATE ,Prosthesis Design ,Disease-Free Survival ,LATERALIZED STEM ,Young Adult ,03 medical and health sciences ,BIOMECANIQUE ,Osseointegration ,Humans ,Survival rate ,Survival analysis ,Aged ,Retrospective Studies ,business.industry ,TOTAL HIP ARTHROPLASTY ,Retrospective cohort study ,CEMENTLESS ,030229 sport sciences ,Protective Factors ,Surgery ,Hip Prosthesis ,Aseptic processing ,business ,Follow-Up Studies - Abstract
Introduction Increasing the femoral offset when performing total hip arthroplasty (THA) theoretically increases the stresses and risks of the stem not integrating itself into bone. But this concept has not been validated for cementless stems; this led us to conduct a retrospective study to determine: (1) the risk factors for the occurrence of symptomatic femoral radiological abnormalities, (2) the incidence of these abnormal radiological findings, (3) the revision rate for aseptic non-integration of a cementless lateralized stem. Hypothesis Young patients with significant femoral canal flare and a small cementless lateralized stem have a higher risk of abnormal osseointegration. Material and methods We analyzed retrospectively 172 consecutive lateralized stems (KHO, Corail™ product line) implanted during primary THA between 2006 and 2012 in 157 patients (mean age 68 years ± 12.6 (20–95), 89% men). Radiographs were used to evaluate osseointegration scores, offset restoration and the Noble index. Kaplan-Meier survival analysis was performed using “symptomatic femoral radiological abnormalities” and “revision for aseptic stem non-integration” as endpoints. Results The mean follow-up was 5.9 years ± 2.7 (range, 2–12.4 years). Being more than 70 years of age (HR = 0.7, 95% CI: [0.3–0.9], P = 0.004) and having a larger stem (HR = 0.6, 95% CI: [0.4–0.9], P = 0.03) were protective against symptomatic femoral radiological abnormalities, while increasing the postoperative femoral offset (HR = 1.1, 95% CI: [1.01–1.2], P = 0.02) was deleterious. The survival free of “symptomatic femoral radiological abnormalities” was 93% (95% CI: 89–97) at 5 years and 84% (95% CI: 75–95) at 8 years. The survival free of “revision for aseptic stem non-integration” was 98% (95% CI: 96.8–100) at 5 years and 97% (95% CI: 95.2–100) at 8 years. Discussion In this study, the risk factors for symptomatic radiological abnormalities were being less than 70 years of age, having a small lateralized stem and restoring a large femoral offset. Lateralized stems used in this study had a 10% rate of symptomatic radiological abnormalities and a 4% rate of revision for aseptic non-integration. Level of evidence IV, retrospective study.
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- 2017
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5. Outcome of cartilage at 12 years of follow-up after anterior cruciate ligament reconstruction
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F. Rongieras, O. Cantin, Nicolas Lefevre, Société française de chirurgie orthopédique et traumatologique, Christophe Hulet, Nicolas Graveleau, Sébastien Lustig, D. Saragaglia, Service de Chirurgie Orthopédique [Centre Albert Trillat], Centre Albert Trillat [Hôpital de la Croix-Rousse - HCL], Hôpital de la Croix-Rousse [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL)-Hôpital de la Croix-Rousse [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Laboratoire de Biomécanique et Mécanique des Chocs (LBMC UMR T9406), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR), Clinique universitaire de chirurgie orthopédique et de traumatologie du sport, Hôpital Sud, CHU de Grenoble, Gestes Medico-chirurgicaux Assistés par Ordinateur (TIMC-IMAG-GMCAO), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Institut de l'appareil locomoteur Nollet, Centre de consultation orthopédique et sportive, Clinique du sport de Bordeaux-Mérignac, Mobilités : Attention, Orientation et Chronobiologie (COMETE), Université de Caen Normandie (UNICAEN), and Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)
