Search

Your search keyword '"O. Marečková"' showing total 8 results
Start Over Author "O. Marečková"
8 results on '"O. Marečková"'

1. Prophylaxis of acute gastroduodenal bleeding after renal transplantation

Author

I. Skála, Matl I, Jiří Lácha, O. Marečková, and Stefan Vitko

Subjects
Nephrology, Adult, Male, medicine.medical_specialty, Transplantation Conditioning, medicine.drug_class, Proton-pump inhibitor, Ranitidine, Gastroenterology, Internal medicine, Cyclosporin a, Medicine, Humans, Prospective Studies, Stomach Ulcer, Kidney transplantation, Omeprazole, Aged, Transplantation, business.industry, Middle Aged, medicine.disease, Anti-Ulcer Agents, Kidney Transplantation, Surgery, Duodenal Ulcer, Acute Disease, Female, business, Gastrointestinal Hemorrhage, Kidney disease, medicine.drug
Abstract

Severe gastroduodenal bleeding after renal transplantation is effectively prevented by H2 receptor blockers. New drugs for prophylaxis include proton pump inhibitors. The aim of the present study was to compare the effects of prophylaxis with the H2 blocker ranitidine and with the proton pump inhibitor omeprazole. One hundred seventy-seven consecutive patients were included in a controlled, prospective, randomized study after cadaveric renal transplantation. In one case, ranitidine failed to prevent exsanguination due to duodenal peptic ulcer bleeding. No bleeding was noted in the omeprazole group. There were no significant differences between the groups in hospitalization time, development of renal function, amount of cyclosporin A, prednisone, azathioprine, or methylprednisolone ingested, or laboratory biochemical parameters. We conclude that prophylaxis of severe gastroduodenal bleeding after renal transplantation with omeprazole is effective. Omeprazole is certainly as good as ranitidine; its advantages are a prolonged effect and a simple dosage, independent of graft function development.

Published
1997

2. Residual kidney function and plasma urea concentration in patients with chronic renal failure

Author

V. Reitschlägerová, O Schück, I. Skála, J. Erben, O. Marečková, H. Nádvorníková, and V. Teplan

Subjects
Nephrology, Male, medicine.medical_specialty, Urology, Extraction ratio, Renal function, Kidney, Kidney Function Tests, Blood Urea Nitrogen, chemistry.chemical_compound, Internal medicine, medicine, Humans, In patient, Blood urea nitrogen, Creatinine, business.industry, Middle Aged, Endocrinology, chemistry, Urea, Chronic renal failure, Kidney Failure, Chronic, Female, business
Abstract

The relationships between the plasma levels of urea (P(urea)), renal clearance of urea (C(urea)) and creatinine (Ccr) at an intake of 0.5 g protein/kg body weight/day were followed in 10 patients with chronic renal failure (CRF) under balance conditions. Under these conditions, P(urea) attained a value of 30 mmol/l when C(urea) had decreased below 3.8 ml/min. By contrast, no correlation could be demonstrated between P(urea) and Ccr under these conditions. The same relationships were followed in another group of 30 outpatients with CRF. Even in patients not followed under balance conditions, C(urea) determination makes it possible to establish whether the high increase in P(urea) is due to the decrease in residual renal function below the critical level or whether extrarenal factors are involved. Likewise, no significant correlation between P(urea) and Ccr could be demonstrated under these conditions. The findings suggest that C(urea) measurement in CRF patients helps to assess residual renal function in terms of P(urea) regulation and provides information that cannot be obtained by Ccr measurement.

Published
1990

3. Estimation of Glomerular Filtration Rate Based on the Modification of Diet in Renal Disease Equation in Patients with Chronic Renal Failure.

