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8. Establishment of an Easy and Convenient Anti-SARS-CoV-2 Neutralizing Antibodies Test Flow Starting from Community Pharmacies: Expansion of Pharmacy Functions Suitable During the Novel Coronavirus Era

Author

Niki, Kazuyuki, primary, Tada, Kozo, additional, Suezawa, Katsumi, additional, Kasashima, Tomoko, additional, Fujisue, Shin, additional, Seichi, Eri, additional, Nakahara, Miki, additional, Ohara, Yoshiko, additional, Yoshida, Akiko, additional, and Ueda, Mikiko, additional

Published
2022
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13. Novel per‐oral endoscopic myotomy method preserving oblique muscle using two penetrating vessels as anatomic landmarks reduces postoperative gastroesophageal reflux

Author

Tanaka, Shinwa, primary, Toyonaga, Takashi, additional, Kawara, Fumiaki, additional, Watanabe, Daisuke, additional, Hoshi, Namiko, additional, Abe, Hirohumi, additional, Ariyoshi, Ryusuke, additional, Ohara, Yoshiko, additional, Takao, Toshitatsu, additional, Morita, Yoshinori, additional, Umegaki, Eiji, additional, and Kodama, Yuzo, additional

Published
2019
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15. Tu1035 DEVELOPMENT AND VALIDITY EVIDENCE FOR A VIDEO ASSESSMENT TOOL OF ENDOSCOPIC SUBMUCOSAL DISSECTION FOR GASTRIC NEOPLASMS

Author

Takao, Madoka, primary, Bilgic, Elif, additional, Waschke, Kevin A., additional, Kaneva, Pepa, additional, Endo, Satoshi, additional, Ohara, Yoshiko, additional, Kawara, Fumiaki, additional, Tanaka, Shinwa, additional, Ishida, Tsukasa, additional, Morita, Yoshinori, additional, Toyonaga, Takashi, additional, Umegaki, Eiji, additional, and Fried, Gerald M., additional

Published
2018
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19. Clinical outcomes of deep invasive submucosal colorectal cancer after ESD

Author

Watanabe, Daisuke, primary, Toyonaga, Takashi, additional, Ooi, Makoto, additional, Yoshizaki, Tetsuya, additional, Ohara, Yoshiko, additional, Tanaka, Shinwa, additional, Kawara, Fumiaki, additional, Ishida, Tsukasa, additional, Morita, Yoshinori, additional, Umegaki, Eiji, additional, Matsuda, Takeru, additional, Sumi, Yasuo, additional, Nishio, Mari, additional, Yokozaki, Hiroshi, additional, and Azuma, Takeshi, additional

Published
2017
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21. Individual testimonies to nursing care after the atomic bombing of Hiroshima in 1945

Author

Yuko, Matsunari, Matsunari, Yuko, Sachie, Nozawa, Nozawa, Sachie, Kayo, Sakata, Sakata, Kayo, Yoshiko, Ohara, Ohara, Yoshiko, Keiko, Takahashi, Takahashi, Keiko, Yukiko, Hyakuta, Hyakuta, Yukiko, Mutsumi, Ueda, Ueda, Mutsumi, Ryoko, Ohara, Ohara, Ryoko, Toshio, Kobayashi, Kobayashi, Toshio, Noriyuki, Kawano, Kawano, Noriyuki, Kazumi, Mizumoto, and Mizumoto, Kazumi

Subjects
Emergency Medical Services, Nuclear Weapons, Nursing staff, social sciences, Nurse's Role, humanities, Life Change Events, Nursing care, Japan, Nursing, Humans, Nursing Care, Radiation Injuries, Psychology, General Nursing, Nuclear Warfare
Abstract

Aim: The aim of the present research is to clarify the nursing care conducted just before and after the atomic bombing of Hiroshima in 1945. Methods: Five surviving nurses, who were registered nursing staff at that time in Hiroshima, offered to participate in this research. Individual interviews were conducted in order to obtain the information concerning the nursing activities in the disaster-stricken areas. The collected information was collated with the documents with regard to the atomic bombing in Hiroshima, and compared with the current studies concerning nursing in disaster. Findings: The five nurses who participated in the study made it clear that, from the day of the bombing, nursing care activities changed moment by moment according to the condition of the radiation victims, the stricken areas and the relief systems. Under these circumstances, the nurses tried to help the victims of the bombing by devising anything useful for nursing care. Conclusion: The research participants left their messages, pointing out that nurses' mental attitude to those in front of them as patients is one of the most important things to keep in mind following any major disaster.

