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Poultry scientists have been charged to opt for natural feed supplements to develop ideal, safe and cost effective feeds as against the synthetic ones. Thus, a 56 day feeding trial was conducted to determine the effect of garlic bulb meal (GBM) as a natural feed additive on growth performance, blood profile, carcass characteristics and cost benefit of broiler chicken. A total of 150, one day old broiler chicks, were randomly allotted into four dietary treatments with three replicate of 12 birds each in a completely randomized design. Four diets were compounded to contain 0, 1, 5, 10 g/kg GBM respectively. Parameters assessed were feed intake, weight gain, feed conversion ratio, haematological, serum biochemical indices, carcass and cost benefits. Results showed that, GBM based diet significantly (P0.05) effect on carcass characteristics of broiler chicken except the spleen. The spleen (0.09 – 0.23%) of the experimental birds increased across the dietary treatments as GBM inclusion levels increased. It was therefore concluded that the garlic powder supplemented at 1g/kg in the diet of broiler chicken supported optimal performance of the birds. Les scientifiques avicoles ont été chargés d'opter pour des compléments alimentaires naturels pour développer des aliments idéaux, sûrs et rentables par rapport aux aliments synthétiques. Ainsi, un essai d'alimentation de 56 jours a été mené pour déterminer l'effet de la farine de bulbes d'ail (FBA) en tant qu'additif alimentaire naturel sur les performances de croissance, le profil sanguin, les caractéristiques de la carcasse et le rapport coût-avantage du poulet à griller. Un total de 150 poussins de chair âgés d'un jour ont été répartis au hasard dans quatre traitements diététiques avec trois répétitions de 12 oiseaux chacune dans une conception entièrement randomisée. Quatre régimes ont été composés pour contenir respectivement 0, 1, 5, 10 g/kg de FBA. Les paramètres évalués étaient l'apport alimentaire, le gain de poids, l'indice de conversion alimentaire, les indices hématologiques et biochimiques sériques, la carcasse et les avantages en termes de coûts. Les résultats ont montré que le régime alimentaire à base de FBA influençait de manière significative (P 0,05) sur les caractéristiques de la carcasse du poulet à griller, à l'exception de la rate. La rate (0,09 à 0,23 %) des oiseaux expérimentaux a augmenté au cours des traitements diététiques à mesure que les niveaux d'inclusion de FBAaugmentaient. Il a donc été conclu que la poudre d'ail supplémentée à 1 g/kg dans l'alimentation des poulets à griller favorisait les performances optimales des oiseaux.

Inadequate consumption of fruit and vegetable is a risk factor for morbidity and mortality associated with non-communicable diseases (NCDs). An understanding of the barriers and facilitators to consumption is important for effectiveness of intervention in Africa. We present insights among church members before developing a church-based multi-component intervention to address the inadequate consumption of fruit and vegetable.We conducted eighteen focus group discussions among 163 church members. All discussions were audio-taped, transcribed verbatim, and were analyzed for thematic content.We identified five main themes; Personal: awareness and knowledge of benefits, choice, habits, and curiosity, dietary restrictions and gastrointestinal symptoms following fruit and vegetable consumption. Familial: practices promoting the ready availability of fruit and vegetables in the home or habits that encourage children to eat vegetables as they transition into adulthood, pre-existing health problems of family members and the long preparation time of some traditional vegetables. Socio-cultural: Cultural practices that encourage FV consumption, the high cost of fruits and vegetables, alternatives foregone, and cultural taboos. Environmental: inadequate farmland and storage facilities, seasonality of several fruit and vegetables, and sharp practices of force-ripening with chemicals. Church-related: inadequate space provided by the church for arable cultivation and lack of knowledge of the benefits among church leaders, church activities that involve serving fruits and vegetables and the biblical support for the consumption of fruits and vegetables.It is essential to leverage practices that promote fruit and vegetable intake and address barriers mentioned by the participants when designing such interventions.

The present experiment was designed to study the histoarchitectural changes in the liver following lactational lead (Pb) intoxication in rats. A total of 12 adult female and 4 male rats were used in the experiment and 32 offspring for the analysis of lactational lead intoxication. The offspring were divided into four groups. Groups B, C and D were administered 10 mg/dL, 30 mg/dL and 70 mg/dL of lead acetate respectively, via drinking water for 21 days through the lactating mothers while group A was control. The livers of the pups were observed using histological methods. One-way ANOVA was used to analyze data, followed by Tukey post hoc test for multiple comparisons. The results from the analysis showed that the total body weight, body length and liver weights were only slightly altered in the Pb intoxicated groups. Using relative liver weights alone revealed some form of hepatomegaly among the experimental groups. The results revealed a dose-dependent increase in blood lead concentration. Histopathological evidences revealed moderate to severe histoarchitectural distortions along Pb concentration gradient. Lactational lead intoxication portends dose dependent histopathological changes in the liver of SD rats.

