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2. Contributors

Author

Agyemang, Amma F., primary, Alsop, Kathryn, additional, Au-Yeung, George, additional, Bates, Susan, additional, Bowtell, David D., additional, Christie, Elizabeth L., additional, Cole, Christopher B., additional, Connolly, Denise C., additional, Craig, Amaranta D., additional, deFazio, Anna, additional, Fereday, Sian, additional, Fojo, Antonio, additional, Freimund, Alison E., additional, Friedlander, Michael, additional, Gao, Bo, additional, Harnett, Paul R., additional, Hoang, Therese, additional, House, Carrie D., additional, Mapagu, Cristina, additional, Moore, Kathleen N., additional, Moujaber, Tania, additional, Odunsi, Kunle O., additional, Peri, Suraj, additional, Pishas, Kathleen, additional, Richardson, Debra L., additional, Sodi, Valerie L., additional, Soragni, Alice, additional, Trivedi, Meghna S., additional, Washington, Christina R., additional, and Waters, Jennifer A., additional

Published
2021
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5. Supplementary Tables 1-4 from Common Variants at the 19p13.1 and ZNF365 Loci Are Associated with ER Subtypes of Breast Cancer and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

Author

Couch, Fergus J., primary, Gaudet, Mia M., primary, Antoniou, Antonis C., primary, Ramus, Susan J., primary, Kuchenbaecker, Karoline B., primary, Soucy, Penny, primary, Beesley, Jonathan, primary, Chen, Xiaoqing, primary, Wang, Xianshu, primary, Kirchhoff, Tomas, primary, McGuffog, Lesley, primary, Barrowdale, Daniel, primary, Lee, Andrew, primary, Healey, Sue, primary, Sinilnikova, Olga M., primary, Andrulis, Irene L., primary, Ozcelik, Hilmi, primary, Mulligan, Anna Marie, primary, Thomassen, Mads, primary, Gerdes, Anne-Marie, primary, Jensen, Uffe Birk, primary, Skytte, Anne-Bine, primary, Kruse, Torben A., primary, Caligo, Maria A., primary, von Wachenfeldt, Anna, primary, Barbany-Bustinza, Gisela, primary, Loman, Niklas, primary, Soller, Maria, primary, Ehrencrona, Hans, primary, Karlsson, Per, primary, Nathanson, Katherine L., primary, Rebbeck, Timothy R., primary, Domchek, Susan M., primary, Jakubowska, Ania, primary, Lubinski, Jan, primary, Jaworska, Katarzyna, primary, Durda, Katarzyna, primary, Złowocka, Elżbieta, primary, Huzarski, Tomasz, primary, Byrski, Tomasz, primary, Gronwald, Jacek, primary, Cybulski, Cezary, primary, Górski, Bohdan, primary, Osorio, Ana, primary, Durán, Mercedes, primary, Tejada, María Isabel, primary, Benitez, Javier, primary, Hamann, Ute, primary, Hogervorst, Frans B.L., primary, van Os, Theo A., primary, van Leeuwen, Flora E., primary, Meijers-Heijboer, Hanne E.J., primary, Wijnen, Juul, primary, Blok, Marinus J., primary, Kets, Marleen, primary, Hooning, Maartje J., primary, Oldenburg, Rogier A., primary, Ausems, Margreet G.E.M., primary, Peock, Susan, primary, Frost, Debra, primary, Ellis, Steve D., primary, Platte, Radka, primary, Fineberg, Elena, primary, Evans, D. Gareth, primary, Jacobs, Chris, primary, Eeles, Rosalind A., primary, Adlard, Julian, primary, Davidson, Rosemarie, primary, Eccles, Diana M., primary, Cole, Trevor, primary, Cook, Jackie, primary, Paterson, Joan, primary, Brewer, Carole, primary, Douglas, Fiona, primary, Hodgson, Shirley V., primary, Morrison, Patrick J., primary, Walker, Lisa, primary, Porteous, Mary E., primary, Kennedy, M. John, primary, Side, Lucy E., primary, Bove, Betsy, primary, Godwin, Andrew K., primary, Stoppa-Lyonnet, Dominique, primary, Fassy-Colcombet, Marion, primary, Castera, Laurent, primary, Cornelis, François, primary, Mazoyer, Sylvie, primary, Léoné, Mélanie, primary, Boutry-Kryza, Nadia, primary, Bressac-de Paillerets, Brigitte, primary, Caron, Olivier, primary, Pujol, Pascal, primary, Coupier, Isabelle, primary, Delnatte, Capucine, primary, Akloul, Linda, primary, Lynch, Henry T., primary, Snyder, Carrie L., primary, Buys, Saundra S., primary, Daly, Mary B., primary, Terry, MaryBeth, primary, Chung, Wendy K., primary, John, Esther M., primary, Miron, Alexander, primary, Southey, Melissa C., primary, Hopper, John L., primary, Goldgar, David E., primary, Singer, Christian F., primary, Rappaport, Christine, primary, Tea, Muy-Kheng M., primary, Fink-Retter, Anneliese, primary, Hansen, Thomas V.O., primary, Nielsen, Finn C., primary, Arason, Aðalgeir, primary, Vijai, Joseph, primary, Shah, Sohela, primary, Sarrel, Kara, primary, Robson, Mark E., primary, Piedmonte, Marion, primary, Phillips, Kelly, primary, Basil, Jack, primary, Rubinstein, Wendy S., primary, Boggess, John, primary, Wakeley, Katie, primary, Ewart-Toland, Amanda, primary, Montagna, Marco, primary, Agata, Simona, primary, Imyanitov, Evgeny N., primary, Isaacs, Claudine, primary, Janavicius, Ramunas, primary, Lazaro, Conxi, primary, Blanco, Ignacio, primary, Feliubadalo, Lidia, primary, Brunet, Joan, primary, Gayther, Simon A., primary, Pharoah, Paul P.D., primary, Odunsi, Kunle O., primary, Karlan, Beth Y., primary, Walsh, Christine S., primary, Olah, Edith, primary, Teo, Soo Hwang, primary, Ganz, Patricia A., primary, Beattie, Mary S., primary, van Rensburg, Elizabeth J., primary, Dorfling, Cecelia M., primary, Diez, Orland, primary, Kwong, Ava, primary, Schmutzler, Rita K., primary, Wappenschmidt, Barbara, primary, Engel, Christoph, primary, Meindl, Alfons, primary, Ditsch, Nina, primary, Arnold, Norbert, primary, Heidemann, Simone, primary, Niederacher, Dieter, primary, Preisler-Adams, Sabine, primary, Gadzicki, Dorothea, primary, Varon-Mateeva, Raymonda, primary, Deissler, Helmut, primary, Gehrig, Andrea, primary, Sutter, Christian, primary, Kast, Karin, primary, Fiebig, Britta, primary, Heinritz, Wolfram, primary, Caldes, Trinidad, primary, de la Hoya, Miguel, primary, Muranen, Taru A., primary, Nevanlinna, Heli, primary, Tischkowitz, Marc D., primary, Spurdle, Amanda B., primary, Neuhausen, Susan L., primary, Ding, Yuan Chun, primary, Lindor, Noralane M., primary, Fredericksen, Zachary, primary, Pankratz, V. Shane, primary, Peterlongo, Paolo, primary, Manoukian, Siranoush, primary, Peissel, Bernard, primary, Zaffaroni, Daniela, primary, Barile, Monica, primary, Bernard, Loris, primary, Viel, Alessandra, primary, Giannini, Giuseppe, primary, Varesco, Liliana, primary, Radice, Paolo, primary, Greene, Mark H., primary, Mai, Phuong L., primary, Easton, Douglas F., primary, Chenevix-Trench, Georgia, primary, Offit, Kenneth, primary, and Simard, Jacques, primary

