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3. Incidence of upper extremity deep vein thrombosis in the retrosternal reconstruction after esophagectomy

Author

Yamada, Leo, Saito, Motonobu, Suzuki, Hiroya, Mochizuki, Shotaro, Endo, Eisei, Kase, Koji, Ito, Misato, Nakano, Hiroshi, Yamauchi, Naoto, Matsumoto, Takuro, Kaneta, Akinao, Kanke, Yasuyuki, Onozawa, Hisashi, Hanayama, Hiroyuki, Okayama, Hirokazu, Fujita, Shotaro, Sakamoto, Wataru, Watanabe, Yohei, Hayase, Suguru, Saze, Zenichiro, Momma, Tomoyuki, Ohki, Shinji, and Kono, Koji

Published
2022
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11. Supplementary Tables 1-3 and Supplemental Figures 1-7 from A TGFβ-Dependent Stromal Subset Underlies Immune Checkpoint Inhibitor Efficacy in DNA Mismatch Repair–Deficient/Microsatellite Instability-High Colorectal Cancer

Author

Endo, Eisei, primary, Okayama, Hirokazu, primary, Saito, Katsuharu, primary, Nakajima, Shotaro, primary, Yamada, Leo, primary, Ujiie, Daisuke, primary, Kase, Koji, primary, Fujita, Shotaro, primary, Endo, Hisahito, primary, Sakamoto, Wataru, primary, Saito, Motonobu, primary, Saze, Zenichiro, primary, Momma, Tomoyuki, primary, Ohki, Shinji, primary, Mimura, Kosaku, primary, and Kono, Koji, primary

Published
2023
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12. Data from A TGFβ-Dependent Stromal Subset Underlies Immune Checkpoint Inhibitor Efficacy in DNA Mismatch Repair–Deficient/Microsatellite Instability-High Colorectal Cancer

Author

Endo, Eisei, primary, Okayama, Hirokazu, primary, Saito, Katsuharu, primary, Nakajima, Shotaro, primary, Yamada, Leo, primary, Ujiie, Daisuke, primary, Kase, Koji, primary, Fujita, Shotaro, primary, Endo, Hisahito, primary, Sakamoto, Wataru, primary, Saito, Motonobu, primary, Saze, Zenichiro, primary, Momma, Tomoyuki, primary, Ohki, Shinji, primary, Mimura, Kosaku, primary, and Kono, Koji, primary

Published
2023
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13. Supplementary Figures 1-6 from Neoadjuvant Chemotherapy Induces IL34 Signaling and Promotes Chemoresistance via Tumor-Associated Macrophage Polarization in Esophageal Squamous Cell Carcinoma

Author

Nakajima, Shotaro, primary, Mimura, Kosaku, primary, Saito, Katsuharu, primary, Thar Min, Aung Kyi, primary, Endo, Eisei, primary, Yamada, Leo, primary, Kase, Koji, primary, Yamauchi, Naoto, primary, Matsumoto, Takuro, primary, Nakano, Hiroshi, primary, Kanke, Yasuyuki, primary, Okayama, Hirokazu, primary, Saito, Motonobu, primary, Neupane, Prajwal, primary, Saze, Zenichiro, primary, Watanabe, Yohei, primary, Hanayama, Hiroyuki, primary, Hayase, Suguru, primary, Kaneta, Akinao, primary, Momma, Tomoyuki, primary, Ohki, Shinji, primary, Ohira, Hiromasa, primary, and Kono, Koji, primary

Published
2023
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14. Data from Neoadjuvant Chemotherapy Induces IL34 Signaling and Promotes Chemoresistance via Tumor-Associated Macrophage Polarization in Esophageal Squamous Cell Carcinoma

