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OBJECTIVE: Psychosexual morbidity is common after prostate cancer treatment, however, long-term prospective research is limited. We report 5-year outcomes from a couples-based intervention in dyads with men treated for localised prostate cancer with surgery. METHODS: A randomised controlled trial was conducted involving 189 heterosexual couples, where the man received a radical prostatectomy for prostate cancer. The trial groups were peer support vs. nurse counselling versus usual care. Primary outcomes were sexual adjustment, unmet sexual supportive care needs, masculine self-esteem, marital satisfaction, and utilisation of erectile aids at 2-, 3-, 4- and 5-year follow-up. RESULTS: The effects of the interventions varied across the primary outcomes. Partners in the peer group had higher sexual adjustment than those in the usual care and nurses group at 2 and 3 years (P = 0.002-0.035). Men in usual care had lower unmet sexual supportive care needs than men in the peer and nurse groups (P = 0.001; P = 0.01) at 3 years. Women in usual care had lower sexual supportive care needs than women in the peer group at 2 and 3 years (P = 0.038; P = 0.001). Men in the peer and nurse group utilised sexual aids more than men in usual care; at 5 years 54% of usual care men versus 87% of men in peer support and 80% of men in the nurse group. CONCLUSION: Peer and nurse-administered psychosexual interventions have potential for increasing men's adherence to treatments for erectile dysfunction. Optimal effects may be achieved through an integrated approach applying these modes of support.

© 2019 John Wiley & Sons, Ltd. Background: Men treated for prostate cancer experience heightened psychological distress and have an increased risk of suicide. Management of this distress and risk is crucial for quality urological care. Objective: To identify risk indicators for poorer trajectories of psychological adjustment and health-related quality of life (QoL) after surgery for localised prostate cancer. Design, Setting, and Participants: Patients were newly diagnosed with localised prostate cancer scheduled for surgical treatment. Patients were assessed at baseline (pre-surgery) and 6 weeks, 3 months, 6 months, 12 months, and 24 months post–surgery. Measurements: Assessment measures included sociodemographics, domain-specific and health-related QoL, and psychological distress. Mixed effects regression models were used to analyse the data. Results and Limitations: A total of 233 patients provided data for this analysis (Mage = 60 years, standard deviation [SD] = 4.02; MPSA = 7.37 ng/mL). At baseline, the prevalence of high psychological distress was 28% reducing to 21% at 24 months. Before treatment, younger age, more comorbidities, and worse bowel function were related to greater psychological distress; and younger age and better urinary, sexual, and bowel function were related to better health-related QoL. By contrast, for changes over time, only bowel function was important with better bowel function predicting decreasing psychological distress for men. Conclusions: Regular distress screening is indicated over the 24 months after surgery for localised prostate cancer. Care pathways for men with prostate cancer need also to respond to age-specific concerns and health problems associated with comorbidities in aging men. Focussed symptom control for bowel bother should be a priority.

The timing of final assembly and initiation of subsequent rifting of Rodinia is disputed. New rutile ages (913 ± 9 Ma, 900 ± 8 Ma and 873 ± 3 Ma) and published zircon, monazite, titanite, biotite, muscovite and xenotime geochronology from the Capricorn Orogen (West Australian Craton) reveal a significant early Neoproterozoic event characterized by very low to low metamorphic grade, abundant metasomatism, minor leucogranitic and pegmatitic magmatism and NW–SE fault reactivation episodes between ca. 955 and 830 Ma. Collectively, these are termed the ca. 955–830 Ma Kuparr Tectonic Event. An age range of ca. 955–830 Ma is concomitant with the final stages of Rodinia assembly and the initial stages of its attempted breakup. Very low- to low-grade metamorphic and structural geological evidence favor a distal north–south compressional regime as the driver for hydrothermal activity during ca. 955–830 Ma. Nearby continental collision or accretion from the west (e.g., South China and/or Tarim) are ruled out. The cessation of metasomatism and magmatism in the West Australian Craton after ca. 830 Ma is concomitant with the emplacement of the Gairdner–Amata dyke swarm and associated magmatic activity in South China and Laurentia, the inception of the Adelaide Rift Complex and the deposition of the Centralian Superbasin. We posit that the cessation of hydrothermal activity in the Capricorn Orogen was caused by a tectonic switch from compressional to extensional at ca. 830 Ma. Magmatic and hydrothermal fluids were transferred away from the Capricorn Orogen to the incipient Adelaide Rift Complex, terminating metasomatism in the West Australian Craton. Ultimately, the Kuparr Tectonic Event marked the final stages of Rodinia assembly and its cessation marks the initial stages of its attempted breakup.