Published
2023
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6. Data from Common Variants at the 19p13.1 and ZNF365 Loci Are Associated with ER Subtypes of Breast Cancer and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

Author

Couch, Fergus J., primary, Gaudet, Mia M., primary, Antoniou, Antonis C., primary, Ramus, Susan J., primary, Kuchenbaecker, Karoline B., primary, Soucy, Penny, primary, Beesley, Jonathan, primary, Chen, Xiaoqing, primary, Wang, Xianshu, primary, Kirchhoff, Tomas, primary, McGuffog, Lesley, primary, Barrowdale, Daniel, primary, Lee, Andrew, primary, Healey, Sue, primary, Sinilnikova, Olga M., primary, Andrulis, Irene L., primary, Ozcelik, Hilmi, primary, Mulligan, Anna Marie, primary, Thomassen, Mads, primary, Gerdes, Anne-Marie, primary, Jensen, Uffe Birk, primary, Skytte, Anne-Bine, primary, Kruse, Torben A., primary, Caligo, Maria A., primary, von Wachenfeldt, Anna, primary, Barbany-Bustinza, Gisela, primary, Loman, Niklas, primary, Soller, Maria, primary, Ehrencrona, Hans, primary, Karlsson, Per, primary, Nathanson, Katherine L., primary, Rebbeck, Timothy R., primary, Domchek, Susan M., primary, Jakubowska, Ania, primary, Lubinski, Jan, primary, Jaworska, Katarzyna, primary, Durda, Katarzyna, primary, Złowocka, Elżbieta, primary, Huzarski, Tomasz, primary, Byrski, Tomasz, primary, Gronwald, Jacek, primary, Cybulski, Cezary, primary, Górski, Bohdan, primary, Osorio, Ana, primary, Durán, Mercedes, primary, Tejada, María Isabel, primary, Benitez, Javier, primary, Hamann, Ute, primary, Hogervorst, Frans B.L., primary, van Os, Theo A., primary, van Leeuwen, Flora E., primary, Meijers-Heijboer, Hanne E.J., primary, Wijnen, Juul, primary, Blok, Marinus J., primary, Kets, Marleen, primary, Hooning, Maartje J., primary, Oldenburg, Rogier A., primary, Ausems, Margreet G.E.M., primary, Peock, Susan, primary, Frost, Debra, primary, Ellis, Steve D., primary, Platte, Radka, primary, Fineberg, Elena, primary, Evans, D. Gareth, primary, Jacobs, Chris, primary, Eeles, Rosalind A., primary, Adlard, Julian, primary, Davidson, Rosemarie, primary, Eccles, Diana M., primary, Cole, Trevor, primary, Cook, Jackie, primary, Paterson, Joan, primary, Brewer, Carole, primary, Douglas, Fiona, primary, Hodgson, Shirley V., primary, Morrison, Patrick J., primary, Walker, Lisa, primary, Porteous, Mary E., primary, Kennedy, M. John, primary, Side, Lucy E., primary, Bove, Betsy, primary, Godwin, Andrew K., primary, Stoppa-Lyonnet, Dominique, primary, Fassy-Colcombet, Marion, primary, Castera, Laurent, primary, Cornelis, François, primary, Mazoyer, Sylvie, primary, Léoné, Mélanie, primary, Boutry-Kryza, Nadia, primary, Bressac-de Paillerets, Brigitte, primary, Caron, Olivier, primary, Pujol, Pascal, primary, Coupier, Isabelle, primary, Delnatte, Capucine, primary, Akloul, Linda, primary, Lynch, Henry T., primary, Snyder, Carrie L., primary, Buys, Saundra S., primary, Daly, Mary B., primary, Terry, MaryBeth, primary, Chung, Wendy K., primary, John, Esther M., primary, Miron, Alexander, primary, Southey, Melissa C., primary, Hopper, John L., primary, Goldgar, David E., primary, Singer, Christian F., primary, Rappaport, Christine, primary, Tea, Muy-Kheng M., primary, Fink-Retter, Anneliese, primary, Hansen, Thomas V.O., primary, Nielsen, Finn C., primary, Arason, Aðalgeir, primary, Vijai, Joseph, primary, Shah, Sohela, primary, Sarrel, Kara, primary, Robson, Mark E., primary, Piedmonte, Marion, primary, Phillips, Kelly, primary, Basil, Jack, primary, Rubinstein, Wendy S., primary, Boggess, John, primary, Wakeley, Katie, primary, Ewart-Toland, Amanda, primary, Montagna, Marco, primary, Agata, Simona, primary, Imyanitov, Evgeny N., primary, Isaacs, Claudine, primary, Janavicius, Ramunas, primary, Lazaro, Conxi, primary, Blanco, Ignacio, primary, Feliubadalo, Lidia, primary, Brunet, Joan, primary, Gayther, Simon A., primary, Pharoah, Paul P.D., primary, Odunsi, Kunle O., primary, Karlan, Beth Y., primary, Walsh, Christine S., primary, Olah, Edith, primary, Teo, Soo Hwang, primary, Ganz, Patricia A., primary, Beattie, Mary S., primary, van Rensburg, Elizabeth J., primary, Dorfling, Cecelia M., primary, Diez, Orland, primary, Kwong, Ava, primary, Schmutzler, Rita K., primary, Wappenschmidt, Barbara, primary, Engel, Christoph, primary, Meindl, Alfons, primary, Ditsch, Nina, primary, Arnold, Norbert, primary, Heidemann, Simone, primary, Niederacher, Dieter, primary, Preisler-Adams, Sabine, primary, Gadzicki, Dorothea, primary, Varon-Mateeva, Raymonda, primary, Deissler, Helmut, primary, Gehrig, Andrea, primary, Sutter, Christian, primary, Kast, Karin, primary, Fiebig, Britta, primary, Heinritz, Wolfram, primary, Caldes, Trinidad, primary, de la Hoya, Miguel, primary, Muranen, Taru A., primary, Nevanlinna, Heli, primary, Tischkowitz, Marc D., primary, Spurdle, Amanda B., primary, Neuhausen, Susan L., primary, Ding, Yuan Chun, primary, Lindor, Noralane M., primary, Fredericksen, Zachary, primary, Pankratz, V. Shane, primary, Peterlongo, Paolo, primary, Manoukian, Siranoush, primary, Peissel, Bernard, primary, Zaffaroni, Daniela, primary, Barile, Monica, primary, Bernard, Loris, primary, Viel, Alessandra, primary, Giannini, Giuseppe, primary, Varesco, Liliana, primary, Radice, Paolo, primary, Greene, Mark H., primary, Mai, Phuong L., primary, Easton, Douglas F., primary, Chenevix-Trench, Georgia, primary, Offit, Kenneth, primary, and Simard, Jacques, primary

