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1. Randomized open-label study of second-generation antipsychotics for the treatment of schizophrenia: 104-week final results of the JUMPs study assessing treatment discontinuation, remission, and social functioning

Author

Ishigooka, Jun, Nakagome, Kazuyuki, Ohmori, Tetsuro, Iwata, Nakao, Inada, Ken, Iga, Jun-ichi, Kishi, Taro, Fujita, Kiyoshi, Kikuchi, Yuka, Shichijo, Toshiaki, Tabuse, Hideaki, Koretsune, Shotatsu, Terada, Hiroshi, Terada, Haruko, Kishimoto, Toshifumi, Tsutsumi, Yuichiro, and Ohi, Kazutaka

Published
2024
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2. Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia

Author

Ripke, Stephan, Neale, Benjamin M., Corvin, Aiden, Walters, James T.R., Farh, Kai-How, Holmans, Peter A., Lee, Phil, Bulik-Sullivan, Brendan, Collier, David A., Huang, Hailiang, Pers, Tune H., Agartz, Ingrid, Agerbo, Esben, Albus, Margot, Alexander, Madeline, Amin, Farooq, Bacanu, Silviu A., Begemann, Martin, Belliveau, Richard A., Jr., Bene, Judit, Bergen, Sarah E., Bevilacqua, Elizabeth, Bigdeli, Tim B., Black, Donald W., Bruggeman, Richard, Buccola, Nancy G., Buckner, Randy L., Byerley, William, Cahn, Wiepke, Cai, Guiqing, Campion, Dominique, Cantor, Rita M., Carr, Vaughan J., Carrera, Noa, Catts, Stanley V., Chambert, Kimberley D., Chan, Raymond C.K., Chan, Ronald Y.L., Chen, Eric Y.H., Cheng, Wei, Cheung, Eric FC., Chong, Siow Ann, Cloninger, C. Robert, Cohen, David, Cohen, Nadine, Cormican, Paul, Craddock, Nick, Crowley, James J., Curtis, David, Davidson, Michael, Davis, Kenneth L., Degenhardt, Franziska, Del Favero, Jurgen, Demontis, Ditte, Dikeos, Dimitris, Dinan, Timothy, Djurovic, Srdjan, Donohoe, Gary, Drapeau, Elodie, Duan, Jubao, Dudbridge, Frank, Durmishi, Naser, Eichhammer, Peter, Eriksson, Johan, Escott-Price, Valentina, Essioux, Laurent, Fanous, Ayman H., Farrell, Martilias S., Frank, Josef, Franke, Lude, Freedman, Robert, Freimer, Nelson B., Friedl, Marion, Friedman, Joseph I., Fromer, Menachem, Genovese, Giulio, Georgieva, Lyudmila, Giegling, Ina, Giusti-Rodríguez, Paola, Godard, Stephanie, Goldstein, Jacqueline I., Golimbet, Vera, Gopal, Srihari, Gratten, Jacob, de Haan, Lieuwe, Hammer, Christian, Hamshere, Marian L., Hansen, Mark, Hansen, Thomas, Haroutunian, Vahram, Hartmann, Annette M., Henskens, Frans A., Herms, Stefan, Hirschhorn, Joel N., Hoffmann, Per, Hofman, Andrea, Hollegaard, Mads V., Hougaard, David M., Ikeda, Masashi, Joa, Inge, Julià, Antonio, Kahn, René S., Kalaydjieva, Luba, Karachanak-Yankova, Sena, Karjalainen, Juha, Kavanagh, David, Keller, Matthew C., Kennedy, James L., Khrunin, Andrey, Kim, Yunjung, Klovins, Janis, Knowles, James A., Konte, Bettina, Kucinskas, Vaidutis, Kucinskiene, Zita Ausrele, Kuzelova-Ptackova, Hana, Kähler, Anna K., Laurent, Claudine, Lee, Jimmy, Lee, S. Hong, Legge, Sophie E., Lerer, Bernard, Li, Miaoxin, Li, Tao, Liang, Kung-Yee, Lieberman, Jeffrey, Limborska, Svetlana, Loughland, Carmel M., Lubinski, Jan, Lönnqvist, Jouko, Macek, Milan, Magnusson, Patrik K.E., Maher, Brion S., Maier, Wolfgang, Mallet, Jacques, Marsal, Sara, Mattheisen, Manuel, Mattingsdal, Morten, McCarley, Robert W., McDonald, Colm, McIntosh, Andrew M., Meier, Sandra, Meijer, Carin J., Melegh, Bela, Melle, Ingrid, Mesholam-Gately, Raquelle I., Metspalu, Andres, Michie, Patricia T., Milani, Lili, Milanova, Vihra, Mokrab, Younes, Morris, Derek W., Mors, Ole, Murphy, Kieran C., Murray, Robin M., Myin-Germeys, Inez, Müller-Myhsok, Bertram, Nelis, Mari, Nenadic, Igor, Nertney, Deborah A., Nestadt, Gerald, Nicodemus, Kristin