Copyright © 2017 John Wiley & Sons, Ltd. Objective: Female partners of men with prostate cancer (PCa) experience heightened psychological distress; however, long-term distress for this group is not well described. We examined partner's psychological and cancer-specific distress over 2 years and predictors of change. Methods: A cohort of 427 female partners (63% response; mean age 62.6 y) of PCa survivors completed baseline (2-4 y post-PCa treatment) assessments of anxiety, depression, and cancer-specific distress and were followed up at 6, 12, 18, and 24 months. Caregiver burden, threat and challenge appraisal, self-efficacy, and dyadic adjustment were assessed as potential predictors of distress. Results: Over time, 23% to 25% of women reported anxiety; 8% to 11% depression; 5% to 6% high cancer-specific distress. Higher caregiver burden and more threat appraisals were associated with increased distress, anxiety, depression, and cancer-specific distress over time. Higher dyadic adjustment over time and more challenge appraisals at 24 months were associated with less distress, anxiety, and depression. Increased partner self-efficacy was associated with lower distress and depression at baseline. Conclusions: A substantial subgroup of partners experience ongoing anxiety, with depression less prevalent but also persistent. Caregiver burden, partner self-efficacy, threat, and challenge appraisals present as potential supportive care targets.

© 2018 International Association for the Study of Lung Cancer Objective: To examine the personal experiences of people with lung cancer and their caregivers and how stigma is manifested throughout a patient's social network. Methods: A qualitative thematic analysis of interviews with 28 patients with lung cancer and their caregivers was conducted. Telephone interviews were conducted and transcribed verbatim. Data analysis was guided by contemporary stigma theory. Results: Patients and caregivers reported feeling high levels of felt stigma and concomitant psychological distress in response to the diagnosis of lung cancer. Three overarching themes emerged: the nexus of lung cancer and smoking, moralization, and attacking the link between lung cancer and smoking. Stigma was inevitably linked to smoking, and this formed the hub around which the other themes were organized. Caregivers reported feeling invisible and noted a lack of support systems for families and caregivers. In addition, there was evidence that caregivers experienced stigma by association as members of the patients’ close networks. Both groups responded ambivalently to stigmatizing antismoking advertisements. Conclusions: The qualitative analysis demonstrated the complex interplay of the social and personal domains in the experience and outcomes of stigma in lung cancer. There is a significant potential for caregivers of patients with lung cancer to experience exacerbations of psychosocial distress as a consequence of widely shared negative views about lung cancer and its prognosis. It remains for researchers and practitioners to incorporate such complexity in addressing stigma and psychosocial distress in both patients and caregivers.

© 2018 Elsevier Ltd Background: Previous trials have found similar early outcomes after robot-assisted laparoscopic prostatectomy and open radical retropubic prostatectomy. We report functional and oncological postoperative outcomes up to 24 months after surgery for these two surgical techniques. Methods: In this randomised controlled phase 3 study, men who had newly diagnosed clinically localised prostate cancer and who had chosen surgery as their treatment approach, and were aged between 35 years and 70 years were eligible and recruited from the Royal Brisbane and Women's Hospital (Brisbane, QLD, Australia). Participants were randomly assigned (1:1) to have either robot-assisted laparoscopic prostatectomy or open radical retropubic prostatectomy. Randomisation was computer generated and occurred in blocks of ten. This was an open trial; however, study investigators involved in data analysis were masked to each patient's surgical treatment. Primary outcomes were urinary function (urinary domain of Expanded Prostate Cancer Index Composite [EPIC]) and sexual function (sexual domain of EPIC and International Index of Erectile Function Questionnaire [IIEF]) at 6 months, 12 months, and 24 months and oncological outcome (biochemical recurrence and imaging evidence of progression). The trial was powered to assess health-related and domain-specific quality-of-life outcomes over 24 months. All analyses were done on a per-protocol basis. The trial was registered with the Australian New Zealand Clinical Trials Registry, number ACTRN12611000661976. Findings: Between Aug 23, 2010, and Nov 25, 2014, 326 men were enrolled, of whom 163 were randomly assigned to robot-assisted laparoscopic prostatectomy and 163 to open radical retropubic prostatectomy. 18 withdrew (12 assigned to radical retropubic prostatectomy and six assigned to robot-assisted laparoscopic prostatectomy); thus, 151 in the radical retropubic prostatectomy group and 157 in the robot-assisted laparoscopic prostatec

