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7. Increased numbers of pre-operative circulating monocytes predict risk of developing cardiac surgery-associated acute kidney injury in conditions requiring cardio pulmonary bypass

Author

Okadome, Yusuke, Morinaga, Jun, Yamanouchi, Yoshinori, Matsunaga, Eiji, Fukami, Hirotaka, Kadomatsu, Tsuyoshi, Horiguchi, Haruki, Sato, Michio, Sugizaki, Taichi, Hayata, Manabu, Sakaguchi, Takeshi, Hirayama, Ryo, Ishimura, Tatsuhiro, Kuwabara, Takashige, Usuku, Koichiro, Yamamoto, Tatsuo, Mukoyama, Masashi, Suzuki, Ryusuke, Fukui, Toshihiro, and Oike, Yuichi

Published
2023
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8. Plasma ANGPTL8 Levels and Risk for Secondary Cardiovascular Events in Japanese Patients With Stable Coronary Artery Disease Receiving Statin Therapy

Author

Morinaga, Jun, Kashiwabara, Kosuke, Torigoe, Daisuke, Okadome, Yusuke, Aizawa, Kenichi, Uemura, Kohei, Kurashima, Ai, Matsunaga, Eiji, Fukami, Hirotaka, Horiguchi, Haruki, Sato, Michio, Sugizaki, Taichi, Miyata, Keishi, Kadomatsu, Tsuyoshi, Mukoyama, Masashi, Miyauchi, Katsumi, Hokimoto, Seiji, Fukumoto, Yoshihiro, Hiro, Takafumi, Hibi, Kiyoshi, Nakagawa, Yoshihisa, Sakuma, Ichiro, Ozaki, Yukio, Iwata, Hiroshi, Iimuro, Satoshi, Daida, Hiroyuki, Shimokawa, Hiroaki, Kimura, Takeshi, Matsuzaki, Masunori, Saito, Yasushi, Matsuyama, Yutaka, Nagai, Ryozo, and Oike, Yuichi

Published
2023
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14. Loss of Dja2 accompanies pH deviation in lysosomes and lysosome‐related organelles.

Author

Terada, Kazutoyo, Endo, Motoyoshi, Kiyonari, Hiroshi, Takeda, Naoki, and Oike, Yuichi

Subjects
ORGANELLES, ALVEOLAR macrophages, PROTEIN C, LYSOSOMES, MECONIUM aspiration syndrome, GLYCOLIPIDS, AMILORIDE
Abstract

The Dja2 knockout (Dja2−/−) mice had respiratory distress, and >60% died within 2 days after birth. The surviving adult Dja2−/− mice were infertile and the lungs of Dja2−/− mice showed several abnormalities, including the processing defect of prosurfactant protein C in the alveolar epithelial type II cells and the accumulation of glycolipids in enlarged alveolar macrophages. The luminal pH of acidic organelles in Dja2−/− cells was shifted to pH 5.37–5.45. This deviated pH was immediately restored to control levels (pH 4.56–4.65) by the addition of a diuretic, ethyl isopropyl amiloride (EIPA). Although the role of DJA2 in maintaining the pH homeostasis of lysosome‐related organelles is currently obscure, this rapid and remarkable pH resilience is best explained by an EIPA‐sensitive proton efflux machinery that is disorganized and overactivated due to the loss of Dja2. [ABSTRACT FROM AUTHOR]

Published
2024
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15. The lncRNA Caren antagonizes heart failure by inactivating DNA damage response and activating mitochondrial biogenesis

Author

Sato, Michio, Kadomatsu, Tsuyoshi, Miyata, Keishi, Warren, Junco S., Tian, Zhe, Zhu, Shunshun, Horiguchi, Haruki, Makaju, Aman, Bakhtina, Anna, Morinaga, Jun, Sugizaki, Taichi, Hirashima, Kaname, Yoshinobu, Kumiko, Imasaka, Mai, Araki, Masatake, Komohara, Yoshihiro, Wakayama, Tomohiko, Nakagawa, Shinichi, Franklin, Sarah, Node, Koichi, Araki, Kimi, and Oike, Yuichi