Published
2008

23. Su1225 Utility and Usefulness of Gastric Endscopic Submucosal Dissection (ESD) for Elderly Patients Older Than 80 Years Old

Author

Sakaguchi, Hiroya, primary, Ohara, Yoshiko, additional, Toyonaga, Takashi, additional, Matsuoka, Kouki, additional, Sako, Tomoya, additional, Ariyoshi, Ryusuke, additional, Abe, Hirofumi, additional, Kawara, Fumiaki, additional, Tanaka, Shinwa, additional, Morita, Yoshinori, additional, Umegaki, Eiji, additional, and Azuma, Takeshi, additional

Published
2017
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25. Efficacy of a new hemostatic forceps during gastric endoscopic submucosal dissection: A prospective randomized controlled trial

Author

Tanaka, Shinwa, primary, Toyonaga, Takashi, additional, Morita, Yoshinori, additional, Ishida, Tsukasa, additional, Hoshi, Namiko, additional, Grimes, Kevin L, additional, Ohara, Yoshiko, additional, Yoshizaki, Tetsuya, additional, Kawara, Fumiaki, additional, Umegaki, Eiji, additional, and Azuma, Takeshi, additional

Published
2017
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27. Efficacy of a Novel Narrow Knife with Water Jet Function for Colorectal Endoscopic Submucosal Dissection

Author

Yoshida, Naohisa, primary, Toyonaga, Takashi, additional, Murakami, Takaaki, additional, Hirose, Ryohei, additional, Ogiso, Kiyoshi, additional, Inada, Yutaka, additional, Rani, Rafiz Abdul, additional, Naito, Yuji, additional, Kishimoto, Mitsuo, additional, Ohara, Yoshiko, additional, Azuma, Takeshi, additional, and Itoh, Yoshito, additional

Published
2017
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28. Gastric plexiform fibromyxoma resected by endoscopic submucosal dissection after observation of chronological changes: A case report

Author

Kawara, Fumiaki, primary, Tanaka, Shinwa, additional, Yamasaki, Takashi, additional, Morita, Yoshinori, additional, Ohara, Yoshiko, additional, Okabe, Yoshihiro, additional, Hoshi, Namiko, additional, Toyonaga, Takashi, additional, Umegaki, Eiji, additional, Yokozaki, Hiroshi, additional, Hirose, Takanori, additional, and Azuma, Takeshi, additional

Published
2017
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29. Efficacy of forced coagulation with low high-frequency power setting during endoscopic submucosal dissection

Author

Ishida, Tsukasa, primary, Toyonaga, Takashi, additional, Ohara, Yoshiko, additional, Nakashige, Tadao, additional, Kitamura, Yasuaki, additional, Ariyoshi, Ryusuke, additional, Takihara, Hiroshi, additional, Baba, Shinichi, additional, Yoshizaki, Tetsuya, additional, Kawara, Fumiaki, additional, Tanaka, Shinwa, additional, Morita, Yoshinori, additional, Umegaki, Eiji, additional, Hoshi, Namiko, additional, and Azuma, Takeshi, additional

Published
2017
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31. Endoscopic submucosal dissection of cecal lesions in proximity to the appendiceal orifice

Author

Jacob, Harold, additional, Toyonaga, Takashi, additional, Ohara, Yoshiko, additional, Tsubouchi, Eiji, additional, Takihara, Hiroshi, additional, Baba, Shinichi, additional, Yoshizaki, Tetsuya, additional, Kawara, Fumiaki, additional, Tanaka, Shinwa, additional, Ishida, Tsukasa, additional, Hoshi, Namiko, additional, Morita, Yoshinori, additional, Umegaki, Eiji, additional, and Azuma, Takeshi, additional

Published
2016
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34. Mo1071 The Usefulness of a Novel Slim Type Flush Knife-BT Compared to the Conventional Flush Knife-BT