© 2018 The Author(s). An integrated interpretation of the east Kimberley, northern Western Australia was completed to determine mineral prospectivity, and was centred on a portion of a magnetotelluric (MT) survey conducted across the entire Kimberley Craton and surrounding orogens. A structural geophysical interpretation used potential field data, and was constrained by geological field observations, petrophysics, remote sensing and understanding of the tectonic history of the region. Potential field forward modelling located along the same survey traverse as the MT data allowed comparison between the two datasets and their interpretations revealing interesting features suggesting the presence of large-scale structures, the presence of mineralization deep in the crust, and where mineralization may be at or near the surface. The King River Fault is shown from both the MT inversion and potential field modelling as a crustal-scale, west-dipping structure, the footwall of which bounds the western side of a large resistive body. A conductive anomaly is also located on the hanging wall of the King River Fault. Our assessment suggests that graphitic rocks, most likely with some sulphide content, contribute to the strength of this anomaly, and highlights the potential of the east Kimberley to host graphite and base metal deposits.

Neoarchean rocks of the Tropicana Zone, including granites with subduction-zone affinities, formed in a terrane adjacent to, or on the margin of, the Yilgarn Craton at the commencement of a long-lived, amphibolite to granulite facies event - the 2722-2554 Ma Atlantis Event. Early stages of this event overlap with extensive komatiite emplacement within the Eastern Goldfields Superterrane (Yilgarn Craton), suggestive of a plume-related rift environment, which was followed by 2660-2630 Ma greenschist facies, orogenic gold mineralization. This indicates differences in the tectonic evolution of the Tropicana Zone compared with within the craton, although isotopic data show similarities in crustal sources. At c. 2520 Ma, the Tropicana Zone was retrogressed to greenschist facies as it was thrust onto the Yamarna Terrane (Yilgarn Craton), forming a northwesterly directed fold-and-thrust belt above the flat-lying Plumridge Detachment. This foldand- thrust belt is host to the c. 2520 Ma, Tropicana gold deposit. The Plumridge Detachment may extend north to the Yamarna greenstone belt, linking to the Yamarna Shear Zone - the boundary between the Burtville and Yamarna Terranes. The fertility of the Tropicana Zone is related to its Neoarchean geodynamic setting within a continental arc environment, implying that deformed margins of Archean cratons may be prospective for Neoarchean Au deposits.

© 2017 Extensional episodes in Precambrian orogens are often difficult to decipher because of subsequent orogenesis and intracontinental reworking. Here, we use geochemical and geochronological constraints of a suite of preserved mafic–ultramafic rocks in the Paleoproterozoic Capricorn Orogen of Western Australia to reveal ophiolites, continental ribbons and aborted rifts. The Capricorn Orogen separates the Archean Yilgarn and Pilbara cratons and includes mafic–ultramafic rocks of the fault-bounded Trillbar Complex and Bryah Sub-basin. The Trillbar Complex is situated within a fault wedge between the Yilgarn Craton and a reworked portion of the craton to the north (Yarlarweelor Gneiss Complex), and has been variously interpreted as an obducted ophiolite, oceanic plateau or continental rift-related magmatic suite. In this study, a new U–Pb zircon age of 2069 ± 9 Ma from the Trillbar Complex indicates that it is at least 40 Myr older than the mafic and ultramafic rocks of the Bryah Sub-basin, with which it has previously been linked. The Trillbar Complex is characterised by E-MORB-like signatures, hydrous crystallization and a lack of crustal contamination, and probably formed in a mid-ocean ridge or, alternatively, an oceanic intraplate setting. Conversely, the 2030–1990 Ma mafic and ultramafic rocks in the Bryah Sub-basin show evidence of crustal contamination and are interpreted to have formed in a continental rift setting. Moreover, there is no evidence for boninites in the Bryah Sub-basin and, therefore, no justification for invoking a fore-arc setting. Thus, these pieces of evidence reveal a different tectonic and geodynamic origin for the Trillbar Complex compared to the Bryah Sub-basin rocks. The tectonic setting for the Trillbar Complex requires oceanic crust to have existed between the Yilgarn Craton and the Yarlarweelor Gneiss Complex. However, almost identical Archean histories of these crustal blocks support a proximal origin for the Yarlarweelor Gneiss C