K., Nikitina-Zake, Liene, Nisenbaum, Laura, Nordin, Annelie, O'Callaghan, Eadbhard, O'Dushlaine, Colm, O'Neill, F. Anthony, Oh, Sang-Yun, Olincy, Ann, Olsen, Line, Van Os, Jim, Pantelis, Christos, Papadimitriou, George N., Papiol, Sergi, Parkhomenko, Elena, Pato, Michele T., Paunio, Tiina, Pejovic-Milovancevic, Milica, Perkins, Diana O., Pietiläinen, Olli, Pimm, Jonathan, Pocklington, Andrew J., Powell, John, Price, Alkes, Pulver, Ann E., Purcell, Shaun M., Quested, Digby, Rasmussen, Henrik B., Reichenberg, Abraham, Reimers, Mark A., Richards, Alexander L., Roffman, Joshua L., Roussos, Panos, Ruderfer, Douglas M., Salomaa, Veikko, Sanders, Alan R., Schall, Ulrich, Schubert, Christian R., Schulze, Thomas G., Schwab, Sibylle G., Scolnick, Edward M., Scott, Rodney J., Seidman, Larry J., Shi, Jianxin, Sigurdsson, Engilbert, Silagadze, Teimuraz, Silverman, Jeremy M., Sim, Kang, Slominsky, Petr, Smoller, Jordan W., So, Hon-Cheong, Spencer, Chris C.A., Stahl, Eli A., Stefansson, Hreinn, Steinberg, Stacy, Stogmann, Elisabeth, Straub, Richard E., Strengman, Eric, Strohmaier, Jana, Stroup, T Scott, Subramaniam, Mythily, Suvisaari, Jaana, Svrakic, Dragan M., Szatkiewicz, Jin P., Söderman, Erik, Thirumalai, Srinivas, Toncheva, Draga, Tosato, Sarah, Veijola, Juha, Waddington, John, Walsh, Dermot, Wang, Dai, Wang, Qiang, Webb, Bradley T., Weiser, Mark, Wildenauer, Dieter B., Williams, Nigel M., Williams, Stephanie, Witt, Stephanie H., Wolen, Aaron R., Wong, Emily H.M., Wormley, Brandon K., Xi, Hualin Simon, Zai, Clement C., Zheng, Xuebin, Zimprich, Fritz, Wray, Naomi R., Stefansson, Kari, Visscher, Peter M., Adolfsson, Rolf, Andreassen, Ole A., Blackwood, Douglas H.R., Bramon, Elvira, Buxbaum, Joseph D., Børglum, Anders D., Cichon, Sven, Darvasi, Ariel, Domenici, Enrico, Ehrenreich, Hannelore, Esko, Tõnu, Gejman, Pablo V., Gill, Michael, Gurling, Hugh, Hultman, Christina M., Iwata, Nakao, Jablensky, Assen V., Jönsson, Erik G., Kendler, Kenneth S., Kirov, George, Knight, Jo, Lencz, Todd, Levinson, Douglas F., Li, Qingqin S., Liu, Jianjun, Malhotra, Anil K., McCarroll, Steven A., McQuillin, Andrew, Moran, Jennifer L., Mortensen, Preben B., Mowry, Bryan J., Nöthen, Markus M., Ophoff, Roel A., Owen, Michael J., Palotie, Aarno, Pato, Carlos N., Petryshen, Tracey L., Posthuma, Danielle, Rietschel, Marcella, Riley, Brien P., Rujescu, Dan, Sham, Pak C., Sklar, Pamela, St Clair, David, Weinberger, Daniel R., Wendland, Jens R., Werge, Thomas, Daly, Mark J., Sullivan, Patrick F., O'Donovan, Michael C., Qin, Shengying, Sawa, Akira, Kahn, Rene, Hong, Kyung Sue, Shi, Wenzhao, Tsuang, Ming, Itokawa, Masanari, Feng, Gang, Glatt, Stephen J., Ma, Xiancang, Tang, Jinsong, Ruan, Yunfeng, Liu, Ruize, Zhu, Feng, Horiuchi, Yasue, Lee, Byung Dae, Joo, Eun-Jeong, Myung, Woojae, Ha, Kyooseob, Won, Hong-Hee, Baek, Ji Hyung, Chung, Young Chul, Kim, Sung-Wan, Kusumawardhani, Agung, Chen, Wei J., Hwu, Hai-Gwo, Hishimoto, Akitoyo, Otsuka, Ikuo, Sora, Ichiro, Toyota, Tomoko, Yoshikawa, Takeo, Kunugi, Hiroshi, Hattori, Kotaro, Ishiwata, Sayuri, Numata, Shusuke, Ohmori, Tetsuro, Arai, Makoto, Ozeki, Yuji, Fujii, Kumiko, Kim, Se Joo, Lee, Heon-Jeong, Ahn, Yong Min, Kim, Se Hyun, Akiyama, Kazufumi, Shimoda, Kazutaka, Kinoshita, Makoto, Hsu, Yu-Han H., Pintacuda, Greta, Nacu, Eugeniu, Kim, April, Tsafou, Kalliopi, Petrossian, Natalie, Crotty, William, Suh, Jung Min, Riseman, Jackson, Martin, Jacqueline M., Biagini, Julia C., Mena, Daya, Ching, Joshua K.T., Malolepsza, Edyta, Li, Taibo, Singh, Tarjinder, Ge, Tian, Egri, Shawn B., Tanenbaum, Benjamin, Stanclift, Caroline R., Apffel, Annie M., Carr, Steven A., Schenone, Monica, Jaffe, Jake, Fornelos, Nadine, Eggan, Kevin C., and Lage, Kasper