Published
2021
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17. ANGPTL2‐mediated epigenetic repression of MHC‐I in tumor cells accelerates tumor immune evasion

Author

Kadomatsu, Tsuyoshi, primary, Hara, Chiaki, additional, Kurahashi, Ryoma, additional, Horiguchi, Haruki, additional, Morinaga, Jun, additional, Miyata, Keishi, additional, Kurano, Sohtaro, additional, Kanemaru, Hisashi, additional, Fukushima, Satoshi, additional, Araki, Kimi, additional, Baba, Masaya, additional, Linehan, W. Marston, additional, Kamba, Tomomi, additional, and Oike, Yuichi, additional

Published
2023
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19. Lung group 2 innate lymphoid cells differentially depend on local IL-7 for their distribution, activation, and maintenance in innate and adaptive immunity-mediated airway inflammation.

Author

Takami, Daichi, Abe, Shinya, Shimba, Akihiro, Asahi, Takuma, Cui, Guangwei, Tani-ichi, Shizue, Hara, Takahiro, Miyata, Keishi, Ikutani, Masashi, Takatsu, Kiyoshi, Oike, Yuichi, and Ikuta, Koichi

Subjects
INNATE lymphoid cells, HOUSE dust mites, AIRWAY (Anatomy), EPITHELIAL cells, BRONCHI
Abstract

Interleukin-7 (IL-7) is a cytokine critical for the development and maintenance of group 2 innate lymphoid cells (ILC2s). ILC2s are resident in peripheral tissues such as the intestine and lung. However, whether IL-7 produced in the lung plays a role in the maintenance and function of lung ILC2s during airway inflammation remains unknown. IL-7 was expressed in bronchoalveolar epithelial cells and lymphatic endothelial cells (LECs). To investigate the role of local IL-7 in lung ILC2s, we generated two types of IL-7 conditional knockout (IL-7cKO) mice: Sftpc-Cre (SPC-Cre) IL-7cKO mice specific for bronchial epithelial cells and type 2 alveolar epithelial cells and Lyve1-Cre IL-7cKO mice specific for LECs. In steady state, ILC2s were located near airway epithelia, although lung ILC2s were unchanged in the two lines of IL-7cKO mice. In papain-induced airway inflammation dependent on innate immunity, lung ILC2s localized near bronchia via CCR4 expression, and eosinophil infiltration and type 2 cytokine production were reduced in SPC-Cre IL-7cKO mice. In contrast, in house dust mite (HDM)-induced airway inflammation dependent on adaptive immunity, lung ILC2s localized near lymphatic vessels via their CCR2 expression 2 weeks after the last challenge. Furthermore, lung ILC2s were decreased in Lyve1-Cre IL-7cKO mice in the HDM-induced inflammation because of decreased cell survival and proliferation. Finally, administration of anti-IL-7 antibody attenuated papain-induced inflammation by suppressing the activation of ILC2s. Thus, this study demonstrates that IL-7 produced by bronchoalveolar epithelial cells and LECs differentially controls the activation and maintenance of lung ILC2s, where they are localized in airway inflammation. [ABSTRACT FROM AUTHOR]

Published
2023
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25. Supplementary Figure Legend from Angiopoietin-like Protein 2 Accelerates Carcinogenesis by Activating Chronic Inflammation and Oxidative Stress

Author

Aoi, Jun, primary, Endo, Motoyoshi, primary, Kadomatsu, Tsuyoshi, primary, Miyata, Keishi, primary, Ogata, Aki, primary, Horiguchi, Haruki, primary, Odagiri, Haruki, primary, Masuda, Tetsuro, primary, Fukushima, Satoshi, primary, Jinnin, Masatoshi, primary, Hirakawa, Satoshi, primary, Sawa, Tomohiro, primary, Akaike, Takaaki, primary, Ihn, Hironobu, primary, and Oike, Yuichi, primary

Published
2023
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26. Data from Angiopoietin-like Protein 2 Accelerates Carcinogenesis by Activating Chronic Inflammation and Oxidative Stress

