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2. Functional and morphological improvement of significant non-culprit coronary artery stenosis by LDL-C reduction with a PCSK9 antibody: Rationale and design of the randomized FITTER trial

Author

Mensink, Frans B., Los, Jonathan, Oemrawsingh, Rohit M., von Birgelen, Clemens, Ijsselmuiden, Alexander, Meuwissen, Martijn, Cheng, Jin M., van Wijk, Diederik F., Smits, Pieter C., Paradies, Valeria, van der Heijden, Dirk J., Rai, Himanshu, ten Cate, Tim JF., Camaro, Cyril, Damman, Peter, van Nunen, Lokien X., Dimitriu-Leen, Aukelien C., van Wely, Marleen H., Cetinyurek-Yavuz, Aysun, Byrne, Robert A., van Royen, Niels, and van Geuns, Robert-Jan M.

Published
2024
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3. Sex differences in plaque characteristics of fractional flow reserve-negative non-culprit lesions after myocardial infarction

Author

Volleberg, Rick H.J.A., Mol, Jan-Quinten, Belkacemi, Anouar, Hermanides, Renicus S., Meuwissen, Martijn, Protopopov, Alexey V., Laanmets, Peep, Krestyaninov, Oleg V., Dennert, Robert, Oemrawsingh, Rohit M., van Kuijk, Jan-Peter, Arkenbout, Karin, van der Heijden, Dirk J., Rasoul, Saman, Lipsic, Erik, Rodwell, Laura, Camaro, Cyril, Damman, Peter, Roleder, Tomasz, Kedhi, Elvin, van Leeuwen, Maarten A.H., van Geuns, Robert-Jan M., and van Royen, Niels

Published
2024
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5. Bifurcation PCI with a hybrid strategy with drug- eluting balloons versus a stepwise provisional two- stent strategy: Rationale and design of the hybrid DEB study

Author

Dillen, Daimy M.M., Vlaar, Pieter Jan, Vermeer, Amy J.E., Paradies, Valeria, van Kuijk, Jan- Peter, Vink, Maarten A., Oemrawsingh, Rohit M., Hofma, Sjoerd H., Magro, Michael, Remkes, Wouter S., de Smet, Bart J.G.L., van Rees, Johannes B., Somi, Samer, Halim, Jonathan, Zimmermann, Frederik M., Wijnbergen, Inge F., Tijssen, Jan G.P., Tonino, Pim A.L., and Teeuwen, Koen

Published
2023
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7. Optical coherence tomography predictors of clinical outcomes after stent implantation: the ILUMIEN IV trial.

Author

Landmesser, Ulf, Ali, Ziad A, Maehara, Akiko, Matsumura, Mitsuaki, Shlofmitz, Richard A, Guagliumi, Giulio, Price, Matthew J, Hill, Jonathan M, Akasaka, Takashi, Prati, Francesco, Bezerra, Hiram G, Wijns, William, Leistner, David, Canova, Paolo, Alfonso, Fernando, Fabbiocchi, Franco, Calligaris, Giuseppe, Oemrawsingh, Rohit M, Achenbach, Stephan, and Trani, Carlo

Subjects
OPTICAL coherence tomography, PERCUTANEOUS coronary intervention, MYOCARDIAL infarction, CONFIDENCE intervals, PEOPLE with diabetes
Abstract

Background and Aims Observational registries have suggested that optical coherence tomography (OCT) imaging-derived parameters may predict adverse events after drug-eluting stent (DES) implantation. The present analysis sought to determine the OCT predictors of clinical outcomes from the large-scale ILUMIEN IV trial. Methods ILUMIEN IV was a prospective, single-blind trial of 2487 patients with diabetes or high-risk lesions randomized to OCT-guided versus angiography-guided DES implantation. All patients underwent final OCT imaging (blinded in the angiography-guided arm). From more than 20 candidates, the independent OCT predictors of 2-year target lesion failure (TLF; the primary endpoint), cardiac death or target-vessel myocardial infarction (TV-MI), ischaemia-driven target lesion revascularization (ID-TLR), and stent thrombosis were analysed by multivariable Cox proportional hazard regression in single treated lesions. Results A total of 2128 patients had a single treated lesion with core laboratory-analysed final OCT. The 2-year Kaplan–Meier rates of TLF, cardiac death or TV-MI, ID-TLR, and stent thrombosis were 6.3% (n = 130), 3.3% (n = 68), 4.3% (n = 87), and 0.9% (n = 18), respectively. The independent predictors of 2-year TLF were a smaller minimal stent area (per 1 mm2 increase: hazard ratio 0.76, 95% confidence interval 0.68–0.89, P <.0001) and proximal edge dissection (hazard ratio 1.77, 95% confidence interval 1.20–2.62, P =.004). The independent predictors of cardiac death or TV-MI were smaller minimal stent area and longer stent length; of ID-TLR were smaller intra-stent flow area and proximal edge dissection; and of stent thrombosis was smaller minimal stent expansion. Conclusions In the ILUMIEN IV trial, the most important OCT-derived post-DES predictors of both safety and effectiveness outcomes were parameters related to stent area, expansion and flow, proximal edge dissection, and stent length. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Safety of the oral factor XIa inhibitor asundexian compared with apixaban in patients with atrial fibrillation (PACIFIC-AF): a multicentre, randomised, double-blind, double-dummy, dose-finding phase 2 study