Colorectal cancer (CRC) screening participation remains unacceptably low. This study investigated the emotion of disgust as a potential deterrent to intention to screen for CRC. The study utilised a convenience sample of individuals' 40-70 years of age to complete an online survey. Participants included 30 men and 118 women recruited between December 1, 2013 and March 31, 2014. Data on socio-demographics, health status, screening intentions and emotional barriers to bowel screening were collected via an on-line survey. Logistic regression analysis was utilised to investigate predictors of screening intention. Individuals were more likely to report intention to screen if they had prior screening experience, and reported fewer emotional concerns to screening for CRC. Results implicate disgust as a predictor of screening avoidance among participants. Specifically, higher reported faecal disgust was predictive of a 3% decrease in screening intention. This study was the first to empirically position disgust alongside other negative emotional states as an affective barrier to screening for CRC. Trait disgust sensitivity was not a reliable predictor of screening intention. This research suggests that anticipated faecal disgust may contribute to avoidance of screening for CRC.

Purpose: Advanced prostate cancer (PC) is associated with substantial psychosocial morbidity. We sought to determine whether mindfulness-based cognitive therapy (MBCT) reduces distress in men with advanced PC. Method(s): Men with advanced PC (proven metastatic and/or castration-resistant biochemical progression) were randomly assigned to an 8-week, group-based MBCT intervention delivered by telephone (n = 94) or to minimally enhanced usual care (n = 95). Primary intervention outcomes were psychological distress, cancer-specific distress, and prostate-specific antigen anxiety. Mindfulness skills were assessed as potential mediators of effect. Participants were assessed at baseline and were followed up at 3, 6, and 9 months. Main statistical analyses were conducted on the basis of intention to treat. Result(s): Fourteen MBCT groups were conducted in the intervention arm. Facilitator adherence ratings were high (> 93%). Using random-effects mixed-regression models, intention-to-treat analyses indicated no significant changes in intervention outcomes or in engagement with mindfulness for men in MBCT compared with those receiving minimally enhanced usual care. Per-protocol analyses also found no differences between arms in outcomes or engagement, with the exception of the mindfulness skill of observing, which increased over time for men in MBCT compared with usual care (P = .032). Conclusion(s): MBCT in this format was not more effective than minimally enhanced usual care in reducing distress in men with advanced PC. Future intervention research for these men should consider approaches that map more closely to masculinity.Copyright © 2016 by American Society of Clinical Oncology.

This study describes sources of support utilised by men with localised prostate cancer in the first year after diagnosis and examines characteristics associated with help-seeking for men with unmet needs. A cross-sectional survey of 331 patients from a population-based sample who were in the first year after diagnosis (M = 9.6, SD = 1.9) was conducted to assess sources of support, unmet supportive care needs, domain-specific quality of life and psychological distress. Overall, 82% of men reported unmet supportive care needs. The top five needs were sexuality (58%); prostate cancer-specific (57%); psychological (47%); physical and daily living (41%); and health system and information (31%). Professional support was most often sought from doctors (51%). Across most domains, men who were older (Ps ≤ 0.03), less well educated (Ps ≤ 0.04) and more depressed (Ps ≤ 0.05) were less likely to seek help for unmet needs. Greater sexual help-seeking was related to better sexual function (P = 0.03), higher education (P ≤ 0.03) and less depression (P = 0.05). Unmet supportive care needs are highly prevalent after localised prostate cancer diagnosis with older age, lower education and higher depression apparent barriers to help-seeking. Interventions that link across medicine, nursing and community based peer support may be an accessible approach to meeting these needs.

This study describes sources of support utilised by men with localised prostate cancer in the first year after diagnosis and examines characteristics associated with help-seeking for men with unmet needs. A cross-sectional survey of 331 patients from a population-based sample who were in the first year after diagnosis (M = 9.6, SD = 1.9) was conducted to assess sources of support, unmet supportive care needs, domain-specific quality of life and psychological distress. Overall, 82% of men reported unmet supportive care needs. The top five needs were sexuality (58%); prostate cancer-specific (57%); psychological (47%); physical and daily living (41%); and health system and information (31%). Professional support was most often sought from doctors (51%). Across most domains, men who were older (Ps ≤ 0.03), less well educated (Ps ≤ 0.04) and more depressed (Ps ≤ 0.05) were less likely to seek help for unmet needs. Greater sexual help-seeking was related to better sexual function (P = 0.03), higher education (P ≤ 0.03) and less depression (P = 0.05). Unmet supportive care needs are highly prevalent after localised prostate cancer diagnosis with older age, lower education and higher depression apparent barriers to help-seeking. Interventions that link across medicine, nursing and community based peer support may be an accessible approach to meeting these needs. Clinical Trial Registry: Trial Registration: ACTRN12611000392965.