Author

Aoi, Jun, primary, Endo, Motoyoshi, primary, Kadomatsu, Tsuyoshi, primary, Miyata, Keishi, primary, Ogata, Aki, primary, Horiguchi, Haruki, primary, Odagiri, Haruki, primary, Masuda, Tetsuro, primary, Fukushima, Satoshi, primary, Jinnin, Masatoshi, primary, Hirakawa, Satoshi, primary, Sawa, Tomohiro, primary, Akaike, Takaaki, primary, Ihn, Hironobu, primary, and Oike, Yuichi, primary

Published
2023
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27. Data from TFE3 Xp11.2 Translocation Renal Cell Carcinoma Mouse Model Reveals Novel Therapeutic Targets and Identifies GPNMB as a Diagnostic Marker for Human Disease

Author

Baba, Masaya, primary, Furuya, Mitsuko, primary, Motoshima, Takanobu, primary, Lang, Martin, primary, Funasaki, Shintaro, primary, Ma, Wenjuan, primary, Sun, Hong-Wei, primary, Hasumi, Hisashi, primary, Huang, Ying, primary, Kato, Ikuma, primary, Kadomatsu, Tsuyoshi, primary, Satou, Yorifumi, primary, Morris, Nicole, primary, Karim, Baktiar O., primary, Ileva, Lilia, primary, Kalen, Joseph D., primary, Wilan Krisna, Luh Ade, primary, Hasumi, Yukiko, primary, Sugiyama, Aiko, primary, Kurahashi, Ryoma, primary, Nishimoto, Koshiro, primary, Oyama, Masafumi, primary, Nagashima, Yoji, primary, Kuroda, Naoto, primary, Araki, Kimi, primary, Eto, Masatoshi, primary, Yao, Masahiro, primary, Kamba, Tomomi, primary, Suda, Toshio, primary, Oike, Yuichi, primary, Schmidt, Laura S., primary, and Linehan, W. Marston, primary

Published
2023
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28. Supplementary Figures 1 - 9 from Angiopoietin-like Protein 2 Accelerates Carcinogenesis by Activating Chronic Inflammation and Oxidative Stress

Author

Aoi, Jun, primary, Endo, Motoyoshi, primary, Kadomatsu, Tsuyoshi, primary, Miyata, Keishi, primary, Ogata, Aki, primary, Horiguchi, Haruki, primary, Odagiri, Haruki, primary, Masuda, Tetsuro, primary, Fukushima, Satoshi, primary, Jinnin, Masatoshi, primary, Hirakawa, Satoshi, primary, Sawa, Tomohiro, primary, Akaike, Takaaki, primary, Ihn, Hironobu, primary, and Oike, Yuichi, primary

Published
2023
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29. Supplemental Figure legends from TFE3 Xp11.2 Translocation Renal Cell Carcinoma Mouse Model Reveals Novel Therapeutic Targets and Identifies GPNMB as a Diagnostic Marker for Human Disease

Author

Baba, Masaya, primary, Furuya, Mitsuko, primary, Motoshima, Takanobu, primary, Lang, Martin, primary, Funasaki, Shintaro, primary, Ma, Wenjuan, primary, Sun, Hong-Wei, primary, Hasumi, Hisashi, primary, Huang, Ying, primary, Kato, Ikuma, primary, Kadomatsu, Tsuyoshi, primary, Satou, Yorifumi, primary, Morris, Nicole, primary, Karim, Baktiar O., primary, Ileva, Lilia, primary, Kalen, Joseph D., primary, Wilan Krisna, Luh Ade, primary, Hasumi, Yukiko, primary, Sugiyama, Aiko, primary, Kurahashi, Ryoma, primary, Nishimoto, Koshiro, primary, Oyama, Masafumi, primary, Nagashima, Yoji, primary, Kuroda, Naoto, primary, Araki, Kimi, primary, Eto, Masatoshi, primary, Yao, Masahiro, primary, Kamba, Tomomi, primary, Suda, Toshio, primary, Oike, Yuichi, primary, Schmidt, Laura S., primary, and Linehan, W. Marston, primary

