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9. Immune responses in humans after 60 days of confinement

Author

Schmitt, D. A, Peres, C, Sonnenfeld, G, Tkackzuk, J, Arquier, M, Mauco, G, and Ohayon, E

Subjects
Behavioral Sciences
Abstract

A confinement experiment in a normobaric diving chamber was undertaken to better understand the effect of confinement and isolation on human psychology and physiology. Pre- and postconfinement blood samples were obtained from four test subjects and control donors to analyze immune responses. No modification in the levels of CD2+, CD3+, CD4+, CD8+, CD19+, and CD56+ cells was observed after confinement. Mitogen-induced T-lymphocyte proliferation and interleukin-2 receptor expression were not altered significantly. Whole blood interferon-alpha and gamma-induction and plasma cortisol levels were also unchanged, as was natural killer cell activity. These data suggest that in humans, no specific components of the immune response are affected by a 2-month isolation and confinement of a small group.

Published
1995
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14. Antigen Society #26 Report (DR3, DR7, DQw2): Part 1

Author

Cambon-Thomsen, A., Calot, M., Sommer, E., Ohayon, E., Goeken, N., Kaplan, C., Mattiuz, P. L., Menicucci, A., Cross, R., Tait, B., Buc, M., Jeannet, M., Irle, C., Mayer, S., Tongio, M. M., Contu, L., Purpura, M., Nikaein, A., Mervart, H., Sullivan, K., Schweizer, R., Hansen, J. A., Du Toit, E., Hammond, M. G., and Dupont, Bo, editor

Published
1989
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19. Absence of imprinting of HLA class Ia genes leads to co-expression of biparental alleles on term human trophoblast cells upon IFN-gamma induction

Author

Maryse Aguerre-Girr, Ohayon E, M. Fort, Françoise Lenfant, Michel Abbal, Anne-Marie Rodriguez, E. Sommer, Agnès Campan, and Le Bouteiller P

Subjects
Male, Transcription, Genetic, Immunology, Genes, MHC Class I, Human leukocyte antigen, HLA-C Antigens, Biology, Genomic Imprinting, Interferon-gamma, Immune system, Antigen, HLA Antigens, Pregnancy, Genetics, medicine, Cytotoxic T cell, Humans, Alleles, Genes, Dominant, Cytotrophoblast, HLA-A Antigens, Trophoblast, Gene Expression Regulation, Developmental, Molecular biology, In vitro, Trophoblasts, medicine.anatomical_structure, HLA-B Antigens, embryonic structures, Female, Genomic imprinting
Abstract

Human trophoblast cells have developed various efficient regulatory mechanisms to prevent cell surface expression of the classical HLA-A, -B, and (but not always) -C class I molecules. This allows them to escape maternal alloimmune attack during pregnancy. However, recent results have demonstrated that such a lack of expression could be reversed in villous cytotrophoblast cells purified from term placenta by in vitro IFN-gamma treatment. In this context, we investigated whether both maternal and paternal HLA class Ia antigens were co-dominantly expressed in such trophoblast cells. Using polymerase chain reaction sequence-specific primers for HLA-A and HLA-C alleles, we detected transcripts of both paternal and maternal origins, showing that these genes were not affected by genomic imprinting, at least in term placenta. After in vitro IFN-gamma treatment, the polymorphic HLA-A and HLA-B antigens of both parental origins become detectable at the cell surface, as assessed by flow cytometry and/or complement-dependent microtoxicity test. Appearance of paternal antigens on trophoblast cells upon IFN-gamma induction raises the question of the in vivo biological consequences of this phenomena, in term of materno-fetal tolerance and in particular of a potential allogeneic cytotoxic immune response.

Published
1998

37. A LIKELIHOOD APPROACH TO HLA SEROLOGY

Author

Clayton, J. F., primary, Lonjou, C., additional, Bourret, P., additional, Cambon-Thomsen, A., additional, Ohayon, E., additional, Hors, J., additional, and Albert, E. D., additional

Published
1992
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49. Genetic analysis of IDDM: The GAW5 multiplex family dataset.

Author

Baur, M. P., Fimmers, R., Fritsche, C., Hümmelink, M., Neugebauer, M., Acton, R. T., Hodge, T., Barbosa, J., Bertrams, J., Fehsel, K., Kolb, H., Rothe, H., Boehm, B., Cambon-Thomsen, A., Avoustin, P., Coppin, H., Darnaud, J., Massabie, P., Ohayon, E., and de Preval, C.

Published
1989
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