Mixture of bovine blood and rumen digesta (BBRDM) was evaluated for 56 days as a replacement for soybean meal (SBM) and groundnut cake (GNC) at 100% on protein to protein basis in the diets of growing pigs to assess the nutritive value of BBRDM on the growth performance, nutrient digestibility and cost benefits. Hence, a total of 18 growing pigs were allotted on weight equalization basis into three dietary treatments consisting of six pigs per treatment in a completely randomized design. Three diets were formulated such that T : served as the control diet without BBRDM but contained both soybean meal and 1 groundnut cake. T : BBRDM replaced soybean meal and T : BBRDM replaced groundnut 2 3 cake. Result indicated that BBRDM contained 28.65% crude protein, 13.17% ether extract, 5.26% crude fibre, 11.29% ash and 31.65% nitrogen free extract. Dietary treatments did not significantly (P>0.05) influenced the growth parameters observed in this study. Although there were no significant (P>0.05) difference on the nutrient digestibility parameters investigated but birds in T recorded highest numerical values for crude protein (77.23), 3 crude fibre (62.46%), ether extract (92.33%), nitrogen free extract (89.61%), ash (70.28%) and nutrient dry matter (91.67%) while the least values were obtained from birds in T . Cost 1 of feed decreased with the inclusion of BBRDM while the cost per weight gain also improved with the replacement of the conventional feed ingredients. The result also showed that an appreciable amount of money was saved when BBRDM was included in the ration of growing pigs. It is therefore concluded that BBRDM could be used as an animal protein source to compliment plant protein source such as soybean meal and groundnut cake in the diet of growing pigs.

Wild cocoyam is a non edible plant found growing around riversides and can serve as source of energy to ruminants. Hence, a twelve weeks study was conducted to investigate the effect of wild cocoyam – urea meal on the growth performance and blood profile of West African dwarf (WAD) goats. Twelve WAD goats with an average weight of 7.25 ± 0.04kg were randomly allotted into four dietary treatments: T1 (raw wild cocoyam), T2 (urea treated wild cocoyam), T3 (urea treated cooked wild cocoyam) and T4 (urea treated fermented wild cocoyam), replicated thrice in a completely randomized design. Results obtained showed that the experimental diets significantly (p < 0.05) influenced the growth performance. Goats fed urea treated cooked wild cocoyam had the best feed conversion ratio (10.35), the highest values of dry matter intake (405.35 g/day) and daily weight gain (39.17 g/day) when compared to other dietary treatments. The dietary treatments did not significantly (p < 0.05) influence the haematological parameters except the red blood cells (9.62 - 11.67×106 mm3),white blood cells (4.07-9.05×106 mm3) and monocytes (1.00-2.50%). No significant (p>0.05) differences among the dietary treatments were observed in all the serum biochemical indices evaluated except for urea which ranged from 15.50 – 28.70mg/dl. It can therefore be concluded that addition of urea with processing, further improved the utilization of the experimental diets thus improving performance of the animals.

A twelve-week trial was conducted to determine the nutrients intake, digestibility and nitrogen utilization of West African dwarf (WAD) goats fed diets containing graded levels of alkaline treated malted sorghum sprout (AMSP) using Panicum maximum as the basal diet. A total number of sixteen (16) WAD goats with an average live weight; 5.8 ± 0.6 kg were allotted on weight equalization into four (4) dietary treatments consisting of four goats per treatments in a completely randomized design. Four (4) diets were formulated to contain 0, 20, 40 and 60% AMSP. Data was collected on nutrients intake, digestibility and Nitrogen utilization parameters. Significant difference (P0.05) in all the nutrient digestibility parameters except the ether extract, ash, cellulose and hemicellulose. The highest Ash (66.16%), cellulose (82.47%) and hemicellulose (82.26%) contents were obtained in goats fed 40% AMSP. There were no significant differences (p>0.05) among the Nitrogen metabolism variables observed except total nitrogen intake and nitrogen balance. Goats fed 40% AMSP based diet recorded the highest Nitrogen retention (62.18%). It can therefore be concluded that 40% AMSP can be used as potential sources of supplements in ruminants feed most especially during dry season as it enhanced nutrient intake, digestibility and nitrogen balance.

Background: Commercial motor vehicle drivers (CMVDs) have worst health profiles among different occupations, yet the presence of clusters of cardiovascular disease (CVD) risk factors in this group have not been described in a resource-limited setting.Objectives: The prevalence of CVD risk factors and the clusters among CMVDs was evaluated.Design: A cross-sectional descriptive study.Setting: Four motor parks in three local government areas of Ibadan city, Nigeria.Participants: Consented and conveniently sampled 152 intra-city CMVDs aged ≥ 18 years. Main outcome measures: Prevalence of CVD risk factors (hypertension, diabetes, high triglyceride, low HDLc, high waist-hip ratio, central obesity, physical inactivity, smoking, alcohol, and overweight/obesity) and their clusters were determined.Results: All participants were male from 20 – 77 years old. Most of the CMVDs were physically inactive (80, 52.6%), take alcohol (78, 51.3%), and few smokes (35, 12.4%). The prevalence of hypertension, diabetes, hypertriglyceridemia,obesity, and central obesity were 36.2%, 5.9%, 23.7%, 4.6%, and 5.3%, respectively. Four clusters of CVD risk factors in the CMVDs with the prevalence of 36.2%. 33.5%, 17.1% and 13.2% were identified with significant differences (p