Author

Nakajima, Shotaro, primary, Mimura, Kosaku, primary, Saito, Katsuharu, primary, Thar Min, Aung Kyi, primary, Endo, Eisei, primary, Yamada, Leo, primary, Kase, Koji, primary, Yamauchi, Naoto, primary, Matsumoto, Takuro, primary, Nakano, Hiroshi, primary, Kanke, Yasuyuki, primary, Okayama, Hirokazu, primary, Saito, Motonobu, primary, Neupane, Prajwal, primary, Saze, Zenichiro, primary, Watanabe, Yohei, primary, Hanayama, Hiroyuki, primary, Hayase, Suguru, primary, Kaneta, Akinao, primary, Momma, Tomoyuki, primary, Ohki, Shinji, primary, Ohira, Hiromasa, primary, and Kono, Koji, primary

Published
2023
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15. Supplementary Table S1 from Neoadjuvant Chemotherapy Induces IL34 Signaling and Promotes Chemoresistance via Tumor-Associated Macrophage Polarization in Esophageal Squamous Cell Carcinoma

Author

Nakajima, Shotaro, primary, Mimura, Kosaku, primary, Saito, Katsuharu, primary, Thar Min, Aung Kyi, primary, Endo, Eisei, primary, Yamada, Leo, primary, Kase, Koji, primary, Yamauchi, Naoto, primary, Matsumoto, Takuro, primary, Nakano, Hiroshi, primary, Kanke, Yasuyuki, primary, Okayama, Hirokazu, primary, Saito, Motonobu, primary, Neupane, Prajwal, primary, Saze, Zenichiro, primary, Watanabe, Yohei, primary, Hanayama, Hiroyuki, primary, Hayase, Suguru, primary, Kaneta, Akinao, primary, Momma, Tomoyuki, primary, Ohki, Shinji, primary, Ohira, Hiromasa, primary, and Kono, Koji, primary

Published
2023
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16. Table S2 from Glycosyltransferase Gene Expression Identifies a Poor Prognostic Colorectal Cancer Subtype Associated with Mismatch Repair Deficiency and Incomplete Glycan Synthesis

Author

Noda, Masaru, primary, Okayama, Hirokazu, primary, Tachibana, Kazunoshin, primary, Sakamoto, Wataru, primary, Saito, Katsuharu, primary, Thar Min, Aung Kyi, primary, Ashizawa, Mai, primary, Nakajima, Takahiro, primary, Aoto, Keita, primary, Momma, Tomoyuki, primary, Katakura, Kyoko, primary, Ohki, Shinji, primary, and Kono, Koji, primary

Published
2023
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17. Supplementary data from Glycosyltransferase Gene Expression Identifies a Poor Prognostic Colorectal Cancer Subtype Associated with Mismatch Repair Deficiency and Incomplete Glycan Synthesis

Author

Noda, Masaru, primary, Okayama, Hirokazu, primary, Tachibana, Kazunoshin, primary, Sakamoto, Wataru, primary, Saito, Katsuharu, primary, Thar Min, Aung Kyi, primary, Ashizawa, Mai, primary, Nakajima, Takahiro, primary, Aoto, Keita, primary, Momma, Tomoyuki, primary, Katakura, Kyoko, primary, Ohki, Shinji, primary, and Kono, Koji, primary

Published
2023
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19. Additional file 1 of Systemic inflammation score as a preoperative prognostic factor for patients with pT2–T4 resectable gastric cancer: a retrospective study

Author

Matsumoto, Takuro, Ohki, Shinji, Kaneta, Akinao, Matsuishi, Akira, Maruyama, Yuya, Yamada, Leo, Tada, Takeshi, Hanayama, Hiroyuki, Watanabe, Yohei, Hayase, Suguru, Okayama, Hirokazu, Sakamoto, Wataru, Momma, Tomoyuki, Saze, Zenichiro, and Kono, Koji

Abstract

Additional file 1: Figure S1. ROC curves of prognostic factors for RFS. Figure S2. ROC curves of prognostic factors for OS.