Author

Auer, Johann, Hubauer, Martin, Pandzic, Sead, Preishuber, Eva, Primus-Grabscheit, Carina, Reitgruber, Dietmar, Schmalzer, Florian, Adlbrecht, Christopher, Schober, Andreas, Hajos, Johannes, Keil, Christoph, Schratter, Alexandra, Frick, Matthias, Benda, Magdalena Anna, Mächler, Maximilian, Mutschlechner, Beatrix, Saely, Christoph, Sprenger, Lukas, Lichtenauer, Michael, Eber, Miriam, Hoppe, Uta, Kolbitsch, Tobias, Jirak, Peter Michael, Mirna, Moritz, Schönbauer, Robert, Bergler-Klein, Jutta, Hengstenberg, Christian, Stojkovic, Stefan, Scherr, Daniel, Manninger-Wünscher, Martin, Rohrer, Ursula, Stühlinger, Markus, Schgoer, Wilfried, Schwarzl, Jana, Pürerfellner, Helmut, Derndorfer, Michael, Ebner, Christian, Eder, Veronika, Kollias, Georgios, Sturmberger, Thomas, Sieghartsleitner, Stefan, Vijgen, Johan, Koopman, Peter, Dujardin, Karl, Anné, Wim, De Ceuninck, Michel, Tavernier, Rene, Duytschaever, Mattias, Knecht, Sébastien, Missault, Luc, Vandekerckhove, Yves, Rossenbacker, Tom, Ector, Bavo, Charlier, Filip, Debruyne, Philippe, Dewilde, Willem, Janssens, Luc, Roosen, John, Vankelecom, Bart, Heidbuchel, Hein, Delesie, Michiel, Vervoort, Gert, Rombouts, Hans, Vanassche, Thomas, Engelen, Matthias, Verhamme, Peter, Willems, Rik, Constance, Christian, Pranno, Nicolas, Cox, Jafna, Bata, Iqbal, Macle, Laurent, Aguilar, Martin, Tourigny, Julia Cadrin, Dubuc, Marc, Dyrda, Katia, Guerra, Peter, Khairy, Paul, Mondésert, Blandine, Rivard, Léna, Roy, Denis, Tadros, Rafik, Talajic, Mario, Thibault, Bernard, Nault, Isabelle, Blier, Louis, Champagne, Jean, Molin, Franck, O'Hara, Gilles, Philippon, François, Plourde, Benoit, Sarrazin, Jean-François, Steinberg, Christian, Coufal, Zdenek, Balazsik, David, Mikulica, Michal, Zapeca, Jakub, Cermak, Ondrej, Drasnar, Tomas, Falc, Matej, Hornof, Josef, Racz, Blazej, Weissova, Danica, Linkova, Hana, Paskova, Eva, Petr, Robert, Sirakova, Andrea, Kettner, Jiri, Benak, Ales, Holek, Martin, Podpera, Ivo, Podperova, Monika, Vancura, Vlastimil, Jandik, Tomas, Smid, Jiri, Dedek, Vratislav, Banik, Jan, Durdil, Vaclav, Hnat, Tomas, Lellouche, Nicolas, Rouffiac, Ségolène, Taldir, Guillaume, Bridonneau, Valentin, Couffon, Philippe, Daudin, Magalie, Hamon, Cécile, Lacaze, Jonathan, Quentin, Anne, Thebault, Christophe, Boiffard, Emmanuel, Billon, Olivier, Miette, Fabien, Pouliquen, Hervé, Turlotte, Guillaume, Gorka, Hervé, Albert, Franck, Bayle, Sandrine, Bensaid, Reda, Dasoveanu, Madalina, Demichili, Thibaud, Dutoiu, Teodora, Khalil, Cliff, Loghin, Caterina, Range, Grégoire, Roussel, Laurent, Socié, Pierre, Thuaire, Christophe, Extramiana, Fabrice, Algalarrondo, Vincent, Boughanmi, Haten, El Mansour, Noreddine, Mohammad, Usman, Sellier, Romain, Elbaz, Meyer, Laperche, Clémence, Maury, Philippe, Kiss, Robert, Borsanyi, Tunde, Gingl, Zoltan, Polgar, Balaza, Benczur, Bela, Bodor, Alexandra, Hepp, Tamas, Malati, Eva, Nagy, Laszlo, Erdei, Norbert, Kapus, Jozsef, Kapus, Katalin, Toth, Brigitta, Matoltsy, Andras, Kiss, Tunde, Merkely, Bela, Herczeg, Szilvia, Kiss, Orsolya, Sallo, Zoltan, Toth, Kalman, Habon, Tamas, Rabai, Miklos, Totsimon, Kinga, Zilahi, Zsolt, Bencze, Gabriella, Santa, Janos, Aradi, Daniel, Kelemen, Barbara, Bolognese, Leonardo, Nesti, Martina, Notarstefano, Pasquale Giovanni, D'Orazio, Simona, Cosmi, Franco, Becattini, Cecilia, Agnelli, Giancarlo, Broccatelli, Belinda, Mosconi, Maria Giulia, Paciaroni, Maurizio, Urbini, Chiara, Parato, Vito Maurizio, Notaristefani, Camilla, Scarano, Michele, Ameri, Pietro, Ghigliotti, Giorgio, Guglielmi, Giulia, Lotti, Roberta, Merlo, Andrea Carlo, Muiesan, Maria Lorenza, Abondio, Andrea, Berasi, Caterina, Mattiuzzo, Elena, Mutti, Claudio, Salvetti, Massimo, Pignatelli, Pasquale, Menichelli, Danilo, Pastori, Daniele, Tamiya, Eiji, Matsumoto, Takahiro, Takabe, Tomosato, Yamamoto, Shoichi, Yamashita, Haruyo, Higashiue, Shinichi, Furuya, Onichi, Hiramatsu, Norihiko, Kasuga, Kensuke, Kojima, Saburo, Komooka, Masatoshi, Kuroyanagi, Satoshi, Matsuura, Makoto, Takemoto, Tetsushi, Yamamoto, Shuji, Saito, Katusmi, Abe, Takuro, Ishida, Issei, Iwanami, Yuji, Kataoka, Shohei, Moriyama, Tetsu, Murohashi, Akira, Sasaki, Akihito, Nakamura, Yuichiro, Ueno, Tetsuya, Shimane, Akira, Hamana, Tomoyo, Ichibori, Hirotoshi, Inoue, Tomohiro, Itoh, Mitsuaki, Iwane, Seigo, Kawai, Hiroya, Kokawa, Tatsuya, Masumoto, Akiko, Matsuo, Koki, Miyata, Taishi, Nakano, Shinsuke, Oishi, Shogo, Onishi, Tetsuari, Sawada, Takahiro, Saito, Takayuki, Shoda, Mitsuhiko, Takahashi, Nobuyuki, Takaya, Tomofumi, Taniguchi, Yasuyo, Tsukamoto, Shota, Tsukishiro, Yasue, Tsukiyama, Yoshiro, Tsunamoto, Hiroshi, Uzu, Kenzo, Yamamoto, Hiroyuki, Yamamoto, Tetsuya, Yokoi, Kiminobu, Yoshida, Chiaki, Watanabe, Nobuhiro, Betsuyaku, Tetsuo, Adachi, Kumiko, Awane, Kouichi, Goto, Daisuke, Sakakibara, Mamoru, Watanabe, Masashi, Ueno, Hideki, Hiroe, Yoshitaka, Matsuo, Koshi, Ayata, Kenji, Fukuda, Ko, Hata, Yoshiki, Hashimoto, Katsushi, Matsumi, Hiroaki, Nikaido, Akira, Okamoto, Shuichi, Sime, Iveta, Stirna, Valters, Reinholde, Ilze, Hansone, Silvija, Kozlovska, Anita, Romanova, Janina, Klincare, Dace, Pontaga, Natalja, Dirmans, Igors, Kalnins, Artis, Upite, Dana, Gersamija, Arcils, Teleznikovs, Arturs, Rozkova, Nadezda, Safro, Jelena, Anguera Camós, Ignasi, Domenico Dallaglio, Paolo, Salguero Bodes, Rafael, Arnbas, Fernando, Borrego, Luis, Marco, Alvaro, Jimenez, Javier Ramos, Gómez-Doblas, Juan José, Pérez Cabeza, Alejandro, Ferreira Gonzålez, Ignacio, Limeres Freire, Javier, Lopez Grau, Merce, Viñolas Prat, Xavier, Moreno Weidmann, Zoraida, Guerra Ramos, Jose Maria, Alonso Martin, Maria Concepcion, Campos Garcia, Bieito, Mogro Carranza, Javier Mauricio, Mendez Zurita, Francisco Javier, Rodriguez Font, Enrique, Gonzales Matos, Carlos Eduardo, García Hernando, Víctor, Lindholm, Carl-Johan, Thulin, Jörgen, Wallén, Håkan, Hagwall, Kristina, Eliasson, Ken, Lundvall, Martin, Olsson, Jens, Kjellman, Björn, Lind, Markus, Johansson, Lars, Svedberg, Niclas, Berglund, Stefan, Söderberg, Julia, Zedigh, Christer, Mooe, Thomas, Axelsson, Mattias, Binsell, Emil, Huber, Daniel, Müller, Christian, Danier, Isabelle, Kühne, Michael, Okamura, Bernhard, Schoepfer, Hadrien, Simmen, Cornelia, Reichlin, Tobias, Chollet, Laurève, Lam, Anna, Wittmer, Severin, Rickli, Hans, Gall, Christian, Hametner, Greta, Intorp, Stephanie, Luescher, Daniel, Haegeli, Laurent, Berg, Jan Christopher, Ebrahimi, Ramin, Auricchio, Angelo, Crljenica, Carmela, Moccetti, Tizziano, Monti, Cristina, Pasotti, Elena, Petrova, Iveta, Rossi, Mariagrazia, Mach, François, Namdar, Mehdi, de Groot, Joris, Proost, Virginnio, Neefs, Joline, Linz, Dominik, van Stipdonk, Twan, den Uijl, Dennis, Alings, Marco, Schaap, Jeroen, Segers, Dolf, Wouters, Noemi, Bartels, Louis, Tieleman, Robert, Pisters, Ron, de Vries, Tim, Selig, Jaap, Kuijper, Aaf, Bot, Pieter, Keijzers, Mitran, Verdel, Gerardus, Tukkie, Raymond, van den Bos, Ewout, Kauer, Floris, Oemrawsingh, Rohit, Stevenhagen, Jeroen, van Es, Jan, Lip, Gregory, Gupta, Dhiraj, Kotalczyk, Agnieszka, Gunstone, Anthony, Brixey, Richard David, Gorog, Diana, Dinarvand, Danial, Gue, Ying, Kanji, Rahim, Memtsas, Vassilios, Senior, Roxy, Bioh, Gabriel, Wong, Yuk-Ki, Child, Nick, Piccini, Jonathan P, Caso, Valeria, Connolly, Stuart J, Fox, Keith A A, Oldgren, Jonas, Jones, W Schuyler, Gorog, Diana A, Durdil, Václav, Viethen, Thomas, Neumann, Christoph, Mundl, Hardi, and Patel, Manesh R

Published
2022
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10. Comparison of Ultrathin- Versus Thin-Strut Stents in Patients With High Bleeding Risk PCI: Results From the COMPARE 60/80 HBR Trial: An OpenLabel, Randomized, Controlled Trial.

