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1. pRAD50: a novel and clinically applicable pharmacodynamic biomarker of both ATM and ATR inhibition identified using mass spectrometry and immunohistochemistry

Author

Jones, Gemma N., Rooney, Claire, Griffin, Nicola, Roudier, Martine, Young, Lucy A., Garcia-Trinidad, Antonio, Hughes, Gareth D., Whiteaker, Jeffrey R., Wilson, Zena, Odedra, Rajesh, Zhao, Lei, Ivey, Richard G., Howat, William J., Harrington, Elizabeth A., Barrett, J. Carl, Ramos-Montoya, Antonio, Lau, Alan, Paulovich, Amanda G., Cadogan, Elaine B., and Pierce, Andrew J.

Published
2018
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2. Video 1 - ATMi increases the rate of mitotic catastrophe in glioma cells when p53 is knocked down. from Orally Bioavailable and Blood–Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice

Author

Karlin, Jeremy, primary, Allen, Jasmine, primary, Ahmad, Syed F., primary, Hughes, Gareth, primary, Sheridan, Victoria, primary, Odedra, Rajesh, primary, Farrington, Paul, primary, Cadogan, Elaine B., primary, Riches, Lucy C., primary, Garcia-Trinidad, Antonio, primary, Thomason, Andrew G., primary, Patel, Bhavika, primary, Vincent, Jennifer, primary, Lau, Alan, primary, Pike, Kurt G., primary, Hunt, Thomas A., primary, Sule, Amrita, primary, Valerie, Nicholas C.K., primary, Biddlestone-Thorpe, Laura, primary, Kahn, Jenna, primary, Beckta, Jason M., primary, Mukhopadhyay, Nitai, primary, Barlaam, Bernard, primary, Degorce, Sebastien L., primary, Kettle, Jason, primary, Colclough, Nicola, primary, Wilson, Joanne, primary, Smith, Aaron, primary, Barrett, Ian P., primary, Zheng, Li, primary, Zhang, Tianwei, primary, Wang, Yingchun, primary, Chen, Kan, primary, Pass, Martin, primary, Durant, Stephen T., primary, and Valerie, Kristoffer, primary

Published
2023
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3. Video 4 - ATMi increases the rate of mitotic catastrophe in glioma cells when p53 is knocked down. from Orally Bioavailable and Blood–Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice

Author

Karlin, Jeremy, primary, Allen, Jasmine, primary, Ahmad, Syed F., primary, Hughes, Gareth, primary, Sheridan, Victoria, primary, Odedra, Rajesh, primary, Farrington, Paul, primary, Cadogan, Elaine B., primary, Riches, Lucy C., primary, Garcia-Trinidad, Antonio, primary, Thomason, Andrew G., primary, Patel, Bhavika, primary, Vincent, Jennifer, primary, Lau, Alan, primary, Pike, Kurt G., primary, Hunt, Thomas A., primary, Sule, Amrita, primary, Valerie, Nicholas C.K., primary, Biddlestone-Thorpe, Laura, primary, Kahn, Jenna, primary, Beckta, Jason M., primary, Mukhopadhyay, Nitai, primary, Barlaam, Bernard, primary, Degorce, Sebastien L., primary, Kettle, Jason, primary, Colclough, Nicola, primary, Wilson, Joanne, primary, Smith, Aaron, primary, Barrett, Ian P., primary, Zheng, Li, primary, Zhang, Tianwei, primary, Wang, Yingchun, primary, Chen, Kan, primary, Pass, Martin, primary, Durant, Stephen T., primary, and Valerie, Kristoffer, primary

Published
2023
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4. Data from Optimizing Therapeutic Effect of Aurora B Inhibition in Acute Myeloid Leukemia with AZD2811 Nanoparticles

Author

Floc'h, Nicolas, primary, Ashton, Susan, primary, Taylor, Paula, primary, Trueman, Dawn, primary, Harris, Emily, primary, Odedra, Rajesh, primary, Maratea, Kim, primary, Derbyshire, Nicola, primary, Caddy, Jacqueline, primary, Jacobs, Vivien N., primary, Hattersley, Maureen, primary, Wen, Shenghua, primary, Curtis, Nicola J., primary, Pilling, James E., primary, Pease, Elizabeth J., primary, and Barry, Simon T., primary