Published
2023
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23. Systemic inflammation score as a preoperative prognostic factor for patients with pT2-T4 resectable gastric cancer: a retrospective study

Author

Matsumoto, Takuro, primary, Ohki, Shinji, additional, Yamada, Leo, additional, Tada, Takeshi, additional, Hanayama, Hiroyuki, additional, Watanabe, Yohei, additional, Hayase, Suguru, additional, Okayama, Hirokazu, additional, Sakamoto, Wataru, additional, Momma, Tomoyuki, additional, Saze, Zenichiro, additional, and Kono, Koji, additional

Published
2022
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25. Clinical Impact of Upper Extremity Deep Vein Thrombosis in the Retrosternal Reconstruction After Esophagectomy

Author

YAMADA, LEO, primary, Saito, Motonobu, additional, Suzuki, Hiroya, additional, Mochizuki, Shotaro, additional, Endo, Eisei, additional, Kase, Koji, additional, Ito, Misato, additional, Nakano, Hiroshi, additional, Yamauchi, Naoto, additional, Matsumoto, Takuro, additional, Kaneta, Akinao, additional, Kanke, Yasuyuki, additional, Onozawa, Hisashi, additional, Hanayama, Hiroyuki, additional, Okayama, Hirokazu, additional, Fujita, Shotaro, additional, Sakamoto, Wataru, additional, Watanabe, Yohei, additional, Hayase, Suguru, additional, Saze, Zenichiro, additional, Momma, Tomoyuki, additional, Ohki, Shinji, additional, and Kono, Koji, additional

Published
2021
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26. Long-term Outcomes of Lower Rectal Cancer Patients Treated with Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection after Preoperative Radiotherapy or Chemoradiotherapy

Author

Sakamoto, Wataru, primary, Ohki, Shinji, additional, Onozawa, Hisashi, additional, Okayama, Hirokazu, additional, Endo, Hisahito, additional, Fujita, Shotaro, additional, Saito, Motonobu, additional, Saze, Zenichiro, additional, Momma, Tomoyuki, additional, Takenoshita, Seiichi, additional, and Kono, Koji, additional

Published
2021
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27. Neoadjuvant Chemotherapy Induces IL34 Signaling and Promotes Chemoresistance via Tumor-Associated Macrophage Polarization in Esophageal Squamous Cell Carcinoma

Author

Nakajima, Shotaro, primary, Mimura, Kosaku, additional, Saito, Katsuharu, additional, Thar Min, Aung Kyi, additional, Endo, Eisei, additional, Yamada, Leo, additional, Kase, Koji, additional, Yamauchi, Naoto, additional, Matsumoto, Takuro, additional, Nakano, Hiroshi, additional, Kanke, Yasuyuki, additional, Okayama, Hirokazu, additional, Saito, Motonobu, additional, Neupane, Prajwal, additional, Saze, Zenichiro, additional, Watanabe, Yohei, additional, Hanayama, Hiroyuki, additional, Hayase, Suguru, additional, Kaneta, Akinao, additional, Momma, Tomoyuki, additional, Ohki, Shinji, additional, Ohira, Hiromasa, additional, and Kono, Koji, additional

Published
2021
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28. Higher modified Glasgow Prognostic Score and multiple stapler firings for rectal transection are risk factors for anastomotic leakage after low anterior resection in rectal cancer

Author

Sakamoto, Wataru, Ohki, Shinji, Kikuchi, Tomohiro, Okayama, Hirokazu, Fujita, Shotaro, Endo, Hisahito, Saito, Motonobu, Saze, Zenichiro, Momma, Tomoyuki, Kono, Koji, Sakamoto, Wataru, Ohki, Shinji, Kikuchi, Tomohiro, Okayama, Hirokazu, Fujita, Shotaro, Endo, Hisahito, Saito, Motonobu, Saze, Zenichiro, Momma, Tomoyuki, and Kono, Koji