Published
2023
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3. Interferon signaling and hypercytokinemia-related gene expression in the blood of antidepressant non-responders

Author

Yamagata, Hirotaka, Tsunedomi, Ryouichi, Kamishikiryo, Toshiharu, Kobayashi, Ayumi, Seki, Tomoe, Kobayashi, Masaaki, Hagiwara, Kosuke, Yamada, Norihiro, Chen, Chong, Uchida, Shusaku, Ogihara, Hiroyuki, Hamamoto, Yoshihiko, Okada, Go, Fuchikami, Manabu, Iga, Jun-ichi, Numata, Shusuke, Kinoshita, Makoto, Kato, Takahiro A., Hashimoto, Ryota, Nagano, Hiroaki, Ueno, Shuichi, Okamoto, Yasumasa, Ohmori, Tetsuro, and Nakagawa, Shin

Published
2023
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5. Optimized protocol for the extraction of RNA and DNA from frozen whole blood sample stored in a single EDTA tube

Author

Yamagata, Hirotaka, Kobayashi, Ayumi, Tsunedomi, Ryouichi, Seki, Tomoe, Kobayashi, Masaaki, Hagiwara, Kosuke, Chen, Chong, Uchida, Shusaku, Okada, Go, Fuchikami, Manabu, Kamishikiryo, Toshiharu, Iga, Jun-ichi, Numata, Shusuke, Kinoshita, Makoto, Kato, Takahiro A., Hashimoto, Ryota, Nagano, Hiroaki, Okamoto, Yasumasa, Ueno, Shuichi, Ohmori, Tetsuro, and Nakagawa, Shin