Author

O. Schück, V. Teplan, O. Marečková, J. Skibová, and M. Štollová

Subjects
DIALYSIS (Chemistry), GLOMERULAR filtration rate, KIDNEY diseases, INULIN, REGRESSION analysis
Abstract

The list of indications for initiating regular dialysis treatment includes residual glomerular filtration rate (GFR). Under the current European Best Practice Guidelines for Hemodialysis, residual GFR (and the presence of one or more symptoms of uremia) should not decrease below 15 ml/min. The present article seeks to determine to what extent the modification of diet in renal disease (MDRD) equation enables the detection of this decrease in GFR. We tried to answer this question using a more detailed analysis of the relationship between MDRD and renal inulin clearance (Cin). Residual GFR based on Cin (under conditions of stable plasma levels and water loading) and GFR calculated using the MDRD equation was measured in 79 individuals with chronic renal failure (with mean Cin = 19.1 ± 10.1 ml/min/1.73 m2). Statistical evaluation was performed using regression analysis, the interchangeability of both methods (Bland-Altman) and receiver-operating characteristic (ROC) curve analysis. Regression analysis demonstrated a significant correlation between MDRD and Cin (r = 0.892; p < 0.001). However, the regression equation line for the correlation differs significantly from the identity line (p < 0.001). The value of the regression coefficient (0.722) is significantly lower than 1.0 (CI50 0.63; 0.81). The mean MDRD – Cin difference was 3.26 ± 4.46 ml/min/1.73 m2 and the value was significantly different from zero (p < 0.001). The mean difference +2 SD was 12.2 ml/min/1.73 m2, and the mean – 2 SD was –5.7 ml/min/1.73 m2. ROC curve analysis (for a cutoff Cin = 15 ml/min/1.73 m2) indicates an area under the curve (AUC) of 0.954 ± 0.023. The best combination of sensitivity and specificity was obtained for a MDRD of 19.7 ml/min/1.73 m2, with a sensitivity of 90.5% and specificity of 87.5%. For cutoff value of Cin = 10 ml/min/1.73 m2, the AUC was 0.939 ± 0.026 (CI95 0.863–0.890). A combination of maximum sensitivity and specificity was obtained with an MDRD of 16.5 ml/min/1.73 m2. With this value, MDRD sensitivity was 100% and specificity 81.5%. A significant correlation between the MDRD equation and the measured creatinine clearance (Ccr) was found (r = 0.883, p < 0.001). The mean difference of MDRD – Ccr was –7.2 ± 6.5 ml/min/1.73 m2. This is significantly different from that of MDRD – Cin (p < 0.001). Our results suggest that MDRD and Cin in individuals with chronic renal failure are not interchangeable methods for a GFR <15 ml/min/1.73 m2 determination. However, MDRD may furnish valuable information in terms of detecting a critical decrease in GFR; but, the MDRD equation for this decrease in GFR (15 ml/min/1.73 m2) will provide a somewhat higher value (19.7 ml/min/1.73 m2).Copyright © 2005 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Published
2005

4. Die biologische Bedeutung von Komplexen oxydierter Lipide mit Eiweiß3. Mitt. Die enzymatische Hydrolyse der Eiweißkomponente in vitro

Author

J. Pokorný, J. Vavříková, O. Marečková, and H. Vavřínková

Subjects
biology, Starch, Trypsin, Molecular biology, Small intestine, chemistry.chemical_compound, Oleic acid, Hydrolysis, medicine.anatomical_structure, chemistry, Pepsin, medicine, biology.protein, Digestion, Food Science, medicine.drug
Abstract

Die Verdauung der lipoproteidischen Komplexe von Albumin mit den Hydroxyketo-derivaten der Lipoperoxydation von Fettsauren wird untersucht. Der Komplex wird durch Erhitzen einer Mischung von Albumin mit Hydroxyketooctadecansaure wahrend 2 h auf 130 °C hergestellt. Es wird seine verschlechterte enzymatische Hydrolyse im Magen nachgewiesen; in den anderen Abschnitten des Verdauungstraktes wird der Komplex recht gut verdaut und verwertet. Eine Beeinflussung des Ernahrungswertes der Eiweiskomponente des Komplexes tritt nicht in Erscheinung.

