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Introduction: Augmented reality (AR) and mixed reality (MR) technologies have revolutionized cranial neurosurgery by overlaying digital information onto the surgical field, enhancing visualization, precision, and training. These technologies enable the real-time integration of preoperative imaging data, aiding in better decision-making and reducing operative risks. Despite challenges such as cost and specialized training needs, AR and MR offer significant benefits, including improved surgical outcomes and personalized surgical plans based on individual patient anatomy. Materials and Methods: This study describes three intracranial surgeries using AR and MR technologies at Hospital Ángeles Universidad, Mexico City, in 2023. Surgeries were performed with VisAR software 3 version and Microsoft HoloLens 2, transforming DICOM images into 3D models. Preoperative MRI and CT scans facilitated planning, and radiopaque tags ensured accurate image registration during surgery. Postoperative outcomes were assessed through clinical and imaging follow-up. Results: Three intracranial surgeries were performed with AR and MR assistance, resulting in successful outcomes with minimal postoperative complications. Case 1 achieved 80% tumor resection, Case 2 achieved near-total tumor resection, and Case 3 achieved complete lesion resection. All patients experienced significant symptom relief and favorable recoveries, demonstrating the precision and effectiveness of AR and MR in cranial surgery. Conclusions: This study demonstrates the successful use of AR and MR in cranial surgery, enhancing precision and clinical outcomes. Despite challenges like training and costs, these technologies offer significant benefits. Future research should focus on long-term outcomes and broader applications to validate their efficacy and cost-effectiveness in neurosurgery. [ABSTRACT FROM AUTHOR]

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