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121 results on '"Ohnishi, Takamasa"'

1. A collision tumor of basal cell carcinoma and atypical fibroxanthoma: A case report.

Author

Suzuki‐Ueno, Mariko, Fujikawa, Yoshiaki, Hamaoka, Dai, Umemura, Kaoru, and Ohnishi, Takamasa

Subjects
BASAL cell carcinoma, CARCINOSARCOMAS, SKIN tumors, DIAGNOSIS
Abstract

Key Clinical Message: An 83‐year‐old man presented an elevated skin lesion in the left temporal area. The resected specimen was identified between a basal cell carcinoma and an atypical fibroxanthoma. A final diagnosis of basal cell carcinoma and atypical fibroxanthoma was made. This study reports a rare case of a cutaneous collision. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Rare Anal Canal Cancer with Secondary Extramammary Paget’s Disease (Pagetoid Spread) Complicated by Squamous Cell Carcinoma of the Skin

Author

Kusuhara, Tatsuki, Ito, Takashi, Matsuoka, Hiroki, Chohno, Teruhiro, Zozumi, Masataka, and Ohnishi, Takamasa

Subjects
Article Subject
Abstract

A 91-year-old man had a node and erythema in the anal area resistant to treatment. A biopsy of the node in the anus showed atypical cells developing as Paget’s disease, and staining revealed that the cells were CK7-positive, CK20-positive, and GCDFP15-negative. Therefore, tumor invasion with pagetoid spread (PS) from the anus to the skin was suspected, and the patient was referred to our department for a close examination and surgical treatment. Lower gastrointestinal endoscopy showed edematous, hemorrhagic mucosa in the anal canal, and he was diagnosed with adenocarcinoma via a biopsy. Additionally, redness and swelling with white moss were observed on the skin around the anus. Biopsy showed that Paget cells were diffusely present in the epithelium, and an image of squamous cell carcinoma directly under the epithelium was obtained. Taken together, the patient was diagnosed with the invasion of anal canal cancer with PS to the skin, and we performed laparoscopic abdominoperineal resection and skin carcinoma resection in the perineum. The histopathological analysis showed adenocarcinoma invading the external anal sphincter and subcutaneous adipose tissue in the vicinity of the pectinate line of the anal canal. Pagetoid spread of the adenocarcinoma was observed in the epidermis, and the open portion was slightly invaded up to the rectal mucosa. The anal skin region of the adenocarcinoma partially continued to the hair follicles, and it was complicated by squamous cell carcinoma invading the dermis. There are a few reports of anal canal cancer with PS, and the coexistence of adenocarcinoma and squamous cell carcinoma, as seen in the present case, is rare. We report our case together with relevant literature.

Published
2021
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19. A high-fat diet increases the incidence of mammary cancer inc-Ha-ras proto-oncogene transgenic rats

Author

Magaki, Mie, Ishii, Hiroko, Yamasaki, Aya, Kitai, Yurika, Kametani, Saeda, Nakai, Reiko, Dabid, Alexander, Tsuda, Hiroyuki, and Ohnishi, Takamasa

Subjects
high-fat diet, mammary cancer, Hras128, Original Article, c-Ha-rasgene
Abstract

Mammary cancer is the most common type of cancer and the fifth most common cause of cancer-related deaths among Japanese women. The recent sharp increase in the number of women diagnosed with mammary cancer per year is thought to be associated with increased fat intake resulting from changes in the dietary habits of contemporary Japanese citizens. In this study, human c-Ha-ras proto-oncogene transgenic (Hras128) rats, which are highly susceptible to mammary carcinogens, were fed high- or low-fat diets to examine the relationship between fat consumption and the development of mammary cancer. Female 7-week-old Hras128 rats and wild-type littermates were administered benzo[a]pyrene. A week later, the animals were randomly assigned to high-fat or low-fat diet groups (45% or 10% of calories from fat, respectively). After 12 weeks, the rats were sacrificed and autopsied, and mammary tumors were excised and processed for microscopic observation. Mammary tumors were found in 11 of the 12 animals in the high-fat diet group and in 5 of the 12 animals in the low-fat diet group, and the numbers of mammary gland tumors per animal in these groups were 1.7 and 0.7, respectively. Notably, the observed differences in incidence and multiplicity of mammary tumors between the two groups were statistically significant. These results suggest a positive relationship between the incidence of breast cancer and high fat intake.