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Adult ,Cartilage, Articular ,Male ,Chondropathy ,medicine.medical_specialty ,Anterior cruciate ligament reconstruction ,Anterior cruciate ligament ,medicine.medical_treatment ,Osteoarthritis ,Meniscus (anatomy) ,Young Adult ,03 medical and health sciences ,BIOMECANIQUE ,0302 clinical medicine ,LONG-TERM OUTCOMES ,Risk Factors ,Humans ,Medicine ,Orthopedics and Sports Medicine ,RECONSTRUCTION ,[PHYS.MECA.BIOM]Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph] ,Retrospective Studies ,2. Zero hunger ,030222 orthopedics ,Anterior Cruciate Ligament Reconstruction ,business.industry ,Anterior Cruciate Ligament Injuries ,Retrospective cohort study ,030229 sport sciences ,Osteoarthritis, Knee ,medicine.disease ,Surgery ,LIGAMENT ,Treatment Outcome ,medicine.anatomical_structure ,OSTEOARTHRITIS ,MENISCUS ,Cohort ,Disease Progression ,Ligament ,Female ,business ,ANTERIOR CRUCIATE LIGAMENT ,Follow-Up Studies - Abstract
Introduction In cases of chronic anterior laxity, reconstruction of the anterior cruciate ligament (ACL) can slow the development of osteoarthritis. This study was conducted to determine the overall prevalence of osteoarthritis and to identify the risk factors after ACL reconstruction. Hypothesis Meniscus tears, time from injury to surgery, body mass index (BMI), residual laxity, and cartilage lesions influence the progression towards osteoarthritis. Materials and methods This multicenter, retrospective study on the outcome of cruciate ligaments at 12years of follow-up was conducted within the 2014 SOFCOT Symposium. The cohort included 675arthroscopic reconstructions of the ACL from January 2002 to December 2003. The clinical evaluation included the objective and subjective IKDC score. Osteoarthritis was analyzed on 589 knee X-rays according to the IKDC classification. The predictive factors of osteoarthritis development studied were age, gender, BMI, time from injury to surgery, activity level, medial or lateral meniscectomy, type of graft, medial or lateral chondropathy, tunnel positioning, and residual laxity. Univariate and multivariate analyses with logistic regression were performed. Results The mean follow-up was 11.9 ± 0.8years. The subjective IKDC score was 83.7 ± 13. At 12years, the rate of moderate to severe osteoarthritis l (IKDC C or D) was 19% (16% medial tibiofemoral osteoarthritis, 4% lateral tibiofemoral osteoarthritis, and 2% patellofemoral osteoarthritis). The prognostic factors were age at surgery greater than 34years (P < 0.05), cartilage lesions at surgery (P < 0.05), medial or lateral meniscectomy (P < 0.05), and residual laxity (P < 0.05). Conclusions This large-scale study identified risk factors for osteoarthritis that should improve the information provided to patients on long-term progression after ACL reconstruction. Level of evidence Retrospective cohort study, level IV.
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- 2016
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6. Occlusion jéjunale après migration d’un ballon intragastrique
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P. Michel, O. Cantin, J. Jarry, V. N’Guyen, and M. Imperato
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Gynecology ,medicine.medical_specialty ,Nutrition and Dietetics ,business.industry ,medicine ,General Medicine ,business ,Obesite morbide ,Quality of Life Research - Abstract
Les ballons intragastriques, dans des indications bien selectionnees, sont un moyen non chirurgical d’obtenir une perte de poids. Ils existent 2 types de ballons, ceux gonfles a l’air et ceux a l’eau. Tous ont le meme effet sur la perte ponderale mais tous n’ont pas la meme securite. Nous rapportons le cas d’une patiente porteuse, depuis 9 mois, d’un ballon intragastrique type Heliosphere™ (gonfle a l’air) ayant presente une occlusion intestinale sur migration du ballon apres degonflement intempestif. Cette occlusion a necessite une prise en charge chirurgicale. Nous passons en revue la litterature sur la securite des ballons intragastriques, en recherchant quels sont les facteurs favorisant cette migration. L’emploi de ballons gonfles a l’eau doit etre privilegie. La surveillance echographique est possible. En cas de complication entrainant une occlusion, l’approche coelioscopique doit etre utilisee en premiere intention.