Author

Smits, Pieter C., Tonino, Pim A. L., Hofma, Sjoerd H., van Kuijk, Jan-Peter, Spano, Fabrizio, Al Mafragi, Amar, Pisters, Ron, Polad, Jawed, Bogaerts, Kris, Oemrawsingh, Rohit M., and Paradies, Valeria

Abstract

BACKGROUND: No randomized data exist on ultrathin-strut stents in patients at high bleeding risk (HBR) undergoing an abbreviated dual antiplatelet therapy after coronary stenting. The aim of this study was to compare the safety and effectiveness of the ultrathin-strut biodegradable-polymer sirolimus-eluting Supraflex Cruz stent with the thin-strut biodegradable-polymer sirolimus-eluting Ultimaster Tansei stent in patients at HBR with abbreviated dual antiplatelet therapy after stenting. METHODS: In the investigator-initiated, randomized, open-label COMPARE 60/80 HBR trial (Comparison of the Supraflex Cruz 60 Micron Stent Strut Versus the Ultimaster Tansei 80 Micron Stent Strut in HBR Percutaneous Coronary Intervention Population), 741 patients at HBR according to the Academic Research Consortium HBR criteria were randomized to receive either the ultrathin-strut biodegradable-polymer sirolimus-eluting Supraflex Cruz stent or thin-strut biodegradable-polymer sirolimus-eluting Ultimaster Tansei stent. Dual antiplatelet therapy was recommended according to the applicable guidelines and trial data for patients at HBR. The primary outcome was net adverse clinical events, the composite of cardiovascular death, myocardial infarction, target vessel revascularization, stroke, and major bleeding, and was powered for noninferiority with an absolute margin of 4.0% at 1-sided 2.5% alpha. RESULTS: Between September 2020 and August 2022, 371 patients were randomized to the ultrathin-strut biodegradablepolymer sirolimus-eluting Supraflex Cruz stent and 370 patients to the thin-strut biodegradable-polymer sirolimus-eluting Ultimaster Tansei stent at 11 sites in the Netherlands. At 1 year, the primary outcome was observed in 56 (15.4%) patients in the ultrathin-strut biodegradable-polymer sirolimus-eluting Supraflex Cruz stent group and 61 (17.1%) in the thin-strut biodegradable-polymer sirolimus-eluting Ultimaster Tansei stent group (risk difference, −1.65%; upper boundary of the 1-sided 95% CI, 3.74; P=0.02 for noninferiority at a 0.025 significance level and P=0.55 for 2-sided superiority at a 0.05 significance level). CONCLUSIONS: Among patients at HBR with abbreviated dual antiplatelet therapy post-stenting, the use of an ultrathinstrut biodegradable-polymer sirolimus-eluting Supraflex Cruz stent was noninferior compared with the use of a thin-strut biodegradable-polymer sirolimus-eluting Ultimaster Tansei stent. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Acute coronary syndrome subphenotypes based on repeated biomarker measurements in relation to long-term mortality risk

Author

Cardiologie, Gezonde Vaten, Circulatory Health, De Bakker, Marie, Scholte, Niels T.B., Oemrawsingh, Rohit M., Umans, Victor A., Kietselaer, Bas, Schotborgh, Carl, Ronner, Eelko, Lenderink, Timo, Aksoy, Ismail, Van Der Harst, Pim, Asselbergs, Folkert W., Maas, Arthur, Ophuis, Anton J.Oude, Krenning, Boudewijn, De Winter, Robbert J., Kie The, S. Hong, Wardeh, Alexander J., Hermans, Walter, Cramer, G. Etienne, Van Schaik, Ron H., De Rijke, Yolanda B., Akkerhuis, K. Martijn, Kardys, Isabella, Boersma, Eric, BIOMArCS Investigators, Cardiologie, Gezonde Vaten, Circulatory Health, De Bakker, Marie, Scholte, Niels T.B., Oemrawsingh, Rohit M., Umans, Victor A., Kietselaer, Bas, Schotborgh, Carl, Ronner, Eelko, Lenderink, Timo, Aksoy, Ismail, Van Der Harst, Pim, Asselbergs, Folkert W., Maas, Arthur, Ophuis, Anton J.Oude, Krenning, Boudewijn, De Winter, Robbert J., Kie The, S. Hong, Wardeh, Alexander J., Hermans, Walter, Cramer, G. Etienne, Van Schaik, Ron H., De Rijke, Yolanda B., Akkerhuis, K. Martijn, Kardys, Isabella, Boersma, Eric, and BIOMArCS Investigators

Published
2024

13. Acute Coronary Syndrome Subphenotypes Based on Repeated Biomarker Measurements in Relation to Long-Term Mortality Risk

Author

de Bakker, Marie, Scholte, Niels T.B., Oemrawsingh, Rohit M., Umans, Victor A., Kietselaer, Bas, Schotborgh, Carl, Ronner, Eelko, Lenderink, Timo, Aksoy, Ismail, van der Harst, Pim, Asselbergs, Folkert W., Maas, Arthur, Oude Ophuis, Anton J., Krenning, Boudewijn, de Winter, Robbert J., The, S. Hong Kie, Wardeh, Alexander J., Hermans, Walter, Cramer, G. Etienne, van Schaik, Ron H., de Rijke, Yolanda B., Akkerhuis, K. Martijn, Kardys, Isabella, Boersma, Eric, de Bakker, Marie, Scholte, Niels T.B., Oemrawsingh, Rohit M., Umans, Victor A., Kietselaer, Bas, Schotborgh, Carl, Ronner, Eelko, Lenderink, Timo, Aksoy, Ismail, van der Harst, Pim, Asselbergs, Folkert W., Maas, Arthur, Oude Ophuis, Anton J., Krenning, Boudewijn, de Winter, Robbert J., The, S. Hong Kie, Wardeh, Alexander J., Hermans, Walter, Cramer, G. Etienne, van Schaik, Ron H., de Rijke, Yolanda B., Akkerhuis, K. Martijn, Kardys, Isabella, and Boersma, Eric

Abstract

BACKGROUND: We aimed to identify patients with subphenotypes of postacute coronary syndrome (ACS) using repeated measurements of high-sensitivity cardiac troponin T, N-terminal pro-B-type natriuretic peptide, high-sensitivity C-reactive protein, and growth differentiation factor 15 in the year after the index admission, and to investigate their association with long-term mortality risk. METHODS AND RESULTS: BIOMArCS (BIOMarker Study to Identify the Acute Risk of a Coronary Syndrome) was an observational study of patients with ACS, who underwent high-frequency blood sampling for 1 year. Biomarkers were measured in a median of 16 repeated samples per individual. Cluster analysis was performed to identify biomarker-based subphenotypes in 723 patients without a repeat ACS in the first year. Patients with a repeat ACS (N=36) were considered a separate cluster. Differences in all-cause death were evaluated using accelerated failure time models (median follow-up, 9.1 years; 141 deaths). Three biomarker-based clusters were identified: cluster 1 showed low and stable biomarker concentrations, cluster 2 had elevated concentrations that subsequently decreased, and cluster 3 showed persistently elevated concentrations. The temporal biomarker patterns of patients in cluster 3 were similar to those with a repeat ACS during the first year. Clusters 1 and 2 had a similar and favorable long-term mortality risk. Cluster 3 had the highest mortality risk. The adjusted survival time ratio was 0.64 (95% CI, 0.44-0.93; P=0.018) compared with cluster 1, and 0.71 (95% CI, 0.39-1.32; P=0.281) compared with patients with a repeat ACS. CONCLUSIONS: Patients with subphenotypes of post-ACS with different all-cause mortality risks during long-term follow-up can be identified on the basis of repeatedly measured cardiovascular biomarkers. Patients with persistently elevated biomarkers have the worst outcomes, regardless of whether they expe

Published
2024

15. Medically Treated Nonischemic Thin-Cap Fibroatheroma Lesions Versus Fractional Flow Reserve-Guided Complete Revascularization in Diabetic Patients

Author

Hommels, Tobias M., primary, Hermanides, Renicus S., additional, Fabris, Enrico, additional, Malinowski, Krzysztof P., additional, Berta, Balázs, additional, Roleder, Tomasz, additional, Alfonso, Fernando, additional, De Luca, Giuseppe, additional, Oemrawsingh, Rohit M., additional, Wojakowski, Wojciech, additional, van ‘t Hof, Arnoud W.J., additional, and Kedhi, Elvin, additional

Published
2023
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16. Fractional Flow Reserve–Negative High-Risk Plaques and Clinical Outcomes After Myocardial Infarction

Author

Mol, Jan-Quinten, primary, Volleberg, Rick H. J. A., additional, Belkacemi, Anouar, additional, Hermanides, Renicus S., additional, Meuwissen, Martijn, additional, Protopopov, Alexey V., additional, Laanmets, Peep, additional, Krestyaninov, Oleg V., additional, Dennert, Robert, additional, Oemrawsingh, Rohit M., additional, van Kuijk, Jan-Peter, additional, Arkenbout, Karin, additional, van der Heijden, Dirk J., additional, Rasoul, Saman, additional, Lipsic, Erik, additional, Rodwell, Laura, additional, Camaro, Cyril, additional, Damman, Peter, additional, Roleder, Tomasz, additional, Kedhi, Elvin, additional, van Leeuwen, Maarten A. H., additional, van Geuns, Robert-Jan M., additional, and van Royen, Niels, additional