Published
2016

21. Cover Image.

Author

Suzuki‐Ueno, Mariko, Fujikawa, Yoshiaki, Hamaoka, Dai, Umemura, Kaoru, and Ohnishi, Takamasa

Abstract

The cover image is based on the Article A collision tumor of basal cell carcinoma and atypical fibroxanthoma: A case report by Mariko Suzuki‐Ueno et al., https://doi.org/10.1002/ccr3.9250 [ABSTRACT FROM AUTHOR]

Published
2024
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23. Effect of intermittent liver ischemia on outcome in patients with hepatocellular carcinoma on liver cirrhosis

Author

Harada, Masamitsu, Yogita, Shiro, Tashiro, Seiki, Narioka, Junji, Horiuchi, Masafumi, Ohnishi, Takamasa, Miyake, Hidenori, Ishikawa, Masashi, Fukuda, Yoh, and Wada, Daisuke

Subjects
hepatic ischemia, vascular occlusion, liver cirrhosis
Abstract

The influence on postoperative liver function of intermittent normothermic hepatic ischemia in cirrhotic patients was studied retrospectively. The mean total ischemia time was 88 (range30 - 140) minutes in the hemi-hepatic occlusion group, and68 (range 10 - 187) minutes in the total occlusion group. There were no operative deaths due to hepatic failure. Postoperative liver function improved within 1 week of the opera-tion. There was no significant difference in the incidence of postoperative complications between the groups. Thus normothermic hepatic ischemia is tolerated for up to 180minutes in the cirrhotic liver when an intermittent technique (15 minutes clamped and5 minutes unclamped) is used.

Published
1999

24. Low susceptibility to N-ethyl-N-nitrosourea-induced transplacental carcinogenesis in Long-Evans Cinnamon (LEC) rats

Author

Tsuchigauchi, Takeshi, Takahashi, Tetsuyuki, Ohnishi, Takamasa, Ogawa, Hirohisa, Bando, Yoshimi, Uehara, Hisanori, Takizawa, Tamotsu, Kaneda, Shinya, Nakai, Tokiko, Shiota, Hiroshi, Izumi, Keisuke, Tsuchigauchi, Takeshi, Takahashi, Tetsuyuki, Ohnishi, Takamasa, Ogawa, Hirohisa, Bando, Yoshimi, Uehara, Hisanori, Takizawa, Tamotsu, Kaneda, Shinya, Nakai, Tokiko, Shiota, Hiroshi, and Izumi, Keisuke

Abstract

The Long-Evans Cinnamon (LEC) rat, an animal model of Wilson’s disease, is resistant to a variety of chemical carcinogenesis except liver and colon. In the present study, N-ethyl-N-nitrosourea (ENU)-induced transplacental carcinogenesis was examined in male and female LEC, Long-Evans Agouti (LEA), a sibling line of the LEC rat, and F344 rats (n=21). ENU was administered to pregnant rats as a single s.c. injection at a dose of 60 mg/kg body weight on the 17th day after conception. Cerebral/spinal gliomas and trigeminal/spinal nerve schwannomas developed in both LEA and F344 rats at 30 weeks of age, but no nervous system tumors developed in LEC rats, the difference being statistically significant. Lung adenomas also developed in LEA and F344 rats, but not in LEC rats. Semiquantitative RT-PCR demonstrated that metallothionein (MT)1a, MT2 and O6-methylguanine-DNA methyltransferase (MGMT) mRNA levels in the liver of LEC rats were higher than those in F344 and LEA rats. In addition, Western blot analysis showed that MT (MT1 plus MT2) in the liver of LEC rats was also higher than that in other strains. Present results suggest that high levels of MT and/or MGMT contribute to the resistance to nitrosamine-induced carcinogenesis in LEC rats.