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- 2011
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7. Étude IRM des deux faisceaux du LCA : bases anatomiques et application aux ruptures partielles
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R. Desmarchelie, Michel-Henri Fessy, Anthony Viste, O. Cantin, and J. Clechet
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Anatomy - Published
- 2012
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8. Arthrolyse antérieure précoce du coude pour raideur congénitale isolée en flexion : à propos d’un cas opéré à l’âge de 16 mois
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A. Gazarian, O. Cantin, Guillaume Mezzadri, J. Bérard, R. Kohler, F. Chotel, and K. Abelin-Genevois
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musculoskeletal diseases ,medicine.medical_specialty ,business.industry ,Elbow ,Bone deformity ,musculoskeletal system ,Neurovascular bundle ,Surgery ,body regions ,Splints ,medicine.anatomical_structure ,Medicine ,Orthopedics and Sports Medicine ,Elbow extension ,Contracture ,medicine.symptom ,business ,Radial nerve ,Lateral approach - Abstract
Summary Isolated congenital elbow contracture is a rare upper-extremity disorder and there are few data about management of this condition. Authors report their experience after aggressive management of a child with isolated congenital elbow contracture in flexion. Because of total absence of ROM improvement despites physical therapy (ROM 90–120°) and bone deformity, an anterior surgical release of the elbow was performed through an extensive lateral approach, at sixteen months of age. After surgery, this child was treated by three casts at maximal gained extension followed by sequential Turnbuckles splints. After five years of follow-up, the result was excellent with ROM 5–135°, normal function and absence of growth disturbance. The limiting factor of this protocol was excessive traction in elbow extension on the neurovascular structures, especially the radial nerve. This treatment represents an aggressive management with multiple general anaesthesiae, but was found to be a valid option.
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- 2012
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9. Compared fixation and survival of 280 lateralised vs 527 standard cementless stems after two years (1–7)
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A. Viste, Jean-Luc Besse, O. Cantin, Michel-Henri Fessy, Romain Desmarchelier, Service de chirurgie orthopédique et traumatologique, hospices Civils de Lyon, Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Laboratoire de Biomécanique et Mécanique des Chocs (LBMC UMR T9406), Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR)
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Adult ,Male ,Reoperation ,medicine.medical_specialty ,Adolescent ,Arthroplasty, Replacement, Hip ,Radiography ,Aseptic loosening ,Total hip replacement ,Coxa vara ,Prosthesis Design ,BIOMECANIQUE ,Young Adult ,Fixation (surgical) ,Bone remodelling ,Femoral offset ,medicine ,HANCHE ,Humans ,Orthopedics and Sports Medicine ,Lateralised stems ,Prosthesis Fixation ,Aged ,Retrospective Studies ,Aged, 80 and over ,PROTHESE ,business.industry ,Retrospective cohort study ,Middle Aged ,musculoskeletal system ,Surgery ,Patient Outcome Assessment ,Case-Control Studies ,[SDV.IB]Life Sciences [q-bio]/Bioengineering ,Female ,Hip Joint ,Hip Prosthesis ,medicine.symptom ,business ,Follow-Up Studies ,Prosthesis Survival - Abstract
Restoring the native hip anatomy increases hip prosthesis survival, whereas increased femoral lateralisation creates high torque stresses that may alter prosthesis fixation. After finding lucent lines around cementless lateralised stems (CorailTM, DePuy Synthes, St Priest, France) in several patients, we evaluated the effects of lateralisation in a large case-series. The objective of our study was to compare lateralised vs standard stems of identical design in terms of radiological osteo-integration and survival. HYPOTHESIS: Lateralised stems, despite being used only when indicated by the anatomical parameters, carry a higher risk of impaired osteo-integration. MATERIALS AND METHODS: A retrospective study was conducted in 807 primary total hip arthroplasties (THAs) performed between 2006 and 2010 in 798 