Published
2023
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11. Whole‐exome sequencing of ovarian cancer families uncovers putative predisposition genes

Author

Zhu, Qianqian, primary, Zhang, Jianmin, additional, Chen, Yanmin, additional, Hu, Qiang, additional, Shen, He, additional, Huang, Ruea‐Yea, additional, Liu, Qian, additional, Kaur, Jasmine, additional, Long, Mark, additional, Battaglia, Sebastiano, additional, Eng, Kevin H., additional, Lele, Shashikant B., additional, Zsiros, Emese, additional, Villella, Jeannine, additional, Lugade, Amit, additional, Yao, Song, additional, Liu, Song, additional, Moysich, Kirsten, additional, and Odunsi, Kunle O., additional

Published
2019
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13. Whole‐exome sequencing of ovarian cancer families uncovers putative predisposition genes.

Author

Zhu, Qianqian, Zhang, Jianmin, Chen, Yanmin, Hu, Qiang, Shen, He, Huang, Ruea‐Yea, Liu, Qian, Kaur, Jasmine, Long, Mark, Battaglia, Sebastiano, Eng, Kevin H., Lele, Shashikant B., Zsiros, Emese, Villella, Jeannine, Lugade, Amit, Yao, Song, Liu, Song, Moysich, Kirsten, and Odunsi, Kunle O.

Subjects
OVARIAN cancer, DNA ligases, DNA replication, OSTEOCHONDROSIS, ETIOLOGY of cancer, GENES, HEREDITARY cancer syndromes, TUMOR suppressor proteins
Abstract

Despite the identification of several ovarian cancer (OC) predisposition genes, a large proportion of familial OC risk remains unexplained. We adopted a two‐stage design to identify new OC predisposition genes. We first carried out a large germline whole‐exome sequencing study on 158 patients from 140 families with significant OC history, but without evidence of genetic predisposition due to BRCA1/2. We then evaluated the potential candidate genes in a large case–control association study involving 381 OC cases in the Cancer Genome Atlas project and 27,173 population controls from the Exome Aggregation Consortium. Two new putative OC risk genes were identified, namely, ANKRD11, a putative tumor suppressor, and POLE, an enzyme involved in DNA repair and replication. These two genes likely confer moderate OC risk. We performed in vitro experiments and showed an ANKRD11 mutation identified in our patients markedly lowered the protein expression by compromising protein stability. Upon future validation and functional characterization, these genes may shed light on cancer etiology along with improving ascertainment power and preventive care of individuals at high risk of OC. What's new? Despite the identification of several ovarian cancer (OC) predisposition genes, familial OC risk largely remains unexplained. Here, the authors report the discovery of two new putative OC predisposition genes based on germline whole‐exome sequencing of 140 families with a strong OC family history but without known BRCA1/2 mutations. By comparing another 381 OC cases with more than 27,000 population controls, they show that the putative tumor suppressor ANKRD11 and POLE, an enzyme involved in DNA repair and replication, moderately increase OC risk. These genes may shed light on cancer etiology and improve ascertainment power of individuals at high OC risk. [ABSTRACT FROM AUTHOR]

Published
2020
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14. Paternal lineage early onset hereditary ovarian cancers: A Familial Ovarian Cancer Registry study

Author

Eng, Kevin H., primary, Szender, J. Brian, additional, Etter, John Lewis, additional, Kaur, Jasmine, additional, Poblete, Samantha, additional, Huang, Ruea-Yea, additional, Zhu, Qianqian, additional, Grzesik, Katherine A., additional, Battaglia, Sebastiano, additional, Cannioto, Rikki, additional, Krolewski, John J., additional, Zsiros, Emese, additional, Frederick, Peter J., additional, Lele, Shashikant B., additional, Moysich, Kirsten B., additional, and Odunsi, Kunle O., additional

Published
2018
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15. CXCL12/CXCR4 Blockade by Oncolytic Virotherapy Inhibits Ovarian Cancer Growth by Decreasing Immunosuppression and Targeting Cancer Initiating Cells1

Author

Gil, Margaret, Komorowski, Marcin P., Seshadri, Mukund, Rokita, Hanna, McGray, A. J Robert, Opyrchal, Mateusz, Odunsi, Kunle O., and Kozbor, Danuta

Subjects
Oncolytic Virotherapy, Ovarian Neoplasms, Receptors, CXCR4, Endothelial Cells, Gene Expression, Vaccinia virus, Dendritic Cells, Mice, SCID, T-Lymphocytes, Regulatory, Article, Chemokine CXCL12, Tumor Burden, Mice, Inbred C57BL, Mice, Neoplastic Stem Cells, Animals, Humans, Female, Carcinoma in Situ, Neoplasm Transplantation, Peritoneal Neoplasms, Cell Proliferation, Signal Transduction
Abstract

