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In this paper, we introduce novel instructional approaches to engage students in using modelling with data to motivate and teach differential equations. Specifically, we introduce a pedagogical framework that will execute instructional modules to teach different solution techniques for differential equations through repositories and notebook environments during real-time instruction. Each of these teaching modules employs a literate programming approach that uses the notebook environment to explain the concepts in a natural language, such as English, interspersed with snippets of macros and traditional source code on a web browser. The pedagogical approach employed is reproducible and leads to openaccess material for students to motivate and teach differential equations efficiently. We will share examples of this framework applied to teaching advanced concepts such as machine learning and neural network approaches for solving ordinary and partial differential equations as well as estimating parameters in these equations for given datasets. More details of the work can be accessed from . [ABSTRACT FROM AUTHOR]

In late 2019, the emergence of COVID-19 in Wuhan, China, led to the implementation of stringent measures forming the zero-COVID policy aimed at eliminating transmission. Zero-COVID policy basically aimed at completely eliminating the transmission of COVID-19. However, the relaxation of this policy in late 2022 reportedly resulted in a rapid surge of COVID-19 cases. The aim of this work is to investigate the factors contributing to this outbreak using a new SEIR-type epidemic model with time-dependent level of immunity. Our model incorporates a time-dependent level of immunity considering vaccine doses administered and time-post-vaccination dependent vaccine efficacy. We find that vaccine efficacy plays a significant role in determining the outbreak size and maximum number of daily infected. Additionally, our model considers under-reporting in daily cases and deaths, revealing their combined effects on the outbreak magnitude. We also introduce a novel Physics Informed Neural Networks (PINNs) approach which is extremely useful in estimating critical parameters and helps in evaluating the predictive capability of our model. [ABSTRACT FROM AUTHOR]