Abstract

type:Text, Objective: Anastomotic leakage (AL) is one of the most devastating complications of rectal cancer surgery. Not only does AL result in reduced quality of life, extended hospitalization and impaired defecatory function, it also has a high local recurrence rate. In this study, we investigated risk factors for AL as it may help to decrease its occurrence and improve patient outcomes. Methods: This study was a retrospective, single-institution study of rectal cancer patients who underwent elective low anterior resection between April 2002 and February 2018 at Fukushima Medical University Hospital. Patients were divided into two groups according to the presence of AL. Patient-, tumor-, and surgery-related variables were examined using univariate and multivariate analyses. Results: One hundred sixty-one patients, average age 63.5±11.5 years, were enrolled in the study. The overall AL rate was 6.8% (11/161). In the univariate analysis, modified Glasgow Prognostic Score (mGPS)=2 (p=0.003), use of multiple staplers (≥3 firings) for rectal transection (p=0.001) and intraoperative bleeding (≥250 g) were significantly associated with AL incidence. Multivariate analysis identified that mGPS = 2 (odds ratio [OR]: 19.6, 95% confidence interval [CI]: 2.96-125.00, p=0.002) and multiple firings (OR: 18.19, CI: 2.31-111.11, p=0.002) were independent risk factors for AL. Conclusion: Higher mGPS score and multiple firings were independent risk factors for AL.

Published
2020

30. ARID1A deficiency in EBV-positive gastric cancer is partially regulated by EBV-encoded miRNAs, but not by DNA promotor hypermethylation

Author

Kase, Koji, primary, Saito, Motonobu, additional, Nakajima, Shotaro, additional, Takayanagi, Daisuke, additional, Saito, Katsuharu, additional, Yamada, Leo, additional, Ashizawa, Mai, additional, Nakano, Hiroshi, additional, Hanayama, Hiroyuki, additional, Onozawa, Hisashi, additional, Okayama, Hirokazu, additional, Endo, Hisahito, additional, Fujita, Shotaro, additional, Sakamoto, Wataru, additional, Saze, Zenichiro, additional, Momma, Tomoyuki, additional, Mimura, Kosaku, additional, Ohki, Shinji, additional, Shiraishi, Kouya, additional, Kohno, Takashi, additional, and Kono, Koji, additional

Published
2020
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31. A TGFβ-Dependent Stromal Subset Underlies Immune Checkpoint Inhibitor Efficacy in DNA Mismatch Repair–Deficient/Microsatellite Instability-High Colorectal Cancer

Author

Endo, Eisei, primary, Okayama, Hirokazu, additional, Saito, Katsuharu, additional, Nakajima, Shotaro, additional, Yamada, Leo, additional, Ujiie, Daisuke, additional, Kase, Koji, additional, Fujita, Shotaro, additional, Endo, Hisahito, additional, Sakamoto, Wataru, additional, Saito, Motonobu, additional, Saze, Zenichiro, additional, Momma, Tomoyuki, additional, Ohki, Shinji, additional, Mimura, Kosaku, additional, and Kono, Koji, additional

Published
2020
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32. Therapeutic potential of anti-VEGF receptor 2 therapy targeting for M2-tumor-associated macrophages in colorectal cancer

Author

Min, Aung Kyi Thar, primary, Mimura, Kosaku, additional, Nakajima, Shotaro, additional, Okayama, Hirokazu, additional, Saito, Katsuharu, additional, Sakamoto, Wataru, additional, Fujita, Shotaro, additional, Endo, Hisahito, additional, Saito, Motonobu, additional, Saze, Zenichiro, additional, Momma, Tomoyuki, additional, Ohki, Shinji, additional, and Kono, Koji, additional

Published
2020
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33. Selective sensitivity of EZH2 inhibitors based on synthetic lethality in ARID1A-deficient gastric cancer

Author

Yamada, Leo, primary, Saito, Motonobu, additional, Thar Min, Aung Kyi, additional, Saito, Katsuharu, additional, Ashizawa, Mai, additional, Kase, Koji, additional, Nakajima, Shotaro, additional, Onozawa, Hisashi, additional, Okayama, Hirokazu, additional, Endo, Hisahito, additional, Fujita, Shotaro, additional, Sakamoto, Wataru, additional, Saze, Zenichiro, additional, Momma, Tomoyuki, additional, Mimura, Kosaku, additional, Ohki, Shinji, additional, and Kono, Koji, additional

