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Background Idiopathic inflammatory myopathies (IIM) are characterised by inflammation and atrophy of skeletal muscles, pulmonary and articular involvement, which limit the mobility/self-sufficiency of patients, and can have a negative impact on body composition. Objectives To assess body composition and physical activity of IIM patients and healthy controls (HC). Methods 54 patients with IIM (45 females/9 males; mean age 57.7; disease duration 5.8 years; polymyositis (PM, 22)/dermatomyositis (DM, 25)/necrotizing myopathy (IMNM, 7)) and 54 age-/sex-matched HC (45 females/9 males, mean age 57.7) without rheumatic diseases were included. PM/DM patients fulfilled Bohan/Peter criteria for PM/DM. Anthropometric parameters and body composition were assessed (by densitometry: iDXA Lunar, and by bioelectric impedance: BIA2000-M), and physical activity was evaluated using Human Activity Profile (HAP) questionnaire. Routine biochemistry analysis was performed after 8 hours of fasting. Muscle involvement was evaluated by manual muscle test (MMT-8) and functional index 2 (FI2). Data are presented as mean ±SD. Results Compared to HC, patients with IIM had a trend towards significantly increased body fat% as assessed by iDXA (BF%: 39.9±7.1 vs. 42.4%±7.1%, p=0.077), but significantly decreased lean body mass as assessed both by iDXA (LBM: 45.6±8.1 vs. 40.6±7.2 kg, p=0.001) and BIA (LBM: 52.6±8.8 vs. 48.7±9.0 kg, p=0.023), and increased extracellular mass/body cell mass (ECM/BCM) ratio (1.06±0.15 vs. 1.44±0.42, p DEXA was associated with worse physical endurance (FI2: r=−0.311, p=0.026) and worse ability to perform physical activity (HAP: r=−0.292, p=0.032). MMT-8 score negatively correlated with ECM/BCM ratio (r=−0.385, p=0.006). Conclusions Compared to healthy age-/sex-matched individuals we found significant negative changes in body composition of our IIM patients, which are associated with their disease duration, inflammatory status, skeletal muscle involvement, and physical activity, and could reflect their impaired nutritional status and predispositions for physical exercise, aerobic fitness and performance. Acknowledgements Supported by AZV-16–33574A and SVV-260373. Disclosure of Interest None declared

Background Systemic sclerosis (SSc) is characterised by fibrosis of the skin and visceral organs, especially digestive tract, and musculoskeletal and lung involvement, which limit mobility/self-sufficiency of patients and can have a negative impact on body composition and physical activity. Objectives To assess body composition and physical activity of SSc patients and healthy controls (HC). Methods 59 patients with SSc [50 females; mean age 52.5; disease duration 6.7 years; limited cutaneous (lcSSc, 34)/diffuse cutaneous (dcSSc, 25)] and 59 age-/sex-matched HC (50 females, mean age 52.5) without rheumatic diseases were included. SSc patients fulfilled ACR/EULAR 2013 criteria. Anthropometric parameters and body composition were assessed (by densitometry: iDXA Lunar, and by bioelectric impedance: BIA-2000-M), and physical activity was evaluated using Human Activity Profile (HAP) questionnaire. Routine biochemistry analysis was performed after 8 hours of fasting. Pulmonary function and diffusing capacity of lung were examined, disease activity was evaluated by ESSG activity index. Data are presented as mean ±SD. Results Compared to HC, patients with SSc had significantly lower body-mass index (BMI:27.9±8.3 vs. 22.4±4.3 kg/m2, p Conclusions Compared to healthy age-/sex-matched individuals we found significant negative changes in body composition of our SSc patients, which are associated with their disease activity and physical activity, and could reflect their nutritional status, and gastrointestinal and musculoskeletal involvement. We found no significant association between lung involvement and changes of body composition. Acknowledgements Supported by AZV-16–33574A and SVV-260373 Disclosure of Interest None declared