Published
2009

25. Enhancement of Endothelial Function Inhibits Left Atrial Thrombi Development in an Animal Model of Spontaneous Left Atrial Thrombosis

Author

Mawatari, Kazuaki, primary, Yoshioka, Emiko, additional, Toda, Satomi, additional, Yasui, Sonoko, additional, Furukawa, Hiroko, additional, Shimohata, Takaaki, additional, Ohnishi, Takamasa, additional, Morishima, Masaki, additional, Harada, Nagakatsu, additional, Takahashi, Akira, additional, Sakaue, Hiroshi, additional, and Nakaya, Yutaka, additional

Published
2014
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27. Prevention of lethal hepatic injury in Long-Evans Cinnamon (LEC) rats by D-galactosamine hydrochloride

Author

Otsuka, Toshihiro, Izumi, Keisuke, Tokunaga, Itsuo, Gotohda, Takako, Ipposhi, Kaneshige, Takiguchi, Yoshiharu, Kaneda, Shinya, Satake, Nobuo, Ohnishi, Takamasa, Tashiro, Seiki, Shimada, Mitsuo, Otsuka, Toshihiro, Izumi, Keisuke, Tokunaga, Itsuo, Gotohda, Takako, Ipposhi, Kaneshige, Takiguchi, Yoshiharu, Kaneda, Shinya, Satake, Nobuo, Ohnishi, Takamasa, Tashiro, Seiki, and Shimada, Mitsuo

Abstract

Repeated injections of D-galactosamine hydrochloride (GalN) increase the survival rate of Long-Evans Cinnamon (LEC) rats, an animal model of Wilson’s disease. The aim of the present study was to investigate the mechanism of GalN for prevention of spontaneous lethal hepatic injury in LEC rats. MaleLEC rats were given a single subcutaneous injection of 300mg/kg of GalN or vehicle (0.9%NaCl) at 14weeks, and killed at 28 weeks of age. Next, 6-week-old male LEC rats were given weekly subcutaneous injections of 300 mg/kg of GalN or vehicle for 3 or 12 weeks, and their hepatic 8-hydroxydeoxy-2’-guanosine (8-OHdG), glutathione peroxidase (GPX), and catalase activities were measured. None of GalN-treated rats died of hepatic injury (0/12), whereas the mortality rate of control rats given 0.9% NaCl was 17% (2/12). GalN administration for 12 weeks decreased the hepatic 8-OHdG, and GalN administration for either 3 or 12weeks increased the glutathione peroxidase activity. GalN administration increased the serum level of alanine aminotransferase, and accelerated megalocytic degeneration of the hepatocytes. GalN treatment is effective in preventing lethal hepatitis in LEC rats and decrease of oxidative DNA damage by GalN plays an important role in increase of the survival rate.

Published
2006

28. Among triple-negative breast cancers, HER2(0) breast cancer shows a strong tendency to be basal-like compared with HER2(1+) breast cancer: preliminary results

Author

Nakagawa, Misako, primary, Bando, Yoshimi, additional, Nagao, Taeko, additional, Takai, Chikako, additional, Ohnishi, Takamasa, additional, Honda, Junko, additional, Moriya, Takuya, additional, Izumi, Keisuke, additional, Takahashi, Masako, additional, Tangoku, Akira, additional, and Sasa, Mitsunori, additional

Published
2011
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29. β‐Adrenergic‐AMPK Pathway Phosphorylates Acetyl‐CoA Carboxylase in a High‐epinephrine Rat Model, SPORTS