Published
2023
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30. Supplementary Figures and Tables from TFE3 Xp11.2 Translocation Renal Cell Carcinoma Mouse Model Reveals Novel Therapeutic Targets and Identifies GPNMB as a Diagnostic Marker for Human Disease

Author

Baba, Masaya, primary, Furuya, Mitsuko, primary, Motoshima, Takanobu, primary, Lang, Martin, primary, Funasaki, Shintaro, primary, Ma, Wenjuan, primary, Sun, Hong-Wei, primary, Hasumi, Hisashi, primary, Huang, Ying, primary, Kato, Ikuma, primary, Kadomatsu, Tsuyoshi, primary, Satou, Yorifumi, primary, Morris, Nicole, primary, Karim, Baktiar O., primary, Ileva, Lilia, primary, Kalen, Joseph D., primary, Wilan Krisna, Luh Ade, primary, Hasumi, Yukiko, primary, Sugiyama, Aiko, primary, Kurahashi, Ryoma, primary, Nishimoto, Koshiro, primary, Oyama, Masafumi, primary, Nagashima, Yoji, primary, Kuroda, Naoto, primary, Araki, Kimi, primary, Eto, Masatoshi, primary, Yao, Masahiro, primary, Kamba, Tomomi, primary, Suda, Toshio, primary, Oike, Yuichi, primary, Schmidt, Laura S., primary, and Linehan, W. Marston, primary

Published
2023
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31. Data from Angiopoietin-like Protein 2 Is an Important Facilitator of Inflammatory Carcinogenesis and Metastasis

Author

Aoi, Jun, primary, Endo, Motoyoshi, primary, Kadomatsu, Tsuyoshi, primary, Miyata, Keishi, primary, Nakano, Masahiro, primary, Horiguchi, Haruki, primary, Ogata, Aki, primary, Odagiri, Haruki, primary, Yano, Masato, primary, Araki, Kimi, primary, Jinnin, Masatoshi, primary, Ito, Takaaki, primary, Hirakawa, Satoshi, primary, Ihn, Hironobu, primary, and Oike, Yuichi, primary

Published
2023
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32. Data from Tumor Cell–Derived Angiopoietin-like Protein ANGPTL2 Is a Critical Driver of Metastasis

Author

Endo, Motoyoshi, primary, Nakano, Masahiro, primary, Kadomatsu, Tsuyoshi, primary, Fukuhara, Shigetomo, primary, Kuroda, Hiroaki, primary, Mikami, Shuji, primary, Hato, Tai, primary, Aoi, Jun, primary, Horiguchi, Haruki, primary, Miyata, Keishi, primary, Odagiri, Haruki, primary, Masuda, Tetsuro, primary, Harada, Masahiko, primary, Horio, Hirotoshi, primary, Hishima, Tsunekazu, primary, Nomori, Hiroaki, primary, Ito, Takaaki, primary, Yamamoto, Yutaka, primary, Minami, Takashi, primary, Okada, Seiji, primary, Takahashi, Takashi, primary, Mochizuki, Naoki, primary, Iwase, Hirotaka, primary, and Oike, Yuichi, primary

Published
2023
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33. Supplementary Video 3 from Tumor Cell–Derived Angiopoietin-like Protein ANGPTL2 Is a Critical Driver of Metastasis

Author

Endo, Motoyoshi, primary, Nakano, Masahiro, primary, Kadomatsu, Tsuyoshi, primary, Fukuhara, Shigetomo, primary, Kuroda, Hiroaki, primary, Mikami, Shuji, primary, Hato, Tai, primary, Aoi, Jun, primary, Horiguchi, Haruki, primary, Miyata, Keishi, primary, Odagiri, Haruki, primary, Masuda, Tetsuro, primary, Harada, Masahiko, primary, Horio, Hirotoshi, primary, Hishima, Tsunekazu, primary, Nomori, Hiroaki, primary, Ito, Takaaki, primary, Yamamoto, Yutaka, primary, Minami, Takashi, primary, Okada, Seiji, primary, Takahashi, Takashi, primary, Mochizuki, Naoki, primary, Iwase, Hirotaka, primary, and Oike, Yuichi, primary