patients with a mean age of 65 ± 14.2 years. Lateralised stems were used in 280 cases (Corail High Offset KHO, n = 169; and Corail coxa vara KLA, n = 111 cases) and standard stems in 527 cases (Corail KA). Mean follow-up was 2.3 years (range, 1-7 years). The clinical evaluation included determination of the Postel-Merle d'Aubigné (PMA) score. Bone fixation and stability of the implants were assessed by determining the Engh and Massin score and the ARA score on the radiographs at last follow-up. Femoral, acetabular and global offset values were determined before and after THA. Nobles's Canal Flare Index was computed. Survival was estimated using the Kaplan-Meier method with surgical revision for aseptic loosening as the end-point. RESULTS: The PMA score improved from 12 (10-15) pre-operatively to 17.7 (14-18) (P < 0.05). After THA, in the lateralised stem group, femoral offset was restored in 217 (77%) hips and the mean change vs the pre-operative offset value was -2 mm; in the standard stem group, femoral offset was restored in 440 (83.5%) hips and the mean change was +1 mm. The Engh and Massin score values were similar in the standard stem and lateralised stem groups (24.4 ± 2.2 and 22.6 ± 2.4, respectively, NS). Revision for aseptic loosening was required in 5 patients with lateralised stems (3 KHO and 2 KLA) versus none of the patients with standard stems. There were no cases of excessive femoral offset and the mean change in offset was -2.3mm (-5.3 to -1.1). Noble's index was increased (4.27 ± 0.5 for the loosened lateralised stems, 3.65 ± 0.8 for the well-fixed lateralised stems and 3.82 ± 0.6 for the standard stems), with no significant difference across groups. Overall survival after 3.5 years of follow-up was 94.6% (95% confidence interval, 88.4-100%) with lateralised stems and 100% with standard stems (P < 0.05). DISCUSSION: The risk of aseptic loosening was significantly higher with the lateralised stem (5/280, 1.8%) than with the standard stem (n = 0). Our findings indicate a need for careful preparation to obtain primary fixation of lateralised stems. LEVEL OF EVIDENCE: III, retrospective case-control study.
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10. Early surgical anterior release for congenital and isolated elbow contracture in flexion: A case report of a 16-month-old child
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F. Chotel, K. Abelin-Genevois, G. Mezzadri, R. Kohler, A. Gazarian, O. Cantin, and J. Bérard
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Male ,musculoskeletal diseases ,medicine.medical_specialty ,Contracture ,Elbow ,Electromyography ,Congenital ,medicine ,Humans ,Orthopedics and Sports Medicine ,General anaesthesia ,Orthopedic Procedures ,Range of Motion, Articular ,Children ,Radial nerve ,Physical Therapy Modalities ,medicine.diagnostic_test ,business.industry ,Surgical release ,Infant ,Neurovascular bundle ,musculoskeletal system ,Magnetic Resonance Imaging ,Surgery ,body regions ,Splints ,Casts, Surgical ,Elbow joint ,medicine.anatomical_structure ,medicine.symptom ,Range of motion ,business ,Flexion - Abstract
SummaryIsolated congenital elbow contracture is a rare upper-extremity disorder and there are few data about management of this condition. Authors report their experience after aggressive management of children with isolated congenital elbow contracture in flexion. Because of total absence of range of motion (ROM) improvement despites physical therapy (ROM 90–120°) and bone deformity, an anterior surgical release of the elbow was performed through an extensive lateral approach, at sixteen months of age. After surgery, this child was treated by three casts at maximal gained extension followed by sequential Turnbuckles splints. After five years of follow-up, the result was excellent with ROM 5–135°, normal function and absence of growth disturbance. The limiting factor of this protocol was excessive traction in elbow extension on the neurovascular structures, especially the radial nerve. This treatment represents an aggressive management with multiple general anaesthesia, but was found to be a valid option.
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11. In vitro and in vivo behavior of ground tadalafil hot-melt extrudates: How the carrier material can effectively assure rapid or controlled drug release.