Author

Ohara, Yoshiko, primary, Toyonaga, Takashi, additional, Tanaka, Shinwa, additional, Ishida, Tsukasa, additional, Ariyoshi, Ryusuke, additional, Abe, Hirofumi, additional, Yoshizaki, Tetsuya, additional, Kawara, Fumiaki, additional, Kitamura, Yasuaki, additional, Morita, Yoshinori, additional, Umegaki, Eiji, additional, and Azuma, Takeshi, additional

Published
2016
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35. Feasibility and safety of endoscopic submucosal dissection for lesions involving the ileocecal valve

Author

Yoshizaki, Tetsuya, additional, Toyonaga, Takashi, additional, Tanaka, Shinwa, additional, Ohara, Yoshiko, additional, Kawara, Fumiaki, additional, Baba, Shinichi, additional, Tsubouchi, Eiji, additional, Takihara, Hiroshi, additional, Watanabe, Daisuke, additional, Ishida, Tsukasa, additional, Hoshi, Namiko, additional, Morita, Yoshinori, additional, Umegaki, Eiji, additional, and Azuma, Takeshi, additional

Published
2016
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38. Peranal endoscopic myectomy (PAEM) for rectal lesions with severe fibrosis and exhibiting the muscle-retracting sign.

Author

Takashi Toyonaga, Yoshiko Ohara, Shinichi Baba, Hiroshi Takihara, Manabu Nakamoto, Hitoshi Orita, Junji Okuda, Toyonaga, Takashi, Ohara, Yoshiko, Baba, Shinichi, Takihara, Hiroshi, Nakamoto, Manabu, Orita, Hitoshi, and Okuda, Junji

Subjects
MYOMECTOMY, RECTUM, FIBROSIS, WOUNDS & injuries, SMOOTH muscle surgery, CANCER invasiveness, HUMAN dissection, RECTUM tumors, SMOOTH muscle, VETERINARY dissection, RETROSPECTIVE studies
Abstract

Background: Although endoscopic submucosal dissection has enabled complete tumor resection and accurate pathological assessment in a manner that is less invasive than surgery, the complete resection of lesions with severe fibrosis in the submucosal layer and exhibiting the muscle-retracting sign is often difficult. We have devised a new method, peranal endoscopic myectomy (PAEM), for rectal lesions with severe fibrosis, in which dissection is performed between the inner circular and outer longitudinal muscles, and have examined the usefulness and safety of this new technique.Methods: All of the patients who underwent PAEM in our hospital and affiliated hospitals between July 2015 and June 2017 were retrospectively reviewed.Results: 10 rectal lesions were treated with PAEM. En bloc resection with a negative vertical margin was achieved in eight patients (80 %), whose lesions were mucosal (n = 2), shallow submucosal (n = 1), deep submucosal (n = 4), and muscle invasive (n = 1). The clinical course of all patients after PAEM was favorable. In patients who underwent additional surgery, anus preservation was achieved on the basis of the pathological results from PAEM.Conclusions: PAEM for lesions with severe fibrosis exhibiting the muscle-retracting sign appears to be both safe and useful. [ABSTRACT FROM AUTHOR]

Published
2018
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39. Clinical outcomes of endoscopic submucosal dissection for superficial esophageal neoplasms extending to the cervical esophagus.

Author

Ryusuke Ariyoshi, Hirofumi Abe, Yoshiko Ohara, Tsukasa Ishida, Yoshinori Morita, Eiji Umegaki, Takeshi Azuma, Takashi Toyonaga, Shinwa Tanaka, Fumiaki Kawara, Ariyoshi, Ryusuke, Abe, Hirofumi, Ohara, Yoshiko, Ishida, Tsukasa, Morita, Yoshinori, Umegaki, Eiji, Azuma, Takeshi, Toyonaga, Takashi, Tanaka, Shinwa, and Kawara, Fumiaki

Subjects
ESOPHAGEAL tumors, PHARYNGEAL muscles, ANATOMY
Abstract

Background: The feasibility and safety of endoscopic submucosal dissection (ESD) for superficial esophageal neoplasms extending to the cervical esophagus currently remain unknown because of the limited number of cases. We aimed to clarify the clinical outcomes of these cases.Methods: This was a case series study conducted at a single institution that enrolled 26 consecutive patients with superficial esophageal neoplasms extending to the cervical esophagus who underwent ESD between July 2003 and December 2015.Results: En bloc and complete resection rates were both 100 % and no major intraprocedural complications occurred. Thirteen patients were treated with prophylactic steroid therapy. The incidence of postoperative stricture in patients with a circumferential mucosal defect of more than three-quarters was 72.7 %. Four patients required entire circumferential resection, with perforation occurring after endoscopic balloon dilation (EBD) in two and EBD being required for more than 1 year in the other two.Conclusions: ESD including the cervical esophagus is technically feasible. Circumferential resection may cause refractory postoperative stricture or post-EBD perforation, so needs to be avoided where possible. [ABSTRACT FROM AUTHOR]