Published
2023
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18. One-year performance of thin-strut cobalt chromium sirolimus-eluting stent versus thicker strut stainless steel biolimus-eluting coronary stent: a propensity-matched analysis of two international all-comers registries

Author

Vlieger, Selina, Danzi, Gian B., Kauer, Floris, Oemrawsingh, Rohit M., Stojkovic, Sinisa, IJsselmuiden, Alexander J.J., Routledge, Helen, Laanmets, Peep, Roffi, Marco, Fröbert, Ole, Baello, Pascual, Wlodarczak, Adrian, Puentes, Angel, Polad, Jawed, and Hildick-Smith, David

Published
2020
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19. Conservative versus Invasive Strategy in Elderly Patients with Non-ST-Elevation Myocardial Infarction: Insights from the International POPular Age Registry

Author

van den Broek, Wout W. A., primary, Gimbel, Marieke E., additional, Chan Pin Yin, Dean R. P. P., additional, Azzahhafi, Jaouad, additional, Hermanides, Renicus S., additional, Runnett, Craig, additional, Storey, Robert F., additional, Austin, David, additional, Oemrawsingh, Rohit, additional, Cooke, Justin, additional, Galasko, Gavin, additional, Walhout, Ronald J., additional, Schellings, Dirk A. A. M., additional, Brinckman, Stijn L., additional, The, Hong Kie, additional, Stoel, Martin G., additional, Heestermans, Antonius A. C. M., additional, Nicastia, Debby, additional, Emans, Mireille E., additional, van ’t Hof, Arnoud W. J., additional, Alber, Hannes, additional, Gerber, Robert, additional, van Bergen, Paul F. M. M., additional, Aksoy, Ismail, additional, Nasser, Abdul, additional, Knaapen, Paul, additional, Botman, Cees-Joost, additional, Liem, Anho, additional, Kelder, Johannes C., additional, and ten Berg, Jurriën M., additional

Published
2023
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24. Longitudinal profile of circulating endothelial cells in post-acute coronary syndrome patients

Author

Centraal Diagnostisch Laboratorium, Circulatory Health, de Bakker, Marie, Kraan, Jaco, Akkerhuis, K. Martijn, Oemrawsingh, Rohit, Asselbergs, Folkert W., Hoefer, Imo, Kardys, Isabella, Boersma, Eric, Centraal Diagnostisch Laboratorium, Circulatory Health, de Bakker, Marie, Kraan, Jaco, Akkerhuis, K. Martijn, Oemrawsingh, Rohit, Asselbergs, Folkert W., Hoefer, Imo, Kardys, Isabella, and Boersma, Eric

Published
2023

25. Serially measured high-sensitivity cardiac troponin T, N-terminal-pro-B-type natriuretic peptide, high-sensitivity C-reactive protein, and growth differentiation factor 15 for risk assessment after acute coronary syndrome:the BIOMArCS cohort

Author

Gürgöze, Muhammed T., Akkerhuis, K. Martijn, Oemrawsingh, Rohit M., Umans, Victor A.W.M., Kietselaer, Bas, Schotborgh, Carl E., Ronner, Eelko, Lenderink, Timo, Aksoy, Ismail, Van Der Harst, Pim, Asselbergs, Folkert W., Maas, Arthur C., Oude Ophuis, Anton J., Krenning, Boudewijn, De Winter, Robbert J., The, Salem H.K., Wardeh, Alexander J., Hermans, Walter R.M., Cramer, G. Etienne, Van Gorp, Ina, De Rijke, Yolanda B., Van Schaik, Ron H.N., Boersma, Eric, Gürgöze, Muhammed T., Akkerhuis, K. Martijn, Oemrawsingh, Rohit M., Umans, Victor A.W.M., Kietselaer, Bas, Schotborgh, Carl E., Ronner, Eelko, Lenderink, Timo, Aksoy, Ismail, Van Der Harst, Pim, Asselbergs, Folkert W., Maas, Arthur C., Oude Ophuis, Anton J., Krenning, Boudewijn, De Winter, Robbert J., The, Salem H.K., Wardeh, Alexander J., Hermans, Walter R.M., Cramer, G. Etienne, Van Gorp, Ina, De Rijke, Yolanda B., Van Schaik, Ron H.N., and Boersma, Eric

Abstract

Aims: Evidence regarding the role of serial measurements of biomarkers for risk assessment in post-acute coronary syndrome (ACS) patients is limited. The aim was to explore the prognostic value of four, serially measured biomarkers in a large, real-world cohort of post-ACS patients. Methods and results: BIOMArCS is a prospective, multi-centre, observational study in 844 post-ACS patients in whom 12 218 blood samples (median 17 per patient) were obtained during 1-year follow-up. The longitudinal patterns of high-sensitivity cardiac troponin T (hs-cTnT), N-terminal-pro-B-type natriuretic peptide (NT-proBNP), high-sensitivity C-reactive protein (hs-CRP), and growth differentiation factor 15 (GDF-15) were analysed in relation to the primary endpoint (PE) of cardiovascular mortality and recurrent ACS using multivariable joint models. Median age was 63 years, 78% were men and the PE was reached by 45 patients. The average biomarker levels were systematically higher in PE compared with PE-free patients. After adjustment for 6-month post-discharge Global Registry of Acute Coronary Events score, 1 standard deviation increase in log[hs-cTnT] was associated with a 61% increased risk of the PE [hazard ratio (HR) 1.61, 95% confidence interval (CI) 1.02-2.44, P = 0.045], while for log[GDF-15] this was 81% (HR 1.81, 95% CI 1.28-2.70, P = 0.001). These associations remained significant after multivariable adjustment, while NT-proBNP and hs-CRP were not. Furthermore, GDF-15 level showed an increasing trend prior to the PE (Structured Graphical Abstract). Conclusion: Longitudinally measured hs-cTnT and GDF-15 concentrations provide prognostic value in the risk assessment of clinically stabilized patients post-ACS. Clinical Trial Registration: The Netherlands Trial Register. Currently available at URL https://trialsearch.who.int/; Unique Identifiers: NTR1698 and NTR1106.

Published
2023

26. Longitudinal profile of circulating endothelial cells in post-acute coronary syndrome patients

Author

de Bakker, Marie, Kraan, Jaco, Akkerhuis, K. Martijn, Oemrawsingh, Rohit, Asselbergs, Folkert W., Hoefer, Imo, Kardys, Isabella, Boersma, Eric, de Bakker, Marie, Kraan, Jaco, Akkerhuis, K. Martijn, Oemrawsingh, Rohit, Asselbergs, Folkert W., Hoefer, Imo, Kardys, Isabella, and Boersma, Eric

Abstract

Introduction: Patients who have experienced an acute coronary syndrome (ACS) are at risk of a recurrent event, but their level of risk varies. Because of their close temporal relationship with vascular injury, longitudinal measurements of circulating endothelial cells (CECs) carry potential to improve individual risk assessment. Methods: We conducted an explorative nested case-control study within our multicenter, prospective, observational biomarker study (BIOMArCS) of 844 ACS patients. Following an index ACS, high-frequency blood sampling was performed during 1-year follow-up. CECs were identified using flow cytometric analyses in 15 cases with recurrent event, and 30 matched controls. Results: Cases and controls had a median (25th-75thpercentile) age of 64.1 (58.1-75.1) years and 80% were men. During the months preceding the endpoint, the mean (95%CI) CEC concentration in cases was persistently higher than in controls (12.8 [8.2-20.0] versus 10.0 [7.0-14.4] cells/ml), although this difference was non-significant (P = 0.339). In controls, the mean cell concentration was significantly (P = 0.030) lower in post 30-day samples compared to samples collected within one day after index ACS: 10.1 (7.5-13.6) versus 17.0 (10.8-26.6) cells/ml. Similar results were observed for CEC subsets co-expressing CD133 and CD309 (VEGFR-2) or CD106 (VCAM-1). Conclusion: Despite their close relation to vascular damage, no increase in cell concentrations were found prior to the occurrence of a secondary adverse cardiac event.

