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14 results on '"Ohtomo-Abe, Akemi"'

1. Biological and biochemical analysis of T cell derived bronchoconstriction

Author

Kouyama, Satoshi, primary, Ohtomo-Abe, Akemi, additional, Kawasaki, Yuichiro, additional, Iwata, Maki, additional, Nakamura, Yuto, additional, Hamada, Yuto, additional, Kamide, Yosuke, additional, Sekiya, Kiyoshi, additional, Fukutomi, Yuma, additional, Ohtomo, Takayuki, additional, Kaminuma, Osamu, additional, and Mori, Akio, additional

Published
2023
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2. Steroid resistance of severe asthma — mechanisms and therapeutic targets

Author

Mori, Akio, primary, Kouyama, Satoshi, additional, Ohtomo-Abe, Akemi, additional, Yamaguchi, Miyako, additional, Kumitani, Chiemi, additional, Iwamoto, Keisuke, additional, Yano, Kouichi, additional, Fujita, Norihiro, additional, Iwata, Maki, additional, Nagayama, Kisako, additional, Ryu, Kai, additional, Nakamura, Yuto, additional, Hamada, Yuto, additional, Watai, Kentaro, additional, Kamide, Yosuke, additional, Sekiya, Kiyoshi, additional, Fukutomi, Yuma, additional, Matsumoto, Koichiro, additional, Tanimoto, Yasushi, additional, Kobayashi, Nobuyuki, additional, Ohtomo, Takayuki, additional, and Kaminuma, Osamu, additional

Published
2022
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3. Molecular characterization of bronchoconstriction induced by activated T cells

Author

Mori, Akio, primary, Kouyama, Satoshi, additional, Yamaguchi, Miyako, additional, Kumitani, Chiemi, additional, Ohtomo-Abe, Akemi, additional, Kawasaki, Yuichiro, additional, Iwamoto, Keisuke, additional, Yano, Koichi, additional, Iwata, Maki, additional, Nagayama, Kisako, additional, Ryu, Kai, additional, Nakamura, Yuto, additional, Hamada, Yuto, additional, Watai, Kentaro, additional, Kamide, Yosuke, additional, Sekiya, Kiyoshi, additional, Fukutomi, Yuma, additional, Ohtomo, Takayuki, additional, and Kaminuma, Osamu, additional

Published
2021
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5. Therapeutic approach to steroid-resistant asthma

Author

Mori, Akio, primary, Kouyama, Satoshi, additional, Yamaguchi, Miyako, additional, Kumitani, Chiemi, additional, Ohtomo-Abe, Akemi, additional, Fujita, Norihiko, additional, Iwata, Maki, additional, Nagayama, Kisako, additional, Ryu, Kai, additional, Nakamura, Yuto, additional, Hamada, Yuto, additional, Hayashi, Hiroaki, additional, Watai, Kentaro, additional, Kamide, Yosuke, additional, Sekiya, Kiyoshi, additional, Fukutomi, Yuma, additional, Taniguchi, Masami, additional, Ohtomo, Takayuki, additional, and Kaminuma, Osamu, additional

Published
2020
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6. Synergistic suppression of T cell-induced eosinophilia by glucocorticoid and CTLA4-Ig

Author

Akio, Mori, primary, Kouyama, Satoshi, additional, Yamaguchi, Miyako, additional, Kumitani, Chiemi, additional, Ohtomo-Abe, Akemi, additional, Fujita, Norihiko, additional, Iwata, Maki, additional, Nagayama, Kisako, additional, Ryu, Kai, additional, Nakamura, Yuto, additional, Tomita, Yasuhiro, additional, Hamada, Yuto, additional, Hayashi, Hiroaki, additional, Watai, Kentaro, additional, Kamide, Yosuke, additional, Sekiya, Kiyoshi, additional, Fukutomi, Yuma, additional, Taniguchi, Masami, additional, Ohtomo, Takayuki, additional, and Kaminuma, Osamu, additional

Published
2019
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7. Late Breaking Abstract - Pharmacological characterization of T cell-induced broncho-constriction in vitro and in vivo

Author

Mori, Akio, primary, Kouyama, Satoshi, additional, Yamaguchi, Miyako, additional, Kumitani, Chiemi, additional, Ohtomo-Abe, Akemi, additional, Fujita, Norihiko, additional, Iwata, Maki, additional, Nagayama, Kisako, additional, Ryu, Kai, additional, Nakamura, Yuto, additional, Tomita, Yasuhiro, additional, Hamada, Yuto, additional, Hayashi, Hiroaki, additional, Watai, Kentaro, additional, Kamide, Yosuke, additional, Sekiya, Kiyoshi, additional, Fukutomi, Yuma, additional, Taniguchi, Masami, additional, Ohtomo, Takayuki, additional, and Kaminuma, Osamu, additional

Published
2018
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8. CTLA4-Ig enhanced glucocorticoid effect on murine asthma

Author

Mori, Akio, primary, Kouyama, Satoshi, additional, Yamaguchi, Miyako, additional, Kumitani, Chiemi, additional, Ohtomo-Abe, Akemi, additional, Nakamura, Yuto, additional, Tomita, Yasuhiro, additional, Hamada, Yuto, additional, Kamide, Yosuke, additional, Hayashi, Hiroaki, additional, Watai, Kentaro, additional, Mitsui, Chihiro, additional, Sekiya, Kiyoshi, additional, Tsuburai, Takahiro, additional, Fukutomi, Yuma, additional, Taniguchi, Masami, additional, Ohtomo, Takayuki, additional, and Kaminuma, Osamu, additional

Published
2017
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9. Blockade of Costimulatory Signal Enhanced Glucocorticoid Suppression of T Cell-Induced Eosinophilia