Objective: This study assessed the coping strategies of Nigerian medical students during the COVID-19 pandemic.Design: We conducted an online descriptive cross-sectional study among medical and dental students attending three of the largest Colleges of Medicine in the Southwestern zone of Nigeria.Settings: Our study involved students across the pre-clinical and clinical levels of the three Colleges of Medicine.Participants: We selected the respondents through a purposive sampling technique and disseminated questionnaires applied using an online survey platform (Google forms https://forms.gle/19yfEzehJKwsme759). A total of 1010 par-ticipants out of 2404 eligible students completed the questionnaires accurately, giving a response rate of 42%.Methods: The Brief-COPE questionnaire assessed the participants' coping strategies (approach and avoidant) during the COVID-19 pandemic. We conducted a bivariate analysis using the chi-square test and multiple regression analysis (p< 0.05) to determine the predictors of avoidant coping strategies.Results: Respondents mean age was 21.8±2.9 years, results were presented as Odds Ratios(OR) at 95% confidence intervals(CI). About 95% of respondents employed an approach coping strategy, while the minority(5%) adopted an avoidant coping strategy. Females were three times more likely to employ an avoidant coping strategy (OR=3.32 (95% CI 1.67-6.21) compared to male students.Conclusion: This study reveals that the majority of the respondents employed an approach coping strategy towards the COVID-19 pandemic. Females were more likely to employ an avoidant coping strategy. We recommend gender-specific programs to help medical students cope with the COVID-19 pandemic.

Introduction: Limited research exists describing young people's knowledge and risk perception of e-cigarettes and hookah in Nigeria. This qualitative study explored the knowledge and risk perception of e-cigarettes and hookah amongst young people in Lagos, Nigeria. Methods: Participants (n = 20), aged 15–24 years who had used e-cigarettes or hookah at least once in the past 12 months, participated in three focus group (FG) discussions in January 2020. Each FG session consisted of 6–7 participants, was facilitated by a trained moderator and lasted approximately 60 min. Sessions were recorded, and notes were taken after informed consent. Recordings were transcribed verbatim and analysed using NVIVO 10 software. Results: An essential element of our findings was that the majority of the participants seemed to be more aware of hookah and used hookah compared to e-cigarettes. The participants mentioned they used these tobacco products mainly to reduce stress, for pleasure and for social acceptance. Most of the study participants reported that they were aware of some adverse health effects associated with e-cigarette or hookah use. Although some participants felt that the use of e-cigarettes or hookah could transform to cigarette smoking, many felt that e-cigarette was a harm reduction tool. Conclusion: Young users of e-cigarettes and hookah continue to use these products though they are aware of some associated adverse health effects. These products are used primarily for relieving stress and for social reasons. Raising awareness of the risks associated with the use of these tobacco products may help to reduce the acceptability of these products amongst youths.

Cardiovascular diseases (CVDs), principally ischemic heart disease (IHD) and stroke, are the leading cause of global mortality and a major contributor to disability. This paper reviews the magnitude of total CVD burden, including 13 underlying causes of cardiovascular death and 9 related risk factors, using estimates from the Global Burden of Disease (GBD) Study 2019. GBD, an ongoing multinational collaboration to provide comparable and consistent estimates of population health over time, used all available population-level data sources on incidence, prevalence, case fatality, mortality, and health risks to produce estimates for 204 countries and territories from 1990 to 2019. Prevalent cases of total CVD nearly doubled from 271 million (95% uncertainty interval [UI]: 257 to 285 million) in 1990 to 523 million (95% UI: 497 to 550 million) in 2019, and the number of CVD deaths steadily increased from 12.1 million (95% UI:11.4 to 12.6 million) in 1990, reaching 18.6 million (95% UI: 17.1 to 19.7 million) in 2019. The global trends for disability-adjusted life years (DALYs) and years of life lost also increased significantly, and years lived with disability doubled from 17.7 million (95% UI: 12.9 to 22.5 million) to 34.4 million (95% UI:24.9 to 43.6 million) over that period. The total number of DALYs due to IHD has risen steadily since 1990, reaching 182 million (95% UI: 170 to 194 million) DALYs, 9.14 million (95% UI: 8.40 to 9.74 million) deaths in the year 2019, and 197 million (95% UI: 178 to 220 million) prevalent cases of IHD in 2019. The total number of DALYs due to stroke has risen steadily since 1990, reaching 143 million (95% UI: 133 to 153 million) DALYs, 6.55 million (95% UI: 6.00 to 7.02 million) deaths in the year 2019, and 101 million (95% UI: 93.2 to 111 million) prevalent cases of stroke in 2019. Cardiovascular diseases remain the leading cause of disease burden in the world. CVD burden continues its decades-long rise for almost all countries outside high-income countries, and alarmingly, the age-standardized rate of CVD has begun to rise in some locations where it was previously declining in high-income countries. There is an urgent need to focus on implementing existing cost-effective policies and interventions if the world is to meet the targets for Sustainable Development Goal 3 and achieve a 30% reduction in premature mortality due to noncommunicable diseases., Central Illustration, Highlights • The burden of CVD, in number of DALYs and deaths, continues to increase globally. • CVD burden attributable to modifiable risk factors continues to increase globally. • Countries should invest in existing cost-effective public health programs and clinical interventions to target modifiable risks, promote healthy aging across the lifespan, and reduce disability and premature death due to CVD.