Published
2021
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13. Decreased serum pyridoxal levels in schizophrenia: meta-analysis and Mendelian randomization analysis

Author

Tomioka, Yukiko, Numata, Shusuke, Kinoshita, Makoto, Umehara, Hidehiro, Watanabe, Shin-ya, Nakataki, Masahito, Iwayama, Yoshimi, Toyota, Tomoko, Ikeda, Masashi, Yamamori, Hidenaga, Shimodera, Shinji, Tajima, Atsushi, Hashimoto, Ryota, Iwata, Nakao, Yoshikawa, Takeo, and Ohmori, Tetsuro

Subjects
Schizophrenia -- Genetic aspects, Single nucleotide polymorphisms -- Health aspects, Health, Psychology and mental health
Abstract

Background: Alterations in one-carbon metabolism have been associated with schizophrenia, and vitamin B6 is one of the key components in this pathway. Methods: We first conducted a case-control study of serum pyridoxal levels and schizophrenia in a large Japanese cohort (n = 1276). Subsequently, we conducted a meta-analysis of association studies (n = 2125). Second, we investigated whether rs4654748, which was identified in a genome-wide association study as a vitamin B6-related single nucleotide polymorphism, was genetically implicated in patients with schizophrenia in the Japanese population (n = 10 689). Finally, we assessed the effect of serum pyridoxal levels on schizophrenia risk using a Mendelian randomization (MR) approach. Results: Serum pyridoxal levels were significantly lower in patients with schizophrenia than in controls, not only in our cohort, but also in the pooled data set of the meta-analysis of association studies (standardized mean difference -0.48, 95% confidence interval [CI] -0.57 to -0.39, p = 9.8 x [10.sup.-24]). We failed to find a significant association between rs4654748 and schizophrenia. Furthermore, an MR analysis failed to find a causal relationship between pyridoxal levels and schizophrenia risk (odds ratio 0.99, 95% CI 0.65- 1.51, p = 0.96). Limitations: Food consumption and medications may have affected serum pyridoxal levels in our cross-sectional study. Sample size, number of instrumental variables and substantial heterogeneity among patients with schizophrenia are limitations of an MR analysis. Conclusion: We found decreased serum pyridoxal levels in patients with schizophrenia in this observational study. However, we failed to obtain data supporting a causal relationship between pyridoxal levels and schizophrenia risk using the MR approach., Introduction Schizophrenia is a devastating psychiatric disorder with a median lifetime prevalence of u.7%-0.8%, (1) and the etiopathogenesis of this disorder is still unknown. (2) One-carbon metabolism is a process [...]

Published
2018
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21. Left DLPFC activity is associated with plasma kynurenine levels and can predict treatment response to escitalopram in major depressive disorder

Author

Kamishikiryo, Toshiharu, primary, Okada, Go, additional, Itai, Eri, additional, Masuda, Yoshikazu, additional, Yokoyama, Satoshi, additional, Takamura, Masahiro, additional, Fuchikami, Manabu, additional, Yoshino, Atsuo, additional, Mawatari, Kazuaki, additional, Numata, Shusuke, additional, Takahashi, Akira, additional, Ohmori, Tetsuro, additional, and Okamoto, Yasumasa, additional

Published
2022
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22. 積極的治療段階のがん患者における心理状態の経時的解析法の試み

Author

Ueoka, Chise, Nakataki, Masahito, Ueoka, Yoshinori, Miyazaki, Atsuko, Taniguchi, Saki, and Ohmori, Tetsuro

Subjects
positive/negative emotions, emotional state map, cancer patients in the active treatment stage, psychological interview records
Abstract

The psychological state and changes over time of cancer patients in the active treatment stage were classified into emotions by the speech and behavior of the patient described in the medical record article of the cancer psychological interview record, and the analysis of the “emotional state map” was attempted. In all cases, positive / negative emotions were mixed and appeared with variation, but a relatively large number of positive emotions, including , , and , were manifested, and the same was true in patients who experienced stressful treatment events. In the background, the existence of appropriate support from medical professionals and psychological characteristics peculiar to the stage of active treatment was inferred, such as the active treatment of the target patient, the hospitalization environment in which mental and physical pain promptly appealed to medical professionals, and the influence of psychological interviews. Cancer patients during active treatment perceived and expressed changes in the body and pain caused by the disease, and after responses from medical professionals and family members, they were conscious of their physical condition and emotions. It is suggested that this analysis method helps to objectively understand and explain the invisible and ever-changing psychological state of cancer patients in the active treatment stage.

