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Your search keyword '"O. P. Yatsenko"' showing total 5 results
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5 results on '"O. P. Yatsenko"'

1. Tissue-Specific Expression of Splice Variants of Human IL-4 and IL-6 Gene mRNA

Author

E. A. Khrapov, Maksim L. Filipenko, Vladimir A. Kozlov, Sergey V. Sennikov, A. N. Silkov, and O. P. Yatsenko

Subjects
Messenger RNA, DNA, Complementary, biology, Interleukin-6, Alternative splicing, General Medicine, Real-Time Polymerase Chain Reaction, Peripheral blood mononuclear cell, Molecular biology, General Biochemistry, Genetics and Molecular Biology, Exon, Haematopoiesis, Fetus, Leukocytes, Mononuclear, biology.protein, Humans, Protein Isoforms, Interleukin-4, RNA, Messenger, Interleukin 6, Gene, Interleukin 4, DNA Primers
Abstract

The spectrum of alternatively spliced IL-4 and IL-6 gene mRNA was studied in peripheral blood mononuclears from healthy donors and in human fetal tissues. It was found that the expression of alternatively spliced IL-4 and IL-6 gene mRNA in fetal tissues is tissue specific and that hemopoiesis- and immunopoiesis-related tissues differ by the amount of IL-4 and IL-4δ2 mRNA. An mRNA variant IL-4alt3 carrying partial exon 3 deletion was for the first time identified in human mononuclear cells.

Published
2012
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3. Alternative Splicing of Murine Interleukin-4 mRNA

Author

E. A. Khrapov, Elena N. Voronina, Sergey V. Sennikov, Vladimir A. Kozlov, O. P. Yatsenko, and Maksim L. Filipenko

Subjects
DNA, Complementary, Bone Marrow Cells, Stimulation, In Vitro Techniques, General Biochemistry, Genetics and Molecular Biology, Mice, Exon, medicine, Animals, Tissue Distribution, RNA, Messenger, Interleukin 4, DNA Primers, Messenger RNA, Base Sequence, Chemistry, Alternative splicing, Exons, General Medicine, Molecular biology, Mice, Inbred C57BL, Alternative Splicing, medicine.anatomical_structure, Mice, Inbred DBA, Interleukin-4, Bone marrow, Spleen
Abstract

We found an alternative form of mRNA with spliced second exon (IL-4delta2 mRNA) in mouse bone marrow and splenic cells. At rest, the amount of IL-4 mRNA markedly surpassed that of IL-4delta2 mRNA. Stimulation increased the content of both mRNA forms, but the alternative variant is accumulated more intensively and rapidly. We did not detect predominance of IL-4delta2 mRNA over full-length mRNA variant in the studied mouse tissues.

Published
2004
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4. Alternative splicing of interleukin-6 mRNA in mice

Author

Maksim L. Filipenko, O. P. Yatsenko, E. A. Khrapov, Sergey V. Sennikov, Vladimir A. Kozlov, and Elena N. Voronina

Subjects
Erythrocytes, Placenta, Pregnancy Trimester, Third, Molecular Sequence Data, Spleen, Biology, General Biochemistry, Genetics and Molecular Biology, Protein Structure, Secondary, Mice, Pregnancy, medicine, Animals, Protein Isoforms, Amino Acid Sequence, RNA, Messenger, Effector functions, Interleukin 6, Receptor, Crosses, Genetic, Sequence Deletion, Messenger RNA, Binding Sites, Sheep, Sequence Homology, Amino Acid, Interleukin-6, Alternative splicing, Placental tissue, Translation (biology), General Medicine, Exons, Molecular biology, Mice, Inbred C57BL, Alternative Splicing, medicine.anatomical_structure, Pregnancy Trimester, Second, Protein Biosynthesis, biology.protein, Mice, Inbred CBA, Female
Abstract

Expression of mRNA for interleukin-6, interleukin-6Delta3, and interleukin-6Delta5 was detected in placental tissue (second and third trimesters of pregnancy) and spleen of mice immunized with sheep erythrocytes in high dose. We hypothesize that translation of mRNA yields proteins capable of binding to individual subunits of the interleukin-6 receptor and possessing effector functions.

Published
2004

5. Alternative Splicing of Murine Interleukin-4 mRNA.

Author

O. P. Yatsenko, M. L. Filipenko, E. N. Voronina, E. A. Khrapov, S. V. Sennikov, and V. A. Kozlov

Abstract

We found an alternative form of mRNA with spliced second exon (IL-4δ2 mRNA) in mouse bone marrow and splenic cells. At rest, the amount of IL-4 mRNA markedly surpassed that of IL-4δ2 mRNA. Stimulation increased the content of both mRNA forms, but the alternative variant is accumulated more intensively and rapidly. We did not detect predominance of IL-4δ2 mRNA over full-lenght mRNA variant in the studied mouse tissues. [ABSTRACT FROM AUTHOR]

Published
2004

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