Published
2023
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34. Supplementary Video 2 from Tumor Cell–Derived Angiopoietin-like Protein ANGPTL2 Is a Critical Driver of Metastasis

Author

Endo, Motoyoshi, primary, Nakano, Masahiro, primary, Kadomatsu, Tsuyoshi, primary, Fukuhara, Shigetomo, primary, Kuroda, Hiroaki, primary, Mikami, Shuji, primary, Hato, Tai, primary, Aoi, Jun, primary, Horiguchi, Haruki, primary, Miyata, Keishi, primary, Odagiri, Haruki, primary, Masuda, Tetsuro, primary, Harada, Masahiko, primary, Horio, Hirotoshi, primary, Hishima, Tsunekazu, primary, Nomori, Hiroaki, primary, Ito, Takaaki, primary, Yamamoto, Yutaka, primary, Minami, Takashi, primary, Okada, Seiji, primary, Takahashi, Takashi, primary, Mochizuki, Naoki, primary, Iwase, Hirotaka, primary, and Oike, Yuichi, primary

Published
2023
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35. Supplementary Figures 1-19, Methods from Angiopoietin-like Protein 2 Is an Important Facilitator of Inflammatory Carcinogenesis and Metastasis

Author

Aoi, Jun, primary, Endo, Motoyoshi, primary, Kadomatsu, Tsuyoshi, primary, Miyata, Keishi, primary, Nakano, Masahiro, primary, Horiguchi, Haruki, primary, Ogata, Aki, primary, Odagiri, Haruki, primary, Yano, Masato, primary, Araki, Kimi, primary, Jinnin, Masatoshi, primary, Ito, Takaaki, primary, Hirakawa, Satoshi, primary, Ihn, Hironobu, primary, and Oike, Yuichi, primary

Published
2023
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36. Supplementary Video 4 from Tumor Cell–Derived Angiopoietin-like Protein ANGPTL2 Is a Critical Driver of Metastasis

Author

Endo, Motoyoshi, primary, Nakano, Masahiro, primary, Kadomatsu, Tsuyoshi, primary, Fukuhara, Shigetomo, primary, Kuroda, Hiroaki, primary, Mikami, Shuji, primary, Hato, Tai, primary, Aoi, Jun, primary, Horiguchi, Haruki, primary, Miyata, Keishi, primary, Odagiri, Haruki, primary, Masuda, Tetsuro, primary, Harada, Masahiko, primary, Horio, Hirotoshi, primary, Hishima, Tsunekazu, primary, Nomori, Hiroaki, primary, Ito, Takaaki, primary, Yamamoto, Yutaka, primary, Minami, Takashi, primary, Okada, Seiji, primary, Takahashi, Takashi, primary, Mochizuki, Naoki, primary, Iwase, Hirotaka, primary, and Oike, Yuichi, primary

Published
2023
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37. Supplementary Methods, Figures 1-18, Movie Legends 1-4, Tables 1-4 from Tumor Cell–Derived Angiopoietin-like Protein ANGPTL2 Is a Critical Driver of Metastasis

Author

Endo, Motoyoshi, primary, Nakano, Masahiro, primary, Kadomatsu, Tsuyoshi, primary, Fukuhara, Shigetomo, primary, Kuroda, Hiroaki, primary, Mikami, Shuji, primary, Hato, Tai, primary, Aoi, Jun, primary, Horiguchi, Haruki, primary, Miyata, Keishi, primary, Odagiri, Haruki, primary, Masuda, Tetsuro, primary, Harada, Masahiko, primary, Horio, Hirotoshi, primary, Hishima, Tsunekazu, primary, Nomori, Hiroaki, primary, Ito, Takaaki, primary, Yamamoto, Yutaka, primary, Minami, Takashi, primary, Okada, Seiji, primary, Takahashi, Takashi, primary, Mochizuki, Naoki, primary, Iwase, Hirotaka, primary, and Oike, Yuichi, primary

Published
2023
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38. Supplementary Video 1 from Tumor Cell–Derived Angiopoietin-like Protein ANGPTL2 Is a Critical Driver of Metastasis

