Tillage and use of organic manure are important agronomic practices that sustain high crop and soil productivity. Hence, a three-year (2007 to 2009) study was conducted to evaluate the effect of site, tillage and poultry manure (PM) treatments on soil and plant nutrients composition, growth and yield of cocoyam (Xanthosoma sagittifolium). The study was a 2 × 5 × 5 factorial experiment with two sites (Owo - site 1 and Obasooto - site 2), five tillage methods; manual clearing (MC), manual ridging (MR), manual mounding (MM), ploughing plus harrowing (P+H) and ploughing plus harrowing twice (P+2H) and five levels of PM (0, 2.5, 5.0, 7.5, 10.0 t ha-1). Treatments were replicated thrice. Soil OM, N, P, K, Ca, Mg and leaf nutrients reduced with increase in tillage intensity, thus MC conserved soil nutrients the most, and increased nutrient uptake. Soil and plant nutrient concentration was lowest under the P+2H treatment. The MC, MR and MM treatments led to faster growth and higher tuber yield. As PM increased from 0 to 10.0 t ha-1 soil pH, OM, soil and plant N, P, K, Ca and Mg increased. The 7.5 t ha-1 PM gave the highest leaf K, Ca and Mg values. Owo site had significantly higher yield and growth parameters of cocoyam compared with Obasooto site. Yield and growth parameters of cocoyam increased with increase in PM level up to 7.5 t ha-1. Out of all tillage cum manure treatments, MC+7.5 t ha-1 PM gave the highest values of yield and growth parameters. [ABSTRACT FROM AUTHOR]