Published
2020
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34. Higher modified Glasgow Prognostic Score and multiple stapler firings for rectal transection are risk factors for anastomotic leakage after low anterior resection in rectal cancer

Author

Sakamoto, Wataru, primary, Ohki, Shinji, additional, Kikuchi, Tomohiro, additional, Okayama, Hirokazu, additional, Fujita, Shotaro, additional, Endo, Hisahito, additional, Saito, Motonobu, additional, Saze, Zenichiro, additional, Momma, Tomoyuki, additional, and Kono, Koji, additional

Published
2020
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35. Tuberculous peritonitis; The effectiveness of diagnostic laparoscopy and the perioperative infectious prevention: A case report

Author

Yamada, Leo, primary, Saito, Motonobu, additional, Aita, Tetsuro, additional, Min, AungKyiThar, additional, Endo, Eisei, additional, Kase, Koji, additional, Ujiie, Daisuke, additional, Hanayama, Hiroyuki, additional, Okayama, Hirokazu, additional, Sakamoto, Wataru, additional, Endo, Hisahito, additional, Fujita, Shotaro, additional, Saze, Zenichiro, additional, Momma, Tomoyuki, additional, Ohki, Shinji, additional, Hamaguchi, Sugihiro, additional, and Kono, Koji, additional

Published
2020
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38. Clinical usefulness of ramucirumab plus paclitaxel for unresectable and recurrent gastric cancer

Author

Hayase, Suguru, Yamada, Leo, Ujiie, Daisuke, Nirei, Azuma, Tada, Takeshi, Hanayama, Hiroyuki, Monma, Tomoyuki, Saze, Zenichiro, Ohki, Shinji, Kono, Koji, Hayase, Suguru, Yamada, Leo, Ujiie, Daisuke, Nirei, Azuma, Tada, Takeshi, Hanayama, Hiroyuki, Monma, Tomoyuki, Saze, Zenichiro, Ohki, Shinji, and Kono, Koji

Abstract

type:Text, Introduction Recently in Japan, Ramucirumab (RAM) became the first anti-angiogenic agent to be approved for second-line treatment of gastric cancer. In the present study, we aimed to evaluate the efficacy and safety of RAM plus paclitaxel (PTX) in patients with unresectable and recurrent gastric cancer in our institution. Patients and Methods The subjects were 11 patients with unresectable and recurrent gastric cancer who received RAM plus PTX as a second- or later-line treatment at our hospital between June 2015 and September 2017, after the failure of previously-attempted treatments. We assessed the efficacy and safety of RAM plus PTX, and also compared them between patients aged <75 years (n=6) and those aged ≥75 (n=5), by performing a retrospective analysis based on the data obtained from daily clinical practice for gastric cancer treatment. Results Objective tumor response was observed in one of the 11 patients (9.1%) with partial response, and disease control was seen in the remaining 10 (90.9%). The median overall survival (OS) and progression-free survival (PFS) of the patients were 20.8 months (95% CI 7.8-NA (not applicable)) and 11.3 months (95% CI 6.5-NA), respectively. There were no serious adverse events. The median OS for the <75 years group and ≥75 years group was NA (due to short follow-up period) and 20.8 months (p = 0.336), respectively, and their respective median PFS rates were 9.4 and 11.3 months (p = 0.492). The difference of rate of adverse events was not significant between the two age groups in the present study, though the number of adverse events was not sufficient. Conclusion The results of the present study suggest that the combination chemotherapy of RAM and PTX was effective in unresectable and recurrent gastric cancer patients as a second- or later-line therapy, and has been shown to be safe and feasible in elderly patients.

