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Your search keyword '"Oisin O’Brien"' showing total 3 results
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3 results on '"Oisin O’Brien"'

2. Dopamine partial agonists and prodopaminergic drugs for schizophrenia: Systematic review and meta-analysis of randomized controlled trials

Author

Martin Osugo, Thomas Whitehurst, Ekaterina Shatalina, Leigh Townsend, Oisin O’Brien, Tsz Lun Allenis Mak, Robert McCutcheon, and Oliver Howes

Subjects
Behavioral Neuroscience, Neuropsychology and Physiological Psychology, Dopamine, Cognitive Neuroscience, Dopamine Agonists, Schizophrenia, Humans, Antipsychotic Agents, Randomized Controlled Trials as Topic
Abstract

Dopaminergic dysfunction is thought to be central to schizophrenia symptomatology. Previous meta-analyses of prodopaminergic drugs in schizophrenia have important limitations, and also did not include dopamine D2/D3 partial agonists. We investigated the effect of medications which increase dopamine signalling on schizophrenia symptoms by meta-analysing double-blind, placebo-controlled RCTs. 59 RCTs were included: 29 of prodopaminergic treatments, 30 of partial agonists. Partial agonists were significantly superior to placebo against positive (SMD=-0.33,p = 1.2 ×10

Published
2022
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3. Immune response to vaccination in people with psychotic disorders relative to healthy controls: prospective study of SARS-CoV-2 vaccination

Author

Oisín O'Brien, Atheeshaan Arumuham, Yuya Mizuno, Luke Baxter, Maria Lobo, Sita Parmar, Stephen Jolles, and Oliver D. Howes

Subjects
Schizophrenia, SARS-CoV-2, immune response, vaccine, health policy, Psychiatry, RC435-571
Abstract

This prospective study examines the immune response to SARS-CoV-2 vaccination in patients with psychotic disorders compared with healthy volunteers. Participants were recruited naturalistically as part of the UK's COVID-19 vaccination programme. Prior to receiving their first COVID-19 vaccine, blood samples were provided by participants to examine anti-SARS-CoV-2 immunoglobulins (IgG) at baseline, followed by a repeat assay 1 month after receiving their first vaccine to assess vaccine response. The increase of IgG levels from baseline to 1 month post-vaccination was significantly lower in patients compared with controls, supporting evidence of impaired vaccine response in people with psychotic disorders. When excluding patients treated with clozapine from the analysis, this difference was no longer significant, suggesting that effects may be particularly marked in people taking clozapine.

Published
2024
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