Modern cryptography targeted towards providing data confidentiality still pose some limitations. The security of public-key cryptography is based on unproven assumptions associated with the hardness /complicatedness of certain mathematical problems. However, public-key cryptography is not unconditionally secure: there is no proof that the problems on which it is based are intractable or even that their complexity is not polynomial. Therefore, public-key cryptography is not immune to unexpectedly strong computational power or better cryptanalysis techniques. The strength of modern cryptography is being weakened and with advances of big data, could gradually be suppressed. Moreover, most of the currently used public-key cryptographic schemes could be cracked in polynomial time with a quantum computer. This paper presents a renewed focus in fortifying the confidentiality of big data by proposing a quantum-cryptographic protocol. A framework was constructed for realizing the protocol, considering some characteristics of big data and conceptualized using defined propositions and theorems.

Background : Tuberculosis [TB] remains a major global public health problem, and particularly in resource-restricted settings with disproportionately high burden. This study is aimed at assessing quality of life [QoL] and the roles of HIV co-infection along with socio-demographic factors on QoL among subjects with TB. Methodology: This is a multi-center cross-sectional study among 440 participants recruited by multi-stage sampling technique across 40 Directly Observed Treatment Short-course [DOTS] centres. Interviews were done using designed questionnaire to collect information on socio-demographic and clinical details of respondents. Subsequently, the World Health Organization Quality of Life-BREF [WHOQOL-BREF] questionnaire was used to evaluate QoL. Results: Most ( 61.1%) of the participants was aged between 21 and 40 years, 61.6% were married and 74.5% had a paid job. Majority of the subjects reported fair QoL across all domains. Employment status and monthly income were significantly associated with participants overall QoL and their satisfaction with health (p

The study was conducted to assess the effect of strain and stocking density on thermo-physiological response of broiler chickens. A total number of two hundred and sixteen (216) day old broiler chicks consisting of three different strains were used for the experiment. These strains were: Marshall, Ross and Abor-acre. The birds were randomly allotted to three different stocking densities which were 10, 12 and 14 birds/m2 respectively. Each treatment group was replicated twice in a 2 × 3 factorial design. Data were collected on thermo-physiological traits of the chickens twice in a week to avoid undue stress on the birds. Data were also collected on ambient temperature and relative humidity of the experimental area. Traits measured were; rectal temperature, pulse rate and respiratory rate. The data were subjected to analysis of variance (ANOVA) and there was significant interaction effect of strain and stocking density on physiological traits of the chicken. Thus, it is recommended that Marshall broiler chicken can be raised on stocking density of 14 birds/m².

The study was conducted to assess mini-livestock production as strategy for food security among households in Iwo, Nigeria. Multi-stage sampling procedure was used to select 150 respondents. A structured interview schedule was used to elicit information from the respondents. Household food security was estimated using food security index to establish the food security status of various households. Thus, households were classified into food secured and food insecured. Data were subjected to both descriptive statistics and regression analysis. Most of the respondents were male (72.8 %), they were within the age bracket of 20-24 years, had secondary education (55 %), with household size between 2 to 5 members (45.7%). The study further revealed that 52.3% of the respondents were Christian, were farmers (35.1%) have 5 to 8 years of experience in mini livestock production. They earned more than N5, 000 as income. Also most of the respondents raised mini-livestock purposely for income generation and sourced their flocks from wild (39.1 %). Most of the respondents were raising snail (25.2 %). Majority of the households in the study area were food secured. There is significant and strong correlation between raising of more than one species of minilivestock and food security of the households. Primary occupation and income realized from sales of mini livestock production were found to be significant determinants of food security among households.

Background:The Nigerian Report card on Physical Activity (PA) in Children and Youth was first developed in 2013 to inform practice and policy on healthy living and prevention of noncommunicable diseases among Nigerian children and youth. This article summarizes the results of the 2016 report card and provides updated evidence on the current situation in Nigeria.Methods:A comprehensive review of literature was undertaken by the Report Card Working Group. Grades were assigned to 10 PA indicators based on the criteria used for the 2013 edition.Results:Grades assigned to the indicators were Overall PA, D; Active Play and Leisure, C; Active Transportation, B; Sedentary Behaviors (screen-based, F and nonscreen-based, D); Overweight and Obesity, A; PA in Schools, C-; Government/Nongovernment Organizations/Private Sector/Policy, B. The following indicators were graded as Incomplete: Organized Sport and PA, Community and Built Environment, and Family and Peers.Conclusions:The overall PA levels of Nigerian children and youth seemed to be declining compared with the 2013 Report card but with slight improvement in active play and leisure, and PA in school settings. A substantial number of Nigerian children and youth still have high sedentary behaviors, overweight and obesity. Efforts are needed to promote PA among them.