Published
2021

23. 周トラウマ反応，PTSD症状，痛み : 日本での鉄道災害における研究

Author

Uchiumi, Chigusa, Kato, Hiroshi, Ishida, Motohiro, Nakataki, Masahito, and Ohmori, Tetsuro

Subjects
peritraumatic reactions, train disaster, PTSD symptoms, pain
Abstract

Objective : The purpose of this study was to examine the relationship between peritraumatic reactions, posttraumatic stress disorder (PTSD) symptoms, and pain in people injured in train disasters. Methods : The participants were injured in a train crash in Japan that left more than 100 dead. There were 218 participants in the analysis, with a mean age of 37.50 ± 14.67 years. Peritraumatic reactions were assessed using the Peritraumatic Distress Inventory. PTSD symptoms were evaluated using the Impact of Event Scale-Revised Japanese-language version. Pain was measured using the Visual Analog Scale. Results : Peritraumatic reactions did not directly affect PTSD symptoms but were found to be associated via latent variables. Regarding pain and PTSD symptoms, intrusive memories were more associated with pain than other symptoms were. There was an associative path from intrusion to pain, but no such path from pain to intrusion. Conclusions : Our results suggest that a therapeutic approach to intrusion may be effective in ameliorating the pain caused by injury. Future research should examine integrated treatment approaches for both PTSD and pain, rather than just for aspects of PTSD.

Published
2021

24. Left DLPFC activity is associated with plasma kynurenine levels and can predict treatment response to escitalopram in major depressive disorder

Author

Kamishikiryo, Toshiharu, Okada, Go, Itai, Eri, Masuda, Yoshikazu, Yokoyama, Satoshi, Takamura, Masahiro, Fuchikami, Manabu, Yoshino, Atsuo, Mawatari, Kazuaki, Numata, Shusuke, Takahashi, Akira, Ohmori, Tetsuro, Okamoto, Yasumasa, Kamishikiryo, Toshiharu, Okada, Go, Itai, Eri, Masuda, Yoshikazu, Yokoyama, Satoshi, Takamura, Masahiro, Fuchikami, Manabu, Yoshino, Atsuo, Mawatari, Kazuaki, Numata, Shusuke, Takahashi, Akira, Ohmori, Tetsuro, and Okamoto, Yasumasa

Abstract

Aim: To establish treatment response biomarkers that reflect the pathophysiology of depression, it is important to use an integrated set of features. This study aimed to determine the relationship between regional brain activity at rest and blood metabolites related to treatment response to escitalopram to identify the characteristics of depression that respond to treatment. Methods: Blood metabolite levels and resting-state brain activity were measured in patients with moderate to severe depression (n = 65) before and after 6–8 weeks of treatment with escitalopram, and these were compared between Responders and Nonresponders to treatment. We then examined the relationship between blood metabolites and brain activity related to treatment responsiveness in patients and healthy controls (n = 36). Results: Thirty-two patients (49.2%) showed a clinical response (>50% reduction in the Hamilton Rating Scale for Depression score) and were classified as Responders, and the remaining 33 patients were classified as Nonresponders. The pretreatment fractional amplitude of low-frequency fluctuation (fALFF) value of the left dorsolateral prefrontal cortex (DLPFC) and plasma kynurenine levels were lower in Responders, and the rate of increase of both after treatment was correlated with an improvement in symptoms. Moreover, the fALFF value of the left DLPFC was significantly correlated with plasma kynurenine levels in pretreatment patients with depression and healthy controls. Conclusion: Decreased resting-state regional activity of the left DLPFC and decreased plasma kynurenine levels may predict treatment response to escitalopram, suggesting that it may be involved in the pathophysiology of major depressive disorder in response to escitalopram treatment.