Published
2023
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5. Supplementary Figures S1-S4 and Tables S1-S2 from Optimizing Therapeutic Effect of Aurora B Inhibition in Acute Myeloid Leukemia with AZD2811 Nanoparticles

Author

Floc'h, Nicolas, primary, Ashton, Susan, primary, Taylor, Paula, primary, Trueman, Dawn, primary, Harris, Emily, primary, Odedra, Rajesh, primary, Maratea, Kim, primary, Derbyshire, Nicola, primary, Caddy, Jacqueline, primary, Jacobs, Vivien N., primary, Hattersley, Maureen, primary, Wen, Shenghua, primary, Curtis, Nicola J., primary, Pilling, James E., primary, Pease, Elizabeth J., primary, and Barry, Simon T., primary

Published
2023
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6. Data from Orally Bioavailable and Blood–Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice

Author

Karlin, Jeremy, primary, Allen, Jasmine, primary, Ahmad, Syed F., primary, Hughes, Gareth, primary, Sheridan, Victoria, primary, Odedra, Rajesh, primary, Farrington, Paul, primary, Cadogan, Elaine B., primary, Riches, Lucy C., primary, Garcia-Trinidad, Antonio, primary, Thomason, Andrew G., primary, Patel, Bhavika, primary, Vincent, Jennifer, primary, Lau, Alan, primary, Pike, Kurt G., primary, Hunt, Thomas A., primary, Sule, Amrita, primary, Valerie, Nicholas C.K., primary, Biddlestone-Thorpe, Laura, primary, Kahn, Jenna, primary, Beckta, Jason M., primary, Mukhopadhyay, Nitai, primary, Barlaam, Bernard, primary, Degorce, Sebastien L., primary, Kettle, Jason, primary, Colclough, Nicola, primary, Wilson, Joanne, primary, Smith, Aaron, primary, Barrett, Ian P., primary, Zheng, Li, primary, Zhang, Tianwei, primary, Wang, Yingchun, primary, Chen, Kan, primary, Pass, Martin, primary, Durant, Stephen T., primary, and Valerie, Kristoffer, primary

Published
2023
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7. Supplementary Information from Orally Bioavailable and Blood–Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice

Author

Karlin, Jeremy, primary, Allen, Jasmine, primary, Ahmad, Syed F., primary, Hughes, Gareth, primary, Sheridan, Victoria, primary, Odedra, Rajesh, primary, Farrington, Paul, primary, Cadogan, Elaine B., primary, Riches, Lucy C., primary, Garcia-Trinidad, Antonio, primary, Thomason, Andrew G., primary, Patel, Bhavika, primary, Vincent, Jennifer, primary, Lau, Alan, primary, Pike, Kurt G., primary, Hunt, Thomas A., primary, Sule, Amrita, primary, Valerie, Nicholas C.K., primary, Biddlestone-Thorpe, Laura, primary, Kahn, Jenna, primary, Beckta, Jason M., primary, Mukhopadhyay, Nitai, primary, Barlaam, Bernard, primary, Degorce, Sebastien L., primary, Kettle, Jason, primary, Colclough, Nicola, primary, Wilson, Joanne, primary, Smith, Aaron, primary, Barrett, Ian P., primary, Zheng, Li, primary, Zhang, Tianwei, primary, Wang, Yingchun, primary, Chen, Kan, primary, Pass, Martin, primary, Durant, Stephen T., primary, and Valerie, Kristoffer, primary

Published
2023
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8. Video 2 - ATMi increases the rate of mitotic catastrophe in glioma cells when p53 is knocked down. from Orally Bioavailable and Blood–Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice

Author

Karlin, Jeremy, primary, Allen, Jasmine, primary, Ahmad, Syed F., primary, Hughes, Gareth, primary, Sheridan, Victoria, primary, Odedra, Rajesh, primary, Farrington, Paul, primary, Cadogan, Elaine B., primary, Riches, Lucy C., primary, Garcia-Trinidad, Antonio, primary, Thomason, Andrew G., primary, Patel, Bhavika, primary, Vincent, Jennifer, primary, Lau, Alan, primary, Pike, Kurt G., primary, Hunt, Thomas A., primary, Sule, Amrita, primary, Valerie, Nicholas C.K., primary, Biddlestone-Thorpe, Laura, primary, Kahn, Jenna, primary, Beckta, Jason M., primary, Mukhopadhyay, Nitai, primary, Barlaam, Bernard, primary, Degorce, Sebastien L., primary, Kettle, Jason, primary, Colclough, Nicola, primary, Wilson, Joanne, primary, Smith, Aaron, primary, Barrett, Ian P., primary, Zheng, Li, primary, Zhang, Tianwei, primary, Wang, Yingchun, primary, Chen, Kan, primary, Pass, Martin, primary, Durant, Stephen T., primary, and Valerie, Kristoffer, primary