Published
2019

39. Characterization of tumor-infiltrating immune cells in relation to microbiota in colorectal cancers

Author

Kikuchi, Tomohiro, primary, Mimura, Kosaku, additional, Ashizawa, Mai, additional, Okayama, Hirokazu, additional, Endo, Eisei, additional, Saito, Katsuharu, additional, Sakamoto, Wataru, additional, Fujita, Shotaro, additional, Endo, Hisahito, additional, Saito, Motonobu, additional, Momma, Tomoyuki, additional, Saze, Zenichiro, additional, Ohki, Shinji, additional, Shimada, Kazunori, additional, Yoshimura, Kiyoshi, additional, Tsunoda, Takuya, additional, and Kono, Koji, additional

Published
2019
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40. KRT17 as a prognostic biomarker for stage II colorectal cancer

Author

Ujiie, Daisuke, primary, Okayama, Hirokazu, primary, Saito, Katsuharu, primary, Ashizawa, Mai, primary, Thar Min, Aung Kyi, primary, Endo, Eisei, primary, Kase, Koji, primary, Yamada, Leo, primary, Kikuchi, Tomohiro, primary, Hanayama, Hiroyuki, primary, Fujita, Shotaro, primary, Sakamoto, Wataru, primary, Endo, Hisahito, primary, Saito, Motonobu, primary, Mimura, Kosaku, primary, Saze, Zenichiro, primary, Momma, Tomoyuki, primary, Ohki, Shinji, primary, and Kono, Koji, primary

Published
2019
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42. A subset of patients with MSS/MSI‑low‑colorectal cancer showed increased CD8(+) TILs together with up‑regulated IFN‑γ

Author

Kikuchi, Tomohiro, primary, Mimura, Kosaku, additional, Okayama, Hirokazu, additional, Nakayama, Yuko, additional, Saito, Katsuharu, additional, Yamada, Leo, additional, Endo, Eisei, additional, Sakamoto, Wataru, additional, Fujita, Shotaro, additional, Endo, Hisahito, additional, Saito, Motonobu, additional, Momma, Tomoyuki, additional, Saze, Zenichiro, additional, Ohki, Shinji, additional, and Kono, Koji, additional

Published
2019
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43. Explore the correlation between ARID1A and ANXA1 expressions in gastric cancer

Author

Yamada, Leo, primary, Saito, Motonobu, additional, Thar Min, Aung Kyi, additional, Saito, Katsuharu, additional, Kase, Koji, additional, Onozawa, Hisashi, additional, Okayama, Hirokazu, additional, Fujita, Shotaro, additional, Endo, Hisahito, additional, Sakamoto, Wataru, additional, Saze, Zenichiro, additional, Momma, Tomoyuki, additional, Ohki, Shinji, additional, Mimura, Kosaku, additional, and Kono, Koji, additional

Published
2019
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44. miRNA-148a-3p Regulates Immunosuppression in DNA Mismatch Repair–Deficient Colorectal Cancer by Targeting PD-L1

Author

Ashizawa, Mai, primary, Okayama, Hirokazu, additional, Ishigame, Teruhide, additional, Thar Min, Aung Kyi, additional, Saito, Katsuharu, additional, Ujiie, Daisuke, additional, Murakami, Yuko, additional, Kikuchi, Tomohiro, additional, Nakayama, Yuko, additional, Noda, Masaru, additional, Tada, Takeshi, additional, Endo, Hisahito, additional, Fujita, Shotaro, additional, Sakamoto, Wataru, additional, Saito, Motonobu, additional, Saze, Zenichiro, additional, Momma, Tomoyuki, additional, Ohki, Shinji, additional, Mimura, Kosaku, additional, and Kono, Koji, additional

Published
2019
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47. TBX19 is overexpressed in colorectal cancer and associated with lymph node metastasis

Author

Ando, Jin, Saito, Motonobu, Imai, Jun-Ichi, Ito, Emi, Yanagisawa, Yuka, Honma, Reiko, Saito, Katsuharu, Tachibana, Kazunoshin, Momma, Tomoyuki, Ohki, Shinji, Ohtake, Tohru, Watanabe, Shinya, Waguri, Satoshi, Kono, Koji, and Takenoshita, Seiichi