Purpose Advanced prostate cancer (PC) is associated with substantial psychosocial morbidity. We sought to determine whether mindfulness-based cognitive therapy (MBCT) reduces distress in men with advanced PC. Methods Men with advanced PC (proven metastatic and/or castration-resistant biochemical progression) were randomly assigned to an 8-week, group-based MBCT intervention delivered by telephone (n = 94) or to minimally enhanced usual care (n = 95). Primary intervention outcomes were psychological distress, cancer-specific distress, and prostate-specific antigen anxiety. Mindfulness skills were assessed as potential mediators of effect. Participants were assessed at baseline and were followed up at 3, 6, and 9 months. Main statistical analyses were conducted on the basis of intention to treat. Results Fourteen MBCT groups were conducted in the intervention arm. Facilitator adherence ratings were high (> 93%). Using random-effects mixed-regression models, intention-to-treat analyses indicated no significant changes in intervention outcomes or in engagement with mindfulness for men in MBCT compared with those receiving minimally enhanced usual care. Per-protocol analyses also found no differences between arms in outcomes or engagement, with the exception of the mindfulness skill of observing, which increased over time for men in MBCT compared with usual care ( P = .032). Conclusion MBCT in this format was not more effective than minimally enhanced usual care in reducing distress in men with advanced PC. Future intervention research for these men should consider approaches that map more closely to masculinity.

The cratonisation of Western Australia during the Proterozoic overlapped with several key events in the evolution of Earth. These include global oxidation events and glaciations, as well as the assembly, accretionary growth, and breakup of the supercontinents Columbia and Rodinia, culminating in the assembly of Gondwana. Globally, Proterozoic mineral systems evolved in response to the coupled evolution of the atmosphere, hydrosphere, biosphere and lithosphere. Consequently, mineral deposits form preferentially in certain times, but they also require a favourable tectonic setting. For Western Australia a distinct plate-margin mineralisation trend is associated with Columbia, whereas an intraplate mineralisation trend is associated with Rodinia and Gondwana, each with associated deposit types. We compare the current Proterozoic record of ore deposits in Western Australia to the estimated likelihood of ore-deposit formation. Overall likelihood is estimated with a simple matrix-based approach that considers two components: The "global secular likelihood" and the "tectonic setting likelihood". This comparative study shows that at least for the studied ore-deposit types, deposits within Western Australia developed at times, and in tectonic settings compatible with global databases. Nevertheless, several deposit types are either absent or poorly-represented relative to the overall likelihood models. Insufficient exploration may partly explain this, but a genuine lack of deposits is also suggested for some deposit types. This may relate either to systemic inadequacies that inhibited ore-deposit formation, or to poor preservation. The systematic understanding on the record of Western Australia helps to understand mineralisation processes within Western Australia and its past connections in Columbia, Rodinia and Gondwana and aids to identify regions of high exploration potential.

© 2017 A regional tectonic model is presented for the formation and evolution of Paleoproterozoic basins over the northern Yilgarn Craton, integrating new and published regional geological, geochronological, geochemical and geophysical data. The basins formed as a response to both extensional and compressional processes in the early Paleoproterozoic along the craton margin. Early rifting and basin formation coincided with the Ophthalmia Orogeny, the result of the convergence and accretion of the Archean to Proterozoic Glenburgh Terrane with the Pilbara Craton, and led to the formation of the Yerrida Basin at c. 2180 Ma as a single sub-basin containing the Windplain Group. This led to the eventual development of the Bryah and Mooloogool Sub-basins of the Yerrida Basin at c. 2030 Ma, and voluminous extrusion and intrusion of mafic rocks. The depth and nature of the Bryah Sub-basin suggests formation in response to rifting, with its orientation corresponding to the rift axis. Continued rifting along the northern Yilgarn margin resulted in subduction of the Yilgarn Craton beneath the composite Glenburgh–Pilbara craton. Eventual collision was marked by cessation of volcanism and rift-sediment deposition in the Bryah and Mooloogool Sub-basins, the onset of a pro-foreland basin (Padbury Basin) in the west, and approximately NE–SW rifting further east (the Earaheedy Basin), all at c. 2000 Ma. Banded iron-formation and granular iron-formation (Robinson Range and Frere Formations) was deposited much later (c. 1890 Ma) in a large basin that deepened from east to west, spanning the Earaheedy and Yerrida Basins. The deepest parts of this basin coincide with the Bryah Sub-basin, which was the most rifted portion of the Yilgarn Craton in this region. Deposition in all basins probably ceased with onset of the Capricorn Orogeny at c. 1820 Ma.