Signals mediated by the chemokine CXCL12 and its receptor CXCR4 are involved in the progression of ovarian cancer through enhancement of tumor angiogenesis and immunosuppressive networks that regulate dissemination of peritoneal metastasis and development of cancer-initiating cells (CICs). In this study, we investigated the antitumor efficacy of a CXCR4 antagonist expressed by oncolytic vaccinia virus (OVV) against an invasive variant of the murine epithelial ovarian cancer cell line ID8-T. This variant harbors a high frequency of CICs that form multilayered spheroid cells and express the hyaluronan receptor CD44, as well as stem cell factor receptor CD117 (c-kit). Using an orthotopic ID8-T tumor model, we observed that i.p. delivery of a CXCR4 antagonist-expressing OVV led to reduced metastatic spread of tumors and improved overall survival compared with oncolysis alone. Inhibition of tumor growth with the armed virus was associated with efficient killing of CICs, reduced expression of ascitic CXCL12 and vascular endothelial growth factor, and decreases in i.p. numbers of endothelial and myeloid cells, as well as plasmacytoid dendritic cells. These changes, together with reduced recruitment of T regulatory cells, were associated with higher ratios of IFN-γ(+)/IL-10(+) tumor-infiltrating T lymphocytes, as well as induction of spontaneous humoral and cellular antitumor responses. Similarly, the CXCR4 antagonist released from virally infected human CAOV2 ovarian carcinoma cells inhibited peritoneal dissemination of tumors in SCID mice, leading to improved tumor-free survival in a xenograft model. Our findings demonstrate that OVV armed with a CXCR4 antagonist represents a potent therapy for ovarian CICs with a broad antitumor repertoire.

Published
2014

18. Aspirin and Acetaminophen Use and the Risk of Cervical Cancer

Author

Friel, Grace, primary, Liu, Cici S., additional, Kolomeyevskaya, Nonna V., additional, Hampras, Shalaka S., additional, Kruszka, Bridget, additional, Schmitt, Kristina, additional, Cannioto, Rikki A., additional, Lele, Shashikant B., additional, Odunsi, Kunle O., additional, and Moysich, Kirsten B., additional

Published
2015
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21. Common Variants at the 19p13.1 and ZNF365 Loci Are Associated with ER Subtypes of Breast Cancer and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