Published
2022

26. 性別に基づく血清葉酸濃度と統合失調症との関連

Author

Tomioka, Yukiko, Kinoshita, Makoto, Umehara, Hidehiro, Nakayama, Tomohiko, Watanabe, Shin-ya, Nakataki, Masahito, Numata, Shusuke, and Ohmori, Tetsuro

Subjects
schizophrenia, ビタミンB6, ホモシステイン, pyridoxal, 統合失調症, homocysteine, folate, 葉酸, vitamin B6
Abstract

Aim: Gender differences in serum folate concentrations are well known, but no studies have investigated the association between serum folate levels and schizophrenia based on gender. In this study in a Japanese population, we examined the difference in serum folate levels between patients with schizophrenia and non‐psychiatric controls stratified by gender. The relationships between serum folate levels, plasma total homocysteine (tHcy) and serum vitamin B6 (pyridoxal) levels were also examined using data from our previous studies. Methods: The serum folate concentrations of 482 patients diagnosed with schizophrenia and 1,350 non‐psychiatric control subjects were measured. We conducted an analysis of covariance to examine the differences in serum folate levels between the two groups based on gender. Spearman’s rank correlation was used to evaluate the relationships between folate, tHcy and vitamin B6 levels. Results: In the control group, serum folate concentrations were higher in women than in men. Lower levels of serum folate were observed in both male and female patients with schizophrenia. An inverse correlation between serum folate and plasma tHcy and a weak positive correlation between serum folate and vitamin B6 were observed in the combined cohort. Conclusion: Our findings suggest that (1) a low serum folate level may be associated with schizophrenia regardless of gender, and (2) folate administration may be beneficial for the treatment of schizophrenia. In schizophrenic patients with low serum folate levels, folate administration might result in improvements in high tHcy and an increase in low vitamin B6 levels.

Published
2020

27. Predictors of life skills in people with schizophrenia

Author

Tominaga, Takeo, Tomotake, Masahito, Takeda, Tomoya, Ueoka, Yoshinori, Tanaka, Tsunehiko, Watanabe, Shin-ya, Kameoka, Naomi, Nakataki, Masahito, Numata, Shusuke, Izaki, Yumiko, Sumitani, Satsuki, Kubo, Hiroko, Kaneda, Yasuhiro, and Ohmori, Tetsuro

Subjects
schizophrenia, life skill, negative symptom, depressive symptom, behavioral disciplines and activities, cognitive function
Abstract

Objective : The purpose of the present study is to examine clinical factors related to life skills in people with schizophrenia. Method : The participants were 51 stabilized outpatients with schizophrenia. Their mean age was 38.91 (SD = 10.73) years. Life skills were assessed using the Life skills profile (LSP). Cognitive function was evaluated with the Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery (MCCB). Clinical symptoms were assessed using the Positive and Negative Syndrome scale (PANSS), the Calgary Depression Scale for Schizophrenia (CDSS) and the Drug-Induced Extrapyramidal Symptoms Scale (DIEPSS). Results : Cognitive function was not correlated with the LSP scores at all. Among clinical symptoms, scores of the PANSS positive and negative syndrome scales, the CDSS, and the DIEPSS had negative correlations with the LSP total score and the subscales. Stepwise regression analyses showed that the CDSS and PANSS negative syndrome scale scores were independent predictors of the LSP total score and two of the subscales. Conclusions : These results indicate that cognitive function is not associated with life skills but clinical symptoms such as depressive and negative symptoms have considerable impacts on life skills in people with schizophrenia.