Risk behaviours including marijuana use, alcohol consumption and cigarette smoking have a significant impact on the present and future health of adolescents. There are limited studies in sub-Saharan Africa to show evidence, if it exists, of the relationship between parental monitoring practices and the prevalence of substance use among adolescents. The aim of this study is to assess the relationship between parental monitoring practices and alcohol consumption, cigarette smoking and marijuana use among in-school adolescents in Mushin Local Government Area of Lagos State, South-Western Nigeria.This was a cross-sectional survey of 437 in-school adolescents randomly selected from two schools in Mushin Local Government Area of Lagos State, Nigeria. Information on socio-demographic characteristics, the three domains of parental monitoring practices (Parental monitoring; negotiated unsupervised time and parental trust) and substance use were elicited using a modified version of parental monitoring practice scale and the Youth Risk Behaviour Surveillance System (YRBSS) questionnaire. Independent T tests and logistic regression models were used to assess relationship between parental monitoring practices and substance use.The overall prevalence of use of any of the substance was 21.7%. Negotiated unsupervised time was significantly associated with use of alcohol (P0.05), marijuana (P0.05) and cigarette smoking (P0.05). After controlling for age and gender, one unit increase in parental monitoring reduced the odds of engaging in any substance use by 10% (AOR = 0.90, 95% CI = 0.81-0.99) while a similar increase in negotiated unsupervised time significantly increases the odds of any substance use by 7% (AOR = 1.07, 95% CI = 1.01-1.14).Of the three domains assessed, negotiated unsupervised time was consistently associated with substance use among these youth. Efforts to educate parents on the need to restrict unsupervised time of their wards may be warranted.

Objectives: The aim of this study is to describe the experience and outcome of higher order multiple (HOM) births in a private tertiary health facility in Nigeria.Materials and Methods: This was a retrospective review of records of HOM over 3 years in a private tertiary health facility in Nigeria. Relevant data on HOM births were extracted from both the patients’ case notes, admission registers and maternity ward and delivery records of the hospital using a predesigned pro forma. Data were analyzed using Statistical Package for Social Sciences Version 22.0.Results: The prevalence of HOM births was 0.72% of 1950 births over the 3 years study period; while for triplets, quadruplets, and quintuplets were 0.56%, 0.1% and 0.05%, respectively. The mean gestational age was 32 ± 3 weeks, and all except three sets of triplets were by Assisted Reproductive Technology (ART). Respiratory distress syndrome, neonatal jaundice, and neonatal sepsis accounted for more than 80% of the neonatal complications noted in HOM births. However, there was no significant difference between neonatal survival of HOM as compared to twin deliveries, P = 0.08.Conclusion: HOM is becoming increasingly common in Nigeria. The strongest risk factor is ART, and neonatal complications are common reinforcing the need to streamline ART protocols in Nigeria.Keywords: Higher order multiple births, neonatal outcome, Nigeria, private health facility

Background: Oral lesions have been reported to be early clinical features of HIV infection. Objective: The purpose of this study was to establish the prevalence of oral lesions in HIV Seropositive female patients and correlate the CD4 count with the appearance of oral lesions in the female patients attending Lagos University Teaching Hospital (LUTH) and University of Benin Teaching Hospital, Benin (UBTH). Methods: A prospective study was undertaken in 172 newly diagnosed adult HIV infected female patients (not on antiretroviral therapy), who attended the PEPFAR clinic at LUTH and the HIV Clinic of the University of Benin Teaching Hospital, Benin City, Nigeria. They were assessed for oral lesions which were evaluated using EEC/WHO (2003) – Classification on the diagnostic criteria for oral lesions in HIV. Data were collected using an interviewer administered questionnaire. Following Oral examination undertaken, oral lesions were detected, recorded and Original Research Article

Background: Hybrid Ameloblastoma is a rare type of ameloblastoma that is presently receiving attention in some quarters. Altogether, less than 30 cases have been reported in the scientific literature, thus calling for the need to report more cases in order to add to the body of knowledge on this lesion. This case report is aimed to add to the number of cases that are building up in the scientific literature. Materials and Methods: A 50-year-old female presented with a 3-year history of an anterior mandibular swelling extending from the body of the mandible on the right to the body of the mandible on the left. Orthopantomograph of the lesion revealed a mixed radiolucent and radiopaque lesion that extended from the distal region of the right mandibular second premolar to distal region of the left mandibular second molar. Segmental mandibulectomy with immediate replacement with reconstruction was undertaken. Results: Specimen which was subjected to histopathologic examination reported a diagnosis of Keratinizing Follicular Ameloblastoma and Desmoplastic Ameloblastoma with Osteoplasia, consistent with a diagnosis of Hybrid Ameloblastoma. There has been no sign of recurrence 7 months after a regular follow-up and the patient is planned for a long term follow-up. Conclusion: Besides histological details that combine both conventional ameloblastoma and desmoplastic ameloblastoma, the present case of hybrid ameloblastoma bears similar clinical features as well as treatment modalities to that of conventional solid multicystic ameloblastoma.