Author

Couch, Fergus J., Gaudet, Mia M., Antoniou, Antonis C., Ramus, Susan J., Kuchenbaecker, Karoline B., Soucy, Penny, Beesley, Jonathan, Chen, Xiaoqing, Wang, Xianshu, Kirchhoff, Tomas, McGuffog, Lesley, Barrowdale, Daniel, Lee, Andrew, Healey, Sue, Sinilnikova, Olga M., Andrulis, Irene L., Ozcelik, Hilmi, Mulligan, Anna Marie, Thomassen, Mads, Gerdes, Anne-Marie, Jensen, Uffe Birk, Skytte, Anne-Bine, Kruse, Torben A., Caligo, Maria A., von Wachenfeldt, Anna, Barbany-Bustinza, Gisela, Loman, Niklas, Soller, Maria, Ehrencrona, Hans, Karlsson, Per, Nathanson, Katherine L., Rebbeck, Timothy R., Domchek, Susan M., Jakubowska, Ania, Lubinski, Jan, Jaworska, Katarzyna, Durda, Katarzyna, Zlowocka, Elzbieta, Huzarski, Tomasz, Byrski, Tomasz, Gronwald, Jacek, Cybulski, Cezary, Gorski, Bohdan, Osorio, Ana, Duran, Mercedes, Isabel Tejada, Maria, Benitez, Javier, Hamann, Ute, Hogervorst, Frans B. L., van Os, Theo A., van Leeuwen, Flora E., Meijers-Heijboer, Hanne E. J., Wijnen, Juul, Blok, Marinus J., Kets, Marleen, Hooning, Maartje J., Oldenburg, Rogier A., Ausems, Margreet G. E. M., Peock, Susan, Frost, Debra, Ellis, Steve D., Platte, Radka, Fineberg, Elena, Evans, D. Gareth, Jacobs, Chris, Eeles, Rosalind A., Adlard, Julian, Davidson, Rosemarie, Eccles, Diana M., Cole, Trevor, Cook, Jackie, Paterson, Joan, Brewer, Carole, Douglas, Fiona, Hodgson, Shirley V., Morrison, Patrick J., Walker, Lisa, Porteous, Mary E., Kennedy, M. John, Side, Lucy E., Bove, Betsy, Godwin, Andrew K., Stoppa-Lyonnet, Dominique, Fassy-Colcombet, Marion, Castera, Laurent, Cornelis, Francois, Mazoyer, Sylvie, Leone, Melanie, Boutry-Kryza, Nadia, Bressac-de Paillerets, Brigitte, Caron, Olivier, Pujol, Pascal, Coupier, Isabelle, Delnatte, Capucine, Akloul, Linda, Lynch, Henry T., Snyder, Carrie L., Buys, Saundra S., Daly, Mary B., Terry, MaryBeth, Chung, Wendy K., John, Esther M., Miron, Alexander, Southey, Melissa C., Hopper, John L., Goldgar, David E., Singer, Christian F., Rappaport, Christine, Tea, Muy-Kheng M., Fink-Retter, Anneliese, Hansen, Thomas V. O., Nielsen, Finn C., Arason, Adalgeir, Vijai, Joseph, Shah, Sohela, Sarrel, Kara, Robson, Mark E., Piedmonte, Marion, Phillips, Kelly, Basil, Jack, Rubinstein, Wendy S., Boggess, John, Wakeley, Katie, Ewart-Toland, Amanda, Montagna, Marco, Agata, Simona, Imyanitov, Evgeny N., Isaacs, Claudine, Janavicius, Ramunas, Lazaro, Conxi, Blanco, Ignacio, Feliubadalo, Lidia, Brunet, Joan, Gayther, Simon A., Pharoah, Paul P. D., Odunsi, Kunle O., Karlan, Beth Y., Walsh, Christine S., Olah, Edith, Teo, Soo Hwang, Ganz, Patricia A., Beattie, Mary S., van Rensburg, Elizabeth J., Dorfling, Cecelia M., Diez, Orland, Kwong, Ava, Schmutzler, Rita K., Wappenschmidt, Barbara, Engel, Christoph, Meindl, Alfons, Ditsch, Nina, Arnold, Norbert, Heidemann, Simone, Niederacher, Dieter, Preisler-Adams, Sabine, Gadzicki, Dorothea, Varon-Mateeva, Raymonda, Deissler, Helmut, Gehrig, Andrea, Sutter, Christian, Kast, Karin, Fiebig, Britta, Heinritz, Wolfram, Caldes, Trinidad, de la Hoya, Miguel, Muranen, Taru A., Nevanlinna, Heli, Tischkowitz, Marcd., Spurdle, Amanda B., Neuhausen, Susan L., Ding, Yuan Chun, Lindor, Noralane M., Fredericksen, Zachary, Pankratz, V. Shane, Peterlongo, Paolo, Manoukian, Siranoush, Peissel, Bernard, Zaffaroni, Daniela, Barile, Monica, Bernard, Loris, Viel, Alessandra, Giannini, Giuseppe, Varesco, Liliana, Radice, Paolo, Greene, Mark H., Mai, Phuong L., Easton, Douglas F., Chenevix-Trench, Georgia, Offit, Kenneth, Simard, Jacques, Couch, Fergus J., Gaudet, Mia M., Antoniou, Antonis C., Ramus, Susan J., Kuchenbaecker, Karoline B., Soucy, Penny, Beesley, Jonathan, Chen, Xiaoqing, Wang, Xianshu, Kirchhoff, Tomas, McGuffog, Lesley, Barrowdale, Daniel, Lee, Andrew, Healey, Sue, Sinilnikova, Olga M., Andrulis, Irene L., Ozcelik, Hilmi, Mulligan, Anna Marie, Thomassen, Mads, Gerdes, Anne-Marie, Jensen, Uffe Birk, Skytte, Anne-Bine, Kruse, Torben A., Caligo, Maria A., von Wachenfeldt, Anna, Barbany-Bustinza, Gisela, Loman, Niklas, Soller, Maria, Ehrencrona, Hans, Karlsson, Per, Nathanson, Katherine L., Rebbeck, Timothy R., Domchek, Susan M., Jakubowska, Ania, Lubinski, Jan, Jaworska, Katarzyna, Durda, Katarzyna, Zlowocka, Elzbieta, Huzarski, Tomasz, Byrski, Tomasz, Gronwald, Jacek, Cybulski, Cezary, Gorski, Bohdan, Osorio, Ana, Duran, Mercedes, Isabel Tejada, Maria, Benitez, Javier, Hamann, Ute, Hogervorst, Frans B. L., van Os, Theo A., van Leeuwen, Flora E., Meijers-Heijboer, Hanne E. J., Wijnen, Juul, Blok, Marinus J., Kets, Marleen, Hooning, Maartje J., Oldenburg, Rogier A., Ausems, Margreet G. E. M., Peock, Susan, Frost, Debra, Ellis, Steve D., Platte, Radka, Fineberg, Elena, Evans, D. Gareth, Jacobs, Chris, Eeles, Rosalind A., Adlard, Julian, Davidson, Rosemarie, Eccles, Diana M., Cole, Trevor, Cook, Jackie, Paterson, Joan, Brewer, Carole, Douglas, Fiona, Hodgson, Shirley V., Morrison, Patrick J., Walker, Lisa, Porteous, Mary E., Kennedy, M. John, Side, Lucy E., Bove, Betsy, Godwin, Andrew K., Stoppa-Lyonnet, Dominique, Fassy-Colcombet, Marion, Castera, Laurent, Cornelis, Francois, Mazoyer, Sylvie, Leone, Melanie, Boutry-Kryza, Nadia, Bressac-de Paillerets, Brigitte, Caron, Olivier, Pujol, Pascal, Coupier, Isabelle, Delnatte, Capucine, Akloul, Linda, Lynch, Henry T., Snyder, Carrie L., Buys, Saundra S., Daly, Mary B., Terry, MaryBeth, Chung, Wendy K., John, Esther M., Miron, Alexander, Southey, Melissa C., Hopper, John L., Goldgar, David E., Singer, Christian F., Rappaport, Christine, Tea, Muy-Kheng M., Fink-Retter, Anneliese, Hansen, Thomas V. O., Nielsen, Finn C., Arason, Adalgeir, Vijai, Joseph, Shah, Sohela, Sarrel, Kara, Robson, Mark E., Piedmonte, Marion, Phillips, Kelly, Basil, Jack, Rubinstein, Wendy S., Boggess, John, Wakeley, Katie, Ewart-Toland, Amanda, Montagna, Marco, Agata, Simona, Imyanitov, Evgeny N., Isaacs, Claudine, Janavicius, Ramunas, Lazaro, Conxi, Blanco, Ignacio, Feliubadalo, Lidia, Brunet, Joan, Gayther, Simon A., Pharoah, Paul P. D., Odunsi, Kunle O., Karlan, Beth Y., Walsh, Christine S., Olah, Edith, Teo, Soo Hwang, Ganz, Patricia A., Beattie, Mary S., van Rensburg, Elizabeth J., Dorfling, Cecelia M., Diez, Orland, Kwong, Ava, Schmutzler, Rita K., Wappenschmidt, Barbara, Engel, Christoph, Meindl, Alfons, Ditsch, Nina, Arnold, Norbert, Heidemann, Simone, Niederacher, Dieter, Preisler-Adams, Sabine, Gadzicki, Dorothea, Varon-Mateeva, Raymonda, Deissler, Helmut, Gehrig, Andrea, Sutter, Christian, Kast, Karin, Fiebig, Britta, Heinritz, Wolfram, Caldes, Trinidad, de la Hoya, Miguel, Muranen, Taru A., Nevanlinna, Heli, Tischkowitz, Marcd., Spurdle, Amanda B., Neuhausen, Susan L., Ding, Yuan Chun, Lindor, Noralane M., Fredericksen, Zachary, Pankratz, V. Shane, Peterlongo, Paolo, Manoukian, Siranoush, Peissel, Bernard, Zaffaroni, Daniela, Barile, Monica, Bernard, Loris, Viel, Alessandra, Giannini, Giuseppe, Varesco, Liliana, Radice, Paolo, Greene, Mark H., Mai, Phuong L., Easton, Douglas F., Chenevix-Trench, Georgia, Offit, Kenneth, and Simard, Jacques

Abstract

Background: Genome-wide association studies (GWAS) identified variants at 19p13.1 and ZNF365 (10q21.2) as risk factors for breast cancer among BRCA1 and BRCA2 mutation carriers, respectively. We explored associations with ovarian cancer and with breast cancer by tumor histopathology for these variants in mutation carriers from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Methods: Genotyping data for 12,599 BRCA1 and 7,132 BRCA2 mutation carriers from 40 studies were combined. Results: We confirmed associations between rs8170 at 19p13.1 and breast cancer risk for BRCA1 mutation carriers [HR, 1.17; 95% confidence interval (CI), 1.07-1.27; P = 7.42 x 10(-4)] and between rs16917302 at ZNF365 (HR, 0.84; 95% CI, 0.73-0.97; P = 0.017) but not rs311499 at 20q13.3 (HR, 1.11; 95% CI, 0.94-1.31; P = 0.22) and breast cancer risk for BRCA2 mutation carriers. Analyses based on tumor histopathology showed that 19p13 variants were predominantly associated with estrogen receptor (ER)-negative breast cancer for both BRCA1 and BRCA2 mutation carriers, whereas rs16917302 at ZNF365 was mainly associated with ER-positive breast cancer for both BRCA1 and BRCA2 mutation carriers. We also found for the first time that rs67397200 at 19p13.1 was associated with an increased risk of ovarian cancer for BRCA1 (HR, 1.16; 95% CI, 1.05-1.29; P = 3.8 x 10(-4)) and BRCA2 mutation carriers (HR, 1.30; 95% CI, 1.10-1.52; P = 1.8 x 10(-3)). Conclusions: 19p13.1 and ZNF365 are susceptibility loci for ovarian cancer and ER subtypes of breast cancer among BRCA1 and BRCA2 mutation carriers. Impact: These findings can lead to an improved understanding of tumor development and may prove useful for breast and ovarian cancer risk prediction for BRCA1 and BRCA2 mutation carriers.