Published
2020

33. The chitinase 3-like 1 gene and schizophrenia: Evidence from a multi-center case–control study and meta-analysis

Author

Ohi, Kazutaka, Hashimoto, Ryota, Yasuda, Yuka, Yoshida, Tetsuhiko, Takahashi, Hidetoshi, Iike, Naomi, Iwase, Masao, Kamino, Kouzin, Ishii, Ryouhei, Kazui, Hiroaki, Fukumoto, Motoyuki, Takamura, Hironori, Yamamori, Hidenaga, Azechi, Michiyo, Ikezawa, Koji, Tanimukai, Hitoshi, Tagami, Shinji, Morihara, Takashi, Okochi, Masayasu, Yamada, Kazuo, Numata, Shusuke, Ikeda, Masashi, Tanaka, Toshihisa, Kudo, Takashi, Ueno, Shu-ichi, Yoshikawa, Takeo, Ohmori, Tetsuro, Iwata, Nakao, Ozaki, Norio, and Takeda, Masatoshi

Published
2010
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34. Discontinuation and remission rates and social functioning in patients with schizophrenia receiving second‐generation antipsychotics: 52‐week evaluation of JUMPs, a randomized, open‐label study

Author

Ishigooka, Jun, primary, Nakagome, Kazuyuki, additional, Ohmori, Tetsuro, additional, Iwata, Nakao, additional, Inada, Ken, additional, Iga, Jun‐ichi, additional, Kishi, Taro, additional, Fujita, Kiyoshi, additional, Kikuchi, Yuka, additional, Shichijo, Toshiaki, additional, Tabuse, Hideaki, additional, Koretsune, Shotatsu, additional, Terada, Hiroshi, additional, Terada, Haruko, additional, Kishimoto, Toshifumi, additional, Tsutsumi, Yuichiro, additional, Kanda, Yoshiki, additional, Ohi, Kazutaka, additional, and Sekiyama, Kanji, additional

Published
2021
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35. Plasma Kynurenine Level is Associated With Left DLPFC Activity and Can Predict Treatment Response in Major Depressive Disorder

Author

Kamishikiryo, Toshiharu, primary, Okada, Go, additional, Itai, Eri, additional, Masuda, Yoshikazu, additional, Yokoyama, Satoshi, additional, Takamura, Masahiro, additional, Fuchikami, Manabu, additional, Yoshino, Atsuo, additional, Mawatari, Kazuaki, additional, Numata, Shusuke, additional, Takahashi, Akira, additional, Ohmori, Tetsuro, additional, and Okamoto, Yasumasa, additional

Published
2021
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36. Negative and positive self-thoughts predict subjective quality of life in people with schizophrenia

Author

Takeda, Tomoya, Nakataki, Masahito, Ohta, Masashi, Hamatani, Sayo, Matsuura, Kanae, Yoshida, Reona, Kameoka, Naomi, Tominaga, Takeo, Umehara, Hidehiro, Kinoshita, Makoto, Watanabe, Shinya, Numata, Shusuke, Sumitani, Satsuki, and Ohmori, Tetsuro

Subjects
schizophrenia, mental disorders, subjective quality of life, objective quality of life, defeatist performance belief, negative and positive automatic thoughts, humanities
Abstract

Purpose: Recently, cognitive variables such as negative and positive self-belief and thoughts have attracted much attention because they are associated with functional outcomes and quality of life (QOL). However, it is unclear how cognitive variables affect subjective and objective QOL. This study aimed to investigate the relationship of negative and positive self-belief and thoughts with subjective and objective QOL. Participants and methods: Thirty-six people with schizophrenia participated in this study. Subjective and objective QOL were assessed with the Schizophrenia Quality of Life Scale (SQLS) and Quality of Life Scale (QLS), respectively. Neurocognitive function was assessed with the Brief Assessment of Cognition in Schizophrenia (BACS). Clinical symptoms were assessed with the Positive and Negative Syndrome Scale and Calgary Depression Scale for Schizophrenia. Side effects were assessed with the Drug-induced Extrapyramidal Symptoms Scale (DIEPSS). Negative and positive self-belief and thoughts were assessed with the Defeatist Performance Belief Scale and Automatic Thoughts Questionnaire-Revised. A generalized linear model was tested, with subjective and objective QOL as the response variable and symptoms, neurocognitive function, and cognitive variables that were significantly correlated with subjective and objective QOL as explanatory variables. Results: In the schizophrenia group, the common objects score on the QLS was predicted by the composite BACS score, and the total QLS score was predicted by the DIEPSS score. Motivation and Energy, Psychosocial, and Symptoms and Side effects scores on the SQLS were predicted by depression and by negative automatic thought (NAT) and positive automatic thought (PAT). Conclusion: Our results indicated that key targets for improving objective and subjective QOL in people with schizophrenia are side effects, neurocognitive function, depression, and NAT and PAT.