Objective: To examine the extent to which mindfulness skills influence psychological distress and health-related quality of life (HRQOL) in men with metastatic or castration-resistant biochemical progression of prostate cancer. Patients and Methods: A cross-sectional survey of 190 men (46 % response; mean age 71 years, SD = 8.7, range 40-91 years) with advanced prostate cancer, assessed psychological and cancer-specific distress, HRQOL. Mindfulness skills were assessed as potential predictors of adjustment outcomes. Result(s): Overall, 39 % of men reported high psychological distress. One third had accessed psychological support previously although only 10 % were under current psychological care. One quarter had accessed a prostate cancer support group in the past six months. Higher HRQOL and lower cancer-specific and global psychological distress were related to non-judging of inner experience (p < 0.001). Higher HRQOL and lower psychological distress were related to acting with awareness (p < 0.001). Lower distress was also related to higher non-reactivity to inner experience and a lower level of observing (p < 0.05). Conclusion(s): Men with advanced prostate cancer are at risk of poor psychological outcomes. Psychological flexibility may be a promising target for interventions to improve adjustment outcomes in this patient group. Clinical Trial Registry: Trial Registration: ACTRN12612000306819Copyright © 2016, The Author(s).

Background: Advanced prostate cancer may be associated with substantial psychological distress but there is little data about effective interventions. A multi-state two-armed randomised controlled trial was conducted to determine the effectiveness of a tele-based mindfulness- based cognitive therapy (MBCT) intervention for men with advanced prostate cancer. Method(s): Participants were recruited through clinicians in the Australian and New Zealand Urogenital and Prostate Cancer Trials Group and from major treatment centres located in Queensland, New South Wales, Western Australia, Victoria, South Australia, and Tasmania. A total of 190 eligible men consented to participate in the trial and were randomly assigned to the tele-based MBCT intervention (n = 94) or a patient education group (n = 95). Self-administered questionnaires were sent to participants at four time points: baseline and at three, six, and nine months after recruitment and intervention commencement. Primary trial outcomes are psychological distress and cancerspecific distress. Secondary trial outcomes are health-related quality of life and benefit finding. Potential mediators of successful intervention outcomes include engagement with mindfulness and adherence to practice. Result(s): At baseline, 39% of participants reported high psychological distress although only 10% were under current psychological care. Preliminary analyses of baseline data indicate that adjustment outcomes were associated with the following facets of mindfulness: non-judging of inner experience, acting with awareness, and non-reactivity to inner experience. Trial outcome data are currently being analysed and results will be presented. Conclusion(s): Trial outcomes will be discussed with regard to models of psychological care and the feasibility of MBCT interventions for men with prostate cancer.

Italy has an indicator of injuries for millions of tep produced lowest than other Countries (0.26 in 2014). Nevertheless the Directorate general for safety - National mining office for hydrocarbons and georesources (DGS-UNMIG) wants to improve the already good safety measures of offshore oil&gas operations in application of D.Lgs 18th august, 2015 n.145 (transportation of Directive 2013/30/UE) and with respect to the D.Lgs 26th june, 2012 n.83. With this prospective DGS-UNMIG started agreements with University, Research Institutions and Authorities obtaining a scientific support (CNR, RSE, INGV, OGS, AMRA, CRIET Navy, Harbor Body and Universities). The interest is on five pillars: “control”, “competence”, “efficiency”, “research & innovation” and “dialog” (Fig. 1). The following tasks have been set up for guarantee-oriented actions:  identification of an measurable index for the evaluation of variation of the offshore installations safety level from the current status and criticalities;  application of a naval-air-satellite integrated system for the daily monitoring of Adriatic Sea, in coordination with MATTM;  check of Adriatic sealines conditions for oil & gas transportation;  check of steel structures conditions of offshore facilities;  offshore operations monitoring: drilling and recording systems for drilling parameters;  evaluation of seismic hazard of existing platforms;  development of feasibility studies for seismic and ground deformation monitoring;  check of the current emissions of installations and their forecast to 2020;  analysis of the environmental effects of the NaTech operations and incident;  collection of information about the activities of Italian institutions for increasing levels of offshore safety and related databases;  geology and stratigraphy analysis of marine areas open to hydrocarbons exploration and production activities;  energetic optimization of the offshore installation even by means of renewable energy sources;  risk