Published
2012
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22. Common Variants at the 19p13.1 and ZNF365 Loci Are Associated with ER Subtypes of Breast Cancer and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

Author

Couch, Fergus J., primary, Gaudet, Mia M., additional, Antoniou, Antonis C., additional, Ramus, Susan J., additional, Kuchenbaecker, Karoline B., additional, Soucy, Penny, additional, Beesley, Jonathan, additional, Chen, Xiaoqing, additional, Wang, Xianshu, additional, Kirchhoff, Tomas, additional, McGuffog, Lesley, additional, Barrowdale, Daniel, additional, Lee, Andrew, additional, Healey, Sue, additional, Sinilnikova, Olga M., additional, Andrulis, Irene L., additional, Ozcelik, Hilmi, additional, Mulligan, Anna Marie, additional, Thomassen, Mads, additional, Gerdes, Anne-Marie, additional, Jensen, Uffe Birk, additional, Skytte, Anne-Bine, additional, Kruse, Torben A., additional, Caligo, Maria A., additional, von Wachenfeldt, Anna, additional, Barbany-Bustinza, Gisela, additional, Loman, Niklas, additional, Soller, Maria, additional, Ehrencrona, Hans, additional, Karlsson, Per, additional, Nathanson, Katherine L., additional, Rebbeck, Timothy R., additional, Domchek, Susan M., additional, Jakubowska, Ania, additional, Lubinski, Jan, additional, Jaworska, Katarzyna, additional, Durda, Katarzyna, additional, Złowocka, Elżbieta, additional, Huzarski, Tomasz, additional, Byrski, Tomasz, additional, Gronwald, Jacek, additional, Cybulski, Cezary, additional, Górski, Bohdan, additional, Osorio, Ana, additional, Durán, Mercedes, additional, Tejada, María Isabel, additional, Benitez, Javier, additional, Hamann, Ute, additional, Hogervorst, Frans B.L., additional, van Os, Theo A., additional, van Leeuwen, Flora E., additional, Meijers-Heijboer, Hanne E.J., additional, Wijnen, Juul, additional, Blok, Marinus J., additional, Kets, Marleen, additional, Hooning, Maartje J., additional, Oldenburg, Rogier A., additional, Ausems, Margreet G.E.M., additional, Peock, Susan, additional, Frost, Debra, additional, Ellis, Steve D., additional, Platte, Radka, additional, Fineberg, Elena, additional, Evans, D. Gareth, additional, Jacobs, Chris, additional, Eeles, Rosalind A., additional, Adlard, Julian, additional, Davidson, Rosemarie, additional, Eccles, Diana M., additional, Cole, Trevor, additional, Cook, Jackie, additional, Paterson, Joan, additional, Brewer, Carole, additional, Douglas, Fiona, additional, Hodgson, Shirley V., additional, Morrison, Patrick J., additional, Walker, Lisa, additional, Porteous, Mary E., additional, Kennedy, M. John, additional, Side, Lucy E., additional, Bove, Betsy, additional, Godwin, Andrew K., additional, Stoppa-Lyonnet, Dominique, additional, Fassy-Colcombet, Marion, additional, Castera, Laurent, additional, Cornelis, François, additional, Mazoyer, Sylvie, additional, Léoné, Mélanie, additional, Boutry-Kryza, Nadia, additional, Bressac-de Paillerets, Brigitte, additional, Caron, Olivier, additional, Pujol, Pascal, additional, Coupier, Isabelle, additional, Delnatte, Capucine, additional, Akloul, Linda, additional, Lynch, Henry T., additional, Snyder, Carrie L., additional, Buys, Saundra S., additional, Daly, Mary B., additional, Terry, MaryBeth, additional, Chung, Wendy K., additional, John, Esther M., additional, Miron, Alexander, additional, Southey, Melissa C., additional, Hopper, John L., additional, Goldgar, David E., additional, Singer, Christian F., additional, Rappaport, Christine, additional, Tea, Muy-Kheng M., additional, Fink-Retter, Anneliese, additional, Hansen, Thomas V.O., additional, Nielsen, Finn C., additional, Arason, Aðalgeir, additional, Vijai, Joseph, additional, Shah, Sohela, additional, Sarrel, Kara, additional, Robson, Mark E., additional, Piedmonte, Marion, additional, Phillips, Kelly, additional, Basil, Jack, additional, Rubinstein, Wendy S., additional, Boggess, John, additional, Wakeley, Katie, additional, Ewart-Toland, Amanda, additional, Montagna, Marco, additional, Agata, Simona, additional, Imyanitov, Evgeny N., additional, Isaacs, Claudine, additional, Janavicius, Ramunas, additional, Lazaro, Conxi, additional, Blanco, Ignacio, additional, Feliubadalo, Lidia, additional, Brunet, Joan, additional, Gayther, Simon A., additional, Pharoah, Paul P.D., additional, Odunsi, Kunle O., additional, Karlan, Beth Y., additional, Walsh, Christine S., additional, Olah, Edith, additional, Teo, Soo Hwang, additional, Ganz, Patricia A., additional, Beattie, Mary S., additional, van Rensburg, Elizabeth J., additional, Dorfling, Cecelia M., additional, Diez, Orland, additional, Kwong, Ava, additional, Schmutzler, Rita K., additional, Wappenschmidt, Barbara, additional, Engel, Christoph, additional, Meindl, Alfons, additional, Ditsch, Nina, additional, Arnold, Norbert, additional, Heidemann, Simone, additional, Niederacher, Dieter, additional, Preisler-Adams, Sabine, additional, Gadzicki, Dorothea, additional, Varon-Mateeva, Raymonda, additional, Deissler, Helmut, additional, Gehrig, Andrea, additional, Sutter, Christian, additional, Kast, Karin, additional, Fiebig, Britta, additional, Heinritz, Wolfram, additional, Caldes, Trinidad, additional, de la Hoya, Miguel, additional, Muranen, Taru A., additional, Nevanlinna, Heli, additional, Tischkowitz, Marc D., additional, Spurdle, Amanda B., additional, Neuhausen, Susan L., additional, Ding, Yuan Chun, additional, Lindor, Noralane M., additional, Fredericksen, Zachary, additional, Pankratz, V. Shane, additional, Peterlongo, Paolo, additional, Manoukian, Siranoush, additional, Peissel, Bernard, additional, Zaffaroni, Daniela, additional, Barile, Monica, additional, Bernard, Loris, additional, Viel, Alessandra, additional, Giannini, Giuseppe, additional, Varesco, Liliana, additional, Radice, Paolo, additional, Greene, Mark H., additional, Mai, Phuong L., additional, Easton, Douglas F., additional, Chenevix-Trench, Georgia, additional, Offit, Kenneth, additional, and Simard, Jacques, additional