Published
2019

41. Association study of the G72 gene with schizophrenia in a Japanese population: A multicenter study

Author

Ohi, Kazutaka, Hashimoto, Ryota, Yasuda, Yuka, Yoshida, Tetsuhiko, Takahashi, Hidetoshi, Iike, Naomi, Fukumoto, Motoyuki, Takamura, Hironori, Iwase, Masao, Kamino, Kouzin, Ishii, Ryouhei, Kazui, Hiroaki, Sekiyama, Ryuji, Kitamura, Yuri, Azechi, Michiyo, Ikezawa, Koji, Kurimoto, Ryu, Kamagata, Eiichiro, Tanimukai, Hitoshi, Tagami, Shinji, Morihara, Takashi, Ogasawara, Masayuki, Okochi, Masayasu, Tokunaga, Hiromasa, Numata, Shusuke, Ikeda, Masashi, Ohnuma, Tohru, Ueno, Shu-ichi, Fukunaga, Tomoko, Tanaka, Toshihisa, Kudo, Takashi, Arai, Heii, Ohmori, Tetsuro, Iwata, Nakao, Ozaki, Norio, and Takeda, Masatoshi

Published
2009
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44. Role of an Atypical Cadherin Gene, Cdh23 in Prepulse Inhibition, and Implication of CDH23 in Schizophrenia

Author

Balan, Shabeesh, Ohnishi, Tetsuo, Watanabe, Akiko, Ohba, Hisako, Iwayama, Yoshimi, Toyoshima, Manabu, Hara, Tomonori, Hisano, Yasuko, Miyasaka, Yuki, Toyota, Tomoko, Shimamoto-Mitsuyama, Chie, Maekawa, Motoko, Numata, Shusuke, Ohmori, Tetsuro, Shimogori, Tomomi, Kikkawa, Yoshiaki, Hayashi, Takeshi, Yoshikawa, Takeo, Balan, Shabeesh, Ohnishi, Tetsuo, Watanabe, Akiko, Ohba, Hisako, Iwayama, Yoshimi, Toyoshima, Manabu, Hara, Tomonori, Hisano, Yasuko, Miyasaka, Yuki, Toyota, Tomoko, Shimamoto-Mitsuyama, Chie, Maekawa, Motoko, Numata, Shusuke, Ohmori, Tetsuro, Shimogori, Tomomi, Kikkawa, Yoshiaki, Hayashi, Takeshi, and Yoshikawa, Takeo

Abstract

We previously identified quantitative trait loci (QTL) for prepulse inhibition (PPI), an endophenotype of schizophrenia, on mouse chromosome 10 and reported Fabp7 as a candidate gene from an analysis of F2 mice from inbred strains with high (C57BL/6N; B6) and low (C3H/HeN; C3H) PPI levels. Here, we reanalyzed the previously reported QTLs with increased marker density. The highest logarithm of odds score (26.66) peaked at a synonymous coding and splice-site variant, c.753G>A (rs257098870), in the Cdh23 gene on chromosome 10; the c.753G (C3H) allele showed a PPI-lowering effect. Bayesian multiple QTL mapping also supported the same variant with a posterior probability of 1. Thus, we engineered the c.753G (C3H) allele into the B6 genetic background, which led to dampened PPI. We also revealed an e-QTL (expression QTL) effect imparted by the c.753G>A variant for the Cdh23 expression in the brain. In a human study, a homologous variant (c.753G>A; rs769896655) in CDH23 showed a nominally significant enrichment in individuals with schizophrenia. We also identified multiple potentially deleterious CDH23 variants in individuals with schizophrenia. Collectively, the present study reveals a PPI-regulating Cdh23 variant and a possible contribution of CDH23 to schizophrenia susceptibility.

Published
2021

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