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Krupa A, Cantin O, Strach B, Wyska E, Tabor Z, Siepmann J, Wróbel A, and Jachowicz R
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- Animals, Calorimetry, Differential Scanning, Chemistry, Pharmaceutical, Male, Rats, Rats, Wistar, Solubility, Drug Compounding, Drug Liberation, Tadalafil chemistry
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Different types of ground hot-melt extrudates loaded with 10, 20 or 30 % of the poorly water-soluble drug tadalafil were prepared and characterized in vitro and in vivo (in rats). Soluplus was used as an amorphous carrier material, whereas mannitol and lactitol were studied as crystalline matrix formers. The systems were characterized using X-ray powder diffraction, thermogravimetric analysis coupled with quadruple mass spectrometry, differential scanning calorimetry, X-ray computed microtomography, in vitro drug release measurements and monitoring of drug plasma levels upon oral administration to rats. The pure drug substance and physical mixtures of tadalafil with the carrier materials were used as references. Importantly, the bioavailability of this poorly water-soluble drug could be substantially increased with the proposed formulations, and the in vitro and in vivo release rates could be effectively adjusted by choosing the appropriate type of carrier material: Whereas mannitol-based ground hot-melt extrudates rapidly released the drug and led to an early rise in drug plasma concentrations, Soluplus-based systems released tadalafil more slowly, resulting in delayed plasma peaks. These behaviors could be explained by the rapid disintegration/dissolution of the porous mannitol-based formulations, whereas Soluplus significantly swelled and the dissolved drug had to diffuse through the polymeric network prior to release. Blending these formulations can be expected to allow providing elevated drug concentrations in vivo during prolonged periods of time upon one single administration with a rapid onset of drug action., (Copyright © 2017 Elsevier B.V. All rights reserved.)
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- 2017
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12. Cementless lateralized stems in primary THA: Mid-term survival and risk factors for failure in 172 stems.
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Courtin C, Viste A, Subtil F, Cantin O, Desmarchelier R, and Fessy MH
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- Adult, Age Factors, Aged, Aged, 80 and over, Arthroplasty, Replacement, Hip adverse effects, Arthroplasty, Replacement, Hip methods, Disease-Free Survival, Female, Femur diagnostic imaging, Follow-Up Studies, Hip Joint diagnostic imaging, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Prosthesis Design, Protective Factors, Radiography, Reoperation, Retrospective Studies, Risk Factors, Survival Rate, Young Adult, Arthroplasty, Replacement, Hip instrumentation, Hip Prosthesis adverse effects, Osseointegration, Prosthesis Failure
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Introduction: Increasing the femoral offset when performing total hip arthroplasty (THA) theoretically increases the stresses and risks of the stem not integrating itself into bone. But this concept has not been validated for cementless stems; this led us to conduct a retrospective study to determine: (1) the risk factors for the occurrence of symptomatic femoral radiological abnormalities, (2) the incidence of these abnormal radiological findings, (3) the revision rate for aseptic non-integration of a cementless lateralized stem., Hypothesis: Young patients with significant femoral canal flare and a small cementless lateralized stem have a higher risk of abnormal osseointegration., Material and Methods: We analyzed retrospectively 172 consecutive lateralized stems (KHO, Corail™ product line) implanted during primary THA between 2006 and 2012 in 157 patients (mean age 68years±12.6 (20-95), 89% men). Radiographs were used to evaluate osseointegration scores, offset restoration and the Noble index. Kaplan-Meier survival analysis was performed using "symptomatic femoral radiological abnormalities" and "revision for aseptic stem non-integration" as endpoints., Results: The mean follow-up was 5.9years±2.7 (range, 2-12.4years). Being more than 70years of age (HR=0.7, 95% CI: [0.3-0.9], P=0.004) and having a larger stem (HR=0.6, 95% CI: [0.4-0.9], P=0.03) were protective against symptomatic femoral radiological abnormalities, while increasing the postoperative femoral offset (HR=1.1, 95% CI: [1.01-1.2], P=0.02) was deleterious. The survival free of "symptomatic femoral radiological abnormalities" was 93% (95% CI: 89-97) at 5years and 84% (95% CI: 75-95) at 8years. The survival free of "revision for aseptic stem non-integration" was 98% (95% CI: 96.8-100) at 5years and 97% (95% CI: 95.2-100) at 8years., Discussion: In this study, the risk factors for symptomatic radiological abnormalities were being less than 70years of age, having a small lateralized stem and restoring a large femoral offset. Lateralized stems used in this study had a 10% rate of symptomatic radiological abnormalities and a 4% rate of revision for aseptic non-integration., Level of Evidence: IV, retrospective study., (Copyright © 2016 Elsevier Masson SAS. All rights reserved.)