Published
2023
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9. Video 3 - ATMi increases the rate of mitotic catastrophe in glioma cells when p53 is knocked down. from Orally Bioavailable and Blood–Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice

Author

Karlin, Jeremy, primary, Allen, Jasmine, primary, Ahmad, Syed F., primary, Hughes, Gareth, primary, Sheridan, Victoria, primary, Odedra, Rajesh, primary, Farrington, Paul, primary, Cadogan, Elaine B., primary, Riches, Lucy C., primary, Garcia-Trinidad, Antonio, primary, Thomason, Andrew G., primary, Patel, Bhavika, primary, Vincent, Jennifer, primary, Lau, Alan, primary, Pike, Kurt G., primary, Hunt, Thomas A., primary, Sule, Amrita, primary, Valerie, Nicholas C.K., primary, Biddlestone-Thorpe, Laura, primary, Kahn, Jenna, primary, Beckta, Jason M., primary, Mukhopadhyay, Nitai, primary, Barlaam, Bernard, primary, Degorce, Sebastien L., primary, Kettle, Jason, primary, Colclough, Nicola, primary, Wilson, Joanne, primary, Smith, Aaron, primary, Barrett, Ian P., primary, Zheng, Li, primary, Zhang, Tianwei, primary, Wang, Yingchun, primary, Chen, Kan, primary, Pass, Martin, primary, Durant, Stephen T., primary, and Valerie, Kristoffer, primary

Published
2023
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10. Supplementary Data Figures 1-8 from Differential Activity of ATR and WEE1 Inhibitors in a Highly Sensitive Subpopulation of DLBCL Linked to Replication Stress

Author

Young, Lucy A., primary, O'Connor, Lenka Oplustil, primary, de Renty, Christelle, primary, Veldman-Jones, Margaret H., primary, Dorval, Thierry, primary, Wilson, Zena, primary, Jones, David R., primary, Lawson, Deborah, primary, Odedra, Rajesh, primary, Maya-Mendoza, Apolinar, primary, Reimer, Corinne, primary, Bartek, Jiri, primary, Lau, Alan, primary, and O'Connor, Mark J., primary

Published
2023
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11. Data from The PARP Inhibitor AZD2461 Provides Insights into the Role of PARP3 Inhibition for Both Synthetic Lethality and Tolerability with Chemotherapy in Preclinical Models

Author

Oplustil O'Connor, Lenka, primary, Rulten, Stuart L., primary, Cranston, Aaron N., primary, Odedra, Rajesh, primary, Brown, Henry, primary, Jaspers, Janneke E., primary, Jones, Louise, primary, Knights, Charlotte, primary, Evers, Bastiaan, primary, Ting, Attilla, primary, Bradbury, Robert H., primary, Pajic, Marina, primary, Rottenberg, Sven, primary, Jonkers, Jos, primary, Rudge, David, primary, Martin, Niall M.B., primary, Caldecott, Keith W., primary, Lau, Alan, primary, and O'Connor, Mark J., primary

Published
2023
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12. Supplementary Tables from Differential Activity of ATR and WEE1 Inhibitors in a Highly Sensitive Subpopulation of DLBCL Linked to Replication Stress

Author

Young, Lucy A., primary, O'Connor, Lenka Oplustil, primary, de Renty, Christelle, primary, Veldman-Jones, Margaret H., primary, Dorval, Thierry, primary, Wilson, Zena, primary, Jones, David R., primary, Lawson, Deborah, primary, Odedra, Rajesh, primary, Maya-Mendoza, Apolinar, primary, Reimer, Corinne, primary, Bartek, Jiri, primary, Lau, Alan, primary, and O'Connor, Mark J., primary

Published
2023
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13. Supplementary Methods Table from Differential Activity of ATR and WEE1 Inhibitors in a Highly Sensitive Subpopulation of DLBCL Linked to Replication Stress