Author

Endo, Motoyoshi, primary, Nakano, Masahiro, primary, Kadomatsu, Tsuyoshi, primary, Fukuhara, Shigetomo, primary, Kuroda, Hiroaki, primary, Mikami, Shuji, primary, Hato, Tai, primary, Aoi, Jun, primary, Horiguchi, Haruki, primary, Miyata, Keishi, primary, Odagiri, Haruki, primary, Masuda, Tetsuro, primary, Harada, Masahiko, primary, Horio, Hirotoshi, primary, Hishima, Tsunekazu, primary, Nomori, Hiroaki, primary, Ito, Takaaki, primary, Yamamoto, Yutaka, primary, Minami, Takashi, primary, Okada, Seiji, primary, Takahashi, Takashi, primary, Mochizuki, Naoki, primary, Iwase, Hirotaka, primary, and Oike, Yuichi, primary

Published
2023
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41. Aortic carboxypeptidase-like protein, a WNT ligand, exacerbates nonalcoholic steatohepatitis

Author

Teratani, Toshiaki, Tomita, Kengo, Suzuki, Takahiro, Furuhashi, Hirotaka, Irie, Rie, Nishikawa, Makoto, Yamamoto, Junji, Hibi, Toshifumi, Miura, Soichiro, Minamino, Tohru, Oike, Yuichi, Hokari, Ryota, and Kanai, Takanori

Subjects
Liver diseases -- Genetic aspects -- Development and progression -- Care and treatment, Cellular proteins -- Health aspects, Cellular signal transduction -- Genetic aspects -- Health aspects, Health care industry
Abstract

Incidence of nonalcoholic steatohepatitis (NASH), which is considered a hepatic manifestation of metabolic syndrome, has been increasing worldwide with the rise in obesity; however, its pathological mechanism is poorly understood. Here, we demonstrate that the hepatic expression of aortic carboxypeptidase-like protein (ACLP), a glycosylated, secreted protein, increases in NASH in humans and mice. Furthermore, we elucidate that ACLP is a ligand, unrelated to WNT proteins, that activates the canonical WNT pathway and exacerbates NASH pathology. In the liver, ACLP is specifically expressed in hepatic stellate cells (HSCs). As fatty liver disease progresses, ACLP expression is enhanced via activation of STAT3 signaling by obesity-related factors in serum. ACLP specifically binds to frizzled-8 and low- density lipoprotein-related receptor 6 to form a ternary complex that activates canonical WNT signaling. Consequently, ACLP activates HSCs by inhibiting PPARy signals. HSC-specific ACLP deficiency inhibits fibrosis progression in NASH by inhibiting canonical WNT signaling in HSCs. The present study elucidates the role of canonical WNT pathway activation by ACLP in NASH pathology, indicating that NASH can be treated by targeting ACLP-induced canonical WNT pathway activation in HSCs., Introduction Nonalcoholic fatty liver disease (NAFLD) is considered the hepatic manifestation of metabolic syndrome. Currently, NAFLD is the most prevalent liver disease in the world, with an estimated 1 billion [...]

Published
2018
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46. Increased numbers of pre-operative circulating monocytes predict risk of developing cardiac surgery-associated acute kidney injury in conditions requiring cardio pulmonary bypass

Author

Okadome, Yusuke, primary, Morinaga, Jun, additional, Yamanouchi, Yoshinori, additional, Matsunaga, Eiji, additional, Fukami, Hirotaka, additional, Kadomatsu, Tsuyoshi, additional, Horiguchi, Haruki, additional, Sato, Michio, additional, Sugizaki, Taichi, additional, Hayata, Manabu, additional, Sakaguchi, Takeshi, additional, Hirayama, Ryo, additional, Ishimura, Tatsuhiro, additional, Kuwabara, Takashige, additional, Usuku, Koichiro, additional, Yamamoto, Tatsuo, additional, Mukoyama, Masashi, additional, Suzuki, Ryusuke, additional, Fukui, Toshihiro, additional, and Oike, Yuichi, additional

