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7 results on '"O. E. Popovkina"'

1. 2022 Prevention of chronic non-communicable diseases in the Russian Federation. National guidelines

Author

O. M. Drapkina, A. V. Kontsevaya, A. M. Kalinina, S. M. Avdeev, M. V. Agaltsov, L. M. Alexandrova, A. A. Antsiferova, D. M. Aronov, N. M. Akhmedzhanov, Yu. A. Balanova, T. V. Balakhonova, S. A. Berns, M. V. Bochkarev, E. V. Bochkareva, M. V. Bubnova, A. V. Budnevsky, M. G. Gambaryan, V. M. Gorbunov, B. E. Gorny, A. Yu. Gorshkov, N. G. Gumanova, V. A. Dadaeva, L. Yu. Drozdova, V. A. Egorov, S. O. Eliashevich, A. I. Ershova, E. S. Ivanova, A. E. Imaeva, P. V. Ipatov, A. D. Kaprin, N. S. Karamnova, Zh. D. Kobalava, A. O. Konradi, O. V. Kopylova, L. S. Korostovtseva, M. B. Kotova, M. S. Kulikova, E. A. Lavrenova, O. V. Lischenko, M. V. Lopatina, Yu. V. Lukina, M. M. Lukyanov, I. V. Mayev, M. N. Mamedov, S. V. Markelova, S. Yu. Martsevich, V. A. Metelskaya, A. N. Meshkov, O. Yu. Milushkina, D. K. Mukaneeva, A. O. Myrzamatova, D. V. Nebieridze, D. O. Orlov, E. A. Poddubskaya, M. V. Popovich, O. E. Popovkina, V. I. Potievskaya, G. G. Prozorova, Yu. S. Rakovskaya, O. P. Rotar, I. A. Rybakov, Yu. V. Sviryaev, I. A. Skripnikova, N. A. Skoblina, M. I. Smirnova, V. V. Starinsky, S. N. Tolpygina, E. V. Usova, Zh. V. Khailova, S. A. Shalnova, R. N. Shepel, V. N. Shishkova, I. S. Yavelov, and B. U. Mardanov

Subjects
профилактика, хронические неинфекционные заболевания, национальное руководство, Diseases of the circulatory (Cardiovascular) system, RC666-701
Published
2022
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2. Cell biobank as a necessary infrastructure for the development and implementation of mesenchymal stem cell-based therapy in the treatment of anthracycline-induced cardiotoxicity. Literature review and own data

Author

L. Yu. Grivtsova, O. E. Popovkina, N. N. Dukhova, O. A. Politiko, V. V. Yuzhakov, L. A. Lepekhina, S. Sh. Kalsina, S. A. Ivanov, and A. D. Kaprin

Subjects
мезенхимальные стволовые клетки, кардиомиобласты, клеточный биобанк, антрациклины, кардиомиоциты, кардиотоксичность, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Cardiovascular diseases, along with cancer, are the leading causes of death worldwide. Although modern pharmacological treatment of various cardiomyopathies can slow the development of myocardial dysfunction, they have limited effectiveness in patients with end-stage disease. Many researchers believe that heart transplantation is the only radical treatment in this case. However, the lack of donors and the high operation cost require careful selection of surgical candidates. With the introduction of molecular and cell biology into medical practice, today, stem cell therapy can become an alternative method of nonsurgical restoration of myocardial functions. The most studied and attractive is the use of mesenchymal stem cells (MSCs). MSCs differ from hematopoietic stem cells used as support for hematopoiesis in high-dose chemotherapy by the following features: pronounced trophic effect, immune tolerance, the ability to suppress alloreactivity and autoimmune disorders. An important stage in the implementation of cell therapy is the creation of a cell biobank of MSCs. In A.F.Tsyb Medical Radiological Research Center, this work has been carried out since1984. Asignificant number of experimental studies have been carried out, confirming the possibility of clinical implementation of this approach. A method for obtaining stable cultures of MSCs and cardiomyoblasts from bone marrow cells was developed and approvals were obtained. Experimental studies of cell therapy are also being conducted to overcome anthracycline-induced cardiotoxicity in cancer patients.This article is devoted to practical application of MSC-based therapy, in particular, in cancer patients with cardiotoxicity, as well as to the issues of creating a cell biobank for treatment with MSCs.