Published
2018
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40. シリョウ エノ サクサン テンカ ガ チョウナイ ケンキセイ サイキンスウ ニ オヨボス エイキョウ

Author

Ohara, Yoshiko and Kamisoyama, Hiroshi

Subjects
acetic acid, digestive, oral, and skin physiology, anaerobic, laying hen, bacteria, digestive system, intestine
Abstract

application/pdf, Experimental diets containing 1 or 2 % acetic acid were fed to Single comb White Leghorn hens ad libitum and collected the contents in jejunum and ileum. Contents were diluted and dilution were cultured for 48 hours at 38 °C in anaerobic condition. The colonies of anaerobic bacteria in jejunum were decreased with addition of acetic acid whereas that in ileum was not changed. These results suggested the possibility that added acetic acid was absorbed at upper part of intestine so acetic acid showed no effect at ileum, lower part of intestine., 単冠白色レグホーン種の雌に酢酸を1および2%添加した飼料を給与し、腸内嫌気性菌に及ぼす影響を調べた。空腸の内容物中に生息する嫌気性菌数は酢酸の添加によって減少する傾向が見られ、1%添加の方が影響の程度は大きくなった。また回腸内容物中の嫌気性細菌数においては酢酸添加の影響はみられず、添加給与した酢酸は腸管の上部で吸収される可能性が示唆された。

Published
2001

41. Risk of stricture after endoscopic submucosal dissection for large rectal neoplasms

Author

Ohara, Yoshiko, additional, Toyonaga, Takashi, additional, Tanaka, Shinwa, additional, Ishida, Tsukasa, additional, Hoshi, Namiko, additional, Yoshizaki, Tetsuya, additional, Kawara, Fumiaki, additional, Lui, Ka, additional, Tepmalai, Kanokkan, additional, Damrongmanee, Alisara, additional, Nagata, Mitsuru, additional, Morita, Yoshinori, additional, Umegaki, Eiji, additional, and Azuma, Takeshi, additional

Published
2015
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43. Disseminated nocardiosis during systemic steroid therapy for the prevention of esophageal stricture after endoscopic submucosal dissection

Author

Ishida, Tsukasa, primary, Morita, Yoshinori, additional, Hoshi, Namiko, additional, Yoshizaki, Tetsuya, additional, Ohara, Yoshiko, additional, Kawara, Fumiaki, additional, Tanaka, Sinwa, additional, Yamamoto, Yuki, additional, Matsuo, Hiroo, additional, Iwata, Kentaro, additional, Toyonaga, Takashi, additional, and Azuma, Takeshi, additional

Published
2014
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46. Feasibility and safety of endoscopic submucosal dissection for lesions involving the ileocecal valve.

Author

Tetsuya Yoshizaki, Takashi Toyonaga, Shinwa Tanaka, Yoshiko Ohara, Fumiaki Kawara, Shinichi Baba, Eiji Tsubouchi, Hiroshi Takihara, Daisuke Watanabe, Tsukasa Ishida, Namiko Hoshi, Yoshinori Morita, Eiji Umegaki, Takeshi Azuma, Yoshizaki, Tetsuya, Toyonaga, Takashi, Tanaka, Shinwa, Ohara, Yoshiko, Kawara, Fumiaki, and Baba, Shinichi

Subjects
RECTAL cancer treatment, TUMOR treatment, ENDOSCOPIC surgery, DISSECTION, TISSUE wounds, THERAPEUTICS, ONCOLOGIC surgery, ILEUM surgery, ADENOMA, ANTHROPOMETRY, CANCER, CANCER relapse, CANCER invasiveness, COMPARATIVE studies, ILEUM, RESEARCH methodology, MEDICAL cooperation, RESEARCH, PILOT projects, EVALUATION research, STENOSIS, TREATMENT effectiveness, CECUM, TUMORS
Abstract