Tobacco use among youth is a major public health problem. Youth outside of formal school settings are often understudied but may be at increased risk.A descriptive cross- sectional study was carried out among 326 young people aged 15-24 years in four randomly selected motor parks in Lagos state. Interviewer-administered questionnaires were used to collect data.The mean age of the respondents was 21.0±2.3yrs. Many 252 (77.3%) dropped out before the end of the third year of secondary schooling. The majority were aware that active (78.2%), and passive smoking (77.3%) are harmful to health. Nearly two-thirds of the respondents disagreed with an outright ban of cigarettes (63.2%) and restriction of cigarette sales to persons below 18 years (67.9%) while 254 (66.8%) supported a ban on tobacco smoking in enclosed public places. One hundred and fifty (46.0%) respondents had experimented with smoking of which 106 (32.5%) had progressed to become current smokers. Half of the current smokers, 54 (50.9%), felt the need for a cigarette first thing in the morning. A multivariate analysis for smoking initiation, showed that for every increasing year of age, respondents were 1.08 times more likely to have initiated cigarette smoking; males and respondents who lived alone or with peers were 2.34 times and 1.77 times more likely to have initiated smoking respectively; those who consume alcohol and marijuana were 7.27 and 1.89 times respectively more likely to have initiated smoking while those who consumed alcohol were 6.17 times more likely to be current smokers.

Resumen pt: Objeti vo: Este estudo epidemiologico analisou a prevalencia, distribuicao e associacao dos fatores eiologicos no desenvolvimento de defeitos do esmalte ...

Background Perioperative hypothermia has been reported to increase the occurrence of cardiovascular complications. By increasing the activity of sympathetic nervous system, perioperative hypothermia also has the potential to increase cardiac injury and dysfunction associated with subarachnoid hemorrhage. Methods The Intraoperative Hypothermia for Aneurysm Surgery Trial randomized patients undergoing cerebral aneurysm surgery to intraoperative hypothermia (n = 499, 33.3 degrees +/- 0.8 degrees C) or normothermia (n = 501, 36.7 degrees +/- 0.5 degrees C). Cardiovascular events (hypotension, arrhythmias, vasopressor use, myocardial infarction, and others) were prospectively followed until 3-month follow-up and were compared in hypothermic and normothermic patients. A subset of 62 patients (hypothermia, n = 33; normothermia, n = 29) also had preoperative and postoperative (within 24 h) measurement of cardiac troponin-I and echocardiography to explore the association between perioperative hypothermia and subarachnoid hemorrhage-associated myocardial injury and left ventricular function. Results There was no difference between hypothermic and normothermic patients in the occurrence of any single cardiovascular event or in composite cardiovascular events. There was no difference in mortality (6%) between groups, and there was only a single primary cardiovascular death (normothermia). There was no difference between hypothermic and normothermic patients in postoperative versus preoperative left ventricular regional wall motion or ejection fraction. Compared with preoperative values, hypothermic patients had no postoperative increase in cardiac troponin-I (median change 0.00 microg/l), whereas normothermic patients had a small postoperative increase (median change + 0.01 microg/l, P = 0.038). Conclusion In patients undergoing cerebral aneurysm surgery, perioperative hypothermia was not associated with an increased occurrence of cardiovascular events.

Background Although hypothermia and barbiturates improve neurologic outcomes in animal temporary focal ischemia models, the clinical efficacy of these interventions during temporary occlusion of the cerebral vasculature during intracranial aneurysm surgery (temporary clipping) is not established. Methods A post hoc analysis of patients from the Intraoperative Hypothermia for Aneurysm Surgery Trial who underwent temporary clipping was performed. Univariate and multivariate logistic regression methods were used to test for associations between hypothermia, supplemental protective drug, and short- (24-h) and long-term (3-month) neurologic outcomes. An odds ratio more than 1 denotes better outcome. Results Patients undergoing temporary clipping (n = 441) were assigned to intraoperative hypothermia (33.3 degrees +/- 0.8 degrees C, n = 208) or normothermia (36.7 degrees +/- 0.5 degrees C, n = 233), with 178 patients also receiving supplemental protective drug (thiopental or etomidate) during temporary clipping. Three months after surgery, 278 patients (63%) had good outcome (Glasgow Outcome Score = 1). Neither hypothermia (P = 0.847; odds ratio = 1.043, 95% CI = 0.678-1.606) nor supplemental protective drug (P = 0.835; odds ratio = 1.048, 95% CI = 0.674-1.631) were associated with 3-month Glasgow Outcome Score. The effect of supplemental protective drug did not significantly vary with temperature. The effects of hypothermia and protective drug did not significantly vary with temporary clip duration. Similar findings were made for 24-h neurologic status and 3-month Neuropsychological Composite Score. Conclusion In the Intraoperative Hypothermia for Aneurysm Surgery Trial, neither systemic hypothermia nor supplemental protective drug affected short- or long-term neurologic outcomes of patients undergoing temporary clipping.