Author

Young, Lucy A., primary, O'Connor, Lenka Oplustil, primary, de Renty, Christelle, primary, Veldman-Jones, Margaret H., primary, Dorval, Thierry, primary, Wilson, Zena, primary, Jones, David R., primary, Lawson, Deborah, primary, Odedra, Rajesh, primary, Maya-Mendoza, Apolinar, primary, Reimer, Corinne, primary, Bartek, Jiri, primary, Lau, Alan, primary, and O'Connor, Mark J., primary

Published
2023
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14. Data from ATR Inhibitor AZD6738 (Ceralasertib) Exerts Antitumor Activity as a Monotherapy and in Combination with Chemotherapy and the PARP Inhibitor Olaparib

Author

Wilson, Zena, primary, Odedra, Rajesh, primary, Wallez, Yann, primary, Wijnhoven, Paul W.G., primary, Hughes, Adina M., primary, Gerrard, Joe, primary, Jones, Gemma N., primary, Bargh-Dawson, Hannah, primary, Brown, Elaine, primary, Young, Lucy A., primary, O'Connor, Mark J., primary, and Lau, Alan, primary

Published
2023
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15. Supplementary Materials and Methods, Supplementary Tables 1 through 3, and Supplementary Figure 1 from The PARP Inhibitor AZD2461 Provides Insights into the Role of PARP3 Inhibition for Both Synthetic Lethality and Tolerability with Chemotherapy in Preclinical Models

Author

Oplustil O'Connor, Lenka, primary, Rulten, Stuart L., primary, Cranston, Aaron N., primary, Odedra, Rajesh, primary, Brown, Henry, primary, Jaspers, Janneke E., primary, Jones, Louise, primary, Knights, Charlotte, primary, Evers, Bastiaan, primary, Ting, Attilla, primary, Bradbury, Robert H., primary, Pajic, Marina, primary, Rottenberg, Sven, primary, Jonkers, Jos, primary, Rudge, David, primary, Martin, Niall M.B., primary, Caldecott, Keith W., primary, Lau, Alan, primary, and O'Connor, Mark J., primary

Published
2023
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16. Supplementary Data from ATR Inhibitor AZD6738 (Ceralasertib) Exerts Antitumor Activity as a Monotherapy and in Combination with Chemotherapy and the PARP Inhibitor Olaparib

Author

Wilson, Zena, primary, Odedra, Rajesh, primary, Wallez, Yann, primary, Wijnhoven, Paul W.G., primary, Hughes, Adina M., primary, Gerrard, Joe, primary, Jones, Gemma N., primary, Bargh-Dawson, Hannah, primary, Brown, Elaine, primary, Young, Lucy A., primary, O'Connor, Mark J., primary, and Lau, Alan, primary

Published
2023
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17. Supplementary Table 4 from CHR-2797: An Antiproliferative Aminopeptidase Inhibitor that Leads to Amino Acid Deprivation in Human Leukemic Cells

Author

Krige, David, primary, Needham, Lindsey A., primary, Bawden, Lindsay J., primary, Flores, Nicolas, primary, Farmer, Hannah, primary, Miles, Lauren E.C., primary, Stone, Erica, primary, Callaghan, Juliana, primary, Chandler, Stephen, primary, Clark, Vanessa L., primary, Kirwin-Jones, Patricia, primary, Legris, Valérie, primary, Owen, Jo, primary, Patel, Thakor, primary, Wood, Steve, primary, Box, Gary, primary, Laber, David, primary, Odedra, Rajesh, primary, Wright, Annette, primary, Wood, L. Michael, primary, Eccles, Suzanne A., primary, Bone, Elisabeth A., primary, Ayscough, Andrew, primary, and Drummond, Alan H., primary

Published
2023
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18. Data from CHR-2797: An Antiproliferative Aminopeptidase Inhibitor that Leads to Amino Acid Deprivation in Human Leukemic Cells