Published
2012
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24. Expression Profiling of the Ovarian Surface Kinome Reveals Candidate Genes for Early Neoplastic Changes

Author

Pejovic, Tanja, primary, Pande, Nupur T., additional, Mori, Motomi, additional, Mhawech-Fauceglia, Paulette, additional, Harrington, Christina, additional, Mongoue-Tchokote, Solange, additional, Dim, Daniel, additional, Andrews, Christopher, additional, Beck, Amy, additional, Tarumi, Yukie, additional, Djilas, Jovana, additional, Cappuccini, Fabio, additional, Caballero, Otavia, additional, Huang, Jiaqi, additional, Levy, Samuel, additional, Tsiamouri, Alexia, additional, Cain, Joanna, additional, Bagby, Grover C., additional, Strausberg, Robert L., additional, Simpson, Andrew J., additional, and Odunsi, Kunle O., additional

Published
2009
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27. Common Variants at the 19p13.1 and ZNF365 Loci Are Associated with ER Subtypes of Breast Cancer and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

Author

Cornelis, Franco̧is, Peterlongo, Paolo, Tejada, María Isabel, Karlsson, Per, Hansen, Thomas V.O., Domchek, Susan M., Sutter, Christian, Godwin, Andrew K., Janavicius, Ramunas, Thomassen, Mads, Kirchhoff, Tomas, Lindor, Noralane M., Van Rensburg, Elizabeth J., Ewart-Toland, Amanda, Agata, Simona, McGuffog, Lesley, Coupier, Isabelle, Evans, D. Gareth, Andrulis, Irene L., Zołwocka, Elzbieta, Fineberg, Elena, Peissel, Bernard, Engel, Christoph, Kennedy, M. John, Meijers-Heijboer, Hanne E.J., Ehrencrona, Hans, Niederacher, Dieter, Porteous, Mary E., Eccles, Diana M., Caligo, Maria A., Rubinstein, Wendy S., Ganz, Patricia A., Huzarski, Tomasz, Tea, Muy Kheng M., Kruse, Torben A., Imyanitov, Evgeny N., Chenevix-Trench, Georgia, Kwong, Ava, Simard, Jacques, Healey, Sue, Varesco, Liliana, Von Wachenfeldt, Anna, Teo, Soo Hwang, Terry, Mary Beth, Buys, Saundra S., Wang, Xianshu, Caron, Olivier, Barile, Monica, Caldes, Trinidad, Beattie, Mary S., Brewer, Carole, Gerdes, Anne Marie, Spurdle, Amanda B., Sarrel, Kara, Miron, Alexander, Mai, Phuong L., Sinilnikova, Olga M., Peock, Susan, Lazaro, Conxi, Byrski, Tomasz, Fredericksen, Zachary, Wakeley, Katie, Brunet, Joan, Van Leeuwen, Flora E., Stoppa-Lyonnet, Dominique, Durań, Mercedes, Couch, Fergus J., Varon-Mateeva, Raymonda, Castera, Laurent, Giannini, Giuseppe, Chung, Wendy K., Lubinski, Jan, Heinritz, Wolfram, Muranen, Taru A., Bernard, Loris, Preisler-Adams, Sabine, Arnold, Norbert, Lynch, Henry T., Kets, Marleen, Diez, Orland, Platte, Radka, Karlan, Beth Y., Loman, Niklas, Daly, Mary B., Chen, Xiaoqing, Odunsi, Kunle O., Snyder, Carrie L., Douglas, Fiona, Hopper, John L., Radice, Paolo, Dorfling, Cecelia M., Arason, Aoalgeir, Jacobs, Chris, Basil, Jack, Piedmonte, Marion, Viel, Alessandra, Jaworska, Katarzyna, Pujol, Pascal, Mulligan, Anna Marie, Jensen, Uffe Birk, Fassy-Colcombet, Marion, Rebbeck, Timothy R., Gehrig, Andrea, Goŕski, Bohdan, Rappaport, Christine, Osorio, Ana, Benitez, Javier, Ditsch, Nina, Kast, Karin, Paterson, Joan, Nevanlinna, Heli, Southey, Melissa C., Goldgar, David E., Manoukian, Siranoush, Bove, Betsy, Boutry-Kryza, Nadia, Durda, Katarzyna, Heidemann, Simone, Kuchenbaecker, Karoline B., Walsh, Christine S., Deissler, Helmut, Meindl, Alfons, Van Os, Theo A., Ozcelik, Hilmi, Phillips, Kelly, Wijnen, Juul, Delnatte, Capucine, Gaudet, Mia M., Morrison, Patrick J., Fink-Retter, Anneliese, De La Hoya, Miguel, Bressac-de Paillerets, Brigitte, Leóne, Meĺanie, Zaffaroni, Daniela, Hodgson, Shirley V., Nielsen, Finn C., Mazoyer, Sylvie, Walker, Lisa, Ausems, Margreet G.E.M., Eeles, Rosalind A., Robson, Mark E., Side, Lucy E., Pharoah, Paul P.D., Antoniou, Antonis C., Lee, Andrew, Greene, Mark H., Adlard, Julian, Gadzicki, Dorothea, Fiebig, Britta, Singer, Christian F., Blok, Marinus J., Soucy, Penny, Easton, Douglas F., Gayther, Simon A., Barrowdale, Daniel, Beesley, Jonathan, Ding, Yuan Chun, Jakubowska, Ania, Davidson, Rosemarie, Schmutzler, Rita K., Boggess, John, Skytte, Anne Bine, Olah, Edith, Hogervorst, Frans B.L., Montagna, Marco, Ramus, Susan J., Vijai, Joseph, Barbany-Bustinza, Gisela, Tischkowitz, Marc D., Offit, Kenneth, Oldenburg, Rogier A., Neuhausen, Susan L., Ellis, Steve D., Cole, Trevor, Cook, Jackie, Pankratz, V. Shane, Soller, Maria, Blanco, Ignacio, Isaacs, Claudine, Frost, Debra, Feliubadalo, Lidia, Akloul, Linda, Shah, Sohela, Hamann, Ute, John, Esther M., Cybulski, Cezary, Wappenschmidt, Barbara, Nathanson, Katherine, Hooning, Maartje J., and Gronwald, Jacek