OBJECTIVE: To examine the extent to which mindfulness skills influence psychological distress and health-related quality of life (HRQOL) in men with metastatic or castration-resistant biochemical progression of prostate cancer. PATIENTS AND METHODS: A cross-sectional survey of 190 men (46 % response; mean age 71 years, SD = 8.7, range 40-91 years) with advanced prostate cancer, assessed psychological and cancer-specific distress, HRQOL. Mindfulness skills were assessed as potential predictors of adjustment outcomes. RESULTS: Overall, 39 % of men reported high psychological distress. One third had accessed psychological support previously although only 10 % were under current psychological care. One quarter had accessed a prostate cancer support group in the past six months. Higher HRQOL and lower cancer-specific and global psychological distress were related to non-judging of inner experience (p < 0.001). Higher HRQOL and lower psychological distress were related to acting with awareness (p < 0.001). Lower distress was also related to higher non-reactivity to inner experience and a lower level of observing (p < 0.05). CONCLUSIONS: Men with advanced prostate cancer are at risk of poor psychological outcomes. Psychological flexibility may be a promising target for interventions to improve adjustment outcomes in this patient group. CLINICAL TRIAL REGISTRY: Trial Registration: ACTRN12612000306819.

OBJECTIVE: This study compared the cost-effectiveness of a psychologist-led, individualised cognitive behavioural intervention (PI) to a nurse-led, minimal contact self-management condition for highly distressed cancer patients and carers. METHODS: This was an economic evaluation conducted alongside a randomised trial of highly distressed adult cancer patients and carers calling cancer helplines. Services used by participants were measured using a resource use questionnaire, and quality-adjusted life years were measured using the assessment of quality of life - eight-dimension - instrument collected through a computer-assisted telephone interview. The base case analysis stratified participants based on the baseline score on the Brief Symptom Inventory. Incremental cost-effectiveness ratio confidence intervals were calculated with a nonparametric bootstrap to reflect sampling uncertainty. The results were subjected to sensitivity analysis by varying unit costs for resource use and the method for handling missing data. RESULTS: No significant differences were found in overall total costs or quality-adjusted life years (QALYs) between intervention groups. Bootstrapped data suggest the PI had a higher probability of lower cost and greater QALYs for both carers and patients with high distress at baseline. For patients with low levels of distress at baseline, the PI had a higher probability of greater QALYs but at additional cost. Sensitivity analysis showed the results were robust. CONCLUSIONS: The PI may be cost-effective compared with the nurse-led, minimal contact self-management condition for highly distressed cancer patients and carers. More intensive psychological intervention for patients with greater levels of distress appears warranted. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd.

BACKGROUND: The absence of trial data comparing robot-assisted laparoscopic prostatectomy and open radical retropubic prostatectomy is a crucial knowledge gap in uro-oncology. We aimed to compare these two approaches in terms of functional and oncological outcomes and report the early postoperative outcomes at 12 weeks. METHOD: In this randomised controlled phase 3 study, men who had newly diagnosed clinically localised prostate cancer and who had chosen surgery as their treatment approach, were able to read and speak English, had no previous history of head injury, dementia, or psychiatric illness or no other concurrent cancer, had an estimated life expectancy of 10 years or more, and were aged between 35 years and 70 years were eligible and recruited from the Royal Brisbane and Women's Hospital (Brisbane, QLD). Participants were randomly assigned (1:1) to receive either robot-assisted laparoscopic prostatectomy or radical retropubic prostatectomy. Randomisation was computer generated and occurred in blocks of ten. This was an open trial; however, study investigators involved in data analysis were masked to each patient's condition. Further, a masked central pathologist reviewed the biopsy and radical prostatectomy specimens. Primary outcomes were urinary function (urinary domain of EPIC) and sexual function (sexual domain of EPIC and IIEF) at 6 weeks, 12 weeks, and 24 months and oncological outcome (positive surgical margin status and biochemical and imaging evidence of progression at 24 months). The trial was powered to assess health-related and domain-specific quality of life outcomes over 24 months. We report here the early outcomes at 6 weeks and 12 weeks. The per-protocol populations were included in the primary and safety analyses. This trial was registered with the Australian New Zealand Clinical Trials Registry (ANZCTR), number ACTRN12611000661976. FINDINGS: Between Aug 23, 2010, and Nov 25, 2014, 326 men were enrolled, of whom 163 were randomly assigned t