Author

Krige, David, primary, Needham, Lindsey A., primary, Bawden, Lindsay J., primary, Flores, Nicolas, primary, Farmer, Hannah, primary, Miles, Lauren E.C., primary, Stone, Erica, primary, Callaghan, Juliana, primary, Chandler, Stephen, primary, Clark, Vanessa L., primary, Kirwin-Jones, Patricia, primary, Legris, Valérie, primary, Owen, Jo, primary, Patel, Thakor, primary, Wood, Steve, primary, Box, Gary, primary, Laber, David, primary, Odedra, Rajesh, primary, Wright, Annette, primary, Wood, L. Michael, primary, Eccles, Suzanne A., primary, Bone, Elisabeth A., primary, Ayscough, Andrew, primary, and Drummond, Alan H., primary

Published
2023
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19. Supplementary Methods and Materials from CHR-2797: An Antiproliferative Aminopeptidase Inhibitor that Leads to Amino Acid Deprivation in Human Leukemic Cells

Author

Krige, David, primary, Needham, Lindsey A., primary, Bawden, Lindsay J., primary, Flores, Nicolas, primary, Farmer, Hannah, primary, Miles, Lauren E.C., primary, Stone, Erica, primary, Callaghan, Juliana, primary, Chandler, Stephen, primary, Clark, Vanessa L., primary, Kirwin-Jones, Patricia, primary, Legris, Valérie, primary, Owen, Jo, primary, Patel, Thakor, primary, Wood, Steve, primary, Box, Gary, primary, Laber, David, primary, Odedra, Rajesh, primary, Wright, Annette, primary, Wood, L. Michael, primary, Eccles, Suzanne A., primary, Bone, Elisabeth A., primary, Ayscough, Andrew, primary, and Drummond, Alan H., primary

Published
2023
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24. ATR Inhibitor AZD6738 (Ceralasertib) Exerts Antitumor Activity as a Monotherapy and in Combination with Chemotherapy and the PARP Inhibitor Olaparib

Author

Wilson, Zena, primary, Odedra, Rajesh, additional, Wallez, Yann, additional, Wijnhoven, Paul W.G., additional, Hughes, Adina M., additional, Gerrard, Joe, additional, Jones, Gemma N., additional, Bargh-Dawson, Hannah, additional, Brown, Elaine, additional, Young, Lucy A., additional, O'Connor, Mark J., additional, and Lau, Alan, additional

Published
2022
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27. Discovery of Novel UDP-N-Acetylglucosamine Acyltransferase (LpxA) Inhibitors with Activity against Pseudomonas aeruginosa

Author

Ryan, M. Dominic, primary, Parkes, Alastair L., additional, Corbett, David, additional, Dickie, Anthony P., additional, Southey, Michelle, additional, Andersen, Ole A., additional, Stein, Daniel B., additional, Barbeau, Olivier R., additional, Sanzone, Angelo, additional, Thommes, Pia, additional, Barker, John, additional, Cain, Ricky, additional, Compper, Christel, additional, Dejob, Magali, additional, Dorali, Alain, additional, Etheridge, Donnya, additional, Evans, Sian, additional, Faulkner, Adele, additional, Gadouleau, Elise, additional, Gorman, Timothy, additional, Haase, Denes, additional, Holbrow-Wilshaw, Maisie, additional, Krulle, Thomas, additional, Li, Xianfu, additional, Lumley, Christopher, additional, Mertins, Barbara, additional, Napier, Spencer, additional, Odedra, Rajesh, additional, Papadopoulos, Kostas, additional, Roumpelakis, Vasileios, additional, Spear, Kate, additional, Trimby, Emily, additional, Williams, Jennifer, additional, Zahn, Michael, additional, Keefe, Anthony D., additional, Zhang, Ying, additional, Soutter, Holly T., additional, Centrella, Paolo A., additional, Clark, Matthew A., additional, Cuozzo, John W., additional, Dumelin, Christoph E., additional, Deng, Boer, additional, Hunt, Avery, additional, Sigel, Eric A., additional, Troast, Dawn M., additional, and DeJonge, Boudewijn L. M., additional

Published
2021
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35. Differential Activity of ATR and WEE1 Inhibitors in a Highly Sensitive Subpopulation of DLBCL Linked to Replication Stress

Author

Young, Lucy A., primary, O'Connor, Lenka Oplustil, additional, de Renty, Christelle, additional, Veldman-Jones, Margaret H., additional, Dorval, Thierry, additional, Wilson, Zena, additional, Jones, David R., additional, Lawson, Deborah, additional, Odedra, Rajesh, additional, Maya-Mendoza, Apolinar, additional, Reimer, Corinne, additional, Bartek, Jiri, additional, Lau, Alan, additional, and O'Connor, Mark J., additional