Author

Mori, Akio, primary, Kouyama, Satoshi, additional, Yamaguchi, Miyako, additional, Ohtomo-Abe, Akemi, additional, Kamide, Yosuke, additional, Hayashi, Hiroaki, additional, Watai, Kentaro, additional, Mitsui, Chihiro, additional, Sekiya, Kiyoshi, additional, Tsuburai, Takahiro, additional, Taniguchi, Masami, additional, Ohtomo, Takayuki, additional, and Kaminuma, Osamu, additional

Published
2017
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10. Synergistic suppression of T cell-induced eosinophilia by CTLA4-Ig and glucocorticoid in murine asthma model

Author

Mori, Akio, primary, Kouyama, Satoshi, additional, Yamaguchi, Miyako, additional, Ohtomo-Abe, Akemi, additional, Kamide, Yosuke, additional, Hayashi, Hiroaki, additional, Watai, Kentaro, additional, Mitsui, Chihiro, additional, Sekiya, Kiyoshi, additional, Tsuburai, Takahiro, additional, Fukutomi, Yuma, additional, Taniguchi, Masami, additional, Ohtomo, Takayuki, additional, and Kaminuma, Osamu, additional

Published
2016
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11. Control of Steroid Responsiveness of Th Cells in Asthma

Author

Mori, Akio, primary, Kouyama, Satoshi, additional, Yamaguchi, Miyako, additional, Iijima, Yo, additional, Ohtomo-Abe, Akemi, additional, Kinoshita, Arisa, additional, Kamide, Yosuke, additional, Hayashi, Hiroaki, additional, Watai, Kentaro, additional, Mitsui, Chihiro, additional, Oshikata, Chiyako, additional, Sekiya, Kiyoshi, additional, Tsuburai, Takahiro, additional, Ohtomo, Mamoru, additional, Fukutomi, Yuma, additional, Taniguchi, Masami, additional, Ohtomo, Takayuki, additional, and Kaminuma, Osamu, additional

Published
2016
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12. Effects of LTRA on T cell-induced bronchoconstriction in the mice

Author

Mori, Akio, primary, Kouyama, Satoshi, additional, Yamaguchi, Miyako, additional, Iijima, Y.O., additional, Ohtomo-Abe, Akemi, additional, Ohtomo, Takayuki, additional, Saito, Natsumi, additional, Kinoshita, Arisa, additional, Watarai, Kentaro, additional, Mitsui, Chihiro, additional, Oshikata, Chiyako, additional, Sekiya, Kiyoshi, additional, Tsuburai, Takahiro, additional, Ohtomo, Mamoru, additional, Fukutomi, Yuma, additional, Taniguchi, Masami, additional, and Kaminuma, Osamu, additional

Published
2015
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13. Pharmacological Characterization of T Cell-Induce Bronchoconstriction in the Mice

Author

Mori, Akio, primary, Kouyama, Satoshi, additional, Yamaguchi, Miyako, additional, Iijima, Yo, additional, Ohtomo-Abe, Akemi, additional, Hayashi, Hiroaki, additional, Watarai, Kentaro, additional, Mitsui, Chihiro, additional, Oshikata, Chiyako, additional, Sekiya, Kiyoshi, additional, Tsuburai, Takahiro, additional, Maeda, Yuji, additional, Ohtomo, Mamoru, additional, Fukutomi, Yuma, additional, Taniguchi, Masami, additional, Akiyama, Kazuo, additional, Ohtomo, Takayuki, additional, and Kaminuma, Osamu, additional

Published
2015
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14. [Steroid resistance of severe asthma - mechanisms and therapeutic targets].

Author

Mori A, Kouyama S, Ohtomo-Abe A, Yamaguchi M, Kumitani C, Iwamoto K, Yano K, Fujita N, Iwata M, Nagayama K, Ryu K, Nakamura Y, Hamada Y, Watai K, Kamide Y, Sekiya K, Fukutomi Y, Matsumoto K, Tanimoto Y, Kobayashi N, Ohtomo T, and Kaminuma O

Subjects
Cytokines, Double-Blind Method, Humans, Japan, Steroids therapeutic use, Asthma
Abstract

Asthma therapy in general has improved a lot in recent years, but it is still a major problem that severe asthma, which accounts for 10 to 20%, still suffers from strong symptoms on a daily basis despite all therapeutic agents used in combination. American SARP and European ENFUMOSA started in 2000 to advance pathophysiological insights of severe asthma. Clinical usage of antibodies and inhibitors against IgE, TNF, IL-5, IL-4, IL-13, and TSLP are also accumulating. Some of these molecular-targeted drugs improve respiratory function and reduce acute exacerbations in patients with severe asthma. Until now, cytokines have been assumed to be involved in chronic inflammation, but it is also interesting to elucidate the pathways of how cytokines are involved in respiratory function and acute exacerbations. We registered approximately 100 steroid-dependent asthma patients in Japan. Although long-lasting poor control of the disease was considered the cause of severe asthma in the past, steroid dependence in one third of the cases occurred within 2-3 years after the onset. Steroid resistance seems a key process from the early stage of the disease. Steroid resistance of T cell level was induced by extracellular co-stimulation and cytokine signals. The inhibition may improve steroid sensitivity and treat steroid-resistant asthma. Therefore, we established a steroid-resistant asthma model for the first time by transferring steroid resistant T cell clones, and analyzed the steroid sensitivity recovery effect of CTLA4-Ig. In addition, a multicenter, double-blind, placebo-controlled exploratory trial was performed as a POC study investigating the efficacy of abatacept in treatment-resistant severe asthma. Elucidation of the pathophysiology and mechanism by which steroids do not work is expected to be a breakthrough for the prevention and treatment of severe asthma.

Published
2022
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