Author

Hattori, Atsushi, primary, Mawatari, Kazuaki, additional, Tsuzuki, Satomi, additional, Yoshioka, Emiko, additional, Toda, Satomi, additional, Yoshida, Masaki, additional, Yasui, Sonoko, additional, Furukawa, Hiroko, additional, Morishima, Masaki, additional, Ono, Katsushige, additional, Ohnishi, Takamasa, additional, Nakano, Masayuki, additional, Harada, Nagakatsu, additional, Takahashi, Akira, additional, and Nakaya, Yutaka, additional

Published
2010
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30. Low susceptibility to N-ethyl-N-nitrosourea-induced transplacental carcinogenesis in Long-Evans Cinnamon (LEC) rats

Author

Tsuchigauchi, Takeshi, primary, Takahashi, Tetsuyuki, additional, Ohnishi, Takamasa, additional, Ogawa, Hirohisa, additional, Bando, Yoshimi, additional, Uehara, Hisanori, additional, Takizawa, Tamotsu, additional, Kaneda, Shinya, additional, Nakai, Tokiko, additional, Shiota, Hiroshi, additional, and Izumi, Keisuke, additional

Published
2009
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46. Transgenic Rats Carrying Human c‐Ha‐rasProto‐oncogene Are Highly Susceptible to N‐Nitrosomethylbenzylamine Induction of Esophageal Tumorigenesis

Author

Asamoto, Makoto, Toriyama‐Baba, Hiroyasu, Ohnishi, Takamasa, Naito, Akihiro, Ota, Tomonori, Ando, Akira, Ochiya, Takahiro, and Tsuda, Hiroyuki

Abstract

A transgenic rat line carrying three copies of the human c‐Ha‐rasproto‐oncogene, including its own promoter region, has been established in our laboratory (Hras128 rats), and shown to be highly susceptible to induction of mammary and urinary bladder tumors. Mutation analysis of induced lesions indicated the majority to contain some but not all cells with transgene mutation. In the present study, the susceptibility of Hras128 rats to N‐nitrosomethylbenzylamine (NMBA) induction of esophageal tumors was examined with a similar mutation analysis of the transgenes. Male 6‐week‐old Hras128 and wild littermate rats were treated with NMBA, 0.5 mg/kg subcutaneously, 3 tunes a week for 5 weeks and then maintained for 5 weeks without any further treatment. Multiple esophageal tumors, squamous cell pappillomas and carcinomas, rapidly developed within this 10–week experimental period in Hras128 rats (11.05+7.83/rat). In contrast, wild‐type litter‐mates had only small numbers of mostly benign tumors (1.67+2.06/rat). The Hras128 rats had no other tumors or abnormalities. In their esophageal lesions, codon 12 GGC to GAC mutations of the transgene were frequently detected by restriction fragment length polymorphisms (RFLP) and subsequent direct sequencing analysis (19/25, 76%). In the endogenous rat c‐Ha‐rasgene they were less frequent (2/25, 8%), than in wild‐type rats (8/14, 57.1%). The densities of mutated bands in the RFLP analysis indicated that mutated cells were major populations in tumors, in contrast to the case with mammary and urinary bladder lesions. Furthermore, activated ras protein, detected by binding to raf protein, was clearly increased in tumors as compared to surrounding epithelium or the normal esophagus of untreated rats. The results show that Hras128 rats are highly susceptible to NMBA esophageal carcinogenesis, as well as induction of mammary and urinary bladder tumors, but that tissue‐specific characteristics exist for the roles of transgene rasmutations.

Published
2002
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47. Effects of Alendronate on Bone Metastases and Hypercalcemia After Surgery for Hepatocellular Carcinoma.

Author

Ohnishi, Takamasa, Takeda, Eiji, Yogita, Shiro, Miyake, Hidenori, Kinoshita, Takafumi, Terashima, Yoshiyasu, Matsumoto, Toshio, and Tashiro, Seiki

Abstract

Investigates the effects of alendronate, a bisphosphonate compound, in patients with hypercalcemia due to bone metastasis of hepatocellular carcinoma. Decrease in corrected serum calcium levels, alpha-fetoprotein levels and bone pain of the two patients after treatment; Alleviation of pain due to bone metastasis after treatment; Improvement of the patients' life.