The Earaheedy Basin is one of several Paleoproterozoic siliciclastic basins in the eastern part of the Capricorn Orogen in Western Australia. In the absence of an adequate chronostratigraphic framework, multiple conflicting models have been proposed for the tectonic history of the basin. We present in situ SHRIMP U–Pb zircon dates of 1971 ± 11 Ma, 1954 ± 5 Ma and 1949 ± 10 Ma from three thin tuff horizons (“micro-tuffs”) in the Yelma Formation at the base of the basin succession. These micro-tuffs are only slightly younger than the 1990 ± 6 Ma Imbin porphyry, which has been interpreted as a basement inlier. Our new dates, combined with field mapping, suggest that the Imbin porphyry is a volcanic–subvolcanic complex within the basin. Micro-tuffs in the Yelma Formation are more than 50 m.y. older than c. 1890 Ma micro-tuffs within the overlying Frere Formation. Deposition of the Yelma Formation was coeval with continent–continent collision farther west in the Orogen marked by the 2005–1950 Ma Glenburgh Orogeny, and the formation is possibly correlative with peripheral foreland deposits of the Padbury Group. The Frere Formation was deposited in shallow marine conditions within an intracratonic basin about 60 m.y. after the Glenburgh Orogeny. The Frere Formation is unconformably or disconformably overlain by the Miningarra Group, the youngest unit of which is the Mulgarra Sandstone. This sandstone was deposited after c. 1865 Ma, and derived either from exposed Frere Formation or from a now-buried source within the Capricorn Orogen that was uplifted by inception of the 1820–1770 Ma Capricorn Orogeny. Therefore, the Earaheedy Basin comprises at least three distinct, unconformity-bound successions deposited in contrasting tectonic settings.

Understanding the regional context of mineral prospectivity is essential for opening areas to effective exploration. The Halls Creek Orogen in Western Australia, is one such region. Here we have completed a multi-commodity mineral systems analysis, which we have used as a basis for the production of semi-automated prospectivity models. Known mineral occurrences or deposits formed over a period dominated by the compressional 1865-1850. Ma Hooper and 1835-1805. Ma Halls Creek orogenies, either followed, or preceded by periods of extension. Prospectivity models were built on knowledge-based fuzzy inference networks for seven commodity groups. The work has demonstrated a link between key model components and the propensity of disparate styles of mineral deposits to occur in this region, which has not been documented before. Different tectonic terranes defined as 'zones' in the Halls Creek Orogen are prospective for different commodity groups. A link between major crustal-scale faults or shear zones and the location of known ore deposits and occurrences in the area has been established. Many structures are either newly discovered, or their extension through the upper crust and down to the Moho has just been established. The lithospheric scale of these structurally weak zones would allow fluid migration from within, or below the lower crust. Of these structures, orogen perpendicular (northwest trending) and orogen oblique (north trending) faults are the most influential structures with respect to ore deposition, especially in regions where they intersect each other. The orogen-parallel structures were found to be less important. The crustal-scale architecture of the region and its link to known mineral occurrences suggests that the mineral prospectivity of the Halls Creek Orogen for commodities such as Ni, Cu, PGEs, Au, Pb, Zn and diamonds could be extended beyond known occurrences into the new zones delineated by the prospectivity analysis.

The east Kimberley region contains well-preserved tectonic structure dating back to the Earth's most significant stage of continental growth: the assembly of the Nuna supercontinent. An integrated geological-geophysical investigation of this region has been conducted and reveals insight into its tectonic evolution, including potential influence of significant crustal-scale structures in the development of regional architecture, the emplacement of magma, and the relationship of these structures to large-scale deformation. Some newly interpreted features include a north-trending structure, and three north-west trending structures that segment the north-east trending orogen. The central segment of the orogen is a zone of higher metamorphic grade, and is host to a distinct gravity high. This gravity high can be explained by excess mass in the mid-crust. This anomaly is consistent with either a large mafic-ultramafic intrusion or a high-density crustal fragment. Possible tectonic models to explain the geophysical and metamorphic anomalies involve, in the latter case, the accretion of a crustal fragment to the Kimberley Craton prior to the 1865-1850 Ma H ooper Orogeny or, in the former case, intrusion of voluminous mafic magmas into the middle crust. Whether by igneous or structural means, we consider the development of this anomalous region to be a result of along-strike variations in subduction dynamics. These were perhaps driven by variations in slab-geometry accommodated by the orogen-normal structures we identify. The orogen-normal structures are interpreted to be crustal-scale faults, along which significant vertical displacement occurred when a crustal fragment collided with Kimberley Craton and exhumed high-grade metamorphic rocks to the surface.