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- 2017
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13. Outcome of cartilage at 12years of follow-up after anterior cruciate ligament reconstruction.
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Cantin O, Lustig S, Rongieras F, Saragaglia D, Lefèvre N, Graveleau N, and Hulet C
- Subjects
- Adult, Anterior Cruciate Ligament Injuries complications, Anterior Cruciate Ligament Injuries physiopathology, Disease Progression, Female, Follow-Up Studies, Humans, Male, Osteoarthritis, Knee diagnosis, Osteoarthritis, Knee etiology, Osteoarthritis, Knee physiopathology, Retrospective Studies, Risk Factors, Treatment Outcome, Young Adult, Anterior Cruciate Ligament Injuries surgery, Anterior Cruciate Ligament Reconstruction, Cartilage, Articular physiopathology, Osteoarthritis, Knee prevention & control
- Abstract
Introduction: In cases of chronic anterior laxity, reconstruction of the anterior cruciate ligament (ACL) can slow the development of osteoarthritis. This study was conducted to determine the overall prevalence of osteoarthritis and to identify the risk factors after ACL reconstruction., Hypothesis: Meniscus tears, time from injury to surgery, body mass index (BMI), residual laxity, and cartilage lesions influence the progression towards osteoarthritis., Materials and Methods: This multicenter, retrospective study on the outcome of cruciate ligaments at 12 years of follow-up was conducted within the 2014 SOFCOT Symposium. The cohort included 675 arthroscopic reconstructions of the ACL from January 2002 to December 2003. The clinical evaluation included the objective and subjective IKDC score. Osteoarthritis was analyzed on 589 knee X-rays according to the IKDC classification. The predictive factors of osteoarthritis development studied were age, gender, BMI, time from injury to surgery, activity level, medial or lateral meniscectomy, type of graft, medial or lateral chondropathy, tunnel positioning, and residual laxity. Univariate and multivariate analyses with logistic regression were performed., Results: The mean follow-up was 11.9±0.8 years. The subjective IKDC score was 83.7±13. At 12 years, the rate of moderate to severe osteoarthritis l (IKDCC or D) was 19% (16% medial tibiofemoral osteoarthritis, 4% lateral tibiofemoral osteoarthritis, and 2% patellofemoral osteoarthritis). The prognostic factors were age at surgery greater than 34 years (P<0.05), cartilage lesions at surgery (P<0.05), medial or lateral meniscectomy (P<0.05), and residual laxity (P<0.05)., Conclusions: This large-scale study identified risk factors for osteoarthritis that should improve the information provided to patients on long-term progression after ACL reconstruction., Level of Evidence: Retrospective cohort study, level IV., (Copyright © 2016 Elsevier Masson SAS. All rights reserved.)