Background and Study Aim: Endoscopic submucosal dissection (ESD) has been applied to treat early colorectal cancers. The aim of this study was to clarify the clinical course of ESD for lesions involving the ileocecal valve (ICV) by evaluating the successful resection rates, and the risk and frequency of adverse events.Patients and Methods: The outcome of ESD on 38 ICV lesions was compared with the outcome of 132 cecal lesions that did not involve the ICV or appendiceal orifice during the same study period. The factors related to longer procedure time, postoperative stricture development, and tumor recurrence were investigated for ESD of ICV lesions.Results: There was no significant difference between the ICV and non-ICV groups in the en block resection rates. The median procedure time was significantly longer in the ICV group than in the non-ICV group, with a point estimate of the difference of 37 minutes (95 % confidence interval [CI] 20.00 to 56.00; P  < 0.01). None of the patients developed symptomatic post-ESD stricture or tumor recurrence. ESD procedure duration was ≥ 120 minutes in 16 lesions and < 120 minutes in 22 lesions of the ICV group. A specimen diameter of ≥ 40 mm and tumor extension into terminal ileum were factors related to a longer procedure time (odds ratio [OR] 8.40, 95 %CI 1.53 to 46.10, P = 0.01; OR 10.60, 95 %CI 2.17 to 51.40, P  < 0.01, respectively).Conclusions: ICV lesions can be resected by ESD without major adverse events or causing symptomatic stricture development. However, ESD for ICV lesions should be performed only by expert endoscopists, as the procedure requires accomplished endoscopic skill and experience. [ABSTRACT FROM AUTHOR]

Published
2016
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47. Risk of stricture after endoscopic submucosal dissection for large rectal neoplasms.

Author

Yoshiko Ohara, Takashi Toyonaga, Shinwa Tanaka, Tsukasa Ishida, Namiko Hoshi, Tetsuya Yoshizaki, Fumiaki Kawara, Ka Luen Lui, Kanokkan Tepmalai, Damrongmanee, Alisara, Nagata, Mitsuru, Yoshinori Morita, Eiji Umegaki, Takeshi Azuma, Ohara, Yoshiko, Toyonaga, Takashi, Tanaka, Shinwa, Ishida, Tsukasa, Hoshi, Namiko, and Yoshizaki, Tetsuya

Subjects
RECTAL surgery, INTESTINAL mucosa, ADENOCARCINOMA, ADENOMA, BOWEL obstructions, LONGITUDINAL method, RECTUM tumors, LOGISTIC regression analysis, SURGICAL complications, TREATMENT effectiveness, RETROSPECTIVE studies, DIAGNOSIS, SURGERY
Abstract

Background and Study Aims: Improvements in the endoscopic submucosal dissection (ESD) technique have made circumferential ESD in the rectum possible. However, little is known about the clinical course after extensive ESD in the rectum. The aim of this study was to determine the stricture risk in the rectum after total or subtotal circumferential ESD.Patients and Methods: A total of 69 patients with 69 rectal tumors that required ≥ 75 % circumferential resection were identified at Kobe University Hospital and an affiliated hospital between April 2005 and May 2014. Among the patients, 61 were available for evaluation of stricture development, either by follow-up colonoscopy or by surgical specimens. The rate and possible risk factors of post-ESD strictures were investigated.Results: Post-ESD rectal strictures developed in 12 patients (19.7 %). Patients who underwent total circumferential ESD developed a stricture (5/7, 71.4 %) more frequently than those with subtotal (≥ 90 %) ESD (7/16, 43.8 %). Patients undergoing an ESD procedure that involved < 90 % of the circumference did not develop strictures. The strictures were membranous or < 10 mm long in all cases. Of the patients with stricture, 11 received endoscopic balloon dilation and one received bougie with short-caliber-tip transparent hood; all strictures improved following dilation therapy. Statistical analysis revealed that ≥ 90 % circumferential resection was an independent risk factor for stricture, whereas morphology and size were not.Conclusions: Patients who underwent total or subtotal circumferential ESD of a rectal tumor had a high risk of stricture formation. Dilation helped to alleviate the stenosis.Study registered at University Hospital Medical Information Network (UMIN 000016559). [ABSTRACT FROM AUTHOR]

Published
2016
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