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Byline: K. Takao, H. Ogishi, H. Kimura, T. Ichida Effects of resin types and their silica contents were studied on corrosion behaviour of organic composite coated steel sheets. The following results were obtained. (1) High corrosion resistance of organic composite coated steel sheets is brought by preservation of corrosion products on the coating. (2) Types of resin and contents of silica strongly affect the corrosion resistance by changing the kind of corrosion products developed on organic composite coatings. Coating with hydrophilic resin shows good resistance with protective ZnC1.SUB.2.4Zn(OH).SUB.2 formation. However, coating with hydrophobic resin forms ZnO which retards the corrosion resistance.

Conclusions: These findings suggest that the down-regulation of interleukin (IL)-5 gene expression in collaboration with the suppression of histamine H(1) receptor (H1R) gene expression in the nasal mucosa provides the basis for better therapeutic effects of preseasonal prophylactic treatment with antihistamines in patients with seasonal allergic rhinitis caused by Japanese cedar pollen., Objectives: The effects of prophylactic administration of antihistamines on the expression of IL-5 and IL-33 mRNA in the nasal mucosa of the patients with pollinosis were investigated., Methods: Eight patients had already visited the hospital before the peak pollen period and started preseasonal prophylactic treatment with antihistamines. Seventeen patients who first visited the hospital during the peak pollen period were designated as the no treatment group. After local anesthesia, nasal mucosa was obtained by scraping the inferior concha with a small spatula during the peak pollen period., Results: During the peak pollen period, the expression of IL-5 mRNA, but not that of IL-33 mRNA, in the nasal mucosa of patients receiving preseasonal prophylactic treatment with antihistamines was significantly lower in comparison with that of patients without treatment. Moreover, there was a significant correlation between the expression of IL-5 mRNA and the nasal symptoms or the expression of H1R mRNA.