Published
2019
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36. Discovery and Characterization of AZD6738, a Potent Inhibitor of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Kinase with Application as an Anticancer Agent

Author

Foote, Kevin M., primary, Nissink, J. Willem M., additional, McGuire, Thomas, additional, Turner, Paul, additional, Guichard, Sylvie, additional, Yates, James W. T., additional, Lau, Alan, additional, Blades, Kevin, additional, Heathcote, Dan, additional, Odedra, Rajesh, additional, Wilkinson, Gary, additional, Wilson, Zena, additional, Wood, Christine M., additional, and Jewsbury, Philip J., additional

Published
2018
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37. Orally Bioavailable and Blood–Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice

Author

Karlin, Jeremy, primary, Allen, Jasmine, additional, Ahmad, Syed F., additional, Hughes, Gareth, additional, Sheridan, Victoria, additional, Odedra, Rajesh, additional, Farrington, Paul, additional, Cadogan, Elaine B., additional, Riches, Lucy C., additional, Garcia-Trinidad, Antonio, additional, Thomason, Andrew G., additional, Patel, Bhavika, additional, Vincent, Jennifer, additional, Lau, Alan, additional, Pike, Kurt G., additional, Hunt, Thomas A., additional, Sule, Amrita, additional, Valerie, Nicholas C.K., additional, Biddlestone-Thorpe, Laura, additional, Kahn, Jenna, additional, Beckta, Jason M., additional, Mukhopadhyay, Nitai, additional, Barlaam, Bernard, additional, Degorce, Sebastien L., additional, Kettle, Jason, additional, Colclough, Nicola, additional, Wilson, Joanne, additional, Smith, Aaron, additional, Barrett, Ian P., additional, Zheng, Li, additional, Zhang, Tianwei, additional, Wang, Yingchun, additional, Chen, Kan, additional, Pass, Martin, additional, Durant, Stephen T., additional, and Valerie, Kristoffer, additional

Published
2018
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38. Abstract 2494: ATR inhibitor AZD6738 as monotherapy and in combination with olaparib or chemotherapy: defining pre-clinical dose-schedules and efficacy modelling

Author

Lau, Alan Y., primary, Yates, James, additional, Wilson, Zena, additional, Young, Lucy A., additional, Hughes, Adina M., additional, Berges, Alienor, additional, Cheung, Amy, additional, Odedra, Rajesh, additional, Brown, Elaine, additional, O'Connor, Mark J., additional, and Hollingsworth, Simon, additional

Published
2017
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39. Optimizing Therapeutic Effect of Aurora B Inhibition in Acute Myeloid Leukemia with AZD2811 Nanoparticles

Author

Floc'h, Nicolas, primary, Ashton, Susan, additional, Taylor, Paula, additional, Trueman, Dawn, additional, Harris, Emily, additional, Odedra, Rajesh, additional, Maratea, Kim, additional, Derbyshire, Nicola, additional, Caddy, Jacqueline, additional, Jacobs, Vivien N., additional, Hattersley, Maureen, additional, Wen, Shenghua, additional, Curtis, Nicola J., additional, Pilling, James E., additional, Pease, Elizabeth J., additional, and Barry, Simon T., additional

Published
2017
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40. Abstract B32: CRLX101, an investigational camptothecin-containing nanoparticle-drug conjugate, combined with DDR agents provides a novel approach to increasing therapeutic index

Author

O'Connor, Lenka Oplustil, primary, Wang, Anderson T., additional, Jones, David, additional, Odedra, Rajesh, additional, Spreadborough, Michael, additional, Wilson, Joanne, additional, Smith, Aaron, additional, Cotton, Peter, additional, Reens, Jaimini, additional, Barnes, Jen, additional, Sheridan, Victoria, additional, Tellez, Andres, additional, Lau, Alan, additional, Sadler, Claire, additional, O'Connor, Mark J., additional, and Eliasof, Scott, additional

Published
2017
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41. The PARP Inhibitor AZD2461 Provides Insights into the Role of PARP3 Inhibition for Both Synthetic Lethality and Tolerability with Chemotherapy in Preclinical Models

