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17 results on '"Ogura, Satomi"'

3. Hydrophobicity Tuning of Cationic Polyaspartamide Derivatives for Enhanced Antisense Oligonucleotide Delivery

Author

Yum, Jongmin, primary, Aulia, Fadlina, additional, Kamiya, Keisuke, additional, Hori, Mao, additional, Qiao, Nan, additional, Kim, Beob Soo, additional, Naito, Mitsuru, additional, Ogura, Satomi, additional, Nagata, Tetsuya, additional, Yokota, Takanori, additional, Uchida, Satoshi, additional, Obika, Satoshi, additional, Kim, Hyun Jin, additional, and Miyata, Kanjiro, additional

Published
2024
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5. In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers

Author

Watanabe, Sumiyo, Hayashi, Kotaro, Toh, Kazuko, Kim, Hyun Jin, Liu, Xueying, Chaya, Hiroyuki, Fukushima, Shigeto, Katsushima, Keisuke, Kondo, Yutaka, Uchida, Satoshi, Ogura, Satomi, Nomoto, Takahiro, Takemoto, Hiroyasu, Cabral, Horacio, Kinoh, Hiroaki, Tanaka, Hiroyoshi Y., Kano, Mitsunobu R., Matsumoto, Yu, Fukuhara, Hiroshi, Uchida, Shunya, Nangaku, Masaomi, Osada, Kensuke, Nishiyama, Nobuhiro, Miyata, Kanjiro, and Kataoka, Kazunori

Published
2019
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6. Unit polyion complex (uPIC) nanocarrier for siRNA delivery to glioblastoma and pancreatic cancer, Cancer Science

Author

Watanabe, Sumiyo, Hayashi, Kotaro, Tho, Kayoko, Kim, Hunjin, Chaya, Hiroyuki, Fukushima, Shigeto, Keisuke Katsushima, Kondo, Yutaka, Ogura, Satomi, Cabral, Horacio, Kensuke, Osada, Nishiyama, Nobuhiro, Miyata, Kanjiro, Kataoka, Kazunori, Watanabe, Sumiyo, Hayashi, Kotaro, Tho, Kayoko, Kim, Hunjin, Chaya, Hiroyuki, Fukushima, Shigeto, Keisuke Katsushima, Kondo, Yutaka, Ogura, Satomi, Cabral, Horacio, Kensuke, Osada, Nishiyama, Nobuhiro, Miyata, Kanjiro, and Kataoka, Kazunori

Abstract

There are critical issues in siRNA therapeutics, as follows, 1) siRNA is immediately degraded in extracellular milieu, such as bloodstream, 2) the size of siRNA is -5nm, so siRNA is readily excreted from the kidney to the urine, and 3) the negative charge of siRNA repels the negatively charged cell membrane, inhibiting the cellular uptake of siRNA. Thus, many previous studies have encapsulated siRNA into -100 nm-sized nanoparticles to stabilize it. However, refractory cancers have tight barriers that prevent the penetration of such nanoparticles into cancer cells. To overcome these hurdles, a new type of siRNA nanocarrier is developed for the cancer-targeted siRNA delivery, using a Y-shaped block catiomer (YBC) with precisely regulated chain length and precisely neutralize their charges. Indeed, two YBCs are bound to a single siRNA in the bloodstream, generating a dynamic polyin-pair, termed uPIC. Owing to both high stability in the bloodstream and ultra-small (or optimal) size (-18 nm) to penetrate fibrotic tissues, uPIC efficiently delivers siRNA into murine models of fibrotic pancreatic cancer and glioblastoma, exerting the significant anticancer activity in vivo.

Published
2022

8. Antisense Oligonucleotides: A 50‐nm‐Sized Micellar Assembly of Thermoresponsive Polymer‐Antisense Oligonucleotide Conjugates for Enhanced Gene Knockdown in Lung Cancer by Intratracheal Administration (Adv. Therap. 2/2020)

Author

Kim, Beob Soo, primary, Osawa, Shigehito, additional, Naito, Mitsuru, additional, Ogura, Satomi, additional, Kamegawa, Rimpei, additional, Ishida, Hiroki, additional, Kim, Hyun Jin, additional, Uchida, Satoshi, additional, and Miyata, Kanjiro, additional

Published
2020
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16. Antiferromagnetic Ordering in the Single-Component Molecular Conductor [Pd(tmdt)2]

Author

Ogura, Satomi, Idobata, Yuki, Zhou, Biao, Kobayashi, Akiko, Takagi, Rina, Miyagawa, Kazuya, Kanoda, Kazushi, Kasai, Hidetaka, Nishibori, Eiji, Satoko, Chikatoshi, and Delley, Bernard

Abstract

Crystals of [Pd(tmdt)2] (tmdt = trimethylenetetrathiafulvalenedithiolate) were prepared in order to investigate their physical properties. The electrical resistivity of [Pd(tmdt)2] was measured on single crystals using two-probe methods and showed that the room-temperature conductivity was 100 S·cm–1. The resistivity behaviors implied that [Pd(tmdt)2] was a semimetal at approximately room temperature and became narrow-gap semiconducting as the temperature was decreased to the lowest temperature. X-ray structural studies on small single crystals of [Pd(tmdt)2] at temperatures of 20–300 K performed using synchrotron radiation at SPring-8 showed no distinct structural change over this temperature region. However, small anomalies were observed at approximately 100 K. Electron spin resonance (ESR) spectra were measured over the temperature range of 2.7–301 K. The ESR intensity increased as the temperature decreased to 100 K and then decreased linearly as the temperature was further decreased to 50 K, where an abrupt decrease in the intensity was observed. To investigate the magnetic state, 1H nuclear magnetic resonance (NMR) measurements were performed in the temperature range of 2.5–271 K, revealing broadening below 100 K. The NMR relaxation rate gradually increased below 100 K and formed a broad peak at approximately 50 K, followed by a gradual decrease down to the lowest temperature. These results suggest that most of the sample undergoes the antiferromagnetic transition at approximately 50 K with the magnetic ordering temperatures distributed over a wide range up to 100 K. These electric and magnetic properties of [Pd(tmdt)2] are quite different from those of the single-component molecular (semi)metals [Ni(tmdt)2] and [Pt(tmdt)2], which retain their stable metallic states down to extremely low temperatures. The experimental results and the band structure calculations at the density functional theory level showed that [Pd(tmdt)2] may be an antiferromagnetic Mott insulator with a strong electron correlation.

Published
2016
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17. Single-component Magnetic Molecular Conductor [Fe(dmdt)2] (dmdt: dimethyltetrathiafulvalenedithiolate).

Author

Biao Zhou, Ogura, Satomi, Kato, Noriko, Idobata, Yuki, Kobayashi, Akiko, and Kobayashi, Hayao

Abstract

Molecular metal complexes with interactions between localized spins and conduction electrons are expected to show interesting electronic and magnetic properties. We prepared magnetic molecular conductors of iron complexes with extended TTF ligands and investigated their crystal structures and electronic and magnetic properties, from which we concluded that the single-component molecular iron complex has the dimeric form of [Fe(dmdt)2]. [ABSTRACT FROM AUTHOR]

Published
2013
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