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Your search keyword '"Oh, H.‐K."' showing total 194 results
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194 results on '"Oh, H.‐K."'

1. Lymph node metastasis following chemoradiotherapy in advanced rectal cancer: ypT2-focused analyses of total mesorectal excision specimens.

Author

Singhi, A. N., Lee, T.-G., Ahn, H.-M., Shin, H.-R., Choi, M. J., Jo, M. H., Oh, H.-K., Kim, D.-W., and Kang, S.-B.

Subjects
LYMPHATIC metastasis, RECTAL cancer, MEDICAL sciences, DISEASE risk factors, ODDS ratio
Abstract

Background: Non-radical management is an option for good responders to neoadjuvant chemoradiotherapy in mid-to-low rectal cancer. This study aimed to analyze risk factors for lymph node metastasis in patients with ypT2 rectal cancer, exploring the possibility of non-radical management. Methods: We included patients with ypT2 rectal cancer who received neoadjuvant chemoradiotherapy followed by total mesorectal excision between January 2004 and December 2022. Clinicopathological parameters were evaluated to identify risk factors for lymph node metastasis. Results: Among the 198 patients, 158 (79.8%) had ypT2N0 and 40 (20.2%) had ypT2N+. In univariable analyses, the risk factors of lymph node metastasis were perineural invasion (48.0% vs. 16.3% without perineural invasion, P < 0.001), female sex (30.0% vs. 14.8% with male sex, P = 0.011), and clinically positive nodes after neoadjuvant chemoradiotherapy (32.6% vs. 16.4% with negative nodes, P = 0.017). These factors were confirmed as independent risk factors in multivariable analyses: perineural invasion (odds ratio [OR]: 4.50; 95% confidence interval [CI]: 1.79–11.29; P < 0.001), female sex (OR: 2.62; 95% CI: 1.24–5.52; P = 0.012) and clinical node involvement after neoadjuvant chemoradiotherapy (OR: 2.28; 95% CI: 1.03–5.05; P = 0.012). The rate of lymph node metastasis in patients with ypT2 rectal cancer without any of these three risk factors was 12.5%. Conclusions: This study revealed a high probability of lymph node metastasis in patients with ypT2 rectal cancer, even in the absence of identifiable risk factors. We confirm that lymph node metastasis should be considered in ypT2 rectal cancer. [ABSTRACT FROM AUTHOR]

Published
2024
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2. 48P Long-term clinical outcomes after the second metastasectomy in patients (pts) with resected metastatic colorectal cancer (mCRC)

Author

Choi, S., primary, Kang, M., additional, Kim, J-W., additional, Kim, J.W., additional, Hwang, Y., additional, Jeon, J.H., additional, Oh, H-K., additional, Lee, H.W., additional, Cho, J.Y., additional, Kim, D-W., additional, Cho, S., additional, Kim, J.H., additional, Kim, K., additional, Kang, S-B., additional, Jheon, S., additional, and Lee, K-W., additional

Published
2022
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19. Predictors of permanent stoma creation in patients with mid or low rectal cancer: results of a multicentre cohort study with preoperative evaluation of anal function.

Author

Kim, S., Kim, M. H., Oh, J. H., Jeong, S.‐Y., Park, K. J., Oh, H.‐K., Kim, D.‐W., and Kang, S.‐B.

Subjects
RECTAL cancer, ILEOSTOMY, ABDOMINOPERINEAL resection, COHORT analysis, CANCER patients
Abstract

Aim: Preoperative factors predictive of permanent stoma creation were investigated in a long‐term follow‐up of patients with mid or low rectal cancer. Method: We included patients who underwent radical resection for mid or low rectal cancer with available data for preoperative anal function measured by manometry and Faecal Incontinence Severity Index questionnaire between January 2005 and December 2015 in three tertiary referral hospitals. A permanent stoma was defined as a stoma present until the patient's last follow‐up visit or death. Preoperative factors that predicted permanent stoma creation were analysed. Results: Over a median follow‐up of 57.4 months (range 12–143 months), a permanent stoma was created in 144/577 (25.0%) patients, including 89 (15.4%) who underwent abdominoperineal resection, one (0.2%) who underwent Hartmann's operation without reversal, 15 (2.6%) with a diverting ileostomy at the time of initial sphincter‐preserving surgery without undergoing stoma reversal, and 39 (6.8%) who underwent permanent ileostomy formation after sphincter‐preserving surgery. Patients with permanent stoma creation had a shorter tumour distance from the anal verge (P < 0.001), larger tumour size (P = 0.020) and higher preoperative Faecal Incontinence Severity Index score (P = 0.020). On multivariable analysis, tumour distance from the anal verge predicted permanent stoma formation (relative risk 0.53 per centimetre increase; 95% confidence interval 0.46–0.60; P < 0.001) but preoperative anal function did not. Conclusion: Tumour distance from the anal verge was the only preoperative determinant of permanent stoma creation in rectal cancer patients. These data may help mid and low rectal cancer patients understand the need for permanent stoma. [ABSTRACT FROM AUTHOR]