Published
1968

5. Die biologische Bedeutung von Komplexen oxydierter Lipide mit Eiweiß February Mitt. Der Ernährungswert der Eiweißkomponente

Author

J. Pokorný, J. Vavříková, and O. Marečková

Subjects
Chemistry, Molecular biology, Food Science
Abstract

Die Produkte der Komplexbildung zwischen Eiweis und oxidierten Fetten verandern die physikalischen, chemischen und biologischen Eigenschaften der Proteine. Nach den Ergebnissen im Tierversuch (Wachstumsversuch) ist eine verschlechterte Verwertung des Caseins in Form seines Komplexes mit den Produkten der Oxydation von Sojaol nur bei gewissen Typen solcher lipoproteidischen Komplexe nachweisbar.

Published
1968

6. Die biologische Bedeutung von Komplexen oxydierter Lipide mit Eiweiß 1. Mitt. Einführung in die Problematik und die Methodik

Author

J. Pokorný, O. Marečková, and J. Vavříková

Subjects
Chemistry, Molecular biology, Food Science, Cottonseed oil
Abstract

Die nativen Lipide bilden mit den Eiweisstoffen durch masige physikalische, chemische oder enzymatische Eingriffe meist leicht spaltbare Komplexe. Mit den oxydierten Lipiden bilden die Eiweisstoffe bei der Zubereitung der Nahrung, bei langfristiger Lagerung und manchmal auch in vivo Komplexe, die sich teils leicht, teils schwierig und ofters unvollstandig spalten. Man kann erwarten, das diese Komplexe beim normalen Verdauungsprozes nicht vollig ausnutzbar sind; auch nach volliger Spaltung ist weder der lipide noch der proteidische Teil im Vergleich mit den Komponenten nativer Lipoproteide vollwertig.

Published
1968

8. Gender-related determinants of advanced subclinical atherosclerosis in patients undergoing kidney transplantation.

Author

Pitha J, Teplan V, Kalousova M, Racek J, Stollova M, Marečková O, and Lanska V

Subjects
Adult, Aged, Atherosclerosis epidemiology, Cross-Sectional Studies, Female, Humans, Kidney Failure, Chronic epidemiology, Male, Middle Aged, Receptor for Advanced Glycation End Products, Receptors, Immunologic blood, Risk Factors, Atherosclerosis blood, Atherosclerosis diagnosis, Kidney Failure, Chronic blood, Kidney Failure, Chronic diagnosis, Kidney Transplantation trends, Sex Characteristics
Abstract

Background: Cardiovascular disease caused by atherosclerosis remains a major cause of morbidity and mortality in patients with end-stage renal disease (ESRD). We evaluated the potential association of cardiovascular risk factors including asymmetric dimethyl L-arginine (ADMA) and the soluble receptor for advanced glycation end products (sRAGE) with preclinical atherosclerosis in patients undergoing kidney transplantation., Patients and Methods: In 92 males and 47 females undergoing the first cadaveric renal transplantation, ADMA, sRAGE and common risk factors including lipid parameters were evaluated as potential predictors of preclinical atherosclerosis defined as the Belcaro score (focused on advanced atherosclerotic changes) measured by ultrasound., Results: The prevalence of atherosclerotic changes was approximately 70% in men and women. In logistic regression, age, history of smoking, presence of diabetes mellitus, and plasma triglycerides were the strongest independent predictors for advanced atherosclerosis in the whole group. In unadjusted analyses advanced atherosclerosis was also associated with sRAGE in men and with the atherogenic index of plasma in women., Conclusion: Apart from traditional cardiovascular risk factors, plasma triglycerides were found to be strong and independent predictors of advanced atherosclerosis in patients with ESRD. In addition, sRAGE was associated with atherosclerosis in men and the atherogenic index of plasma in women., (Copyright © 2010 S. Karger AG, Basel.)

Published
2010
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results