Published
2022
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49. A circulating subset of iNKT cells mediates antitumor and antiviral immunity

Author

Cui, Guangwei, primary, Shimba, Akihiro, additional, Jin, Jianshi, additional, Ogawa, Taisaku, additional, Muramoto, Yukiko, additional, Miyachi, Hitoshi, additional, Abe, Shinya, additional, Asahi, Takuma, additional, Tani-ichi, Shizue, additional, Dijkstra, Johannes M., additional, Iwamoto, Yayoi, additional, Kryukov, Kirill, additional, Zhu, Yuanbo, additional, Takami, Daichi, additional, Hara, Takahiro, additional, Kitano, Satsuki, additional, Xu, Yan, additional, Morita, Hajime, additional, Zhang, Moyu, additional, Zreka, Lynn, additional, Miyata, Keishi, additional, Kanaya, Takashi, additional, Okumura, Shinya, additional, Ito, Takashi, additional, Hatano, Etsuro, additional, Takahashi, Yoshimasa, additional, Watarai, Hiroshi, additional, Oike, Yuichi, additional, Imanishi, Tadashi, additional, Ohno, Hiroshi, additional, Ohteki, Toshiaki, additional, Minato, Nagahiro, additional, Kubo, Masato, additional, Holländer, Georg A., additional, Ueno, Hideki, additional, Noda, Takeshi, additional, Shiroguchi, Katsuyuki, additional, and Ikuta, Koichi, additional

Published
2022
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50. Serum Angiopoietin-Like Protein 2 and NT-Pro BNP Levels and Their Associated Factors in Patients with Chronic Heart Failure Participating in a Phase III Cardiac Rehabilitation Program

Author

Tanaka, Chiharu, Kurose, Satoshi, Morinaga, Jun, Takao, Nana, Miyauchi, Takumi, Tsutsumi, Hiromi, Shiojima, Ichiro, Oike, Yuichi, and Kimura, Yutaka

Subjects
Heart Failure, Inflammation, Male, Cardiac Rehabilitation, Exercise Tolerance, Anaerobic Threshold, Hand Strength, Stroke Volume, Blood Proteins, Middle Aged, Peptide Fragments, Ventricular Function, Left, Angiopoietin-like Proteins, C-Reactive Protein, Cross-Sectional Studies, Echocardiography, Case-Control Studies, Chronic Disease, Multivariate Analysis, Natriuretic Peptide, Brain, Body Composition, Humans, Female, Biomarkers, Aged
Abstract

令和3年度, Angiopoietin-like protein 2 (ANGPTL2) promotes chronic inflammation and plays a key role in the pathogenesis of heart failure. Cardiac rehabilitation (CR) is an integral component of heart failure management and has been shown to have anti-inflammatory effects. However, ANGPTL2 concentration in chronic heart failure patients undergoing CR has not been evaluated. This study aimed to investigate serum ANGPTL2 levels and their associated factors and compare the results with those of N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with chronic heart failure undergoing phase III CR.A total of 56 patients were enrolled. Clinical characteristics including body composition, grip strength, exercise tolerance, duration of CR, blood counts and biochemistry, and echocardiographic parameters were evaluated for their association with serum ANGPTL2 and NT-proBNP levels.The median (first and third quartiles) value of ANGPTL2 was 4.05 (2.70-5.57) ng/mL. Clinical parameters that correlated with serum ANGPTL2 levels were body weight, body mass index, body fat mass, body fat percentage, anaerobic threshold (AT), C-reactive protein, and total protein (TP), which were mostly distinct from those that correlated with serum NT-proBNP levels. A multivariate analysis revealed that AT and TP were independent factors related to ANGPTL2 levels, whereas age, left ventricular ejection fraction, and left atrial dimension were independently related to NT-proBNP levels.These observations suggest that CR increases the exercise tolerance and exhibits anti-inflammatory effects simultaneously, and this situation is reflected by decreased serum ANGPLT2 and TP levels. ANGPTL2 may be a useful marker of inflammation and impaired exercise tolerance in patients with chronic heart failure.

Published
2021

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