- Published
- 2016
- Full Text
- View/download PDF
14. Compared fixation and survival of 280 lateralised vs 527 standard cementless stems after two years (1-7).
- Author
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Cantin O, Viste A, Desmarchelier R, Besse JL, and Fessy MH
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Case-Control Studies, Female, Follow-Up Studies, Hip Joint diagnostic imaging, Humans, Male, Middle Aged, Radiography, Reoperation, Retrospective Studies, Young Adult, Arthroplasty, Replacement, Hip, Hip Prosthesis, Patient Outcome Assessment, Prosthesis Design
- Abstract
Background: Restoring the native hip anatomy increases hip prosthesis survival, whereas increased femoral lateralisation creates high torque stresses that may alter prosthesis fixation. After finding lucent lines around cementless lateralised stems (Corail™, DePuy Synthes, St Priest, France) in several patients, we evaluated the effects of lateralisation in a large case-series. The objective of our study was to compare lateralised vs standard stems of identical design in terms of radiological osteo-integration and survival., Hypothesis: Lateralised stems, despite being used only when indicated by the anatomical parameters, carry a higher risk of impaired osteo-integration., Materials and Methods: A retrospective study was conducted in 807 primary total hip arthroplasties (THAs) performed between 2006 and 2010 in 798 patients with a mean age of 65 ± 14.2 years. Lateralised stems were used in 280 cases (Corail High Offset KHO, n = 169; and Corail coxa vara KLA, n = 111 cases) and standard stems in 527 cases (Corail KA). Mean follow-up was 2.3 years (range, 1-7 years). The clinical evaluation included determination of the Postel-Merle d'Aubigné (PMA) score. Bone fixation and stability of the implants were assessed by determining the Engh and Massin score and the ARA score on the radiographs at last follow-up. Femoral, acetabular and global offset values were determined before and after THA. Nobles's Canal Flare Index was computed. Survival was estimated using the Kaplan-Meier method with surgical revision for aseptic loosening as the end-point., Results: The PMA score improved from 12 (10-15) pre-operatively to 17.7 (14-18) (P < 0.05). After THA, in the lateralised stem group, femoral offset was restored in 217 (77%) hips and the mean change vs the pre-operative offset value was -2 mm; in the standard stem group, femoral offset was restored in 440 (83.5%) hips and the mean change was +1 mm. The Engh and Massin score values were similar in the standard stem and lateralised stem groups (24.4 ± 2.2 and 22.6 ± 2.4, respectively, NS). Revision for aseptic loosening was required in 5 patients with lateralised stems (3 KHO and 2 KLA) versus none of the patients with standard stems. There were no cases of excessive femoral offset and the mean change in offset was -2.3mm (-5.3 to -1.1). Noble's index was increased (4.27 ± 0.5 for the loosened lateralised stems, 3.65 ± 0.8 for the well-fixed lateralised stems and 3.82 ± 0.6 for the standard stems), with no significant difference across groups. Overall survival after 3.5 years of follow-up was 94.6% (95% confidence interval, 88.4-100%) with lateralised stems and 100% with standard stems (P < 0.05)., Discussion: The risk of aseptic loosening was significantly higher with the lateralised stem (5/280, 1.8%) than with the standard stem (n = 0). Our findings indicate a need for careful preparation to obtain primary fixation of lateralised stems., Level of Evidence: III, retrospective case-control study., (Copyright © 2015 Elsevier Masson SAS. All rights reserved.)
- Published
- 2015
- Full Text
- View/download PDF
15. The role of high tibial osteotomy in the treatment of knee laxity: a comprehensive review.
- Author
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Cantin O, Magnussen RA, Corbi F, Servien E, Neyret P, and Lustig S
- Subjects
- Humans, Reoperation, Joint Instability surgery, Knee Joint surgery, Osteotomy methods, Tibia surgery
- Abstract
Purpose: The purpose of this study is to review the indications for and outcomes of high tibial osteotomy in the treatment of patients with chronic knee laxity., Methods: A comprehensive literature review was performed to identify surgical indications and results of high tibial osteotomy for the treatment of chronic knee laxity., Results: Four distinct situations were identified in which a high tibial osteotomy may be advantageous: (1) anterior laxity with varus osteoarthritis, (2) chronic anterior laxity in the setting of varus with lateral ligamentous laxity, (3) chronic anterior laxity in the setting of a high tibial slope, and (4) chronic posterior laxity or posterolateral corner injury. A total of 24 studies were included in this report, including reports of the treatment of 410 knees as well as several review articles. The most frequently reported indication for that addition of HTO was anterior laxity in the setting of varus OA, which was noted to have good results, minimizing anterior knee laxity and allowing return to sports, while reducing the progression of osteoarthritis. More advanced cases in which lateral structures have also become stretched and incompetent are an excellent indication for HTO, with the need for subsequent lateral procedures dependent on the degree of varus laxity and especially hyperextension that is present. Excessive tibial slope has been identified as a cause of ACL reconstruction failure, and some authors have recommended addressing very high slope in revision cases. In knees with chronic posterior or posterolateral instability, correction of alignment first is generally recommended, with subsequent ligamentous procedures performed when instability persists., Conclusions: Knees with chronic instability pose a difficult treatment challenge. In all cases, the contribution of coronal plane alignment to varus-valgus knee stability must be carefully considered and addressed prior to ligament surgery. Sagittal plane alignment is also key and must not be overlooked. Such considerations drive the indication for osteotomy as well as the type of osteotomy that is chosen. Level of evidence IV.