Subjects
Adult, Homeodomain Proteins, Male, diagnostic biomarker, lymph node metastasis, TBX19, colorectal cancer, cytoplasmic granular signal, Middle Aged, digestive system diseases, Proto-Oncogene Proteins p21(ras), Cell Line, Tumor, Lymphatic Metastasis, 494.65, Mutation, Humans, Female, Original Article, RNA, Messenger, Colorectal Neoplasms, T-Box Domain Proteins, Aged
Abstract

The T-box 19 (TBX19) gene encodes a transcription factor characterized by a highly conserved DNA-binding motif (T-box). Recent studies have revealed that TBX19 has been identified as one of the genes activated by KRAS mutations, and is upregulated in colon adenoma. These results indicate that TBX19 may work as an oncogene in colorectal cancer (CRC). However, the expression and role of TBX19 have yet to be investigated. Here, we investigated TBX19 mRNA and protein expressions in colon cancer cells or surgically resected CRC. We found that TBX19 mRNA expression was significantly increased in tumorous tissues compared to that in non-tumorous tissues, and increased TBX19 mRNA expression was associated with positive lymph node metastasis in our cohort. The expression of TBX19 mRNA was not correlated with that of TBX19 protein in tissue sample taken from the CRC patients. Moreover, TBX19 showed positive staining even in the normal colonic tissues and the adjacent non-tumorous tissues. These results suggest that the expression of TBX19 protein is not correlated with the expression of TBX19 mRNA. In addition, our results promote further investigations into the impact of TBX19 upregulation on colorectal carcinogenesis, as well as the underlying mechanisms.

Published
2017

48. Immunotherapy for esophageal squamous cell carcinoma: a review

Author

Mimura, Kosaku, Yamada, Leo, Ujiie, Daisuke, Hayase, Suguru, Tada, Takeshi, Hanayama, Hiroyuki, Aung Kyi Thar Min, Shibata, Masahiko, Momma, Tomoyuki, Saze, Zenichiro, Ohki, Shinji, Kono, Koji, Mimura, Kosaku, Yamada, Leo, Ujiie, Daisuke, Hayase, Suguru, Tada, Takeshi, Hanayama, Hiroyuki, Aung Kyi Thar Min, Shibata, Masahiko, Momma, Tomoyuki, Saze, Zenichiro, Ohki, Shinji, and Kono, Koji

Abstract

type:Text, Cancer vaccines and immune checkpoint inhibitors (ICI) have recently been employed as immunotherapies for esophageal squamous cell carcinoma (ESCC). Cancer vaccines for ESCC have yielded several promising results from investigator-initiated phase I and II clinical trials. Furthermore, a Randomized Controlled Trial as an adjuvant setting after curative surgery is in progress in Japan. On the other hand, ICI, anti-CTLA-4 mAb and anti-PD-1 mAb, have demonstrated tumor shrinkage and improved overall survival in patients with multiple cancer types. For ESCC, several clinical trials using anti-PD-1/anti-PD-L1 mAb are underway with several recent promising results. In this review, cancer vaccines and ICI are discussed as novel therapeutic strategies for ESCC.

Published
2018

49. Prognostic impact of preoperative lymphocyte-to-monocyte ratio in patients with colorectal cancer with special reference to myeloid-derived suppressor cells

Author

Shimura, Tatsuo, Shibata, Masahiko, Gonda, Kenji, Hayase, Suguru, Sakamoto, Wataru, Okayama, Hirokazu, Fujita, Shotaro, Saito, Motonobu, Momma, Tomoyuki, Ohki, Shinji, Kono, Koji, Shimura, Tatsuo, Shibata, Masahiko, Gonda, Kenji, Hayase, Suguru, Sakamoto, Wataru, Okayama, Hirokazu, Fujita, Shotaro, Saito, Motonobu, Momma, Tomoyuki, Ohki, Shinji, and Kono, Koji