Published
2000
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49. [Improvement of tissue fibrosis in TAFRO syndrome by prednisolone monotherapy].

Author

Kashiwagi T, Kashiwagi Y, Suzuki T, Shingu M, Kashiwagi S, Hirata T, Hori J, Miyata K, Takechi M, Kishi M, Ohnishi T, Katayama Y, Iwai M, and Matsui T

Subjects
Humans, Male, Middle Aged, Castleman Disease drug therapy, Castleman Disease pathology, Fibrosis, Treatment Outcome, Syndrome, Prednisolone administration & dosage
Abstract

We report the case of a 48-year-old man who presented with fatigue and weight loss. A local physician observed elevated alkaline phosphatase levels, anemia, thrombocytopenia, and renal dysfunction. Fever also appeared, and the patient was admitted to our hospital. Computed tomography revealed hepatosplenomegaly, pleural and ascitic fluid, and left axillary lymphadenopathy. Bone marrow biopsy indicated hyperplasia with increased megakaryocytes and reticulin fibrosis. Axillary lymph node biopsy showed Castleman's disease-like features. Liver biopsy revealed proliferation of reticulin fibrosis. Therefore, TAFRO syndrome was diagnosed and treatment with 1 mg/kg prednisolone was started. Anemia and thrombocytopenia improved, and after 24 weeks of treatment, serum hyaluronic acid and type IV collagen decreased to the normal range. Bone marrow biopsy after 18 weeks of treatment showed decreased reticular fibers. In TAFRO syndrome, improvement of liver and bone marrow fibrosis can be expected with adequate intervention, and serum hyaluronic acid and type IV collagen are useful for evaluating fibrosis.

Published
2024
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50. Expression of p53, Ki-67, E-cadherin, N-cadherin and TOP2A in triple-negative breast cancer.

Author

Nakagawa M, Bando Y, Nagao T, Morimoto M, Takai C, Ohnishi T, Honda J, Moriya T, Izumi K, Takahashi M, Sasa M, and Tangoku A

Subjects
Breast Neoplasms pathology, Female, Humans, Immunohistochemistry, Middle Aged, Poly-ADP-Ribose Binding Proteins, Receptor, ErbB-2 biosynthesis, Receptors, Estrogen biosynthesis, Receptors, Progesterone biosynthesis, Antigens, CD biosynthesis, Antigens, Neoplasm biosynthesis, Breast Neoplasms metabolism, Cadherins biosynthesis, DNA Topoisomerases, Type II biosynthesis, DNA-Binding Proteins biosynthesis, Ki-67 Antigen biosynthesis, Tumor Suppressor Protein p53 biosynthesis
Abstract

Background: Elucidation of the biological features of triple negative breast cancer (TNBC) is important for deciding treatment strategies. The expression of a number of biomarkers in TNBC was analyzed to elucidate those features., Patients and Methods: The subjects were 134 TNBC patients. Immunohistochemical staining was employed to analyze for eight biomarkers: cytokeratin 5/6 (CK5/6), epidermal growth factor receptor (EGFR), p53, Ki-67 antigen (Ki-67), E-cadherin, N-cadherin, topoisomerase 2 alpha (TOP2A) and B-cell lymphoma 2 (BCL-2), which were then correlated with the nuclear grade (NG), tumor diameter, and the presence/absence of lymph node metastasis, distant recurrence and lymphatic infiltration., Results: Significantly more high than low NG TNBC exhibited positive p53, Ki-67, E-cadherin and TOP2A. High N-cadherin and TOP2A expression was shown significantly in TNBC with lymphatic infiltration, and N-cadherin was also significantly positively expressed in node metastasis-positive cases. EGFR and CK5/6 were positively expressed in high NG TNBC, but not significantly., Conclusion: Analysis for expression of p53, Ki-67, E-cadherin, N-cadherin and TOP2A is meaningful for deciding treatment strategies for TNBC.

Published
2011

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