- Published
- 2015
- Full Text
- View/download PDF
16. Early surgical anterior release for congenital and isolated elbow contracture in flexion: a case report of a 16-month-old child.
- Author
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Cantin O, Mezzadri G, Gazarian A, Abelin-Genevois K, Kohler R, Bérard J, and Chotel F
- Subjects
- Casts, Surgical, Contracture diagnosis, Electromyography, Humans, Infant, Magnetic Resonance Imaging, Male, Physical Therapy Modalities, Range of Motion, Articular, Contracture surgery, Elbow Joint surgery, Orthopedic Procedures methods
- Abstract
Isolated congenital elbow contracture is a rare upper-extremity disorder and there are few data about management of this condition. Authors report their experience after aggressive management of children with isolated congenital elbow contracture in flexion. Because of total absence of range of motion (ROM) improvement despites physical therapy (ROM 90-120°) and bone deformity, an anterior surgical release of the elbow was performed through an extensive lateral approach, at sixteen months of age. After surgery, this child was treated by three casts at maximal gained extension followed by sequential Turnbuckles splints. After five years of follow-up, the result was excellent with ROM 5-135°, normal function and absence of growth disturbance. The limiting factor of this protocol was excessive traction in elbow extension on the neurovascular structures, especially the radial nerve. This treatment represents an aggressive management with multiple general anaesthesia, but was found to be a valid option., (Copyright © 2012. Published by Elsevier Masson SAS.)
- Published
- 2012
- Full Text
- View/download PDF
17. Automated SNP detection in expressed sequence tags: statistical considerations and application to maritime pine sequences.
- Author
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Dantec LL, Chagné D, Pot D, Cantin O, Garnier-Géré P, Bedon F, Frigerio JM, Chaumeil P, Léger P, Garcia V, Laigret F, De Daruvar A, and Plomion C
- Subjects
- Algorithms, Alleles, Gene Frequency, Point Mutation, Reproducibility of Results, Expressed Sequence Tags, Pinus genetics, Polymorphism, Single Nucleotide, Sequence Analysis, DNA methods
- Abstract
We developed an automated pipeline for the detection of single nucleotide polymorphisms (SNPs) in expressed sequence tag (EST) data sets, by combining three DNA sequence analysis programs: Phred, Phrap and PolyBayes. This application requires access to the individual electrophoregram traces. First, a reference set of 65 SNPs was obtained from the sequencing of 30 gametes in 13 maritime pine (Pinus pinaster Ait.) gene fragments (6671 bp), resulting in a frequency of 1 SNP every 102.6 bp. Second, parameters of the three programs were optimized in order to retrieve as many true SNPs, while keeping the rate of false positive as low as possible. Overall, the efficiency of detection of true SNPs was 83.1%. However, this rate varied largely as a function of the rare SNP allele frequency: down to 41% for rare SNP alleles (frequency < 10%), up to 98% for allele frequencies above 10%. Third, the detection method was applied to the 18498 assembled maritime pine (Pinus pinaster Ait.) ESTs, allowing to identify a total of 1400 candidate SNPs, in contigs containing between 4 and 20 sequence reads. These genetic resources, described for the first time in a forest tree species, were made available at http://www.pierroton.inra/genetics/Pinesnps. We also derived an analytical expression for the SNP detection probability as a function of the SNP allele frequency, the number of haploid genomes used to generate the EST sequence database, and the sample size of the contigs considered for SNP detection. The frequency of the SNP allele was shown to be the main factor influencing the probability of SNP detection.
- Published
- 2004
- Full Text
- View/download PDF
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