Published
2020
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3. 2022 Prevention of chronic non-communicable diseases in Of the Russian Federation. National guidelines

Author

O. M. Drapkina, A. V. Kontsevaya, A. M. Kalinina, S. M. Avdeev, M. V. Agaltsov, L. M. Alexandrova, A. A. Antsiferova, D. M. Aronov, N. M. Akhmedzhanov, Yu. A. Balanova, T. V. Balakhonova, S. A. Berns, M. V. Bochkarev, E. V. Bochkareva, M. V. Bubnova, A. V. Budnevsky, M. G. Gambaryan, V. M. Gorbunov, B. E. Gorny, A. Yu. Gorshkov, N. G. Gumanova, V. A. Dadaeva, L. Yu. Drozdova, V. A. Egorov, S. O. Eliashevich, A. I. Ershova, E. S. Ivanova, A. E. Imaeva, P. V. Ipatov, A. D. Kaprin, N. S. Karamnova, Zh. D. Kobalava, A. O. Konradi, O. V. Kopylova, L. S. Korostovtseva, M. B. Kotova, M. S. Kulikova, E. A. Lavrenova, O. V. Lischenko, M. V. Lopatina, Yu. V. Lukina, M. M. Lukyanov, I. V. Mayev, M. N. Mamedov, S. V. Markelova, S. Yu. Martsevich, V. A. Metelskaya, A. N. Meshkov, O. Yu. Milushkina, D. K. Mukaneeva, A. O. Myrzamatova, D. V. Nebieridze, D. O. Orlov, E. A. Poddubskaya, M. V. Popovich, O. E. Popovkina, V. I. Potievskaya, G. G. Prozorova, Yu. S. Rakovskaya, O. P. Rotar, I. A. Rybakov, Yu. V. Sviryaev, I. A. Skripnikova, N. A. Skoblina, M. I. Smirnova, V. V. Starinsky, S. N. Tolpygina, E. V. Usova, Zh. V. Khailova, S. A. Shalnova, R. N. Shepel, V. N. Shishkova, and I. S. Yavelov

Subjects
Cardiology and Cardiovascular Medicine, Education
Published
2022

4. Syngeneic and Xenogeneic Transplantations of Mesenchymal Stromal Cells Modify the Production of Reactive Oxygen Species by Blood Mononuclears of Mice

Author

I. V. Semenkova, A. G. Konoplyannikov, E. V. Sayapina, V. N. Petrov, L. A. Lepekhina, O. E. Popovkina, and E. V. Agaeva

Subjects
0301 basic medicine, Transplantation, Heterologous, Mesenchymal Stem Cell Transplantation, General Biochemistry, Genetics and Molecular Biology, Proinflammatory cytokine, Mice, 03 medical and health sciences, 0302 clinical medicine, In vivo, medicine, Animals, Humans, Transplantation, Homologous, Cells, Cultured, chemistry.chemical_classification, Reactive oxygen species, Chemistry, Macrophages, Mesenchymal stem cell, Mesenchymal Stem Cells, General Medicine, Phenotype, Transplantation, 030104 developmental biology, medicine.anatomical_structure, Immunology, Leukocytes, Mononuclear, Cancer research, Bone marrow, Reactive Oxygen Species, Reprogramming, 030217 neurology & neurosurgery
Abstract

In vivo modifying effects of bone marrow mesenchymal stromal cells of humans and laboratory mice on ROS production by mouse blood mononuclears are studied by luminol-dependent zymosan-induced chemiluminescence after syngeneic and xenogeneic transplantation into systemic blood flow. The chemiluminescent activity of mouse blood mononuclears has increased early (1 day) after syngeneic (mouse mesenchymal stromal cells) and xenogeneic (human mesenchymal stromal cells) transplantation. Later, 7-21 days after syngeneic and xenogeneic transplantation, the chemiluminescent activity of mouse mononuclears is suppressed. The probable mechanisms of involvement of the transplanted mesenchymal stromal cells in reprogramming of the blood mononuclear phagocytes from proinflammatory (M1) to anti-inflammatory (M2) phenotype under conditions of their in vivo interactions are discussed; a frequent manifestation of this reprogramming is transition of the phase of activation into inhibition of ROS-producing activity of macrophages.