Published
2023

27. Impact of Multisite artery disease on Clinical Outcomes After Percutaneous Coronary Intervention : An Analysis from the e-Ultimaster Registry

Author

Kobo, Ofer, Saada, Majdi, von Birgelen, Clemens, Tonino, Pim A. L., Íñiguez-Romo, Andres, Fröbert, Ole, Halabi, Majdi, Oemrawsingh, Rohit M., Polad, Jawed, IJsselmuiden, Alexander J. J., Roffi, Marco, Aminian, Adel, Mamas, Mamas A., Roguin, Ariel, Kobo, Ofer, Saada, Majdi, von Birgelen, Clemens, Tonino, Pim A. L., Íñiguez-Romo, Andres, Fröbert, Ole, Halabi, Majdi, Oemrawsingh, Rohit M., Polad, Jawed, IJsselmuiden, Alexander J. J., Roffi, Marco, Aminian, Adel, Mamas, Mamas A., and Roguin, Ariel

Abstract

BACKGROUND: Multisite artery disease is considered a 'malignant' type of atherosclerotic disease associated with an increased cardiovascular risk, but the impact of multisite artery disease on clinical outcomes after percutaneous coronary intervention (PCI) is unknown. METHODS: Patients enrolled in the large, prospective e-Ultimaster study were grouped into 1) those without known prior vascular disease; 2) those with known single-territory vascular disease 3) those with known 2-3 territories (i.e, coronary, cerebrovascular, or peripheral) vascular disease (multisite artery disease). The primary outcome was coronary target lesion failure (TLF) defined as the composite of cardiac death, target vessel-related myocardial infarction, and clinically driven target lesion revascularization at 1-year. Inverse propensity score weighted (IPSW) analysis was performed to address differences in baseline patient and lesion characteristics. RESULTS: Of the 37,198 patients included in the study, 62.3% had no prior known vascular disease, 32.6% had single-territory vascular disease, and 5.1% multisite artery disease. Patients with known vascular disease were older and were more likely to be men and to have more co-morbidities. After IPSW, the TLF rate incrementally increased with the number of diseased vascular beds (3.16%, 4.44% and 6.42% for no, single- and multisite artery disease, p<0.01 for all comparisons). This was also true for all cause death (2.22%, 3.28% and 5.29%, p<0.01 for all comparisons) and cardiac mortality (1.26%, 1.91% and 3.62%, p≤0.01 for all comparisons). CONCLUSIONS: Patients with previously known vascular disease experienced an increased risk for adverse cardiovascular events and mortality post percutaneous coronary intervention. This risk is highest among patients with multisite artery disease., Funding agency:Terumo Europe, Leuven, Belgium

Published
2023
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28. Serially Measured hs-cTnT, NT-proBNP, hs-CRP and GDF-15 for Risk Assessment After Acute Coronary Syndrome: the BIOMArCS Cohort

Author

Gürgöze, Muhammed T, primary, Akkerhuis, K Martijn, additional, Oemrawsingh, Rohit M, additional, Umans, Victor A W M, additional, Kietselaer, Bas, additional, Schotborgh, Carl E, additional, Ronner, Eelko, additional, Lenderink, Timo, additional, Aksoy, Ismail, additional, van der Harst, Pim, additional, Asselbergs, Folkert W, additional, Maas, Arthur C, additional, Ophuis, Anton J Oude, additional, Krenning, Boudewijn, additional, de Winter, Robbert J, additional, The, Salem H K, additional, Wardeh, Alexander J, additional, Hermans, Walter R M, additional, Cramer, G Etienne, additional, van Gorp, Ina, additional, de Rijke, Yolanda B, additional, van Schaik, Ron H N, additional, and Boersma, Eric, additional

Published
2023
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29. Plasma concentrations of molecular lipid species in relation to coronary plaque characteristics and cardiovascular outcome: Results of the ATHEROREMO-IVUS study

Author

Cheng, Jin M., Suoniemi, Matti, Kardys, Isabella, Vihervaara, Terhi, de Boer, Sanneke P.M., Akkerhuis, K. Martijn, Sysi-Aho, Marko, Ekroos, Kim, Garcia-Garcia, Hector M., Oemrawsingh, Rohit M., Regar, Evelyn, Koenig, Wolfgang, Serruys, Patrick W., van Geuns, Robert-Jan, Boersma, Eric, and Laaksonen, Reijo

Published
2015
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33. Prognostic value of syntax score, intravascular ultrasound and near-infrared spectroscopy to identify low-risk patients with coronary artery disease 5-year results from the ATHEROREMO and IBIS-3 cohorts

Author

Vlieger, Selina, primary, Oemrawsingh, Rohit M., additional, Cheng, Jin M., additional, Schuurman, Anne-Sophie, additional, Vroegindewey, Maxime, additional, Kardys, Isabella, additional, Van Geuns, Robert-Jan, additional, Daemen, Joost, additional, Van Mieghem, Nicolaas M., additional, Akkerhuis, K. Martijn, additional, and Boersma, Eric, additional

Published
2022
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34. Relation of C-Reactive Protein to Coronary Plaque Characteristics on Grayscale, Radiofrequency Intravascular Ultrasound, and Cardiovascular Outcome in Patients With Acute Coronary Syndrome or Stable Angina Pectoris (from the ATHEROREMO-IVUS Study)

Author

Cheng, Jin M., Oemrawsingh, Rohit M., Garcia-Garcia, Hector M., Akkerhuis, K. Martijn, Kardys, Isabella, de Boer, Sanneke P.M., Langstraat, Jannette S., Regar, Evelyn, van Geuns, Robert-Jan, Serruys, Patrick W., and Boersma, Eric

Published
2014
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36. High-Frequency Biomarker Measurements of Troponin, NT-proBNP, and C-Reactive Protein for Prediction of New Coronary Events After Acute Coronary Syndrome: BIOMArCS Study

Author

Oemrawsingh, Rohit M., Akkerhuis, K. Martijn, de Mulder, Maarten, Umans, Victor A., Kietselaer, Bas, Schotborgh, Carl, Ronner, Eelko, Lenderink, Timo, Liem, Anho, Haitsma, David, van der Harst, Pim, Asselbergs, Folkert W., Maas, Arthur, Oude Ophuis, Anton J., Ilmer, Ben, Dijkgraaf, Rene, de Winter, Robbert J., Kie The, S. Hong, Wardeh, Alexander J., Hermans, Walter, Cramer, Etienne, van Schaik, Ron H., Hoefer, Imo E., Doevendans, Pieter A., Simoons, Maarten L., and Boersma, Eric

Published
2019
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37. Associations of 26 Circulating Inflammatory and Renal Biomarkers with Near-Infrared Spectroscopy and Long-term Cardiovascular Outcome in Patients Undergoing Coronary Angiography (ATHEROREMO-NIRS Substudy)

Author

Anroedh, Sharda S., Akkerhuis, K. Martijn, Oemrawsingh, Rohit M., Garcia-Garcia, Hector M., Brankovic, Milos, Regar, Evelyn, van Geuns, Robert-Jan, Serruys, Patrick W., Daemen, Joost, van Mieghem, Nicolas M., Boersma, Eric, and Kardys, Isabella

Published
2018
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38. A Multicenter, Phase 2, Randomized, Placebo-Controlled, Double-Blind, Parallel-Group, Dose-Finding Trial of the Oral Factor XIa Inhibitor Asundexian to Prevent Adverse Cardiovascular Outcomes After Acute Myocardial Infarction