Subjects
endocrine system diseases, skin and connective tissue diseases, 3. Good health
Abstract

Genome-wide association studies (GWAS) identified variants at 19p13.1 and ZNF365 (10q21.2) as risk factors for breast cancer among BRCA1 and BRCA2 mutation carriers, respectively. We explored associations with ovarian cancer and with breast cancer by tumor histopathology for these variants in mutation carriers from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA).

28. Recruitment of Intratumoral CD103 + Dendritic Cells by a CXCR4 Antagonist-Armed Virotherapy Enhances Antitumor Immunity.

Author

Mistarz A, Komorowski MP, Graczyk MA, Gil M, Jiang A, Opyrchal M, Rokita H, Odunsi KO, and Kozbor D

Abstract

Intratumoral dendritic cells play an important role in stimulating cytotoxic T cells and driving antitumor immunity. Using a metastatic ovarian tumor model in syngeneic mice, we explored whether therapy with a CXCR4 antagonist-armed oncolytic vaccinia virus activates endogenous CD103 + dendritic cell responses associated with the induction of adaptive immunity against viral and tumor antigens. The overall goal of this study was to determine whether expansion of CD103 + dendritic cells by the virally delivered CXCR4 antagonist augments overall survival and in situ boosting with a tumor antigen peptide-based vaccine. We found that locoregional delivery of the CXCR4-A-armed virus reduced the tumor load and the immunosuppressive network in the tumor microenvironment, leading to infiltration of CD103 + dendritic cells that were capable of phagocytic clearance of cellular material from virally infected cancer cells. Further expansion of tumor-resident CD103 + DCs by injecting the FMS-related tyrosine kinase 3 ligand, the formative cytokine for CD103 + DCs, provided a platform for a booster immunization with the Wilms tumor antigen 1 peptide-based vaccine delivered intraperitoneally with polyriboinosinic:polyribocytidylic acid as an adjuvant. The vaccine-induced antitumor responses inhibited tumor growth and increased overall survival, indicating that expansion of intratumoral CD103 + dendritic cells by CXCR4-A-armed oncovirotherapy treatment can potentiate in situ cancer vaccine boosting.

Published
2019
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29. Reprogramming antitumor immunity against chemoresistant ovarian cancer by a CXCR4 antagonist-armed viral oncotherapy.

Author

Komorowski MP, McGray AR, Kolakowska A, Eng K, Gil M, Opyrchal M, Litwinska B, Nemeth MJ, Odunsi KO, and Kozbor D

Abstract

Ovarian cancer remains the most lethal gynecologic malignancy owing to late detection, intrinsic and acquired chemoresistance, and remarkable heterogeneity. Here, we explored approaches to inhibit metastatic growth of murine and human ovarian tumor variants resistant to paclitaxel and carboplatin by oncolytic vaccinia virus expressing a CXCR4 antagonist to target the CXCL12 chemokine/CXCR4 receptor signaling axis alone or in combination with doxorubicin. The resistant variants exhibited augmented expression of the hyaluronan receptor CD44 and CXCR4 along with elevated Akt and ERK1/2 activation and displayed an increased susceptibility to viral infection compared with the parental counterparts. The infected cultures were more sensitive to doxorubicin-mediated killing both in vitro and in tumor-challenged mice. Mechanistically, the combination treatment increased apoptosis and phagocytosis of tumor material by dendritic cells associated with induction of antitumor immunity. Targeting syngeneic tumors with this regimen increased intratumoral infiltration of antitumor CD8 + T cells. This was further enhanced by reducing the immunosuppressive network by the virally-delivered CXCR4 antagonist, which augmented antitumor immune responses and led to tumor-free survival. Our results define novel strategies for treatment of drug-resistant ovarian cancer that increase immunogenic cell death and reverse the immunosuppressive tumor microenvironment, culminating in antitumor immune responses that control metastatic tumor growth.

Published
2016
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30. Higher than expected frequencies of non-ovarian cancers within a large familial ovarian cancer registry.

Author

Brightwell RM, Grzankowski KS, Kaur J, Poblete S, Miller A, Lele SB, Sucheston-Campbell L, Moysich K, and Odunsi KO

Abstract

Our objective was to determine whether the frequencies of non-ovarian cancers (NOC) within families in a large Familial Ovarian Cancer Registry (FOCR) are significantly different from the frequencies listed in the SEER database. The FOCR was established in 1981. Registry members are families with two or more first degree relatives who have a diagnosis of ovarian cancer, three or more cases of cancer on one side of the family with at least one being ovarian, at least one female with two or more primary cancers in which one is ovary, or a history of two or more cancers in the family with at least one being ovarian cancer diagnosed before the age of 45. The data was analyzed to find relative rates of 10 of the most common cancers found within the database, with the exception of ovarian and breast. These include bladder, CNS, cervical, colorectal, liver, lung, pancreas, prostate, stomach, and uterine. Cancers were further stratified by age at diagnosis, and compared to information in the SEER database. There are 2,671 pedigrees and a total of 50,454 individuals within the FOCR. There are 1,938 families with two or more relatives with ovarian cancer, accounting for 4,816 individuals with ovarian cancer. The total number of individuals with ovarian cancer is 5,421. Of these individuals with ovarian cancer, 2,249 have been verified with testing or physician correspondence. The frequencies of the NOCs within the registry were higher than that of the general population as described in the SEER database. In particular, the overall frequencies of cancers of the bladder, cervix, prostate, and uterus were higher within the FOCR at 2.3, 7.4, 25.2, and 11.9 per 1,000 respectively. Furthermore, diagnoses of both cervical and uterine cancers tended to occur at an earlier age within the FOCR. The overall frequencies of cancers of the bladder, cervix, prostate, and uterus are higher in the FOCR compared with a general population database. Future studies on segregation analysis and genome-wide linkage studies are warranted on families with NOC within the Familial Ovarian Cancer Registry.

Published
2015

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