Author

Oplustil O'Connor, Lenka, primary, Rulten, Stuart L., additional, Cranston, Aaron N., additional, Odedra, Rajesh, additional, Brown, Henry, additional, Jaspers, Janneke E., additional, Jones, Louise, additional, Knights, Charlotte, additional, Evers, Bastiaan, additional, Ting, Attilla, additional, Bradbury, Robert H., additional, Pajic, Marina, additional, Rottenberg, Sven, additional, Jonkers, Jos, additional, Rudge, David, additional, Martin, Niall M.B., additional, Caldecott, Keith W., additional, Lau, Alan, additional, and O'Connor, Mark J., additional

Published
2016
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42. Abstract 3721: A camptothecin-containing nanoparticle-drug conjugate combination with DDR agents provides a novel approach to increasing therapeutic index

Author

Oplustil O’Connor, Lenka, primary, Wang, Anderson T., additional, Jones, David R., additional, Odedra, Rajesh, additional, Spreadborough, Michael, additional, Wilson, Joanne, additional, Smith, Aaron, additional, Cotton, Peter, additional, Reens, Jaimini, additional, Barnes, Jen, additional, Sheridan, Victoria, additional, Eliasof, Scott, additional, Tellez, Andres, additional, Lau, Alan, additional, Sadler, Claire, additional, and O’Connor, Mark J., additional

Published
2016
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43. Aurora kinase inhibitor nanoparticles target tumors with favorable therapeutic index in vivo

Author

Ashton, Susan, primary, Song, Young Ho, additional, Nolan, Jim, additional, Cadogan, Elaine, additional, Murray, Jim, additional, Odedra, Rajesh, additional, Foster, John, additional, Hall, Peter A., additional, Low, Susan, additional, Taylor, Paula, additional, Ellston, Rebecca, additional, Polanska, Urszula M., additional, Wilson, Joanne, additional, Howes, Colin, additional, Smith, Aaron, additional, Goodwin, Richard J. A., additional, Swales, John G., additional, Strittmatter, Nicole, additional, Takáts, Zoltán, additional, Nilsson, Anna, additional, Andren, Per, additional, Trueman, Dawn, additional, Walker, Mike, additional, Reimer, Corinne L., additional, Troiano, Greg, additional, Parsons, Donald, additional, De Witt, David, additional, Ashford, Marianne, additional, Hrkach, Jeff, additional, Zale, Stephen, additional, Jewsbury, Philip J., additional, and Barry, Simon T., additional

Published
2016
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46. Abstract 5409: AZD1152-hQPA Accurins: Nanoparticle formulations showing extended release and the potential for improved therapeutic index

Author

Barry, Simon T., primary, Cadogan, Elaine, additional, Odedra, Rajesh, additional, Ashton, Susan, additional, Foster, John, additional, Song, Young Ho, additional, Low, Susan, additional, Taylor, Paula, additional, Ellston, Rebecca, additional, Polanska, Urszula, additional, Wilson, Joanne, additional, Howes, Colin, additional, Trueman, Dawn, additional, Walker, Mike, additional, Witt, David De, additional, Ashford, Marianne, additional, Hrkach, Jeff, additional, and Jewsbury, Phil, additional

Published
2014
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49. Abstract 3343: The pre-clinical in vitro and in vivo activity of AZD6738: A potent and selective inhibitor of ATR kinase.

Author

Guichard, Sylvie M., primary, Brown, Elaine, additional, Odedra, Rajesh, additional, Hughes, Adina, additional, Heathcote, Dan, additional, Barnes, Jen, additional, Lau, Alan, additional, Powell, Steve, additional, Jones, Clifford D., additional, Nissink, Willem, additional, Foote, Kevin M., additional, Jewsbury, Philip J., additional, and Pass, Martin, additional

Published
2013
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50. Abstract 2348: Discovery of AZD6738, a potent and selective inhibitor with the potential to test the clinical efficacy of ATR kinase inhibition in cancer patients.

Author

Jones, Clifford D., primary, Blades, Kevin, additional, Foote, Kevin M., additional, Guichard, Sylvie M., additional, Jewsbury, Philip J., additional, McGuire, Thomas, additional, Nissink, Johannes W., additional, Odedra, Rajesh, additional, Tam, Kin, additional, Thommes, Pia, additional, Turner, Paul, additional, Wilkinson, Gary, additional, Wood, Christine, additional, and Yates, James W., additional

Published
2013
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