Author

Rao, Sunil V., primary, Kirsch, Bodo, additional, Bhatt, Deepak L., additional, Budaj, Andrzej, additional, Coppolecchia, Rosa, additional, Eikelboom, John, additional, James, Stefan K., additional, Jones, W. Schuyler, additional, Merkely, Bela, additional, Keller, Lars, additional, Hermanides, Renicus S., additional, Campo, Gianluca, additional, Ferreiro, José Luis, additional, Shibasaki, Taro, additional, Mundl, Hardi, additional, Alexander, John H., additional, Hengstenberg, Christian, additional, Steinwender, Clemens, additional, Alber, Hannes, additional, Steringer-Mascherbauer, Regina, additional, Schober, Andreas, additional, Auer, Johann, additional, Roithinger, Franz Xaver, additional, von Lewinski, Dirk, additional, Moertl, Deddo, additional, Huber, Kurt, additional, Coussement, Patrick, additional, Hoffer, Etienne, additional, Beauloye, Christophe, additional, Janssens, Luc, additional, Vranckx, Pascal, additional, De Raedt, Herbert, additional, Vanassche, Thomas, additional, Vrolix, Matthias, additional, Rokyta, Richard, additional, Parenica, Jiri, additional, Pelouch, Radek, additional, Motovska, Zuzanna, additional, Alan, David, additional, Kettner, Jiri, additional, Polasek, Rostislav, additional, Cermak, Ondrej, additional, Sedlon, Pavel, additional, Hanis, Jiri, additional, Novak, Martin, additional, Belohlavek, Jan, additional, Horacek, Thomas, additional, Leggewie, Stefan, additional, Wenzel, Philip, additional, vom Dahl, Juergen, additional, Sievers, Burkhard, additional, Pulz, Jan, additional, Schellong, Sebastian, additional, Clemmensen, Peter, additional, Muller-Hennessen, Matthias, additional, Rassaf, Tienush, additional, Falukozi, Jozsef, additional, Ruzsa, Zoltan, additional, Tomcsanyi, Janos, additional, Csanadi, Zoltan, additional, Herczeg, Bela, additional, Koszegi, Zsolt, additional, Vorobcsuk, Andras, additional, Kiss, Robert, additional, Baranyai, Csaba, additional, Dezsi, Csaba, additional, Lupkovics, Geza, additional, Rossini, Roberta, additional, Scherillo, Marino, additional, Sergio Saba, Pier, additional, Calogero Campo, Gianluca, additional, Calo, Leonardo, additional, Nassiacos, Daniele, additional, Quadri, Giorgio, additional, Sciahbasi, Alessandro, additional, Silvio Marenzi, Gian Carlo, additional, Reimers, Bernhard, additional, Perna, Gian Piero, additional, Sacca, Salvatore, additional, Fattore, Luciano, additional, Brunelli, Claudio, additional, Picchi, Andrea, additional, Kuramochi, Takehiko, additional, Kondo, Kazuhisa, additional, Aoyama, Takahiko, additional, Kudoh, Takashi, additional, Yamamoto, Tadashi, additional, Takaya, Tomofumi, additional, Mukai, Yasushi, additional, Fukui, Kazuki, additional, Morioka, Nobuyuki, additional, Ando, Kenji, additional, Yamamuro, Atsushi, additional, Morita, Yasuhiro, additional, Koga, Yasuaki, additional, Watanabe, Tetsuya, additional, Sakamoto, Tomohiro, additional, Maebuchi, Daisuke, additional, Takahashi, Akihiko, additional, Yonetsu, Taishi, additional, Kakuta, Tsunekazu, additional, Nishina, Hidetaka, additional, Oemrawsingh, Rohit, additional, Dorman, Reinhart, additional, Oude Ophius, Ton, additional, Prins, Paco, additional, al Windy, N.Y.Y., additional, Zoet-Nugteren, S.K., additional, Hermanides, Rik, additional, van Eck, Martijn, additional, Scherptong, Roderick, additional, Cornel, J.H., additional, Damman, Peter, additional, Bech, Gerhard, additional, Torquay, R., additional, Kietselaer, Bas, additional, Grzelakowski, Pawel, additional, Krzysztof, Dyrbus, additional, Miekus, Pawel, additional, Przybylski, Andrzej, additional, Zarebinski, Maciej, additional, Balsam, Pawel, additional, Szachniewicz, Joanna, additional, Gierlotka, Marek, additional, Tycinska, Agnieszka, additional, Iniguez Romo, Andres, additional, Fernandez Ortiz, Antonio, additional, Carrasquer Cucarella, Anna, additional, Sanmartin Fernandez, Marcelo, additional, Sionis, Alessandro, additional, Bueno Zamora, Hector, additional, Ferreiro Gutierrez, Jose Luis, additional, Almenar, Luis, additional, Ferreira Gonzalez, Ignacio, additional, Pascual Figal, Domingo A., additional, Almendro Delia, Manuel, additional, Jimenez Fernandez, Miriam, additional, Skeppholm, Mika, additional, Zedigh, Crister, additional, Angeras, Oskar, additional, Lauermann, Jorg, additional, Erlinge, David, additional, Gustafsson, Robin, additional, Mooe, Thomas, additional, Utreras, Alejandro, additional, James, Stefan, additional, Grimfjard, Per, additional, Pedrazzini, Giovanni, additional, Mach, Francois, additional, Fournier, Stephane, additional, Haegeli, Laurent, additional, Beer, Jurg H., additional, Leibundgut, Gregor, additional, Kobza, Richard, additional, Kaiser, Christoph, additional, Kunadian, Vijay, additional, Al-Lamee, Rasha, additional, Gorog, Diana, additional, Khan, Sohail, additional, Trevelyan, Jasper, additional, Toor, Iqbal, additional, Smith, James, additional, Purushottam, Bhaskar, additional, Treasure, Charles, additional, Arena, Frank, additional, Vedere, Amarnath, additional, Henderson, David, additional, Gilani, Syed, additional, Jones, Alonzo, additional, Carrillo-Jimenez, Rodolfo, additional, Gillespie, Eve, additional, Marhefka, Gregary, additional, Wang, David, additional, Olson, Charles, additional, Bloom, Stephen, additional, Iftikhar, Faizan, additional, Brabham, David, additional, McGinty, John, additional, Thompson, Charles, additional, Talano, James, additional, Ginete, Wilson, additional, Williams, Marcus, additional, Masud, Ali, additional, Ariani, Mehrdad, additional, Bitar, Fahed, additional, Wang, Thomas, additional, and Samuelson, Bradley, additional

Published
2022
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41. Serially measured high-sensitivity cardiac troponin T, N-terminal-pro-B-type natriuretic peptide, high-sensitivity C-reactive protein, and growth differentiation factor 15 for risk assessment after acute coronary syndrome: the BIOMArCS cohort.

Author

Gürgöze, Muhammed T, Akkerhuis, K Martijn, Oemrawsingh, Rohit M, Umans, Victor A W M, Kietselaer, Bas, Schotborgh, Carl E, Ronner, Eelko, Lenderink, Timo, Aksoy, Ismail, van der Harst, Pim, Asselbergs, Folkert W, Maas, Arthur C, Oude Ophuis, Anton J, Krenning, Boudewijn, de Winter, Robbert J, The, Salem H K, Wardeh, Alexander J, Hermans, Walter R M, Cramer, G Etienne, and van Gorp, Ina

Published
2023
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44. Impact of multisite artery disease on clinical outcomes after percutaneous coronary intervention: an analysis from the e-Ultimaster registry

Author

Kobo, Ofer, primary, Saada, Majdi, additional, von Birgelen, Clemens, additional, Tonino, Pim A L, additional, Íñiguez-Romo, Andres, additional, Fröbert, Ole, additional, Halabi, Majdi, additional, Oemrawsingh, Rohit M, additional, Polad, Jawed, additional, IJsselmuiden, Alexander J J, additional, Roffi, Marco, additional, Aminian, Adel, additional, Mamas, Mamas A, additional, and Roguin, Ariel, additional

Published
2022
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45. Prognostic value of syntax score, intravascular ultrasound and near-infrared spectroscopy to identify low-risk patients with coronary artery disease 5-year results from the ATHEROREMO and IBIS-3 cohorts

Author

Vlieger, Selina, Oemrawsingh, Rohit M., Cheng, Jin M., Schuurman, Anne Sophie, Vroegindewey, Maxime, Kardys, Isabella, Van Geuns, Robert Jan, Daemen, Joost, Van Mieghem, Nicolaas M., Akkerhuis, K. Martijn, Boersma, Eric, Vlieger, Selina, Oemrawsingh, Rohit M., Cheng, Jin M., Schuurman, Anne Sophie, Vroegindewey, Maxime, Kardys, Isabella, Van Geuns, Robert Jan, Daemen, Joost, Van Mieghem, Nicolaas M., Akkerhuis, K. Martijn, and Boersma, Eric

Abstract

The prognostic value of SYNTAX score (SS), intravascular ultrasound (IVUS)-derived plaque burden (PB) and near-infrared spectroscopy (NIRS)-derived lipid core burden index (LCBI) for identification of high-risk patients for major adverse cardiovascular events (MACE) has been proven in previous studies. The majority of patients presenting in the cathlab however do not endure MACE over time, and identification of low-risk groups has remained underexposed. This study evaluates the combined prognostic value of SS, PB and LCBI in identifying patients with low MACE risk. This post-hoc analysis combines the ATHEROREMO and IBIS-3 studies and included 798 patients undergoing coronary angiography. Anatomical SS was calculated (N = 617) and ≥40mm non-stenotic segment of a non-target vessel was investigated with IVUS (N = 645) and NIRS (N = 273) to determine PB and maximum 4mm LCBI (LCBI 4mm). During five-year follow-up, 191 MACE were observed. Patients with PB ≤70%, LCBI 4mm ≤227 (median), or SS ≤8 (median) had lower MACE incidence than their counterparts with higher values. Combined into one model, LCBI 4mm ≤227 (adjusted hazard ratio [aHR] 0.49, 95% confidence interval [CI] 0.30–0.78; p-value = 0.003) and SS ≤8 (aHR 0.67, 95%CI 0.48–0.96, p-value = 0.027) were independently associated with (lower) MACE rate, but PB was not. Additionally, negative predictive value (NPV) of this model was high (SS<8: 0.80, PB<70%: 0.77, LCBI 4mm<227: 0.79). In this cohort, SS and LCBI 4mm proved to be independent predictors of MACE-free survival during five-year followup. Combination of SS and LCBI 4mm is useful to identify a low-risk population. Furthermore, NPV of SS, PB and LCBI 4mm for prediction of MACE is high.

