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The gut microbiota dysbiosis that often occurs in cancer therapy requires more efficient treatment options to be developed. In this concern, the present research approach is to develop drug delivery systems based on magnetite nanoparticles (MNPs) as nanocarriers for bioactive compounds. First, MNPs were synthesized through the spraying-assisted coprecipitation method, followed by loading bee pollen or bee bread extracts and an antitumoral drug (5-fluorouracil/5-FU). The loaded-MNPs were morphologically and structurally characterized through transmission electron microscopy (TEM), selected area electron diffraction (SAED), scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), Dynamic Light Scattering (DLS), and thermogravimetric analysis. UV-Vis spectroscopy was applied to establish the release profiles and antioxidant activity. Furthermore, the antibacterial and antitumoral activity of loaded-MNPs was assessed. The results demonstrate that MNPs with antioxidant, antibacterial, antiproliferative, and prebiotic properties are obtained. Moreover, the data highlight the improvement of 5-FU antibacterial activity by loading on the MNPs' surface and the synergistic effects between the anticancer drug and phenolic compounds (PCs). In addition, the prolonged release behavior of PCs for many hours (70–75 h) after the release of 5-FU from the developed nanocarriers is an advantage, at least from the point of view of the antioxidant activity of PCs. Considering the enhancement of L. rhamnosus MF9 growth and antitumoral activity, this study developed promising drug delivery alternatives for colorectal cancer therapy. [ABSTRACT FROM AUTHOR]

The document "Natural Bioactive Compounds and Human Health" provides an overview of the field of natural bioactive compounds and their potential benefits for human health. It discusses the structural diversity and mechanisms of action of these compounds, as well as advancements in extraction and characterization techniques. The document explores the therapeutic applications of natural bioactive compounds in chronic diseases, metabolic disorders, infectious diseases, and cancer. It also mentions emerging trends and future directions in the field, such as synergistic interactions and computational approaches. The document includes a list of specific contributions from studies that have investigated the bioactive properties of different natural compounds, covering topics such as antioxidant, anti-inflammatory, anticancer, and antimicrobial activities. It concludes with a declaration of no conflicts of interest and acknowledges the contributions of the authors and reviewers. This document is a compilation of research articles published in the journal Molecules, which explore the chemical composition and therapeutic properties of natural compounds derived from plants and other sources. [Extracted from the article]

Copyright of Farmacia is the property of Societatea de Stiinte Farmaceutice Romania and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Farmacia is the property of Societatea de Stiinte Farmaceutice Romania and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The study was aimed to investigate antimicrobial and antioxidant activity of ethanol extracts obtain from leaves, seeds and sheaths of R. pseudoacacia. Total phenolic content (TPC, Folin-Ciocalteu method), antioxidant activity (TEAC assay) and antimicrobial activity (agar disk diffusion method and broth dilution method) of vegetative and reproductive organs of R. pseudoacacia were done. The highest content of polyphenols (expressed as gallic acid equivalents, GAE) obtained for R. pseudoacacia leaves extract (266.7 μg GAE mL-1 extract) followed by seeds extract (232.2 μg GAE mL-1 extract). The HPLC analysis showed presence of catechin (0.925 μg mL-1), rutin (0.831 μg mL-1), resveratrol (0.664 μg mL-1) and quercetin (0.456 μg mL-1) in leaves and catechin (0.127 μg mL-1), epicatechin (0.239 μg mL-1) and rutin (0.231 μg mL-1) in seeds extract. The results showed that the studied extracts exhibited a selective antimicrobial effect directed against Gram-positive (Staphylococcus aureus, Bacillus subtilis) and Gram-negative (Pseudomonas aeruginosa, Klebsiella pneumonie and Escherichia coli) bacterial strains. The combination leaves extract / antibiotic had the highest synergistic effect when compared to seeds and sheaths extracts. The same extract with penicillin, kanamycin and rifampin had highest synergetic effect against methicillin resistant S. aureus strain (MRSA), a strain which it has gained a great interest of microbiologists within past decades. The chemical characterization of ethanol extracts from the vegetative and reproductive organs of Robinia pseudoacacia, synergistic effects of certain antibiotics and acacia extracts, potential to increase antimicrobial activity of some commercial antibiotics against MRSA were done for the first time.

Copyright of Farmacia is the property of Societatea de Stiinte Farmaceutice Romania and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Farmacia is the property of Societatea de Stiinte Farmaceutice Romania and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Farmacia is the property of Societatea de Stiinte Farmaceutice Romania and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)