Rapid population in developing nations has imposed stress on groundwater resources, thus the need to assess physicochemical and bacteriological impact of microbes on hand-dug wells along some major markets in Ibadan Southwestern Nigeria. Water samples from hand-dug wells were measured sequentially, and total dissolved solute (TDS), pH, electrical conductivity (EC), salinity, and temperature were measured in situ. Water samples were analyzed at a Microbiology Laboratory. Most probable techniques used for micro-organism analysis were in three stages: presumptive test used for confirmation of Escherichia coli, confirmed test for total viable bacteria count (TVBC), and complete test to reconfirm the presence of coliform. Presumptive test showed high rate of E. coli in most of the hand-dug wells with (37.5 %). Confirmed test revealed Staphylococcus aureus to be 25 %, followed by Proteus vulgaris (14.6 %), Bacillus species (12.5 %), Pseudomonas aeruginosa (8.3 %), and Klebsiella spp. (2.1 %) respectively. Total viable bacteria counts are 500 to 192,000. Physicochemical results (total dissolved solute (TDS), pH, electrical conductivity (EC), salinity, temperature) when compared with WHO (2006) and SON (2007) revealed all the parameters to be within the permissible limits except pH (5.8 to 9.56), and high values of the parameters were caused by organic matter. High E. coli in the study area revealed influence of human and animal fecal that could lead to urinary tract infection; Staphylococcus aureus that comes from sewage could lead to diarrhea, gastrointestinal disease, and multiplication in tissues. High value of pH and E. coli above the permissible limits showed contamination of hand-dug wells in the study area.

Epidemiological evidences indicate close association between inorganic arsenic exposure via drinking water and cardiovascular diseases. While the exact mechanism of this arsenic-mediated increase in cardiovascular risk factors remains enigmatic, epidemiological studies indicate a role for paraoxonase 1 (PON1) in cardiovascular diseases. To investigate the association between inorganic arsenic exposure and cardiovascular diseases, rats were exposed to sodium arsenite (trivalent; 50, 100, and 150 ppm As) and sodium arsenate (pentavalent; 100, 150, and 200 ppm As) in their drinking water for 12 weeks. PON1 activity towards paraoxon (PONase) and phenylacetate (AREase) in plasma, lipoproteins, hepatic, and brain microsomal fractions were determined. Inhibition of PONase and AREase in plasma and HDL characterized the effects of the two arsenicals. While the trivalent arsenite inhibited PONase by 33% (plasma) and 46% (HDL), respectively, the pentavalent arsenate inhibited the enzyme by 41 and 34%, respectively. AREase activity was inhibited by 52 and 48% by arsenite, whereas the inhibition amounted to 72 and 67%, respectively by arsenate. The pattern of inhibition in plasma and HDL indicates that arsenite induced a dose-dependent inhibition of PONase whereas arsenate induced a dose-dependent inhibition of AREase. In the VLDL + LDL, arsenate inhibited PONase and AREase while arsenite inhibited PONase. In the hepatic and brain microsomal fractions, only the PONase enzyme was inhibited by the two arsenicals. The inhibition was more pronounced in the hepatic microsomes where a 70% inhibition was observed at the highest dose of pentavalent arsenic. Microsomal cholesterol was increased by the two arsenicals resulting in increased cholesterol/phospholipid ratios. Our findings indicate that decreased PON1 activity observed in arsenic exposure may be an incipient biochemical event in the cardiovascular effects of arsenic. Modulation of PON1 activity by arsenic may also be mediated through changes in membrane fluidity brought about by changes in the concentration of cholesterol in the microsomes.

Sexually transmitted infections constitute economic burden for developing countries, exposure to causative agents is an occupational hazard for female sex workers. Targeted interventions for this population can reduce the incidence and prevalence of sexually transmitted infections including human immunodeficiency virus, but barriers exists which can hinder effective implementation of such programs. This descriptive cross sectional study sought to assess the prevalence, knowledge and treatment practices of sexually transmitted infections among brothel based female sex workers. Three hundred and twenty three consenting female sex workers were surveyed using pre tested, interviewer administered questionnaires. More than half of the respondents (54.2%) had poor knowledge of symptoms of sexually transmitted infections. Only 13.9% were aware that sexually transmitted infections could be asymptomatic. The self reported prevalence of symptomatic sexually transmitted infections was 36.5%. About half of those with sexually transmitted infectionss sought treatment in a hospital or health centre while 32.5% from a patent medicine vendor. Most respondents (53.8%) mentioned the perceived quality of care as the main reason for seeking treatment in their chosen place. More of the respondents with good knowledge of sexually transmitted infections reported symptoms compared to those with fair and poor knowledge. The knowledge of sexually transmitted infections among these female sex workers is poor and the prevalence is relatively high. Efforts to improve knowledge promote and encourage preventive as well as effective treatment practices must be made for this population.

To determine the perception of pain and discomfort associated with orthodontic separator placement in patients attending the Lagos University Teaching Hospital, Lagos, Nigeria.Sixty four patients scheduled for treatment with fixed orthodontic appliances completed questionnaires before insertion of separators and after placement at 4 hours, 24 hours and 7 days. The level of pain and discomfort during these time periods was assessed by a visual analogue scale.There was a significant increase in the level of pain/discomfort 4 hours and 24 hours after placement of the separators for all the activities. The level of pain/discomfort peaked at 4 hours but did not return to baseline levels after 7 days. Patients more than 16 years old reported significantly more pain/discomfort over time than those 16 years and under. No significant difference in pain/discomfort was found between the sexes.Patients experience pain/discomfort following placement of orthodontic separators. Pretreatment counselling and analgesics are recommended.