Published
2022

46. Relation of Iron Status to Prognosis After Acute Coronary Syndrome

Author

Team Medisch, Circulatory Health, Gürgöze, Muhammed T, Kardys, Isabella, Akkerhuis, K Martijn, Oemrawsingh, Rohit M, Groot, Hilde E, van der Harst, Pim, Umans, Victor A, Kietselaer, Bas, Ronner, Eelko, Lenderink, Timo, Asselbergs, Folkert W, Manintveld, Olivier C, Boersma, Eric, Team Medisch, Circulatory Health, Gürgöze, Muhammed T, Kardys, Isabella, Akkerhuis, K Martijn, Oemrawsingh, Rohit M, Groot, Hilde E, van der Harst, Pim, Umans, Victor A, Kietselaer, Bas, Ronner, Eelko, Lenderink, Timo, Asselbergs, Folkert W, Manintveld, Olivier C, and Boersma, Eric

Published
2022

47. The Utility of the SYNTAX Score II and SYNTAX Score 2020 for Identifying Patients with Three-Vessel Disease Eligible for Percutaneous Coronary Intervention in the Multivessel TALENT Trial: A Prospective Pilot Experience

Author

Ninomiya, Kai, primary, Serruys, Patrick W., primary, Garg, Scot, primary, Hara, Hironori, primary, Masuda, Shinichiro, primary, Kageyama, Shigetaka, primary, Kotoku, Nozomi, primary, Sevestre, Emelyne, primary, Kumar, Abhishek, primary, O’Kane, Peter, primary, Zaman, Azfar, primary, Farah, Bruno, primary, Magro, Michael, primary, Oemrawsingh, Rohit M., primary, Möllmann, Helge, primary, Meneveau, Nicolas, primary, Achenbach, Stephan, primary, Lemoine, Julien, primary, Allali, Abdelhakim, primary, Gallagher, Sean, primary, Wykrzykowska, Joanna, primary, Lesiak, Maciej, primary, Silvestri, Marc, primary, Wijns, William, primary, Sharif, Faisal, primary, and Onuma, Yoshinobu, primary

Published
2022
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48. Safety of the oral factor XIa inhibitor asundexian compared with apixaban in patients with atrial fibrillation (PACIFIC-AF): a multicentre, randomised, double-blind, double-dummy, dose-finding phase 2 study

