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499 results on '"Obopilwe, Elifho"'

20. Medial meniscal extrusion greater than 4 mm reduces medial tibiofemoral compartment contact area: a biomechanical analysis of tibiofemoral contact area and pressures with varying amounts of meniscal extrusion

Author

Debieux, Pedro, Jimenez, Andrew E., Novaretti, João Victor, Kaleka, Camila Cohen, Kriscenski, Danielle E., Astur, Diego Costa, Obopilwe, Elifho, Tamburini, Lisa M., Muench, Lukas N., Cote, Mark P., Cohen, Moises, and Coyner, Katherine J.

Published
2021
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21. Biomechanical Changes to the Hindfoot After Zadek Osteotomy.

Author

Bellas, Nicholas, Nayak, Raghunandan, Pasha, Mehreen, Wolf, Megan, McDonald, Thomas, Obopilwe, Elifho, and Geaney, Lauren E.

Abstract

Background: Insertional Achilles tendinopathy (IAT) is a common source of heel pain in active adults and athletes. The Zadek osteotomy (ZO) is a calcaneal dorsal closing wedge osteotomy that has demonstrated clinical success as a treatment for IAT, purported to favorably improve tendon mechanics, decrease impingement, and decrease pressure within the retrocalcaneal bursa. The present study aims to evaluate the biomechanical effects of ZO on Achilles strain, position of the Haglund prominence relative to the Achilles insertion, and retrocalcaneal pressure. Methods: The ZO was performed on 10 fresh-frozen foot and ankle mid tibia-fibula cadaveric specimens. An osteotomy was performed using a 1-cm dorsal closing wedge procedure secured with a 7.0 mm cannulated screw. Point pressure sensor catheters and differential variable reluctance transducers were used to measure the retrocalcaneal pressure and Achilles strain, respectively, pre- and postosteotomy. Paired t-tests were utilized to detect statistical differences (P <.05). Results: After the ZO, the Haglund prominence was translated 9.9 mm anteriorly with respect to the insertion of the Achilles (P <.05) and the Achilles tendon insertion was translated 3.4 mm proximally (P <.05). The ratio of calcaneal length to greater tuberosity length, the X/Y ratio, increased from 2.56 to 3.52 with the osteotomy (P <.05). At maximum dorsiflexion, retrocalcaneal pressure decreased from 117 to 66 mm Hg (44%, P =.018). The Achilles strain changed from 0.00362 to 0.00436 in the anterior fibers (P =.484) and changed from 0.00467 to 0.00283 in the posterior fibers (P =.088). Conclusion: Biomechanical testing in a cadaveric model demonstrates that the ZO decreased retrocalcaneal pressure, shifted the Achilles tendon insertion proximally, increased the X/Y ratio of the calcaneus, and did not significantly change the strain of the Achilles tendon. Clinical Relevance: Despite the clinical success demonstrated in recent literature, there are no biomechanical studies describing the effect of the ZO on the biomechanics of the hindfoot, and the mechanism of symptom relief of the ZO for IAT is not well understood. The present study measures two potential ZO effects relative to Haglund prominence by measuring retrocalcaneal pressure and displacement of the Achilles tendon with respect to the Haglund prominence, and measures one ZO effect relative to calcification of the tendon by measuring the Achilles tendon strain. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Micro-Nanostructured Polymeric Scaffolds for Bone Tissue Engineering.

Author

Abdulmalik, Sama, Wijekoon, Suranji, Danazumi, Khadija Basiru, Srinivasan, Sai Sadhananth, Vobbineni, Laxmi, Obopilwe, Elifho, and Kumbar, Sangamesh G.

Subjects
MESENCHYMAL stem cells, MESENCHYMAL stem cell differentiation, BIOMIMETIC polymers, HUMAN stem cells, TISSUE scaffolds, BONE regeneration, CANCELLOUS bone
Abstract

While bone tissue allograft and autograft are commonly used in bone healing, their application is limited by factors such as availability, donor site morbidity, and immune response to the grafted tissue. Tissue-engineered implants, such as acellular or cellular polymeric structures, offer a promising alternative, and are a current trend in tissue engineering. Leveraging recent advancements in bone tissue engineering (BTE), we utilize 3D printing to develop biodegradable scaffolds that combine mechanical strength and bioactivity to facilitate bone repair and regeneration. This study focuses on the design and fabrication of mechanically competent 3D printed poly (L-lactic acid) (PLLA) micro-structured scaffolds. These scaffolds are enhanced with collagen type I nanofibrils to create bioactive scaffolds that promote tissue regeneration. The performance of these mechanically competent, micro-nanostructured polymeric matrices, in combination with bone marrow stromal cells (BMSCs), is evaluated in PLLA and PLLA-collagen scaffolds. The resulting micro-nanostructured PLLA-Collagen scaffolds mimic trabecular bone architecture, mechanical strength, and the extracellular matrix environment found in native bone tissue. The composite PLLA-collagen scaffolds exhibit mechanical properties in the mid-range of human trabecular bone. Both PLLA and PLLA-Collagen scaffolds support human BMSCs adhesion, proliferation, and osteogenic differentiation. A significantly higher number of implanted host cells are distributed in the PLLA-Collagen scaffolds with greater bone density, more uniform cell distribution, and attachment compared to the PLLA microstructure. Additionally, the biomimetic collagen nanostructure potently induces osteogenic transcription evidenced by increased alkaline phosphatase activity and upregulation of bone markers such as sialoprotein and collagen type I, ultimately guiding stem cell-mediated formation of a mature, mineralized bone matrix throughout the interconnected scaffold pores. This study underscores the benefits of micro-nanostructured scaffolds in successfully generating the inductive microenvironment of native bone extracellular matrix, triggering the cascade of cellular events required for functional bone regeneration, repairing critical-sized bone defects, and ultimately serving as an alternative material platform for bone regeneration, thereby instilling confidence in the potential of our research. [ABSTRACT FROM AUTHOR]

Published
2024
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49. Biomechanischer Vergleich zwischen Gracilis- und Semitendinosus-Sehnentransplantat bei Ein- und Zwei-Tunnel-Techniken zur coraco-clavicularen Bandrekonstruktion

Author

Otto, Alexander, Friedman, Jamie, Szolomayer, Lauren K, Baldino, Joshua B., Obopilwe, Elifho, Cote, Mark P, Mazzocca, Augustus D., and Arciero, Robert A.

Subjects
Zwei-Tunnel-Technik, Ein-Tunnel-Technik, coraco-claviculare Bandrekonstruktion, Semitendinosussehne, Gracilissehne, Medicine and health
Abstract

Fragestellung: Trotz der Entwicklung zu einer anatomischen Rekonstruktion bei der operativen Versorgung des coraco-clavicularen (CC-)Bandapparats, herrscht aktuell keine einheitliche Empfehlung zur Anzahl und Position der Bohrkanäle sowie bezüglich des optimalen Sehnentransplantats. Ziel dieser [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Published
2022
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