Abstract

type:Text, Aims: We aimed to investigate the relationship of colorectal cancer prognosis and inflammatory parameters, including neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR), with reference to circulating myeloid-derived suppressor cells (MDSCs) in the current study. Patients and Methods: Thirty-five patients who underwent curative-intent surgery were enrolled. A receiver-operating characteristic curve (ROC) was used to assess the usefulness of candidates for prognostic factors. Recurrence-free survival (RFS) was calculated using the Kaplan-Meier method, and the candidates for prognostic factors were assessed by a Cox proportional hazard model. Results: ROC curve analyses determined cutoff values for NLR and LMR as 2.9 and 2.4, respectively. The percentage of MDSCs in patients with LMR ≤ 2.4 was statistically higher than in those with LMR > 2.4 (p = 0.012). The patients with LMR ≤ 2.4 exhibited a statistically lower RFS than those with LMR > 2.4 (p = 0.008). These results were also observed in patients with stage II + III disease. LMR was an independent prognostic factor of RFS in colorectal cancer patients (hazard ratio: 7.757, 95% confidence interval: 1.462-41.152, p = 0.016). Conclusion: Lower LMR was associated with poor prognosis in colorectal cancer patients; whereas, higher circulating MDSCs were observed in patients with lower LMR.

Published
2018

50. ARID1A deficiency in EBV-positive gastric cancer is partially regulated by EBV-encoded miRNAs, but not by DNA promotor hypermethylation.

Author

Kase, Koji, Saito, Motonobu, Nakajima, Shotaro, Takayanagi, Daisuke, Saito, Katsuharu, Yamada, Leo, Ashizawa, Mai, Nakano, Hiroshi, Hanayama, Hiroyuki, Onozawa, Hisashi, Okayama, Hirokazu, Endo, Hisahito, Fujita, Shotaro, Sakamoto, Wataru, Saze, Zenichiro, Momma, Tomoyuki, Mimura, Kosaku, Ohki, Shinji, Shiraishi, Kouya, and Kohno, Takashi

Subjects
STOMACH cancer, MICRORNA, TUMOR suppressor genes, DNA, PROTEIN deficiency, DNA mismatch repair, PLANT gene silencing
Abstract

AT-rich interactive domain 1A (ARID1A), which is a tumor suppressor gene, is frequently mutated in Epstein-Barr virus-positive gastric cancer [EBV (+) GC]. While most ARID1A mutations in GC are truncating mutations, leading to loss of ARID1A protein expression, epigenetic modifications appear to contribute to ARID1A deficiency in EBV (+) GC harboring wild-type ARID1A. Based on the significant role of epigenetic modifications in EBV (+) GC that contributes to ARID1A deficiency, the methylation status of ARID1A was evaluated in EBV-infected cells and GC patients using a publicly available microarray and the Cancer Genome Atlas (TCGA) database. EBV-encoded miRNAs that potentially target ARID1A were identified as an additional epigenetic modulator by computational prediction. In vitro experiments were conducted to evaluate how EBV-encoded miRNAs affected ARID1A mRNA and protein levels. In clinical GC samples, the expression of predicted miRNAs and ARID1A and the mutation status of ARID1A was evaluated. As results, ARID1A was not hypermethylated in EBV (+) GC samples or EBV-infected GC cells. EBV infection did not alter ARID1A mRNA levels, suggesting that ARID1A protein deficiency was caused by post-transcriptional gene silencing in ARID1A -WT EBV (+) GC. Overexpression of miR-BART11-3p and miR-BART12, which were identified as miRNAs that potentially bind ARID1A , suppressed ARID1A protein expression in MKN7 and NCI-N87 cells. Highly expressed miR-BART11-3p and miR-BART12 were correlated with decreased ARID1A levels in GC tumors which did not harbor ARID1A mutations. The present findings revealed that ARID1A expression was epigenetically regulated by miR-BART11-3p and miR-BART12 in EBV (+) GC. [ABSTRACT FROM AUTHOR]

Published
2021
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