Author

Piccini, Jonathan P, primary, Caso, Valeria, additional, Connolly, Stuart J, additional, Fox, Keith A A, additional, Oldgren, Jonas, additional, Jones, W Schuyler, additional, Gorog, Diana A, additional, Durdil, Václav, additional, Viethen, Thomas, additional, Neumann, Christoph, additional, Mundl, Hardi, additional, Patel, Manesh R, additional, Auer, Johann, additional, Hubauer, Martin, additional, Pandzic, Sead, additional, Preishuber, Eva, additional, Primus-Grabscheit, Carina, additional, Reitgruber, Dietmar, additional, Schmalzer, Florian, additional, Adlbrecht, Christopher, additional, Schober, Andreas, additional, Hajos, Johannes, additional, Keil, Christoph, additional, Schratter, Alexandra, additional, Frick, Matthias, additional, Benda, Magdalena Anna, additional, Mächler, Maximilian, additional, Mutschlechner, Beatrix, additional, Saely, Christoph, additional, Sprenger, Lukas, additional, Lichtenauer, Michael, additional, Eber, Miriam, additional, Hoppe, Uta, additional, Kolbitsch, Tobias, additional, Jirak, Peter Michael, additional, Mirna, Moritz, additional, Schönbauer, Robert, additional, Bergler-Klein, Jutta, additional, Hengstenberg, Christian, additional, Stojkovic, Stefan, additional, Scherr, Daniel, additional, Manninger-Wünscher, Martin, additional, Rohrer, Ursula, additional, Stühlinger, Markus, additional, Schgoer, Wilfried, additional, Schwarzl, Jana, additional, Pürerfellner, Helmut, additional, Derndorfer, Michael, additional, Ebner, Christian, additional, Eder, Veronika, additional, Kollias, Georgios, additional, Sturmberger, Thomas, additional, Sieghartsleitner, Stefan, additional, Vijgen, Johan, additional, Koopman, Peter, additional, Dujardin, Karl, additional, Anné, Wim, additional, De Ceuninck, Michel, additional, Tavernier, Rene, additional, Duytschaever, Mattias, additional, Knecht, Sébastien, additional, Missault, Luc, additional, Vandekerckhove, Yves, additional, Rossenbacker, Tom, additional, Ector, Bavo, additional, Charlier, Filip, additional, Debruyne, Philippe, additional, Dewilde, Willem, additional, Janssens, Luc, additional, Roosen, John, additional, Vankelecom, Bart, additional, Heidbuchel, Hein, additional, Delesie, Michiel, additional, Vervoort, Gert, additional, Rombouts, Hans, additional, Vanassche, Thomas, additional, Engelen, Matthias, additional, Verhamme, Peter, additional, Willems, Rik, additional, Constance, Christian, additional, Pranno, Nicolas, additional, Cox, Jafna, additional, Bata, Iqbal, additional, Macle, Laurent, additional, Aguilar, Martin, additional, Tourigny, Julia Cadrin, additional, Dubuc, Marc, additional, Dyrda, Katia, additional, Guerra, Peter, additional, Khairy, Paul, additional, Mondésert, Blandine, additional, Rivard, Léna, additional, Roy, Denis, additional, Tadros, Rafik, additional, Talajic, Mario, additional, Thibault, Bernard, additional, Nault, Isabelle, additional, Blier, Louis, additional, Champagne, Jean, additional, Molin, Franck, additional, O'Hara, Gilles, additional, Philippon, François, additional, Plourde, Benoit, additional, Sarrazin, Jean-François, additional, Steinberg, Christian, additional, Coufal, Zdenek, additional, Balazsik, David, additional, Mikulica, Michal, additional, Zapeca, Jakub, additional, Cermak, Ondrej, additional, Drasnar, Tomas, additional, Falc, Matej, additional, Hornof, Josef, additional, Racz, Blazej, additional, Weissova, Danica, additional, Linkova, Hana, additional, Paskova, Eva, additional, Petr, Robert, additional, Sirakova, Andrea, additional, Kettner, Jiri, additional, Benak, Ales, additional, Holek, Martin, additional, Podpera, Ivo, additional, Podperova, Monika, additional, Vancura, Vlastimil, additional, Jandik, Tomas, additional, Smid, Jiri, additional, Dedek, Vratislav, additional, Banik, Jan, additional, Durdil, Vaclav, additional, Hnat, Tomas, additional, Lellouche, Nicolas, additional, Rouffiac, Ségolène, additional, Taldir, Guillaume, additional, Bridonneau, Valentin, additional, Couffon, Philippe, additional, Daudin, Magalie, additional, Hamon, Cécile, additional, Lacaze, Jonathan, additional, Quentin, Anne, additional, Thebault, Christophe, additional, Boiffard, Emmanuel, additional, Billon, Olivier, additional, Miette, Fabien, additional, Pouliquen, Hervé, additional, Turlotte, Guillaume, additional, Gorka, Hervé, additional, Albert, Franck, additional, Bayle, Sandrine, additional, Bensaid, Reda, additional, Dasoveanu, Madalina, additional, Demichili, Thibaud, additional, Dutoiu, Teodora, additional, Khalil, Cliff, additional, Loghin, Caterina, additional, Range, Grégoire, additional, Roussel, Laurent, additional, Socié, Pierre, additional, Thuaire, Christophe, additional, Extramiana, Fabrice, additional, Algalarrondo, Vincent, additional, Boughanmi, Haten, additional, El Mansour, Noreddine, additional, Mohammad, Usman, additional, Sellier, Romain, additional, Elbaz, Meyer, additional, Laperche, Clémence, additional, Maury, Philippe, additional, Kiss, Robert, additional, Borsanyi, Tunde, additional, Gingl, Zoltan, additional, Polgar, Balaza, additional, Benczur, Bela, additional, Bodor, Alexandra, additional, Hepp, Tamas, additional, Malati, Eva, additional, Nagy, Laszlo, additional, Erdei, Norbert, additional, Kapus, Jozsef, additional, Kapus, Katalin, additional, Toth, Brigitta, additional, Matoltsy, Andras, additional, Kiss, Tunde, additional, Merkely, Bela, additional, Herczeg, Szilvia, additional, Kiss, Orsolya, additional, Sallo, Zoltan, additional, Toth, Kalman, additional, Habon, Tamas, additional, Rabai, Miklos, additional, Totsimon, Kinga, additional, Zilahi, Zsolt, additional, Bencze, Gabriella, additional, Santa, Janos, additional, Aradi, Daniel, additional, Kelemen, Barbara, additional, Bolognese, Leonardo, additional, Nesti, Martina, additional, Notarstefano, Pasquale Giovanni, additional, D'Orazio, Simona, additional, Cosmi, Franco, additional, Becattini, Cecilia, additional, Agnelli, Giancarlo, additional, Broccatelli, Belinda, additional, Mosconi, Maria Giulia, additional, Paciaroni, Maurizio, additional, Urbini, Chiara, additional, Parato, Vito Maurizio, additional, Notaristefani, Camilla, additional, Scarano, Michele, additional, Ameri, Pietro, additional, Ghigliotti, Giorgio, additional, Guglielmi, Giulia, additional, Lotti, Roberta, additional, Merlo, Andrea Carlo, additional, Muiesan, Maria Lorenza, additional, Abondio, Andrea, additional, Berasi, Caterina, additional, Mattiuzzo, Elena, additional, Mutti, Claudio, additional, Salvetti, Massimo, additional, Pignatelli, Pasquale, additional, Menichelli, Danilo, additional, Pastori, Daniele, additional, Tamiya, Eiji, additional, Matsumoto, Takahiro, additional, Takabe, Tomosato, additional, Yamamoto, Shoichi, additional, Yamashita, Haruyo, additional, Higashiue, Shinichi, additional, Furuya, Onichi, additional, Hiramatsu, Norihiko, additional, Kasuga, Kensuke, additional, Kojima, Saburo, additional, Komooka, Masatoshi, additional, Kuroyanagi, Satoshi, additional, Matsuura, Makoto, additional, Takemoto, Tetsushi, additional, Yamamoto, Shuji, additional, Saito, Katusmi, additional, Abe, Takuro, additional, Ishida, Issei, additional, Iwanami, Yuji, additional, Kataoka, Shohei, additional, Moriyama, Tetsu, additional, Murohashi, Akira, additional, Sasaki, Akihito, additional, Nakamura, Yuichiro, additional, Ueno, Tetsuya, additional, Shimane, Akira, additional, Hamana, Tomoyo, additional, Ichibori, Hirotoshi, additional, Inoue, Tomohiro, additional, Itoh, Mitsuaki, additional, Iwane, Seigo, additional, Kawai, Hiroya, additional, Kokawa, Tatsuya, additional, Masumoto, Akiko, additional, Matsuo, Koki, additional, Miyata, Taishi, additional, Nakano, Shinsuke, additional, Oishi, Shogo, additional, Onishi, Tetsuari, additional, Sawada, Takahiro, additional, Saito, Takayuki, additional, Shoda, Mitsuhiko, additional, Takahashi, Nobuyuki, additional, Takaya, Tomofumi, additional, Taniguchi, Yasuyo, additional, Tsukamoto, Shota, additional, Tsukishiro, Yasue, additional, Tsukiyama, Yoshiro, additional, Tsunamoto, Hiroshi, additional, Uzu, Kenzo, additional, Yamamoto, Hiroyuki, additional, Yamamoto, Tetsuya, additional, Yokoi, Kiminobu, additional, Yoshida, Chiaki, additional, Watanabe, Nobuhiro, additional, Betsuyaku, Tetsuo, additional, Adachi, Kumiko, additional, Awane, Kouichi, additional, Goto, Daisuke, additional, Sakakibara, Mamoru, additional, Watanabe, Masashi, additional, Ueno, Hideki, additional, Hiroe, Yoshitaka, additional, Matsuo, Koshi, additional, Ayata, Kenji, additional, Fukuda, Ko, additional, Hata, Yoshiki, additional, Hashimoto, Katsushi, additional, Matsumi, Hiroaki, additional, Nikaido, Akira, additional, Okamoto, Shuichi, additional, Sime, Iveta, additional, Stirna, Valters, additional, Reinholde, Ilze, additional, Hansone, Silvija, additional, Kozlovska, Anita, additional, Romanova, Janina, additional, Klincare, Dace, additional, Pontaga, Natalja, additional, Dirmans, Igors, additional, Kalnins, Artis, additional, Upite, Dana, additional, Gersamija, Arcils, additional, Teleznikovs, Arturs, additional, Rozkova, Nadezda, additional, Safro, Jelena, additional, Anguera Camós, Ignasi, additional, Domenico Dallaglio, Paolo, additional, Salguero Bodes, Rafael, additional, Arnbas, Fernando, additional, Borrego, Luis, additional, Marco, Alvaro, additional, Jimenez, Javier Ramos, additional, Gómez-Doblas, Juan José, additional, Pérez Cabeza, Alejandro, additional, Ferreira Gonzålez, Ignacio, additional, Limeres Freire, Javier, additional, Lopez Grau, Merce, additional, Viñolas Prat, Xavier, additional, Moreno Weidmann, Zoraida, additional, Guerra Ramos, Jose Maria, additional, Alonso Martin, Maria Concepcion, additional, Campos Garcia, Bieito, additional, Mogro Carranza, Javier Mauricio, additional, Mendez Zurita, Francisco Javier, additional, Rodriguez Font, Enrique, additional, Gonzales Matos, Carlos Eduardo, additional, García Hernando, Víctor, additional, Lindholm, Carl-Johan, additional, Thulin, Jörgen, additional, Wallén, Håkan, additional, Hagwall, Kristina, additional, Eliasson, Ken, additional, Lundvall, Martin, additional, Olsson, Jens, additional, Kjellman, Björn, additional, Lind, Markus, additional, Johansson, Lars, additional, Svedberg, Niclas, additional, Berglund, Stefan, additional, Söderberg, Julia, additional, Zedigh, Christer, additional, Mooe, Thomas, additional, Axelsson, Mattias, additional, Binsell, Emil, additional, Huber, Daniel, additional, Müller, Christian, additional, Danier, Isabelle, additional, Kühne, Michael, additional, Okamura, Bernhard, additional, Schoepfer, Hadrien, additional, Simmen, Cornelia, additional, Reichlin, Tobias, additional, Chollet, Laurève, additional, Lam, Anna, additional, Wittmer, Severin, additional, Rickli, Hans, additional, Gall, Christian, additional, Hametner, Greta, additional, Intorp, Stephanie, additional, Luescher, Daniel, additional, Haegeli, Laurent, additional, Berg, Jan Christopher, additional, Ebrahimi, Ramin, additional, Auricchio, Angelo, additional, Crljenica, Carmela, additional, Moccetti, Tizziano, additional, Monti, Cristina, additional, Pasotti, Elena, additional, Petrova, Iveta, additional, Rossi, Mariagrazia, additional, Mach, François, additional, Namdar, Mehdi, additional, de Groot, Joris, additional, Proost, Virginnio, additional, Neefs, Joline, additional, Linz, Dominik, additional, van Stipdonk, Twan, additional, den Uijl, Dennis, additional, Alings, Marco, additional, Schaap, Jeroen, additional, Segers, Dolf, additional, Wouters, Noemi, additional, Bartels, Louis, additional, Tieleman, Robert, additional, Pisters, Ron, additional, de Vries, Tim, additional, Selig, Jaap, additional, Kuijper, Aaf, additional, Bot, Pieter, additional, Keijzers, Mitran, additional, Verdel, Gerardus, additional, Tukkie, Raymond, additional, van den Bos, Ewout, additional, Kauer, Floris, additional, Oemrawsingh, Rohit, additional, Stevenhagen, Jeroen, additional, van Es, Jan, additional, Lip, Gregory, additional, Gupta, Dhiraj, additional, Kotalczyk, Agnieszka, additional, Gunstone, Anthony, additional, Brixey, Richard David, additional, Gorog, Diana, additional, Dinarvand, Danial, additional, Gue, Ying, additional, Kanji, Rahim, additional, Memtsas, Vassilios, additional, Senior, Roxy, additional, Bioh, Gabriel, additional, Wong, Yuk-Ki, additional, and Child, Nick, additional

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2022
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