Published
2020
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22. Comparative and multimodal analysis of the EGFR, HER2, c-MYC, and MET copy number alteration using in situ hybridization in Korean colorectal cancer patients with integration of array-based copy number data from The Cancer Genome Atlas

Author

Kwak, Y., primary, Yun, S., additional, Nam, S.K., additional, Seo, A.N., additional, Lee, K.S., additional, Oh, H-K., additional, Kim, D.W., additional, Kang, S.B., additional, Kim, W.H., additional, and Lee, H.S., additional

Published
2017
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25. Assessment of Intellectual and Visuo Spatial Abilities in Children and Adults with Williams Syndrome

Author

Nunes, M M, Honjo, R S, Dutra, R L, Amaral, V S, Amaral, V A S, Oh, H K, Bertola, D R, Albano, L Μ J, Assumpção Júnior, F Β, Kim, C A, and Teixeira, M C T V

Subjects
Williams Syndrome, cognition, assessment, Intelligence, inteligencia, evaluación, Alteración genética, visual-spatial abilities, investigación cuantitativa, habilidades visuoespaciales, cognición, Síndrome de Williams, Genetic Disorder, biomarcador, Quantitative Research, Biomarkers
Abstract

The Williams-Beuren syndrome (SWB), also known as Williams syndrome, is a contiguous gene deletion of the region 7q.11.23. The main clinical characteristics are typical faces, supravalvular aortic stenosis, failure to thrive, short stature, transient neonatal hypercalcemia, delayed language, friendly personality, hyperacusis and intellectual disability. The diagnosis of SWB is confirmed by the detection of micro deletion by different techniques of molecular cytogenetics, FISH, MLPA or polymorphic markers. This study assessed the verbal intelligence quotient (IQ) and performance and visuo-spatial skills in children and adults with WBS. The composed group was of 31 WBS patients (19 M and 12 F), whose ages ranged from 9 to 26 years (M 14.45 y). All patients had the diagnosis confirmed molecularly. The tests used were the WISC-III, WAIS-III and Rey-Osterrieth Complex Figure Test. The results indicated a total IQ ranged from 51 to 86 (M 63): 22 with mild intellectual disability, 4 with moderate intellectual disability, 4 borderlines and 1 below the normal media. All patients had marked visual-spatial deficits. The results suggest nonverbal reasoning, visuo-spatial perception, spatial representation, working memory, motor planning and executive functions are very affected in this group. El síndrome de Williams-Beuren (SWB), también conocido como síndrome de Williams, es un síndrome de deleción de genes contiguos de la región 7q.11.23. Se caracteriza por dimorfismo facial típico asociado a anomalías cardiovasculares, personalidad amigable, hiperacusia y deficiencia intelectual. El diagnóstico del SWB es confirmado por la detección de microdeleción a partir de las diferentes técnicas de citogenética molecular: FISH, marcadores polimórficos o MLPA. Este estudio evaluó el cociente intelectual verbal y manipulativo, así como las habilidades visuoespaciales en niños y adultos con SWB. El grupo estuvo formado por 31 pacientes con SWB (19 de sexo masculino y 12 de sexo femenino), cuyas edades variaron entre 9 y 26 años (media 14.45 años). Todos los pacientes tenían el diagnóstico confirmado molecularmente. Los test utilizados fueron las escalas WISC-III, WAIS-III y el Test Figuras Complejas Rey-Osterrieth. Los resultados indicaron un cociente intelectual que osciló de 51 a 86 (media 63), distribuido así: 22 con deficiencia intelectual leve, 4 con deficiencia intelectual moderada, 4 limítrofes, 1 en la media inferior. Todos los pacientes presentaron déficit visuoespacial. Los resultados sugieren que el razonamiento no verbal, la percepción visuoespacial, la representación espacial, la memoria de trabajo, la planificación motora y las funciones ejecutivas están muy comprometidos en el grupo estudiado.

Published
2013

45. Effects of Alendronate on A Disintegrin and Metalloproteinase with Thrombospondin Motifs Expression in the Developing Epiphyseal Cartilage in Rats

Author

Kim, M. S., primary, Kim, J. H., additional, Lee, M. R., additional, Kang, J. H., additional, Kim, H. J., additional, Ko, H. M., additional, Choi, C. H., additional, Jung, J. Y., additional, Koh, J. T., additional, Kim, B. K., additional, Oh, H. K., additional, Kim, W. J., additional, Lee, E. J., additional, and Kim, S. H., additional

Published
2009
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