A study was carried out using water hyacinth as a pollution monitor for the simultaneous removal of heavy metals such as copper (Cu), cadmium (Cd), iron (Fe), zinc (Zn), lead (Pb), chromium (Cr) and aluminium (Al). Effluents were collected from eight industries including paint, textiles, aluminium, galvanizing and battery industries situated in Lagos State, Nigeria. After cultivation of the plant for seven days in a plastic bowl containing each effluent, while sampling was carried out from the bowl everyday, the collected samples were analyzed for Pb, Fe, Zn, Cr and Cu at wavelengths 248.3, 213.7, 357.9 and 324.9 nm respectively using atomic absorption spectrophotometry. Aluminium was determined using UVspectrophotometry and potassium was determined using a flame photometer. The results of the analysis indicated that the range of the heavy metal in the effluents before the cleaning process were Pb (0.1 to 4.4 ppm), Cr (0.39 to 0.5 ppm), Cu (0.08 to 1.65 ppm), Zn (0.7 to 8.7 ppm), Fe (1.2 to 7.5 ppm), Al (0.15 to 1.05 ppm) and Ni (0.6 to 49.2 ppm) while Cd was not detected in none of the effluents. The values were higher than the Federal Ministry of Environment and the World Health Organization effluent limitation guidelines recommended levels. The cleaning experiment showed that water hyacinth has the ability to clean-up the effluents of their heavy metals content by removing about 70 to 90% of their initial concentrations within four to six days of the experimental set-up. Key words: Industrial effluents, heavy metals, water hyacinth, health impact, environmental pollution.

Cervical cancer is the commonest gynaecological cancer in Nigeria and women of low socio-economic status are at high risk of this condition. A study was conducted on the awareness of cervical cancer, attitude towards the disease and screening practice of women residing in two urban slums of Lagos, Nigeria. It also determined the prevalence of major risk factors for cervical cancer among the women. Multistage sampling was used to select 240 women who were interviewed with a structured questionnaire and data collected was analyzed with Epi-info version 3.5.1 statistical software. Only 10 (4.2%) women in this study were aware of cervical cancer and none of them believed they were at risk of developing the disease. Most (73.3%) were willing to undergo a cervical cancer screening test. Age, education and previous history of vaginal examination were positively associated with willingness to undergo screening (p0.05). The respondents had a high prevalence of major risk factors for cervical cancer such as early age at sexual debut, multiple sexual partners and male partner with other female partners. Efforts need to be intensified to increase awareness of this condition and to promote low-cost cervical cancer screening among this underserved population.

Odontogenic myxoma (OM) is a locally aggressive neoplasm whose clinicopathological characteristics have not been extensively reported in Nigerians.To describe the clinicopathological characteristics of cases of OM seen at the Lagos University Teaching Hospital in Nigeria.A review of both clinical and histopathological records of sixty-three cases of OM diagnosed over a period of thirty-seven years was undertaken. The cases were analyzed for age, sex, site, size, duration and histological contents of collagenization, odontogenic epithelium and calcification.Odontogenic myxoma represented 63(11.2%) cases of odontogenic tumours, was commonest in the second to forth decades and rare below age 10 and above 70 years. It was more common in females. Maxillary lesions were more common with respect to both central and peripheral histologic types, but occurred in equal frequencies in mandible and maxilla with respect to the central histologic type. Forty-seven (74.6%) cases were fibromyxoma and sixteen (25.4%) myxoma. Odontogenic epithelium was rare and observed in 5 (9.5%) cases while calcific material was present in sixteen (25.4%) cases. Late presentation was a common feature and surgical excision was the treatment of choice.Odontogenic myxoma is un-common among Nigerians when compared with ameloblastoma. Clinicopathological characteristics in this series are similar to information in the scientific literature.

This article reports 3 cases of melanin pigmented lesions among 75 histologically diagnosed periradicular lesions of extracted teeth. Case 1 was a 25-year old male who presented with one week history of toothache involving a tender carious left mandibular second molar tooth (37), with periapical radiolucency and diagnosed clinically as acute apical periodontitis. The lesion was diagnosed histologically (using Haematoxylin and Eosin) as periapical granuloma, while histochemical examination (using Masson-Fontana technique) showed the presence of round/oval shaped melanin pigmented macrophages (melanophage) in the lesion. Case 2 was a 54-year old male with one week history of toothache associated with tender carious right maxillary first molar tooth (16) with periapical radiolucency. A clinical diagnosis of acute apical periodontitis was made, but histological and histochemical examination showed a melanin pigmented periapical granuloma with spindle shaped melanophage. Case 3 was a 28-year old female who presented with 4 days history of toothache, involving the tender left mandibular first molar tooth (36). The lesion had periapical radiolucency and a clinical diagnosis of acute apical periodontitis. On examination histologically and histochemically, the lesion was diagnosed as an intraosseous melanocytic naevi with dark-brown nests of round naevus cells. In conclusion, this article shows the rarity of melanin pigmented periradicular lesions in the jaws. The cases reported suggest that the trigger for formation of melanin-pigmented cells in the periradicular lesions may be related to the acute phase of the lesions. Further study is recommended to determine if the remnants of the migratory neural crest cells are the precursors of melanin-pigmented cells in the periradicular region.