Published
2017

5. Modifying Effect of Autotransfusion of Mesenchymal Stromal Cells on the Production of Reactive Oxygen Species and Cytokines by Mononuclear Cells in Patients with Chronic Heart Failure

Author

A. G. Konoplyannikov, V. N. Petrov, I. V. Semenkova, E. V. Agaeva, E. V. Sayapina, O. E. Popovkina, M. A. Kaplan, and L. A. Lepekhina

Subjects
0301 basic medicine, Lipopolysaccharides, Stromal cell, Primary Cell Culture, Mesenchymal Stem Cell Transplantation, Peripheral blood mononuclear cell, Transplantation, Autologous, General Biochemistry, Genetics and Molecular Biology, Dinoprostone, 03 medical and health sciences, Interferon-gamma, 0302 clinical medicine, In vivo, Interleukin-1alpha, Medicine, Humans, Lymphotoxin-alpha, chemistry.chemical_classification, Heart Failure, Reactive oxygen species, business.industry, Tumor Necrosis Factor-alpha, Mesenchymal stem cell, Granulocyte-Macrophage Colony-Stimulating Factor, Mesenchymal Stem Cells, General Medicine, In vitro, Interleukin-10, 030104 developmental biology, chemistry, Gene Expression Regulation, Immunology, Leukocytes, Mononuclear, Tumor necrosis factor alpha, business, Reactive Oxygen Species, 030217 neurology & neurosurgery, Autotransfusion, Signal Transduction
Abstract

We studied in vivo modifying effect of autotransfusion of human bone marrow mesenchymal stromal cells on ROS generation and production of cytokines (TNFα,TNFβ, IL-1α, IL-10, IFNγ, and GM-CSF) and PGE2 by mononuclear cells of patients (N=21) with chronic heart failure. These parameters were evaluated prior to (control) and after (immediately and on day 14) intravenous administration of stromal cells in doses of 100-200×106. Immediately after autotransfusion, significant increase of in vitro zymosan-induced chemiluminescence of blood mononuclear cells from 10 patients was observed. At later terms after autotransfusion (day 14), inhibition of chemiluminescent activity of blood mononuclear cells was revealed in 50% patients. We discuss possible mechanisms of involvement of transplanted autologous bone marrow mesenchymal stromal cells in reprogramming of blood mononuclear phagocytes from the pro- to anti-inflammatory phenotype under conditions of their in vivo interaction manifesting in transition from activation to inhibition of ROS-producing activity of macrophages and significant suppression of in vitro LPS-induced production of TNFα and GM-CSF by blood mononuclears against the background of significantly elevated TNFβ, IL-10, and IL-1α concentrations.

Published
2017

6. Cardiovascular diseases in cancer patients

Author

O. E. Popovkina, V. I. Potievskaya, L. V. Bolotina, S. T. Matskeplishvili, Andrey Kaprin, M. V. Poluektova, and A. V. Shklyaeva

Subjects
medicine.medical_specialty, business.industry, Medicine, business, Dermatology
Published
2019

7. [Possibilities of the low-intensity infrared laser therapy in atherosclerotic lesions of the cardiovascular system]

Author

A F, Tsyb, M A, Kaplan, N P, Tkachenko, and O E, Popovkina

Subjects
Male, Leg, Time Factors, Arteriosclerosis, Infrared Rays, Ultrasonography, Doppler, Arteriosclerosis Obliterans, Coronary Artery Disease, Intracranial Arteriosclerosis, Angina Pectoris, Rats, Disease Models, Animal, Treatment Outcome, Photochemotherapy, Cardiovascular Diseases, Animals, Humans, Low-Level Light Therapy, Diabetic Angiopathies, Tomography, Emission-Computed
Published
2004

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